JP2014043462A5 - - Google Patents
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- JP2014043462A5 JP2014043462A5 JP2013244692A JP2013244692A JP2014043462A5 JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5 JP 2013244692 A JP2013244692 A JP 2013244692A JP 2013244692 A JP2013244692 A JP 2013244692A JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- amino
- nucleic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- -1 2-oxo-1,2-dihydropyrimidin-1-yl group Chemical group 0.000 claims 22
- 238000001668 nucleic acid synthesis Methods 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009248979 | 2009-10-29 | ||
| JP2009248979 | 2009-10-29 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Division JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014043462A JP2014043462A (ja) | 2014-03-13 |
| JP2014043462A5 true JP2014043462A5 (https=) | 2014-05-29 |
| JP5669073B2 JP5669073B2 (ja) | 2015-02-12 |
Family
ID=43921860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
| JP2013244692A Active JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8541562B2 (https=) |
| EP (1) | EP2495248B1 (https=) |
| JP (2) | JPWO2011052436A1 (https=) |
| CN (1) | CN102596983B (https=) |
| AU (1) | AU2010312751B2 (https=) |
| CA (1) | CA2778171C (https=) |
| WO (1) | WO2011052436A1 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5875006B2 (ja) * | 2010-08-31 | 2016-03-02 | 国立大学法人大阪大学 | オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤 |
| EP2792746A4 (en) | 2011-12-12 | 2015-09-16 | Nat Cerebral & Cardiovascular Ct | OLIGONUCLEOTIDE AND THERAPEUTIC FOR HYPERLIPIDEMIA WITH THIS AS AN ACTIVE SUBSTANCE |
| WO2013191129A1 (ja) | 2012-06-18 | 2013-12-27 | 第一三共株式会社 | ヌクレオシド類縁体の製造中間体及びその製造方法 |
| US10377789B2 (en) * | 2012-09-21 | 2019-08-13 | Osaka University | Oligonucleotide and artificial nucleoside having guanidine bridge |
| JP6270742B2 (ja) * | 2013-01-10 | 2018-01-31 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| WO2014112463A1 (ja) * | 2013-01-15 | 2014-07-24 | 国立大学法人大阪大学 | スルホンアミド構造を有するヌクレオシドおよびヌクレオチド |
| EP2957567B1 (en) * | 2013-02-18 | 2019-06-05 | Shionogi & Co., Ltd. | Nucleoside and nucleotide, having nitrogen-containing hetercycle structure |
| WO2015020194A1 (ja) * | 2013-08-09 | 2015-02-12 | 国立大学法人大阪大学 | Ａｃｓｌ１に対するアンチセンスオリゴヌクレオチド |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| JP6722586B2 (ja) * | 2014-07-10 | 2020-07-15 | 賢二 中野 | アンチセンス抗悪性腫瘍剤 |
| CN107109411B (zh) | 2014-10-03 | 2022-07-01 | 冷泉港实验室 | 核基因输出的定向增加 |
| JP2018140938A (ja) * | 2015-07-24 | 2018-09-13 | 日産化学株式会社 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| EP3359685B1 (en) | 2015-10-09 | 2026-01-28 | University Of Southampton | Modulation of gene expression for deregulated protein expression |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| EP3933041B1 (en) | 2015-12-14 | 2024-01-31 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of autosomal dominant retardation |
| JP6569920B2 (ja) * | 2016-01-07 | 2019-09-04 | 国立大学法人大阪大学 | α−シヌクレイン発現抑制剤 |
| WO2017131124A1 (ja) | 2016-01-26 | 2017-08-03 | 日産化学工業株式会社 | 一本鎖オリゴヌクレオチド |
| WO2017142054A1 (ja) | 2016-02-17 | 2017-08-24 | 国立大学法人東京工業大学 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| JP2020055750A (ja) * | 2017-01-30 | 2020-04-09 | 賢二 中野 | 癌浸潤または転移阻害核酸薬 |
| CN110337495B (zh) | 2017-02-06 | 2024-03-29 | 日产化学株式会社 | 单链寡核苷酸 |
| WO2018155450A1 (ja) | 2017-02-21 | 2018-08-30 | 国立大学法人大阪大学 | アンチセンスオリゴ核酸 |
| JP7138349B2 (ja) * | 2017-02-21 | 2022-09-16 | 国立大学法人大阪大学 | 核酸化合物およびオリゴヌクレオチド |
| WO2018181428A1 (ja) | 2017-03-29 | 2018-10-04 | 塩野義製薬株式会社 | 核酸医薬及び多分岐脂質の複合体 |
| WO2018180005A1 (ja) | 2017-03-31 | 2018-10-04 | 国立研究開発法人日本医療研究開発機構 | コンドロイチン硫酸生合成を阻害するアンチセンス核酸 |
| US11273222B2 (en) | 2017-05-26 | 2022-03-15 | National Cerebral And Cardiovascular Center | Antisense nucleic acid targeting PCSK9 |
| WO2019009299A1 (ja) | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制するＥＮＡアンチセンスオリゴヌクレオチド |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| AU2018307294B2 (en) | 2017-07-26 | 2025-04-17 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| SG11202001590RA (en) | 2017-08-25 | 2020-03-30 | Stoke Therapeutics Inc | Antisense oligomers for treatment of conditions and diseases |
