BR112013003004A2 - processos para a preparação de tubulisinas - Google Patents
processos para a preparação de tubulisinasInfo
- Publication number
- BR112013003004A2 BR112013003004A2 BR112013003004A BR112013003004A BR112013003004A2 BR 112013003004 A2 BR112013003004 A2 BR 112013003004A2 BR 112013003004 A BR112013003004 A BR 112013003004A BR 112013003004 A BR112013003004 A BR 112013003004A BR 112013003004 A2 BR112013003004 A2 BR 112013003004A2
- Authority
- BR
- Brazil
- Prior art keywords
- tubulisins
- processes
- naturally occurring
- preparation
- turbulisins
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- LTYOQGRJFJAKNA-VFLPNFFSSA-N malonyl-coa Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-VFLPNFFSSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37143310P | 2010-08-06 | 2010-08-06 | |
| PCT/US2011/046797 WO2012019123A1 (en) | 2010-08-06 | 2011-08-05 | Processes for preparing tubulysins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013003004A2 true BR112013003004A2 (pt) | 2016-06-14 |
Family
ID=45559842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013003004A BR112013003004A2 (pt) | 2010-08-06 | 2011-08-05 | processos para a preparação de tubulisinas |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8889880B2 (https=) |
| EP (1) | EP2600866A4 (https=) |
| JP (1) | JP2013535220A (https=) |
| KR (1) | KR20130096712A (https=) |
| CN (1) | CN103140227B (https=) |
| AU (1) | AU2011285532B2 (https=) |
| BR (1) | BR112013003004A2 (https=) |
| CA (1) | CA2807511A1 (https=) |
| EA (1) | EA025471B1 (https=) |
| MX (1) | MX2013001402A (https=) |
| SG (1) | SG187728A1 (https=) |
| WO (1) | WO2012019123A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| CN101909441B (zh) | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| JP2013535220A (ja) | 2010-08-06 | 2013-09-12 | エンドサイト，インコーポレイテッド | ツブリシンを調製するためのプロセス |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) * | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| BR112015008365A2 (pt) | 2012-10-16 | 2017-07-04 | Endocyte Inc | composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente |
| EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
| US20140249315A1 (en) * | 2013-03-01 | 2014-09-04 | Endocyte, Inc. | Processes for preparing tubulysins |
| WO2015113760A1 (en) * | 2014-01-28 | 2015-08-06 | Tube Pharmaceuticals Gmbh | Cytotoxic tubulysin compounds for conjugation |
| SG11201608192SA (en) | 2014-04-11 | 2016-10-28 | Medimmune Llc | Bispecific her2 antibodies |
| RU2715905C2 (ru) | 2014-10-01 | 2020-03-04 | МЕДИММЬЮН, ЭлЭлСи | Способ конъюгации полипептида |
| US10808007B2 (en) * | 2015-02-25 | 2020-10-20 | William Marsh Rice University | Desacetoxytubulysin H and analogs thereof |
| MY192146A (en) | 2015-11-10 | 2022-08-01 | Medimmune Llc | Binding molecules specific for asct2 and uses thereof |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| CN108495653A (zh) | 2016-01-27 | 2018-09-04 | 免疫医疗有限责任公司 | 用于制备具有定义的糖基化模式抗体的方法 |
| GEP20227398B (en) | 2016-04-15 | 2022-07-25 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof |
| AR111963A1 (es) | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| MA51447A (fr) | 2017-08-01 | 2020-06-10 | Medimmune Llc | Conjugué anticorps monoclonal-médicament dirigé contre bcma |
| WO2019108685A1 (en) | 2017-11-29 | 2019-06-06 | William March Rice University | Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith |
| BR112023004415A2 (pt) | 2020-09-11 | 2023-05-09 | Medimmune Ltd | Moléculas terapêuticas de ligação a b7-h4 |
| US11807685B2 (en) | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
| US12065496B2 (en) | 2021-11-10 | 2024-08-20 | Astrazeneca Ab | Antibody molecules and conjugates |
| GB202117928D0 (en) | 2021-12-11 | 2022-01-26 | Cancer Research Tech Ltd | Immunotherapy for cancer |
| EP4489859A1 (en) | 2022-03-09 | 2025-01-15 | Astrazeneca AB | Binding molecules against fr alpha |
| CA3259492A1 (en) | 2022-06-27 | 2024-01-04 | Astrazeneca Ab | COMBINATIONS INVOLVING EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER |
| CN120936382A (zh) | 2023-02-16 | 2025-11-11 | 阿斯利康(瑞典)有限公司 | 采用治疗性结合分子治疗癌症的组合疗法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627165A (en) | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US7776814B2 (en) | 2002-07-09 | 2010-08-17 | R&D-Biopharmaceuticals Gmbh | Tubulysin conjugates |
| DK1523493T3 (da) | 2002-07-09 | 2013-12-02 | Alexander Doemling | Nye tubulysinanaloge |
| DE10254439A1 (de) | 2002-11-21 | 2004-06-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Tubulysine, Herstellungsverfahren und Tubulysin-Mittel |
