CA2988992A1 - Pharmaceutical composition of carboplatin based co-crystals and use thereof - Google Patents

Pharmaceutical composition of carboplatin based co-crystals and use thereof

Info

Publication number
CA2988992A1
CA2988992A1 CA2988992A CA2988992A CA2988992A1 CA 2988992 A1 CA2988992 A1 CA 2988992A1 CA 2988992 A CA2988992 A CA 2988992A CA 2988992 A CA2988992 A CA 2988992A CA 2988992 A1 CA2988992 A1 CA 2988992A1
Authority
CA
Canada
Prior art keywords
crystal
nmp
cbp
group
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2988992A
Other languages
English (en)
French (fr)
Inventor
Xiaozhong Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syn Nat Products Enterprise LLC
Original Assignee
Syn Nat Products Enterprise LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syn Nat Products Enterprise LLC filed Critical Syn Nat Products Enterprise LLC
Publication of CA2988992A1 publication Critical patent/CA2988992A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2988992A 2015-06-19 2016-06-20 Pharmaceutical composition of carboplatin based co-crystals and use thereof Abandoned CA2988992A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562182142P 2015-06-19 2015-06-19
US62/182,142 2015-06-19
PCT/US2016/038340 WO2016205785A1 (en) 2015-06-19 2016-06-20 Pharmaceutical composition of carboplatin based co-crystals and use thereof

Publications (1)

Publication Number Publication Date
CA2988992A1 true CA2988992A1 (en) 2016-12-22

Family

ID=57546414

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2988992A Abandoned CA2988992A1 (en) 2015-06-19 2016-06-20 Pharmaceutical composition of carboplatin based co-crystals and use thereof

Country Status (9)

Country Link
US (1) US10421770B2 (enExample)
EP (1) EP3297636B1 (enExample)
JP (1) JP6768716B2 (enExample)
KR (1) KR20180018800A (enExample)
CN (1) CN107847508B (enExample)
AU (1) AU2016279099B2 (enExample)
BR (1) BR112017027285A2 (enExample)
CA (1) CA2988992A1 (enExample)
WO (1) WO2016205785A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180008594A (ko) * 2015-05-18 2018-01-24 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 및 그의 용도
JP6768716B2 (ja) 2015-06-19 2020-10-14 シン−ナット プロダクツ エンタープライズ エルエルシー カルボプラチンベースの共結晶の医薬組成物及びその用途
EP3297440A4 (en) 2015-06-19 2019-04-10 Syn-Nat Products Enterprise LLC COMPOSITION WITH CARBOPLATIN AND USE
KR20180021805A (ko) 2015-06-25 2018-03-05 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 조성물 및 이의 용도

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922689A (en) 1995-09-11 1999-07-13 Unitech Pharmaceuticals, Inc. Cisplatin analogs for cancer treatment
US6297245B1 (en) 1998-08-04 2001-10-02 Unitech Pharmaceuticals Cisplatin and folic acid administered to treat breast cancer
KR100317473B1 (ko) 1999-05-11 2001-12-22 이계호 신규의 백금(ｉｖ)착제 및 그 제조방법
CN1121380C (zh) 2000-03-03 2003-09-17 北京兴大豪斯科技有限公司 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
AUPQ641100A0 (en) 2000-03-23 2000-04-15 Australia Nuclear Science & Technology Organisation Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
US7259270B2 (en) 2001-11-30 2007-08-21 Jingzun Wang Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions
WO2004078163A2 (en) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
EA200500234A1 (ru) 2002-08-19 2005-08-25 Пфайзер Продактс Инк. Комбинированная терапия гиперпролиферативных болезней
WO2004099224A1 (de) 2003-05-05 2004-11-18 Universität Regensburg Carboplatin-artige platin (ii)- komplexe
CA2535762A1 (en) 2003-08-13 2005-03-17 University Of South Florida Methods for inhibiting tumor cell proliferation
JP2007516259A (ja) * 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー 活性剤との混合相共結晶の調製方法
EP1845974A1 (en) * 2005-01-21 2007-10-24 Astex Therapeutics Limited Pharmaceutical compounds
CN100500219C (zh) * 2005-04-06 2009-06-17 山东蓝金生物工程有限公司 一种含铂类化合物的抗实体肿瘤药物组合物
KR20080096682A (ko) 2006-01-30 2008-10-31 플라트코 테크놀로지스 (프로프라이어터리) 리미티드 백금(ⅱ) 착물의 제조법
JP2009545601A (ja) 2006-08-02 2009-12-24 サネシス ファーマシューティカルズ， インコーポレイテッド （＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の組合せ使用
RU2483064C2 (ru) * 2007-03-02 2013-05-27 Новартис Аг Твердые формы ингибитора raf-киназы
KR100957125B1 (ko) * 2008-01-14 2010-05-11 한국과학기술원 생체 고분자와 난용성 물질의 접합체 및 그의 제조방법
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
BRPI0913485A2 (pt) 2008-09-15 2016-06-07 Kasina Laila Innova Pharmaceuticals Private Ltd medicamentos anticâncer e usos relacionados para melanoma maligno metastático e outros cânceres.
CZ302618B6 (cs) 2009-09-10 2011-08-03 Univerzita Palackého Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii
US20110287110A1 (en) 2010-04-23 2011-11-24 Mark Wesley Dewhirst Combination cancer treatment
JP5179628B2 (ja) * 2011-07-15 2013-04-10 ユニーテック株式会社 ４価白金錯体及びそれを含む医薬組成物
US9220705B2 (en) * 2013-03-07 2015-12-29 James David Hoeschele Method of treating colorectal cancer
KR102411227B1 (ko) * 2013-10-17 2022-06-21 버텍스 파마슈티칼스 인코포레이티드 Dna-pk 억제제로서 (s)-n-메틸-8-(1-((2'-메틸-[4,5'-비피리미딘]-6-일)아미노)프로판-2-일)퀴놀린-4-카복스아미드 및 이의 듀테로화된 유도체의 공결정
CN107167482B (zh) * 2014-08-13 2020-07-14 北京默加农生物技术发展有限公司 一种以双环铂为有效成分的药物的检测方法
CN104127402B (zh) 2014-08-15 2019-08-30 北京默加农生物技术发展有限公司 双环铂在制备抗病毒药物和抗菌药物中的应用
CN104693245A (zh) * 2015-03-13 2015-06-10 卓越同达医药科技开发（苏州）有限公司 超分子抗癌药物双环铂的制备方法
CN106132408B (zh) 2015-04-10 2018-02-13 新纳特产品公司 一种双环铂的制备方法
CN107530309A (zh) 2015-04-22 2018-01-02 新纳特产品公司 共晶组合物及其药物用途
KR20180008594A (ko) 2015-05-18 2018-01-24 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 및 그의 용도
EP3297440A4 (en) 2015-06-19 2019-04-10 Syn-Nat Products Enterprise LLC COMPOSITION WITH CARBOPLATIN AND USE
JP6768716B2 (ja) 2015-06-19 2020-10-14 シン−ナット プロダクツ エンタープライズ エルエルシー カルボプラチンベースの共結晶の医薬組成物及びその用途
KR20180021805A (ko) 2015-06-25 2018-03-05 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 조성물 및 이의 용도

Also Published As

Publication number Publication date
JP2018524320A (ja) 2018-08-30
EP3297636A1 (en) 2018-03-28
AU2016279099B2 (en) 2021-09-23
EP3297636A4 (en) 2018-11-14
US20180179240A1 (en) 2018-06-28
KR20180018800A (ko) 2018-02-21
BR112017027285A2 (pt) 2018-09-11
EP3297636B1 (en) 2021-02-17
JP6768716B2 (ja) 2020-10-14
US10421770B2 (en) 2019-09-24
CN107847508B (zh) 2020-10-02
AU2016279099A1 (en) 2018-01-04
WO2016205785A1 (en) 2016-12-22
CN107847508A (zh) 2018-03-27

Similar Documents

Publication Publication Date Title
US11685757B2 (en) Pharmaceutical co-crystal composition and use thereof
AU2017282871B2 (en) Crystalline forms of triazolopyrimidine compound
EP3297624B1 (en) A pharmaceutical co-crystal and use thereof
CA2854836C (en) Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction
AU2016279099B2 (en) Pharmaceutical composition of carboplatin based co-crystals and use thereof
CN103191121B (zh) 二(喹唑啉-4-基)二硒醚化合物在制备抗癌药物中的用途
CA3027246C (en) Crystalline forms of triazolopyrimidine compound
BR122024009277A2 (pt) Formas cristalinas de um composto de triazolopirimidina
BR112018076443B1 (pt) Processo de preparação de formas cristalinas de um composto de triazolopirimidina
CN104693189A (zh) 一种嘧啶化合物及其制备方法和应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210614

FZDE Discontinued

Effective date: 20231220