JP6768716B2 - カルボプラチンベースの共結晶の医薬組成物及びその用途 - Google Patents
カルボプラチンベースの共結晶の医薬組成物及びその用途 Download PDFInfo
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- JP6768716B2 JP6768716B2 JP2017566028A JP2017566028A JP6768716B2 JP 6768716 B2 JP6768716 B2 JP 6768716B2 JP 2017566028 A JP2017566028 A JP 2017566028A JP 2017566028 A JP2017566028 A JP 2017566028A JP 6768716 B2 JP6768716 B2 JP 6768716B2
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- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
- 239000002897 polymer film coating Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 239000011863 silicon-based powder Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 210000004500 stellate cell Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002076 thermal analysis method Methods 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562182142P | 2015-06-19 | 2015-06-19 | |
| US62/182,142 | 2015-06-19 | ||
| PCT/US2016/038340 WO2016205785A1 (en) | 2015-06-19 | 2016-06-20 | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524320A JP2018524320A (ja) | 2018-08-30 |
| JP2018524320A5 JP2018524320A5 (enExample) | 2019-07-11 |
| JP6768716B2 true JP6768716B2 (ja) | 2020-10-14 |
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| JP2017566028A Expired - Fee Related JP6768716B2 (ja) | 2015-06-19 | 2016-06-20 | カルボプラチンベースの共結晶の医薬組成物及びその用途 |
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| US (1) | US10421770B2 (enExample) |
| EP (1) | EP3297636B1 (enExample) |
| JP (1) | JP6768716B2 (enExample) |
| KR (1) | KR20180018800A (enExample) |
| CN (1) | CN107847508B (enExample) |
| AU (1) | AU2016279099B2 (enExample) |
| BR (1) | BR112017027285A2 (enExample) |
| CA (1) | CA2988992A1 (enExample) |
| WO (1) | WO2016205785A1 (enExample) |
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| KR20180008594A (ko) * | 2015-05-18 | 2018-01-24 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 약제학적 공-결정 및 그의 용도 |
| JP6768716B2 (ja) | 2015-06-19 | 2020-10-14 | シン−ナット プロダクツ エンタープライズ エルエルシー | カルボプラチンベースの共結晶の医薬組成物及びその用途 |
| EP3297440A4 (en) | 2015-06-19 | 2019-04-10 | Syn-Nat Products Enterprise LLC | COMPOSITION WITH CARBOPLATIN AND USE |
| KR20180021805A (ko) | 2015-06-25 | 2018-03-05 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 약제학적 공-결정 조성물 및 이의 용도 |
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| US5922689A (en) | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
| US6297245B1 (en) | 1998-08-04 | 2001-10-02 | Unitech Pharmaceuticals | Cisplatin and folic acid administered to treat breast cancer |
| KR100317473B1 (ko) | 1999-05-11 | 2001-12-22 | 이계호 | 신규의 백금(ｉｖ)착제 및 그 제조방법 |
| CN1121380C (zh) | 2000-03-03 | 2003-09-17 | 北京兴大豪斯科技有限公司 | 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物 |
| AUPQ641100A0 (en) | 2000-03-23 | 2000-04-15 | Australia Nuclear Science & Technology Organisation | Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents |
| US7259270B2 (en) | 2001-11-30 | 2007-08-21 | Jingzun Wang | Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions |
| WO2004078163A2 (en) * | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| EA200500234A1 (ru) | 2002-08-19 | 2005-08-25 | Пфайзер Продактс Инк. | Комбинированная терапия гиперпролиферативных болезней |
| WO2004099224A1 (de) | 2003-05-05 | 2004-11-18 | Universität Regensburg | Carboplatin-artige platin (ii)- komplexe |
| CA2535762A1 (en) | 2003-08-13 | 2005-03-17 | University Of South Florida | Methods for inhibiting tumor cell proliferation |
| JP2007516259A (ja) * | 2003-12-09 | 2007-06-21 | メッドクリスタルフォームズ、エルエルシー | 活性剤との混合相共結晶の調製方法 |
| EP1845974A1 (en) * | 2005-01-21 | 2007-10-24 | Astex Therapeutics Limited | Pharmaceutical compounds |
| CN100500219C (zh) * | 2005-04-06 | 2009-06-17 | 山东蓝金生物工程有限公司 | 一种含铂类化合物的抗实体肿瘤药物组合物 |
| KR20080096682A (ko) | 2006-01-30 | 2008-10-31 | 플라트코 테크놀로지스 (프로프라이어터리) 리미티드 | 백금(ⅱ) 착물의 제조법 |
| JP2009545601A (ja) | 2006-08-02 | 2009-12-24 | サネシス ファーマシューティカルズ， インコーポレイテッド | （＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の組合せ使用 |
| RU2483064C2 (ru) * | 2007-03-02 | 2013-05-27 | Новартис Аг | Твердые формы ингибитора raf-киназы |
| KR100957125B1 (ko) * | 2008-01-14 | 2010-05-11 | 한국과학기술원 | 생체 고분자와 난용성 물질의 접합체 및 그의 제조방법 |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| BRPI0913485A2 (pt) | 2008-09-15 | 2016-06-07 | Kasina Laila Innova Pharmaceuticals Private Ltd | medicamentos anticâncer e usos relacionados para melanoma maligno metastático e outros cânceres. |
| CZ302618B6 (cs) | 2009-09-10 | 2011-08-03 | Univerzita Palackého | Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
| US20110287110A1 (en) | 2010-04-23 | 2011-11-24 | Mark Wesley Dewhirst | Combination cancer treatment |
| JP5179628B2 (ja) * | 2011-07-15 | 2013-04-10 | ユニーテック株式会社 | ４価白金錯体及びそれを含む医薬組成物 |
| US9220705B2 (en) * | 2013-03-07 | 2015-12-29 | James David Hoeschele | Method of treating colorectal cancer |
| KR102411227B1 (ko) * | 2013-10-17 | 2022-06-21 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-pk 억제제로서 (s)-n-메틸-8-(1-((2'-메틸-[4,5'-비피리미딘]-6-일)아미노)프로판-2-일)퀴놀린-4-카복스아미드 및 이의 듀테로화된 유도체의 공결정 |
| CN107167482B (zh) * | 2014-08-13 | 2020-07-14 | 北京默加农生物技术发展有限公司 | 一种以双环铂为有效成分的药物的检测方法 |
| CN104127402B (zh) | 2014-08-15 | 2019-08-30 | 北京默加农生物技术发展有限公司 | 双环铂在制备抗病毒药物和抗菌药物中的应用 |
| CN104693245A (zh) * | 2015-03-13 | 2015-06-10 | 卓越同达医药科技开发（苏州）有限公司 | 超分子抗癌药物双环铂的制备方法 |
| CN106132408B (zh) | 2015-04-10 | 2018-02-13 | 新纳特产品公司 | 一种双环铂的制备方法 |
| CN107530309A (zh) | 2015-04-22 | 2018-01-02 | 新纳特产品公司 | 共晶组合物及其药物用途 |
| KR20180008594A (ko) | 2015-05-18 | 2018-01-24 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 약제학적 공-결정 및 그의 용도 |
| EP3297440A4 (en) | 2015-06-19 | 2019-04-10 | Syn-Nat Products Enterprise LLC | COMPOSITION WITH CARBOPLATIN AND USE |
| JP6768716B2 (ja) | 2015-06-19 | 2020-10-14 | シン−ナット プロダクツ エンタープライズ エルエルシー | カルボプラチンベースの共結晶の医薬組成物及びその用途 |
| KR20180021805A (ko) | 2015-06-25 | 2018-03-05 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 약제학적 공-결정 조성물 및 이의 용도 |
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2016
- 2016-06-20 JP JP2017566028A patent/JP6768716B2/ja not_active Expired - Fee Related
- 2016-06-20 WO PCT/US2016/038340 patent/WO2016205785A1/en not_active Ceased
- 2016-06-20 US US15/736,178 patent/US10421770B2/en active Active
- 2016-06-20 AU AU2016279099A patent/AU2016279099B2/en not_active Ceased
- 2016-06-20 KR KR1020187001613A patent/KR20180018800A/ko not_active Ceased
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- 2016-06-20 EP EP16812609.2A patent/EP3297636B1/en not_active Not-in-force
- 2016-06-20 BR BR112017027285A patent/BR112017027285A2/pt not_active Application Discontinuation
- 2016-06-20 CA CA2988992A patent/CA2988992A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018524320A (ja) | 2018-08-30 |
| EP3297636A1 (en) | 2018-03-28 |
| AU2016279099B2 (en) | 2021-09-23 |
| EP3297636A4 (en) | 2018-11-14 |
| US20180179240A1 (en) | 2018-06-28 |
| CA2988992A1 (en) | 2016-12-22 |
| KR20180018800A (ko) | 2018-02-21 |
| BR112017027285A2 (pt) | 2018-09-11 |
| EP3297636B1 (en) | 2021-02-17 |
| US10421770B2 (en) | 2019-09-24 |
| CN107847508B (zh) | 2020-10-02 |
| AU2016279099A1 (en) | 2018-01-04 |
| WO2016205785A1 (en) | 2016-12-22 |
| CN107847508A (zh) | 2018-03-27 |
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