| WO2004069159A2 (en) | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| DE102009032972A1 (de) | 2009-07-14 | 2011-01-20 | Erbe Elektromedizin Gmbh | Vorrichtung zur Herstellung von Anastomosen |
| WO2011069116A1 (en) | 2009-12-04 | 2011-06-09 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| CA2790577A1 (en) | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| JP2013535220A (ja) * | 2010-08-06 | 2013-09-12 | エンドサイト，インコーポレイテッド | ツブリシンを調製するためのプロセス |
-
2011
- 2011-08-05 JP JP2013524130A patent/JP2013535220A/ja not_active Ceased
- 2011-08-05 EP EP11815381.6A patent/EP2600866A4/en not_active Withdrawn
- 2011-08-05 CN CN201180048479.0A patent/CN103140227B/zh not_active Expired - Fee Related
- 2011-08-05 EA EA201390203A patent/EA025471B1/ru not_active IP Right Cessation
- 2011-08-05 KR KR1020137004980A patent/KR20130096712A/ko not_active Ceased
- 2011-08-05 BR BR112013003004A patent/BR112013003004A2/pt not_active IP Right Cessation
- 2011-08-05 SG SG2013008909A patent/SG187728A1/en unknown
- 2011-08-05 AU AU2011285532A patent/AU2011285532B2/en not_active Ceased
- 2011-08-05 CA CA2807511A patent/CA2807511A1/en not_active Abandoned
- 2011-08-05 MX MX2013001402A patent/MX2013001402A/es active IP Right Grant
- 2011-08-05 US US13/814,336 patent/US8889880B2/en not_active Expired - Fee Related
- 2011-08-05 WO PCT/US2011/046797 patent/WO2012019123A1/en not_active Ceased
-
2014
- 2014-10-20 US US14/518,568 patent/US9273091B2/en not_active Expired - Fee Related
-
2016
- 2016-02-26 US US15/054,342 patent/US9499849B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130096712A (ko) | 2013-08-30 |
| US8889880B2 (en) | 2014-11-18 |
| CN103140227B (zh) | 2016-01-20 |
| CA2807511A1 (en) | 2012-02-09 |
| AU2011285532B2 (en) | 2015-09-10 |
| CN103140227A (zh) | 2013-06-05 |
| MX2013001402A (es) | 2013-08-29 |
| SG187728A1 (en) | 2013-03-28 |
| US9273091B2 (en) | 2016-03-01 |
| WO2012019123A1 (en) | 2012-02-09 |
| AU2011285532A1 (en) | 2013-02-21 |
| EA201390203A1 (ru) | 2013-08-30 |
| EA025471B1 (ru) | 2016-12-30 |
| HK1185558A1 (zh) | 2014-02-21 |
| EP2600866A4 (en) | 2013-12-11 |
| US9499849B2 (en) | 2016-11-22 |
| US20160177363A1 (en) | 2016-06-23 |
| EP2600866A1 (en) | 2013-06-12 |
| JP2013535220A (ja) | 2013-09-12 |
| US20150225447A1 (en) | 2015-08-13 |
| US20130137139A1 (en) | 2013-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013003004A2 (pt) | processos para a preparação de tubulisinas | |
| UY33735A (es) | Compuestos antivirales | |
| ECSP18048718A (es) | Imidazolilimidazoles condensados como compuestos antivirales | |
| CR20150370A (es) | Compuestos antivirales | |
| GT201400063A (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
| CY1119143T1 (el) | Διεργασια για την παρασκευη παραγωγων και ενδιαμεσων καρβαμουλοπυριδονης | |
| CU20140081A7 (es) | Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| PE20180318A1 (es) | Procedimiento para preparar isoquinolinonas y formas solidas de isoquinolinonas | |
| CU20140095A7 (es) | Nuevos derivados fosfatos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| IN2015DN00137A (https=) | ||
| ECSP11011517A (es) | Compuestos antivirales | |
| CU20140089A7 (es) | Nuevos derivados de indolizina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CR20140106A (es) | Compuestos y composiciones como inhibidores de la quinasa c-kit | |
| EP2938616A4 (en) | PROCESSING METHOD FOR THE PRODUCTION OF TOFACITINIB AND INTERMEDIATE PRODUCTS THEREOF | |
| GT201400085A (es) | Profármaco de adrenomedulina basado en polietilenglicol y su uso | |
| MX2018002318A (es) | Proceso mejorado para producir fucoxantina y/o polisacaridos de microalgas. | |
| UA116889C2 (uk) | Фармацевтична композиція, що містить суміш ізоформ apg101 (cd95-fc) | |
| MX2015001051A (es) | Derivados de manosa, un proceso para su preparacion y sus usos como un farmaco. | |
| ECSP14002542A (es) | Nuevos 2hindazoles como antagonistas del receptor ep2 | |
| MX2014010433A (es) | Nueva forma cristalina de sulfato de sitagliptina. | |
| TN2013000313A1 (en) | Isoxazolidine derivatives | |
| EA201400444A1 (ru) | Производные 2-оксопиперидинила | |
| CY1119871T1 (el) | Στερεη μορφη αλατος της aλφa-6-mpeg6-o- υδροξυκωδονης ως αγωνιστες οπιοειδων και χρησεις αυτων | |
| PH12015500534B1 (en) | Isoxazolidine derivatives | |
| ES2403549R1 (es) | Co-cristales de agomelatina con formadores de co-cristales |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2473 DE 29-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |