JP2014043462A5 - - Google Patents
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- JP2014043462A5 JP2014043462A5 JP2013244692A JP2013244692A JP2014043462A5 JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5 JP 2013244692 A JP2013244692 A JP 2013244692A JP 2013244692 A JP2013244692 A JP 2013244692A JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- amino
- nucleic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- -1 2-oxo-1,2-dihydropyrimidin-1-yl group Chemical group 0.000 claims 22
- 238000001668 nucleic acid synthesis Methods 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009248979 | 2009-10-29 | ||
| JP2009248979 | 2009-10-29 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Division JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014043462A JP2014043462A (ja) | 2014-03-13 |
| JP2014043462A5 true JP2014043462A5 (https=) | 2014-05-29 |
| JP5669073B2 JP5669073B2 (ja) | 2015-02-12 |
Family
ID=43921860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
| JP2013244692A Active JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8541562B2 (https=) |
| EP (1) | EP2495248B1 (https=) |
| JP (2) | JPWO2011052436A1 (https=) |
| CN (1) | CN102596983B (https=) |
| AU (1) | AU2010312751B2 (https=) |
| CA (1) | CA2778171C (https=) |
| WO (1) | WO2011052436A1 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9127280B2 (en) | 2010-08-31 | 2015-09-08 | Osaka University | Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient |
| EP2792746A4 (en) | 2011-12-12 | 2015-09-16 | Nat Cerebral & Cardiovascular Ct | OLIGONUCLEOTIDE AND THERAPEUTIC FOR HYPERLIPIDEMIA WITH THIS AS AN ACTIVE SUBSTANCE |
| EP2862868B1 (en) * | 2012-06-18 | 2020-04-08 | Daiichi Sankyo Company, Limited | Intermediate for production of nucleoside analogue, and method for producing same |
| KR101707437B1 (ko) | 2012-09-21 | 2017-02-16 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 구아니딘 가교를 갖는 인공 뉴클레오시드 및 올리고뉴클레오티드 |
| WO2014109384A1 (ja) * | 2013-01-10 | 2014-07-17 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| US20150337002A1 (en) * | 2013-01-15 | 2015-11-26 | Shionogi & Co., Ltd. | Nucleoside and nucleotide having sulfonamide structure |
| WO2014126229A1 (ja) | 2013-02-18 | 2014-08-21 | 塩野義製薬株式会社 | 含窒素複素環構造を有するヌクレオシド及びヌクレオチド |
| WO2015020194A1 (ja) * | 2013-08-09 | 2015-02-12 | 国立大学法人大阪大学 | Ａｃｓｌ１に対するアンチセンスオリゴヌクレオチド |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| JP6722586B2 (ja) * | 2014-07-10 | 2020-07-15 | 賢二 中野 | アンチセンス抗悪性腫瘍剤 |
| AU2015327836B2 (en) | 2014-10-03 | 2021-07-01 | Cold Spring Harbor Laboratory | Targeted augmentation of nuclear gene output |
| JP2018140938A (ja) * | 2015-07-24 | 2018-09-13 | 日産化学株式会社 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| CN108603230A (zh) | 2015-10-09 | 2018-09-28 | 南安普敦大学 | 基因表达的调节与蛋白质表达失调的筛选 |
| WO2017106377A1 (en) | 2015-12-14 | 2017-06-22 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| WO2017119463A1 (ja) * | 2016-01-07 | 2017-07-13 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| WO2017131124A1 (ja) | 2016-01-26 | 2017-08-03 | 日産化学工業株式会社 | 一本鎖オリゴヌクレオチド |
| EP3418289B1 (en) | 2016-02-17 | 2026-04-08 | Institute Of Science Tokyo | Artificial nucleoside and artificial nucleotide, and artificial oligonucleotide |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| JP2020055750A (ja) * | 2017-01-30 | 2020-04-09 | 賢二 中野 | 癌浸潤または転移阻害核酸薬 |
| AU2018215440B2 (en) | 2017-02-06 | 2024-10-24 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| EP3587576A4 (en) | 2017-02-21 | 2021-01-06 | Osaka University | ANTISENSE OLIGONUCLEIC ACID |
| US11286275B2 (en) | 2017-02-21 | 2022-03-29 | Osaka University | Nucleic acid compound and oligonucleotide |
| EP3603648B1 (en) | 2017-03-29 | 2025-09-17 | Shionogi & Co., Ltd | Complex of nucleic acid medicine and multibranched lipid |
| JP7141621B2 (ja) | 2017-03-31 | 2022-09-26 | 学校法人 愛知医科大学 | コンドロイチン硫酸生合成を阻害するアンチセンス核酸 |
| US11273222B2 (en) | 2017-05-26 | 2022-03-15 | National Cerebral And Cardiovascular Center | Antisense nucleic acid targeting PCSK9 |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| WO2019009299A1 (ja) | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制するＥＮＡアンチセンスオリゴヌクレオチド |
| BR112020001430A2 (pt) | 2017-07-26 | 2020-07-28 | Nissan Chemical Corporation | oligonucleotídeo de fita simples |
| KR102318434B1 (ko) | 2017-08-25 | 2021-11-01 | 스톡 테라퓨틱스, 인크. | 병태 및 질환 치료용 안티센스 올리고머 |
