JP2018524320A5 - - Google Patents
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- JP2018524320A5 JP2018524320A5 JP2017566028A JP2017566028A JP2018524320A5 JP 2018524320 A5 JP2018524320 A5 JP 2018524320A5 JP 2017566028 A JP2017566028 A JP 2017566028A JP 2017566028 A JP2017566028 A JP 2017566028A JP 2018524320 A5 JP2018524320 A5 JP 2018524320A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutical composition
- crystal
- cyclic amide
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000013078 crystal Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 8
- 150000003950 cyclic amides Chemical class 0.000 claims 8
- 190000008236 carboplatin Chemical compound 0.000 claims 5
- 229960004562 carboplatin Drugs 0.000 claims 5
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- -1 phosphoryl group Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 241001116389 Aloe Species 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical group N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 238000009098 adjuvant therapy Methods 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- 229940110767 coenzyme Q10 Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562182142P | 2015-06-19 | 2015-06-19 | |
| US62/182,142 | 2015-06-19 | ||
| PCT/US2016/038340 WO2016205785A1 (en) | 2015-06-19 | 2016-06-20 | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524320A JP2018524320A (ja) | 2018-08-30 |
| JP2018524320A5 true JP2018524320A5 (enExample) | 2019-07-11 |
| JP6768716B2 JP6768716B2 (ja) | 2020-10-14 |
Family
ID=57546414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566028A Expired - Fee Related JP6768716B2 (ja) | 2015-06-19 | 2016-06-20 | カルボプラチンベースの共結晶の医薬組成物及びその用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10421770B2 (enExample) |
| EP (1) | EP3297636B1 (enExample) |
| JP (1) | JP6768716B2 (enExample) |
| KR (1) | KR20180018800A (enExample) |
| CN (1) | CN107847508B (enExample) |
| AU (1) | AU2016279099B2 (enExample) |
| BR (1) | BR112017027285A2 (enExample) |
| CA (1) | CA2988992A1 (enExample) |
| WO (1) | WO2016205785A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3297624B1 (en) * | 2015-05-18 | 2021-03-03 | Syn-Nat Products Enterprise LLC | A pharmaceutical co-crystal and use thereof |
| AU2016279099B2 (en) | 2015-06-19 | 2021-09-23 | Syn-Nat Products Enterprise LLC | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
| CN108697093A (zh) | 2015-06-19 | 2018-10-23 | 新纳特产品公司 | 含卡铂的组合物及其用途 |
| EP3297640A4 (en) | 2015-06-25 | 2019-01-02 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922689A (en) | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
| US6297245B1 (en) | 1998-08-04 | 2001-10-02 | Unitech Pharmaceuticals | Cisplatin and folic acid administered to treat breast cancer |
| KR100317473B1 (ko) | 1999-05-11 | 2001-12-22 | 이계호 | 신규의 백금(ｉｖ)착제 및 그 제조방법 |
| CN1121380C (zh) | 2000-03-03 | 2003-09-17 | 北京兴大豪斯科技有限公司 | 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物 |
| AUPQ641100A0 (en) | 2000-03-23 | 2000-04-15 | Australia Nuclear Science & Technology Organisation | Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents |
| DE60138739D1 (de) * | 2001-11-30 | 2009-06-25 | Jingzun Wang | Supermolekulare carboplatinderivate, deren herstellung und pharmazeutische zusammensetzungen, die diese als wirkstoffe enthalten, sowie anwendungen der zusammensetzungen |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| RS20050106A (sr) | 2002-08-19 | 2007-11-15 | Pfizer Products Inc., | Kombinovana terapija hiperproliferativnih bolesti |
