JP2018520147A5 - - Google Patents
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- Publication number
- JP2018520147A5 JP2018520147A5 JP2017567249A JP2017567249A JP2018520147A5 JP 2018520147 A5 JP2018520147 A5 JP 2018520147A5 JP 2017567249 A JP2017567249 A JP 2017567249A JP 2017567249 A JP2017567249 A JP 2017567249A JP 2018520147 A5 JP2018520147 A5 JP 2018520147A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- diacid
- crystal
- pharmaceutical composition
- ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003057 platinum Chemical class 0.000 claims 20
- 239000013078 crystal Substances 0.000 claims 18
- 238000000634 powder X-ray diffraction Methods 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 241001116389 Aloe Species 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- 229940110767 coenzyme Q10 Drugs 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562184591P | 2015-06-25 | 2015-06-25 | |
| US62/184,591 | 2015-06-25 | ||
| PCT/US2016/039572 WO2016210418A1 (en) | 2015-06-25 | 2016-06-27 | Pharmaceutical co-crystal composition and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520147A JP2018520147A (ja) | 2018-07-26 |
| JP2018520147A5 true JP2018520147A5 (enExample) | 2019-07-18 |
| JP6929234B2 JP6929234B2 (ja) | 2021-09-01 |
Family
ID=57586692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567249A Expired - Fee Related JP6929234B2 (ja) | 2015-06-25 | 2016-06-27 | 医薬共結晶組成物及びその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10428099B2 (enExample) |
| EP (1) | EP3297640A4 (enExample) |
| JP (1) | JP6929234B2 (enExample) |
| KR (1) | KR20180021805A (enExample) |
| CN (2) | CN116854745A (enExample) |
| AU (1) | AU2016284816B2 (enExample) |
| CA (1) | CA2989001A1 (enExample) |
| WO (1) | WO2016210418A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10751318B2 (en) | 2015-05-18 | 2020-08-25 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal and use thereof |
| BR112017027285A2 (pt) | 2015-06-19 | 2018-09-11 | Syn Nat Products Entpr Llc | ?cocristal, composição farmacêutica e método para o tratamento de uma doença? |
| BR112017027277A2 (pt) | 2015-06-19 | 2018-09-04 | Syn Nat Products Entpr Llc | ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula? |
| US10428099B2 (en) | 2015-06-25 | 2019-10-01 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
| WO2019101040A1 (zh) * | 2017-11-21 | 2019-05-31 | 湖南湘源美东医药科技有限公司 | 含有双环铂的组合产品、其制备方法及其用途 |
| KR102645496B1 (ko) * | 2018-09-01 | 2024-03-07 | 베이징 서우바이 파마슈티컬 컴퍼니 리미티드 | 백금계 화합물 인산염 및 그 제조 방법 |
| CN111205332B (zh) * | 2020-02-25 | 2025-03-21 | 华东理工大学 | 奥沙利铂-黄酮药物共晶及其制备方法和应用 |
| US20250387405A1 (en) * | 2021-11-26 | 2025-12-25 | Medoncare Pharmaceutical Co., Ltd | Pharmaceutical composition containing platinum drugs or platinum drug cocrystals, and use thereof |
| CN116143705B (zh) * | 2023-04-11 | 2023-06-30 | 齐泽(云南)生物科技有限公司 | 一种药用化合物 |
| CN116217628B (zh) * | 2023-05-08 | 2023-07-14 | 华东理工常熟研究院有限公司 | 奥沙利铂Pt(IV)配合物的共晶及其制备方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922689A (en) | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
| US6297245B1 (en) | 1998-08-04 | 2001-10-02 | Unitech Pharmaceuticals | Cisplatin and folic acid administered to treat breast cancer |
| KR100317473B1 (ko) * | 1999-05-11 | 2001-12-22 | 이계호 | 신규의 백금(ｉｖ)착제 및 그 제조방법 |
| CN1121380C (zh) * | 2000-03-03 | 2003-09-17 | 北京兴大豪斯科技有限公司 | 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物 |
| AUPQ641100A0 (en) | 2000-03-23 | 2000-04-15 | Australia Nuclear Science & Technology Organisation | Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents |
| ATE431352T1 (de) * | 2001-11-30 | 2009-05-15 | Jingzun Wang | Supermolekulare carboplatinderivate, deren herstellung und pharmazeutische zusammensetzungen,die diese als wirkstoffe enthalten, sowie anwendungen der zusammensetzungen |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| JP3835763B2 (ja) | 2002-08-19 | 2006-10-18 | ファイザー・プロダクツ・インク | 増殖亢進疾患のための組み合わせ治療 |
