JP2013535220A5 - - Google Patents
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- Publication number
- JP2013535220A5 JP2013535220A5 JP2013524130A JP2013524130A JP2013535220A5 JP 2013535220 A5 JP2013535220 A5 JP 2013535220A5 JP 2013524130 A JP2013524130 A JP 2013524130A JP 2013524130 A JP2013524130 A JP 2013524130A JP 2013535220 A5 JP2013535220 A5 JP 2013535220A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- preparing
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC(*)C(N(COC(*)=O)C(*)CC(*)c1nc(*)c[s]1)=O Chemical compound CC(*)C(N(COC(*)=O)C(*)CC(*)c1nc(*)c[s]1)=O 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37143310P | 2010-08-06 | 2010-08-06 | |
| US61/371,433 | 2010-08-06 | ||
| PCT/US2011/046797 WO2012019123A1 (en) | 2010-08-06 | 2011-08-05 | Processes for preparing tubulysins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013535220A JP2013535220A (ja) | 2013-09-12 |
| JP2013535220A5 true JP2013535220A5 (https=) | 2014-10-16 |
Family
ID=45559842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524130A Ceased JP2013535220A (ja) | 2010-08-06 | 2011-08-05 | ツブリシンを調製するためのプロセス |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8889880B2 (https=) |
| EP (1) | EP2600866A4 (https=) |
| JP (1) | JP2013535220A (https=) |
| KR (1) | KR20130096712A (https=) |
| CN (1) | CN103140227B (https=) |
| AU (1) | AU2011285532B2 (https=) |
| BR (1) | BR112013003004A2 (https=) |
| CA (1) | CA2807511A1 (https=) |
| EA (1) | EA025471B1 (https=) |
| MX (1) | MX2013001402A (https=) |
| SG (1) | SG187728A1 (https=) |
| WO (1) | WO2012019123A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| CN101909441B (zh) | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| JP2013535220A (ja) | 2010-08-06 | 2013-09-12 | エンドサイト，インコーポレイテッド | ツブリシンを調製するためのプロセス |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) * | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| BR112015008365A2 (pt) | 2012-10-16 | 2017-07-04 | Endocyte Inc | composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente |
| EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
| US20140249315A1 (en) * | 2013-03-01 | 2014-09-04 | Endocyte, Inc. | Processes for preparing tubulysins |
| WO2015113760A1 (en) * | 2014-01-28 | 2015-08-06 | Tube Pharmaceuticals Gmbh | Cytotoxic tubulysin compounds for conjugation |
| SG11201608192SA (en) | 2014-04-11 | 2016-10-28 | Medimmune Llc | Bispecific her2 antibodies |
| RU2715905C2 (ru) | 2014-10-01 | 2020-03-04 | МЕДИММЬЮН, ЭлЭлСи | Способ конъюгации полипептида |
| US10808007B2 (en) * | 2015-02-25 | 2020-10-20 | William Marsh Rice University | Desacetoxytubulysin H and analogs thereof |
| MY192146A (en) | 2015-11-10 | 2022-08-01 | Medimmune Llc | Binding molecules specific for asct2 and uses thereof |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| CN108495653A (zh) | 2016-01-27 | 2018-09-04 | 免疫医疗有限责任公司 | 用于制备具有定义的糖基化模式抗体的方法 |
| GEP20227398B (en) | 2016-04-15 | 2022-07-25 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof |
| AR111963A1 (es) | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| MA51447A (fr) | 2017-08-01 | 2020-06-10 | Medimmune Llc | Conjugué anticorps monoclonal-médicament dirigé contre bcma |
| WO2019108685A1 (en) | 2017-11-29 | 2019-06-06 | William March Rice University | Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith |
| BR112023004415A2 (pt) | 2020-09-11 | 2023-05-09 | Medimmune Ltd | Moléculas terapêuticas de ligação a b7-h4 |
| US11807685B2 (en) | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
| US12065496B2 (en) | 2021-11-10 | 2024-08-20 | Astrazeneca Ab | Antibody molecules and conjugates |
| GB202117928D0 (en) | 2021-12-11 | 2022-01-26 | Cancer Research Tech Ltd | Immunotherapy for cancer |
| EP4489859A1 (en) | 2022-03-09 | 2025-01-15 | Astrazeneca AB | Binding molecules against fr alpha |
| CA3259492A1 (en) | 2022-06-27 | 2024-01-04 | Astrazeneca Ab | COMBINATIONS INVOLVING EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER |
| CN120936382A (zh) | 2023-02-16 | 2025-11-11 | 阿斯利康(瑞典)有限公司 | 采用治疗性结合分子治疗癌症的组合疗法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627165A (en) | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US7776814B2 (en) | 2002-07-09 | 2010-08-17 | R&D-Biopharmaceuticals Gmbh | Tubulysin conjugates |
| DK1523493T3 (da) | 2002-07-09 | 2013-12-02 | Alexander Doemling | Nye tubulysinanaloge |
| DE10254439A1 (de) | 2002-11-21 | 2004-06-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Tubulysine, Herstellungsverfahren und Tubulysin-Mittel |
| WO2004069159A2 (en) | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| DE102009032972A1 (de) | 2009-07-14 | 2011-01-20 | Erbe Elektromedizin Gmbh | Vorrichtung zur Herstellung von Anastomosen |
| WO2011069116A1 (en) | 2009-12-04 | 2011-06-09 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| CA2790577A1 (en) | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| JP2013535220A (ja) * | 2010-08-06 | 2013-09-12 | エンドサイト，インコーポレイテッド | ツブリシンを調製するためのプロセス |
-
2011
- 2011-08-05 JP JP2013524130A patent/JP2013535220A/ja not_active Ceased
- 2011-08-05 EP EP11815381.6A patent/EP2600866A4/en not_active Withdrawn
- 2011-08-05 CN CN201180048479.0A patent/CN103140227B/zh not_active Expired - Fee Related
- 2011-08-05 EA EA201390203A patent/EA025471B1/ru not_active IP Right Cessation
- 2011-08-05 KR KR1020137004980A patent/KR20130096712A/ko not_active Ceased
- 2011-08-05 BR BR112013003004A patent/BR112013003004A2/pt not_active IP Right Cessation
- 2011-08-05 SG SG2013008909A patent/SG187728A1/en unknown
- 2011-08-05 AU AU2011285532A patent/AU2011285532B2/en not_active Ceased
- 2011-08-05 CA CA2807511A patent/CA2807511A1/en not_active Abandoned
- 2011-08-05 MX MX2013001402A patent/MX2013001402A/es active IP Right Grant
- 2011-08-05 US US13/814,336 patent/US8889880B2/en not_active Expired - Fee Related
- 2011-08-05 WO PCT/US2011/046797 patent/WO2012019123A1/en not_active Ceased
-
2014
- 2014-10-20 US US14/518,568 patent/US9273091B2/en not_active Expired - Fee Related
-
2016
- 2016-02-26 US US15/054,342 patent/US9499849B2/en not_active Expired - Fee Related
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