PT3712152T - Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase - Google Patents
Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinaseInfo
- Publication number
- PT3712152T PT3712152T PT201716339T PT20171633T PT3712152T PT 3712152 T PT3712152 T PT 3712152T PT 201716339 T PT201716339 T PT 201716339T PT 20171633 T PT20171633 T PT 20171633T PT 3712152 T PT3712152 T PT 3712152T
- Authority
- PT
- Portugal
- Prior art keywords
- hexahydroimidazo
- imidazo
- tetrahydro
- pyridine
- kinase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1519381.6A GB201519381D0 (en) | 2015-11-03 | 2015-11-03 | Kinase inhibitors |
GB201606968 | 2016-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3712152T true PT3712152T (pt) | 2021-04-15 |
Family
ID=57256356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT201716339T PT3712152T (pt) | 2015-11-03 | 2016-11-02 | Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase |
Country Status (8)
Country | Link |
---|---|
US (1) | US10851097B2 (pt) |
EP (3) | EP3865481A1 (pt) |
CA (1) | CA3037243A1 (pt) |
DK (1) | DK3712152T3 (pt) |
ES (1) | ES2864035T3 (pt) |
PL (1) | PL3712152T3 (pt) |
PT (1) | PT3712152T (pt) |
WO (1) | WO2017077283A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017077288A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
US10100049B2 (en) | 2015-11-03 | 2018-10-16 | Theravance Biopharma R&D Ip, Llc | JAK kinase inhibitor compounds for treatment of respiratory disease |
DK3592742T3 (da) | 2017-03-09 | 2021-08-09 | Theravance Biopharma R&D Ip Llc | JAK inhibitorer med en 4-leddet heterocyclisk amid |
TW201900170A (zh) | 2017-05-01 | 2019-01-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 使用jak抑制劑化合物之治療方法 |
AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
TWI808083B (zh) | 2017-05-01 | 2023-07-11 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶型式 |
MY200629A (en) | 2017-08-01 | 2024-01-06 | Theravance Biopharma R&D Ip Llc | Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors |
MX2021002273A (es) | 2018-09-04 | 2021-05-27 | Theravance Biopharma R&D Ip Llc | Proceso para preparar inhibidores de las jak y productos intermedios de estos. |
AR116115A1 (es) | 2018-09-04 | 2021-03-31 | Theravance Biopharma R&D Ip Llc | Dimetil amino azetidina amidas como inhibidores de jak |
CN112703037B (zh) * | 2018-09-04 | 2023-10-20 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的5至7元杂环酰胺 |
EP3853229A1 (en) * | 2018-10-29 | 2021-07-28 | Theravance Biopharma R&D IP, LLC | 2-azabicyclo hexane compound as jak inhibitor |
EP3914348A1 (en) * | 2019-01-23 | 2021-12-01 | Theravance Biopharma R&D IP, LLC | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
CN114075200A (zh) * | 2020-08-14 | 2022-02-22 | 河南迈英诺医药科技有限公司 | 用于治疗重症肺炎的jak抑制剂化合物 |
PE20212069A1 (es) | 2019-02-25 | 2021-10-26 | Henan Medinno Pharmaceutical Tech Co Ltd | Compuesto inhibidor de jak y uso del mismo |
TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
WO2022268080A1 (zh) * | 2021-06-21 | 2022-12-29 | 河南迈英诺医药科技有限公司 | Trk激酶抑制剂化合物及其用途 |
CN117343063A (zh) * | 2022-07-04 | 2024-01-05 | 河南迈英诺医药科技有限公司 | 作为trk抑制剂和/或ret抑制剂的化合物及其用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ582188A (en) | 2007-07-11 | 2012-03-30 | Pfizer | Pharmaceutical compositions and methods of treating dry eye disorders |
US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
FR2981917B1 (fr) | 2011-10-26 | 2013-11-15 | Cadorit Ag | Recipient pour emballer un premier fluide et un deuxieme fluide |
KR102061382B1 (ko) | 2012-06-22 | 2019-12-31 | 미메토젠 파르마슈티칼스 인크. | 베타-턴 펩티도미메틱 환상 화합물의 합성 |
EP3143021B1 (en) | 2014-05-14 | 2019-06-12 | Pfizer Inc | Pyrazolopyridines and pyrazolopyrimidines |
LT3303348T (lt) | 2015-05-28 | 2019-11-25 | Theravance Biopharma R&D Ip Llc | Naftiridino junginiai, kaip jak kinazės inhibitoriai |
WO2017077288A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
US10100049B2 (en) | 2015-11-03 | 2018-10-16 | Theravance Biopharma R&D Ip, Llc | JAK kinase inhibitor compounds for treatment of respiratory disease |
AU2016359494B2 (en) | 2015-11-24 | 2021-01-07 | Theravance Biopharma R&D Ip, Llc | Prodrugs of a JAK inhibitor compound for treatment of gastrointestinal inflammatory disease |
BR112018072168A2 (pt) | 2016-04-28 | 2019-02-12 | Theravance Biopharma R&D Ip, Llc | compostos derivados da pirimidina como inibidores da quinase jak |
-
2016
- 2016-11-02 PT PT201716339T patent/PT3712152T/pt unknown
- 2016-11-02 EP EP21151168.8A patent/EP3865481A1/en not_active Withdrawn
- 2016-11-02 DK DK20171633.9T patent/DK3712152T3/da active
- 2016-11-02 CA CA3037243A patent/CA3037243A1/en not_active Abandoned
- 2016-11-02 PL PL20171633T patent/PL3712152T3/pl unknown
- 2016-11-02 EP EP16793973.5A patent/EP3371184A1/en not_active Withdrawn
- 2016-11-02 WO PCT/GB2016/053387 patent/WO2017077283A1/en active Application Filing
- 2016-11-02 US US15/772,861 patent/US10851097B2/en active Active
- 2016-11-02 EP EP20171633.9A patent/EP3712152B1/en active Active
- 2016-11-02 ES ES20171633T patent/ES2864035T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
WO2017077283A1 (en) | 2017-05-11 |
US10851097B2 (en) | 2020-12-01 |
ES2864035T3 (es) | 2021-10-13 |
EP3712152A1 (en) | 2020-09-23 |
CA3037243A1 (en) | 2017-05-11 |
US20180319791A1 (en) | 2018-11-08 |
EP3712152B1 (en) | 2021-01-13 |
PL3712152T3 (pl) | 2021-08-02 |
EP3865481A1 (en) | 2021-08-18 |
EP3371184A1 (en) | 2018-09-12 |
DK3712152T3 (da) | 2021-03-22 |
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