| CA2514092C (en) * | 2003-01-21 | 2013-03-19 | S.S.C.I., Inc. | Novel cocrystallization of hydrochloric acid salt of an active agent |
| EP1631260A2 (en) * | 2003-02-28 | 2006-03-08 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2004099224A1 (de) | 2003-05-05 | 2004-11-18 | Universität Regensburg | Carboplatin-artige platin (ii)- komplexe |
| WO2005016946A2 (en) | 2003-08-13 | 2005-02-24 | University Of South Florida | Platinum complexes for the treatment of tumors |
| CN101972240B (zh) * | 2003-09-04 | 2012-07-25 | 赛福伦公司 | 莫达芬尼组合物 |
| EP1727520A2 (en) * | 2003-12-09 | 2006-12-06 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| CA2594474C (en) | 2005-01-21 | 2016-03-29 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US7956208B2 (en) | 2006-01-30 | 2011-06-07 | Platco Technologies (Proprietary) Limited | Preparation of platinum (II) complexes |
| PL2049109T3 (pl) | 2006-08-02 | 2016-05-31 | Sunesis Pharmaceuticals Inc | Skojarzone zastosowanie kwasu (+)-1,4-dihydro-7-[(3s,4s)-3-metoksy-4-(metyloamino)-1-pirolidynylo]-4-okso-1-(2-tiazolilo)-1,8-naftyrydyno-3-karboksylowego i cytarabiny (Ara-C) do leczenia białaczki |
| CN102149703B (zh) | 2008-09-15 | 2014-09-10 | 卡斯娜莱拉伊诺制药私人有限公司 | 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 |
| CZ302618B6 (cs) | 2009-09-10 | 2011-08-03 | Univerzita Palackého | Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
| US20130017265A1 (en) * | 2009-12-16 | 2013-01-17 | Massachusetts Institute Of Technology | Particles for multiple agent delivery |
| US20110287110A1 (en) | 2010-04-23 | 2011-11-24 | Mark Wesley Dewhirst | Combination cancer treatment |
| CN102863474A (zh) * | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
| JP5179628B2 (ja) | 2011-07-15 | 2013-04-10 | ユニーテック株式会社 | ４価白金錯体及びそれを含む医薬組成物 |
| CN102993239A (zh) * | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
| US9220705B2 (en) | 2013-03-07 | 2015-12-29 | James David Hoeschele | Method of treating colorectal cancer |
| SG11201602962PA (en) | 2013-10-17 | 2016-05-30 | Vertex Pharma | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
| CN104127402B (zh) | 2014-08-15 | 2019-08-30 | 北京默加农生物技术发展有限公司 | 双环铂在制备抗病毒药物和抗菌药物中的应用 |
| MX2017012985A (es) | 2015-04-10 | 2018-05-22 | Syn Nat Products Entpr Llc | Proceso para la preparacion de dicicloplatino. |
| KR102569221B1 (ko) | 2015-04-22 | 2023-08-21 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 공결정 조성물 및 그의 약제학적 용도 |
| US10751318B2 (en) | 2015-05-18 | 2020-08-25 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal and use thereof |
| BR112017027285A2 (pt) | 2015-06-19 | 2018-09-11 | Syn Nat Products Entpr Llc | ?cocristal, composição farmacêutica e método para o tratamento de uma doença? |
| BR112017027277A2 (pt) | 2015-06-19 | 2018-09-04 | Syn Nat Products Entpr Llc | ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula? |
| US10428099B2 (en) | 2015-06-25 | 2019-10-01 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
-
2016
- 2016-06-27 US US15/736,179 patent/US10428099B2/en active Active
- 2016-06-27 JP JP2017567249A patent/JP6929234B2/ja not_active Expired - Fee Related
- 2016-06-27 CN CN202310745029.1A patent/CN116854745A/zh active Pending
- 2016-06-27 AU AU2016284816A patent/AU2016284816B2/en not_active Ceased
- 2016-06-27 WO PCT/US2016/039572 patent/WO2016210418A1/en not_active Ceased
- 2016-06-27 KR KR1020187001706A patent/KR20180021805A/ko not_active Ceased
- 2016-06-27 CA CA2989001A patent/CA2989001A1/en not_active Abandoned
- 2016-06-27 EP EP16815489.6A patent/EP3297640A4/en not_active Withdrawn
- 2016-06-27 CN CN201680037094.7A patent/CN107847521A/zh active Pending
-
2019
- 2019-08-15 US US16/541,504 patent/US20190367547A1/en not_active Abandoned
-
2020
- 2020-12-15 US US17/122,380 patent/US11685757B2/en active Active