| CA2514733A1 (en) * | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2004099224A1 (de) | 2003-05-05 | 2004-11-18 | Universität Regensburg | Carboplatin-artige platin (ii)- komplexe |
| DE602004015811D1 (de) | 2003-08-13 | 2008-09-25 | Univ South Florida | Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden |
| JP2007516259A (ja) * | 2003-12-09 | 2007-06-21 | メッドクリスタルフォームズ、エルエルシー | 活性剤との混合相共結晶の調製方法 |
| KR101345002B1 (ko) * | 2005-01-21 | 2013-12-31 | 아스텍스 테라퓨틱스 리미티드 | 제약 화합물 |
| CN100500219C (zh) * | 2005-04-06 | 2009-06-17 | 山东蓝金生物工程有限公司 | 一种含铂类化合物的抗实体肿瘤药物组合物 |
| JP2009525273A (ja) | 2006-01-30 | 2009-07-09 | プラットコー テクノロジーズ （プロプライエタリー） リミテッド | 白金（ｉｉ）錯体の調製 |
| US20080063642A1 (en) | 2006-08-02 | 2008-03-13 | Adelman Daniel C | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of certain hematologic disorders |
| WO2008140850A1 (en) * | 2007-03-02 | 2008-11-20 | Novartis Ag | Solid forms of a raf kinase inhibitor |
| KR100957125B1 (ko) * | 2008-01-14 | 2010-05-11 | 한국과학기술원 | 생체 고분자와 난용성 물질의 접합체 및 그의 제조방법 |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| CA2736732A1 (en) | 2008-09-15 | 2010-03-18 | Kasina Laila Innova Pharmaceuticals Private Limited | Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers |
| CZ302618B6 (cs) | 2009-09-10 | 2011-08-03 | Univerzita Palackého | Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
| US20110287110A1 (en) | 2010-04-23 | 2011-11-24 | Mark Wesley Dewhirst | Combination cancer treatment |
| JP5179628B2 (ja) * | 2011-07-15 | 2013-04-10 | ユニーテック株式会社 | ４価白金錯体及びそれを含む医薬組成物 |
| US9220705B2 (en) * | 2013-03-07 | 2015-12-29 | James David Hoeschele | Method of treating colorectal cancer |
| PL3424920T3 (pl) * | 2013-10-17 | 2020-11-16 | Vertex Pharmaceuticals Incorporated | Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK |
| CN104122280B (zh) * | 2014-08-13 | 2017-03-22 | 北京默加农生物技术发展有限公司 | 一种以双环铂为有效成分的药物的检测方法 |
| CN104127402B (zh) | 2014-08-15 | 2019-08-30 | 北京默加农生物技术发展有限公司 | 双环铂在制备抗病毒药物和抗菌药物中的应用 |
| CN104693245A (zh) * | 2015-03-13 | 2015-06-10 | 卓越同达医药科技开发（苏州）有限公司 | 超分子抗癌药物双环铂的制备方法 |
| EP3280408B1 (en) | 2015-04-10 | 2019-10-23 | Syn-Nat Products Enterprise LLC | Process for the preparation of dicycloplatin |
| AU2016250616B2 (en) | 2015-04-22 | 2021-01-21 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| EP3297624B1 (en) | 2015-05-18 | 2021-03-03 | Syn-Nat Products Enterprise LLC | A pharmaceutical co-crystal and use thereof |
| AU2016279099B2 (en) | 2015-06-19 | 2021-09-23 | Syn-Nat Products Enterprise LLC | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
| CN108697093A (zh) | 2015-06-19 | 2018-10-23 | 新纳特产品公司 | 含卡铂的组合物及其用途 |
| EP3297640A4 (en) | 2015-06-25 | 2019-01-02 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
-
2016
- 2016-06-20 AU AU2016279099A patent/AU2016279099B2/en not_active Ceased
- 2016-06-20 WO PCT/US2016/038340 patent/WO2016205785A1/en not_active Ceased
- 2016-06-20 JP JP2017566028A patent/JP6768716B2/ja not_active Expired - Fee Related
- 2016-06-20 CA CA2988992A patent/CA2988992A1/en not_active Abandoned
- 2016-06-20 CN CN201680035450.1A patent/CN107847508B/zh active Active
- 2016-06-20 EP EP16812609.2A patent/EP3297636B1/en not_active Not-in-force
- 2016-06-20 BR BR112017027285A patent/BR112017027285A2/pt not_active Application Discontinuation
- 2016-06-20 US US15/736,178 patent/US10421770B2/en active Active
- 2016-06-20 KR KR1020187001613A patent/KR20180018800A/ko not_active Ceased