| IL272864B2 (en) | 2017-08-31 | 2024-03-01 | Mitsubishi Tanabe Pharma Corp | Il-33 antagonist-containing therapeutic agent for endometriosis |
| BR112020018902A2 (pt) | 2018-03-20 | 2021-01-26 | Tokyo Institute Of Technology | oligonucleotídeo antissenso com toxicidade reduzida |
| CA3099280A1 (en) | 2018-05-04 | 2019-11-07 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| JP7473113B2 (ja) * | 2018-07-31 | 2024-04-23 | 国立大学法人大阪大学 | オリゴヌクレオチドを含有する小細胞肺癌治療薬 |
| AU2020227825B2 (en) | 2019-02-27 | 2026-03-26 | Stoke Therapeutics, Inc. | Antisense oligomers for treatment of conditions and diseases |
| WO2020203896A1 (ja) | 2019-03-29 | 2020-10-08 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| SG11202112741XA (en) | 2019-05-31 | 2021-12-30 | Aligos Therapeutics Inc | Modified gapmer oligonucleotides and methods of use |
| JP7692829B2 (ja) | 2019-07-30 | 2025-06-16 | 塩野義製薬株式会社 | Ｍｕｒｆ１を標的とする核酸医薬 |
| US20220282248A1 (en) | 2019-08-27 | 2022-09-08 | National University Corporation Tokai National Higher Education And Research System | Molecular targeted nucleic acid medicine for gastric cancer |
| WO2021127406A1 (en) * | 2019-12-19 | 2021-06-24 | The Regents Of The University Of California | Methods of producing target capture nucleic acids |
| WO2021132648A1 (ja) * | 2019-12-27 | 2021-07-01 | ルクサナバイオテク株式会社 | Ｒｅｃｑｌの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途 |
| WO2021177267A1 (ja) | 2020-03-02 | 2021-09-10 | 田辺三菱製薬株式会社 | ｍｉＲ－３３ｂ阻害物質による動脈瘤の予防または治療 |
| US20230113556A1 (en) | 2020-03-26 | 2023-04-13 | National Cerebral And Cardiovascular Center | Antisense nucleic acid targeting apoc3 |
| CN115916262A (zh) | 2020-04-21 | 2023-04-04 | 旗舰创业股份有限公司 | 双官能分子及其使用方法 |
| CN115867657A (zh) | 2020-05-11 | 2023-03-28 | 斯托克制药公司 | 用于治疗疾患和疾病的opa1反义寡聚物 |
| CN116322706B (zh) | 2020-09-25 | 2025-12-05 | 株式会社理真思 | 新人工核酸、其制造方法和用途 |
| CN116507727A (zh) | 2020-11-06 | 2023-07-28 | 住友制药株式会社 | Rps25基因的表达和/或功能调节剂 |
| US20240148775A1 (en) | 2021-02-25 | 2024-05-09 | Osaka University | Oligonucleotide for inducing n-exon skipping during rest mrna precursor processing |
| EP4331606A4 (en) | 2021-04-30 | 2025-05-07 | Kyoto University | PREVENTION OR TREATMENT OF MYOPATHY USING A MIR-33B INHIBITOR |
| US20240247263A1 (en) | 2021-05-06 | 2024-07-25 | Luxna Biotech Co., Ltd. | Method for designing oligonucleotide having reduced central toxicity |
| TW202313975A (zh) | 2021-05-28 | 2023-04-01 | 日商住友製藥股份有限公司 | 反義核酸 |
| US20240390508A1 (en) | 2021-08-21 | 2024-11-28 | Takeda Pharmaceutical Company Limited | Human transferrin receptor binding peptide-drug conjugate |
| EP4458836A4 (en) | 2021-12-27 | 2025-05-21 | Riken Genesis Co., Ltd. | Novel artificial nucleic acid, method for producing same, and use of same |
| EP4495242A1 (en) | 2022-03-17 | 2025-01-22 | Aichi Medical University | Antisense nucleic acid capable of inhibiting biosynthesis of chondroitin sulfate |
| WO2024101446A1 (ja) | 2022-11-10 | 2024-05-16 | ルクサナバイオテク株式会社 | 架橋部にグアニジノ構造を有する修飾ヌクレオシドおよびそれを用いたオリゴヌクレオチドの製造方法 |
| JPWO2024181416A1 (https=) | 2023-02-28 | 2024-09-06 | ||
| JPWO2024257847A1 (https=) | 2023-06-16 | 2024-12-19 | ||
| JPWO2025005265A1 (https=) * | 2023-06-30 | 2025-01-02 | ||
| US20250368996A1 (en) | 2024-05-14 | 2025-12-04 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| JP2002516256A (ja) | 1998-05-26 | 2002-06-04 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | 二環式糖成分を有する新規ヌクレオシド |
| EP1481983A4 (en) | 2002-02-13 | 2008-04-02 | Takeshi Imanishi | NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF |
| EP1661905B9 (en) * | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| US9127280B2 (en) * | 2010-08-31 | 2015-09-08 | Osaka University | Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient |
-
2010
- 2010-10-19 CA CA2778171A patent/CA2778171C/en active Active
- 2010-10-19 US US13/502,611 patent/US8541562B2/en active Active
- 2010-10-19 AU AU2010312751A patent/AU2010312751B2/en active Active
- 2010-10-19 CN CN201080049279.2A patent/CN102596983B/zh active Active
- 2010-10-19 JP JP2011538366A patent/JPWO2011052436A1/ja not_active Ceased
- 2010-10-19 EP EP10826568.7A patent/EP2495248B1/en active Active
- 2010-10-19 WO PCT/JP2010/068409 patent/WO2011052436A1/ja not_active Ceased
-
2013
- 2013-11-27 JP JP2013244692A patent/JP5669073B2/ja active Active
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