JP2018524326A5 - - Google Patents
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- JP2018524326A5 JP2018524326A5 JP2017566332A JP2017566332A JP2018524326A5 JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5 JP 2017566332 A JP2017566332 A JP 2017566332A JP 2017566332 A JP2017566332 A JP 2017566332A JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5
- Authority
- JP
- Japan
- Prior art keywords
- nkp46
- antigen binding
- binding protein
- polypeptide
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000025171 antigen binding proteins Human genes 0.000 claims 16
- 108091000831 antigen binding proteins Proteins 0.000 claims 16
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 14
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000009089 cytolysis Effects 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000589301 Homo sapiens Natural cytotoxicity triggering receptor 1 Proteins 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 102100024184 Polymerase delta-interacting protein 3 Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 239000004161 brilliant blue FCF Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 102000053350 human FCGR3B Human genes 0.000 claims 1
- 102000050738 human NCR1 Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/064063 | 2015-06-23 | ||
| PCT/EP2015/064063 WO2015197593A1 (en) | 2014-06-27 | 2015-06-23 | MULTISPECIFIC NKp46 BINDING PROTEINS |
| US201562271459P | 2015-12-28 | 2015-12-28 | |
| US62/271,459 | 2015-12-28 | ||
| PCT/EP2016/064537 WO2016207278A1 (en) | 2015-06-23 | 2016-06-23 | Multispecific nk engager proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524326A JP2018524326A (ja) | 2018-08-30 |
| JP2018524326A5 true JP2018524326A5 (cg-RX-API-DMAC7.html) | 2019-07-04 |
| JP6971153B2 JP6971153B2 (ja) | 2021-11-24 |
Family
ID=57584697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566332A Active JP6971153B2 (ja) | 2015-06-23 | 2016-06-23 | 多重特異的ｎｋエンゲイジャータンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10113003B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3313881A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6971153B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016284871B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016207278A1 (cg-RX-API-DMAC7.html) |
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| JP6944925B2 (ja) | 2015-07-24 | 2021-10-06 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 組織浸潤ｎｋ細胞を検出する方法 |
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| US20240279331A1 (en) * | 2021-06-11 | 2024-08-22 | The Regents Of The University Of California | Antibodies that stimulate nk cell-mediated cytotoxicity |
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| JP6822849B2 (ja) * | 2014-06-27 | 2021-01-27 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 多重特異的ＮＫｐ４６結合タンパク質 |
| AU2015279321B2 (en) | 2014-06-27 | 2021-03-04 | Innate Pharma, S.A. | Multispecific antigen binding proteins |
| EP3313876B1 (en) | 2015-06-23 | 2025-01-22 | Innate Pharma | Multispecific antigen binding proteins |
| AU2016284871B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific NK engager proteins |
| EP3397645A1 (en) * | 2015-12-28 | 2018-11-07 | Innate Pharma | VARIABLE REGIONS FOR NKp46 BINDING PROTEINS |
-
2016
- 2016-06-23 AU AU2016284871A patent/AU2016284871B2/en active Active
- 2016-06-23 JP JP2017566332A patent/JP6971153B2/ja active Active
- 2016-06-23 US US15/190,337 patent/US10113003B2/en active Active
- 2016-06-23 EP EP16734592.5A patent/EP3313881A1/en active Pending
- 2016-06-23 WO PCT/EP2016/064537 patent/WO2016207278A1/en not_active Ceased
-
2018
- 2018-10-29 US US16/173,150 patent/US12252543B2/en active Active
- 2018-10-29 US US16/173,114 patent/US11267897B2/en active Active
-
2025
- 2025-01-06 US US19/010,723 patent/US20250215107A1/en active Pending
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