| MY199245A (en) | 2017-08-31 | 2023-10-23 | Hyogo College Medicine | Il-33 antagonist-containing therapeutic agent for endometriosis |
| MX2020009765A (es) | 2018-03-20 | 2021-01-08 | Tokyo Inst Tech | Oligonucleotido antisentido reducido en toxicidad. |
| US12060558B2 (en) | 2018-05-04 | 2024-08-13 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| WO2020027227A1 (ja) | 2018-07-31 | 2020-02-06 | 国立大学法人大阪大学 | オリゴヌクレオチドを含有する小細胞肺癌治療薬 |
| KR20210134003A (ko) | 2019-02-27 | 2021-11-08 | 스톡 테라퓨틱스, 인크. | 병태 및 질환의 치료를 위한 안티센스 올리고머 |
| WO2020203896A1 (ja) | 2019-03-29 | 2020-10-08 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| CN113905744A (zh) | 2019-05-31 | 2022-01-07 | 阿利戈斯治疗公司 | 经修饰的间隙子寡核苷酸及其使用方法 |
| WO2021020412A1 (ja) | 2019-07-30 | 2021-02-04 | 塩野義製薬株式会社 | Ｍｕｒｆ１を標的とする核酸医薬 |
| EP4023297A4 (en) | 2019-08-27 | 2024-07-31 | National University Corporation Tokai National Higher Education and Research System | Nucleic acid medicine for targeting gastric cancer molecule |
| WO2021127406A1 (en) * | 2019-12-19 | 2021-06-24 | The Regents Of The University Of California | Methods of producing target capture nucleic acids |
| WO2021132648A1 (ja) * | 2019-12-27 | 2021-07-01 | ルクサナバイオテク株式会社 | Ｒｅｃｑｌの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途 |
| EP4129338A4 (en) | 2020-03-02 | 2024-04-10 | Mitsubishi Tanabe Pharma Corporation | PREVENTION OR TREATMENT OF ANEURYSMS WITH MIR-33B INHIBITOR |
| WO2021193965A1 (ja) | 2020-03-26 | 2021-09-30 | 国立研究開発法人国立循環器病研究センター | Ａｐｏｃ３を標的としたアンチセンス核酸 |
| AU2021260934A1 (en) | 2020-04-21 | 2022-11-24 | Flagship Pioneering, Inc. | Bifunctional molecules and methods of using thereof |
| BR112022022889A2 (pt) | 2020-05-11 | 2023-04-04 | Stoke Therapeutics Inc | Oligômeros antissentido de opa1 para tratamento de condições e doenças |
| JP7725490B2 (ja) | 2020-09-25 | 2025-08-19 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| EP4252846A4 (en) | 2020-11-06 | 2025-12-03 | Sumitomo Pharma Co Ltd | REGULATOR FOR THE EXPRESSION AND/OR FUNCTION OF THE RPS25 GENE |
| JPWO2022181807A1 (https=) | 2021-02-25 | 2022-09-01 | ||
| JPWO2022230987A1 (https=) | 2021-04-30 | 2022-11-03 | ||
| US20240247263A1 (en) | 2021-05-06 | 2024-07-25 | Luxna Biotech Co., Ltd. | Method for designing oligonucleotide having reduced central toxicity |
| TW202313975A (zh) | 2021-05-28 | 2023-04-01 | 日商住友製藥股份有限公司 | 反義核酸 |
| US20240390508A1 (en) | 2021-08-21 | 2024-11-28 | Takeda Pharmaceutical Company Limited | Human transferrin receptor binding peptide-drug conjugate |
| JPWO2023127857A1 (https=) | 2021-12-27 | 2023-07-06 | ||
| US20250223596A1 (en) | 2022-03-17 | 2025-07-10 | Aichi Medical University | Antisense nucleic acid capable of inhibiting biosynthesis of chondroitin sulfate |
| CN120187739A (zh) | 2022-11-10 | 2025-06-20 | 璐库萨那生物技术株式会社 | 桥联部具有胍基结构的修饰核苷和使用其的寡核苷酸的制造方法 |
| WO2024181416A1 (ja) | 2023-02-28 | 2024-09-06 | 国立大学法人大阪大学 | オリゴヌクレオチド、ならびにそれを用いるｒｅｓｔ発現抑制剤および医薬組成物 |
| TW202511485A (zh) | 2023-06-16 | 2025-03-16 | 日商住友製藥股份有限公司 | 調節ｒｐｓ２５基因之表現及／或其功能的反義寡核苷酸 |
| WO2025005265A1 (ja) * | 2023-06-30 | 2025-01-02 | 日産化学株式会社 | 毒性が低減されたアンチセンスオリゴヌクレオチド |
| WO2025240506A1 (en) | 2024-05-14 | 2025-11-20 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| CA2333380A1 (en) * | 1998-05-26 | 1999-12-02 | Icn Pharmaceuticals, Inc. | Novel nucleosides having bicyclic sugar moiety |
| EP1481983A4 (en) | 2002-02-13 | 2008-04-02 | Takeshi Imanishi | NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF |
| EP1661905B9 (en) | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| JP5875006B2 (ja) * | 2010-08-31 | 2016-03-02 | 国立大学法人大阪大学 | オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤 |
-
2010
- 2010-10-19 AU AU2010312751A patent/AU2010312751B2/en active Active
- 2010-10-19 JP JP2011538366A patent/JPWO2011052436A1/ja not_active Ceased
- 2010-10-19 EP EP10826568.7A patent/EP2495248B1/en active Active
- 2010-10-19 WO PCT/JP2010/068409 patent/WO2011052436A1/ja not_active Ceased
- 2010-10-19 CN CN201080049279.2A patent/CN102596983B/zh active Active
- 2010-10-19 US US13/502,611 patent/US8541562B2/en active Active
- 2010-10-19 CA CA2778171A patent/CA2778171C/en active Active
-
2013
- 2013-11-27 JP JP2013244692A patent/JP5669073B2/ja active Active
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