JP2018528275A5 - - Google Patents
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- Publication number
- JP2018528275A5 JP2018528275A5 JP2018534521A JP2018534521A JP2018528275A5 JP 2018528275 A5 JP2018528275 A5 JP 2018528275A5 JP 2018534521 A JP2018534521 A JP 2018534521A JP 2018534521 A JP2018534521 A JP 2018534521A JP 2018528275 A5 JP2018528275 A5 JP 2018528275A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- hydrogen
- alkoxy
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- 239000001257 hydrogen Substances 0.000 claims 50
- 150000002431 hydrogen Chemical class 0.000 claims 47
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000003545 alkoxy group Chemical group 0.000 claims 38
- 125000004423 acyloxy group Chemical group 0.000 claims 36
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 125000003282 alkyl amino group Chemical group 0.000 claims 27
- 125000004663 dialkyl amino group Chemical group 0.000 claims 25
- 125000002252 acyl group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 23
- -1 hydroxy, amino Chemical group 0.000 claims 21
- 125000000547 substituted alkyl group Chemical group 0.000 claims 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 19
- 125000001769 aryl amino group Chemical group 0.000 claims 18
- 125000004104 aryloxy group Chemical group 0.000 claims 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 16
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 16
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 150000001408 amides Chemical class 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000003302 alkenyloxy group Chemical group 0.000 claims 9
- 125000006323 alkenyl amino group Chemical group 0.000 claims 8
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 6
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 5
- 150000001241 acetals Chemical class 0.000 claims 5
- 125000000033 alkoxyamino group Chemical group 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 5
- 150000002373 hemiacetals Chemical class 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 125000005035 acylthio group Chemical group 0.000 claims 4
- BWOVZCWSJFYBRM-UHFFFAOYSA-N carbononitridic isocyanate Chemical group O=C=NC#N BWOVZCWSJFYBRM-UHFFFAOYSA-N 0.000 claims 4
- 125000005241 heteroarylamino group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222632P | 2015-09-23 | 2015-09-23 | |
| US62/222,632 | 2015-09-23 | ||
| PCT/US2016/053545 WO2017053868A1 (en) | 2015-09-23 | 2016-09-23 | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528275A JP2018528275A (ja) | 2018-09-27 |
| JP2018528275A5 true JP2018528275A5 (https=) | 2019-11-07 |
| JP7074674B2 JP7074674B2 (ja) | 2022-05-24 |
Family
ID=57137257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534521A Active JP7074674B2 (ja) | 2015-09-23 | 2016-09-23 | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11584775B2 (https=) |
| EP (1) | EP3353190B1 (https=) |
| JP (1) | JP7074674B2 (https=) |
| KR (1) | KR102796889B1 (https=) |
| CN (1) | CN108290922B (https=) |
| AU (1) | AU2016326704B2 (https=) |
| BR (1) | BR112018005861B1 (https=) |
| CA (1) | CA2998681C (https=) |
| EA (1) | EA201890767A1 (https=) |
| ES (1) | ES2865163T3 (https=) |
| IL (1) | IL258185B (https=) |
| MX (1) | MX386256B (https=) |
| NZ (1) | NZ741082A (https=) |
| WO (1) | WO2017053868A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| AR096046A1 (es) | 2013-04-24 | 2015-12-02 | Abbvie Inc | Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso |
| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| CN108299541B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用 |
| CN108191944B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用 |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| CN109248168A (zh) * | 2018-10-30 | 2019-01-22 | 武汉卫无忧生物科技有限公司 | 齐墩果酸在制备抗幽门螺杆菌的药物中的用途 |
| TWI752400B (zh) | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| EP3999522B1 (en) * | 2019-07-19 | 2025-09-03 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| AU2021397631A1 (en) | 2020-12-11 | 2023-07-20 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
| MX2023008454A (es) * | 2021-01-18 | 2023-08-07 | Reata Pharmaceuticals Inc | Derivados sintéticos de ácido ursólico y métodos de uso de estos. |
| CN113185570A (zh) * | 2021-05-12 | 2021-07-30 | 张洪胜 | 一种治疗银屑病的齐墩果酸衍生物及其制备方法 |
| CN117964678A (zh) * | 2024-01-29 | 2024-05-03 | 烟台大学 | C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途 |
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| US6369101B1 (en) | 1999-02-26 | 2002-04-09 | Regents Of The University Of Minnesota | Therapeutic method to treat herpes virus infection |
| DE60043400D1 (de) | 1999-05-14 | 2010-01-07 | Nereus Pharmaceuticals Inc | Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren |
| US6649654B1 (en) | 1999-11-23 | 2003-11-18 | The Regents Of The University Of California | Methods for identifying and using IKK inhibitors |
| WO2002003996A1 (en) | 2000-07-12 | 2002-01-17 | RAJKUMAR, Sujatha | Use of dammarane-type tritepenoid saporins |
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| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
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| WO2016033132A1 (en) | 2014-08-26 | 2016-03-03 | Trustees Of Dartmouth College | Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole |
| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| EP3999522B1 (en) | 2019-07-19 | 2025-09-03 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| CA3159778A1 (en) | 2019-12-19 | 2021-06-24 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids with nitrogen-based substituents at c-17 and methods of use thereof |
-
2016
- 2016-09-23 JP JP2018534521A patent/JP7074674B2/ja active Active
- 2016-09-23 EA EA201890767A patent/EA201890767A1/ru unknown
- 2016-09-23 BR BR112018005861-0A patent/BR112018005861B1/pt active IP Right Grant
- 2016-09-23 KR KR1020187011430A patent/KR102796889B1/ko active Active
- 2016-09-23 CN CN201680067912.8A patent/CN108290922B/zh active Active
- 2016-09-23 ES ES16781915T patent/ES2865163T3/es active Active
- 2016-09-23 MX MX2018003569A patent/MX386256B/es unknown
- 2016-09-23 US US15/760,662 patent/US11584775B2/en active Active
- 2016-09-23 NZ NZ741082A patent/NZ741082A/en unknown
- 2016-09-23 EP EP16781915.0A patent/EP3353190B1/en active Active
- 2016-09-23 AU AU2016326704A patent/AU2016326704B2/en active Active
- 2016-09-23 CA CA2998681A patent/CA2998681C/en active Active
- 2016-09-23 WO PCT/US2016/053545 patent/WO2017053868A1/en not_active Ceased
-
2018
- 2018-03-18 IL IL258185A patent/IL258185B/en unknown
-
2023
- 2023-01-04 US US18/149,696 patent/US12545701B2/en active Active
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