JP2018518152A5 - - Google Patents
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- JP2018518152A5 JP2018518152A5 JP2017550493A JP2017550493A JP2018518152A5 JP 2018518152 A5 JP2018518152 A5 JP 2018518152A5 JP 2017550493 A JP2017550493 A JP 2017550493A JP 2017550493 A JP2017550493 A JP 2017550493A JP 2018518152 A5 JP2018518152 A5 JP 2018518152A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- acid sequence
- equivalent
- lhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 54
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 41
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 37
- 102000023108 LH Receptors Human genes 0.000 claims description 31
- 108010011942 LH Receptors Proteins 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 30
- 229920001184 polypeptide Polymers 0.000 claims description 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 22
- 150000007523 nucleic acids Chemical group 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 19
- 239000013598 vector Substances 0.000 claims description 17
- 239000000427 antigen Substances 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 16
- 239000000523 sample Substances 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 12
- 239000012472 biological sample Substances 0.000 claims description 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108091035707 Consensus sequence Proteins 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 230000001575 pathological effect Effects 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 230000004614 tumor growth Effects 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 2
- 102000003735 Mesothelin Human genes 0.000 claims description 2
- 108090000015 Mesothelin Proteins 0.000 claims description 2
- 102100023123 Mucin-16 Human genes 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims description 2
- 108091008039 hormone receptors Proteins 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 229940040129 luteinizing hormone Drugs 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 238000003364 immunohistochemistry Methods 0.000 description 4
- 206010033128 Ovarian cancer Diseases 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562139623P | 2015-03-27 | 2015-03-27 | |
| US62/139,623 | 2015-03-27 | ||
| PCT/US2016/024354 WO2016160618A2 (en) | 2015-03-27 | 2016-03-25 | Car t-cell therapy directed to lhr for the treatment of solid tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518152A JP2018518152A (ja) | 2018-07-12 |
| JP2018518152A5 true JP2018518152A5 (enExample) | 2019-05-09 |
Family
ID=57007252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550493A Pending JP2018518152A (ja) | 2015-03-27 | 2016-03-25 | 充実性腫瘍を処置するためのｌｈｒに指向されたｃａｒ ｔ細胞治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11136401B2 (enExample) |
| EP (1) | EP3273994B1 (enExample) |
| JP (1) | JP2018518152A (enExample) |
| CN (1) | CN107530427A (enExample) |
| AU (1) | AU2016243124A1 (enExample) |
| CA (1) | CA2981142A1 (enExample) |
| ES (1) | ES2904573T3 (enExample) |
| IL (1) | IL254701A0 (enExample) |
| WO (1) | WO2016160618A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016243124A1 (en) | 2015-03-27 | 2017-11-02 | University Of Southern California | CAR T-cell therapy directed to LHR for the treatment of solid tumors |
| CN107847601A (zh) | 2015-06-04 | 2018-03-27 | 南加利福尼亚大学 | Lym‑1和lym‑2靶向的car细胞免疫疗法 |
| TWI691510B (zh) | 2016-07-12 | 2020-04-21 | 美商凱特製藥公司 | 抗原結合分子和使用彼之方法 |
| CA3037528A1 (en) * | 2016-09-23 | 2018-03-29 | University Of Southern California | Chimeric antigen receptors and compositions and methods of use thereof |
| KR20250072712A (ko) | 2016-12-02 | 2025-05-26 | 앤젤레스 테라퓨틱스, 인코포레이티드 | 합성 면역 수용체 및 이의 사용 방법 |
| CN110650743B (zh) * | 2017-03-13 | 2023-12-29 | 波赛达治疗公司 | 用于选择性消除和替换造血干细胞的组合物和方法 |
| CN107354199A (zh) * | 2017-07-04 | 2017-11-17 | 武汉波睿达生物科技有限公司 | 一种检测靶向cd30的cart细胞中car表达的荧光定量试剂盒 |
| US10844371B2 (en) | 2017-09-22 | 2020-11-24 | Kite Pharma, Inc. | Antigen binding molecules and methods of use thereof |
| US11786557B2 (en) | 2017-10-02 | 2023-10-17 | Fred Hutchinson Cancer Center | Luteinizing hormone receptor binding agents and luteinizing hormone agonists to identify, expand, ablate and modify stem cells |
| SG11202011895VA (en) | 2018-06-04 | 2020-12-30 | Intrexon Corp | Muc16 specific chimeric antigen receptors and uses thereof |
| EP3844282A4 (en) * | 2018-08-29 | 2022-06-01 | Nanjing Legend Biotech Co., Ltd. | ANTI-MESOTHELIN CHIMERAL ANTIGEN RECEPTOR (CAR) CONSTRUCTS AND THEIR USES |
| EP3864414A4 (en) * | 2018-10-13 | 2023-03-29 | Memorial Sloan-Kettering Cancer Center | METHODS AND COMPOSITIONS FOR THE IDENTIFICATION AND TREATMENT OF SUBJECTS AT RISK OF A POOR RESPONSE TO CAR T CELL THERAPY |
| PH12021551619A1 (en) * | 2019-01-06 | 2022-05-23 | Abintus Bio Inc | Car t cell methods and constructs |
| MX2021009744A (es) | 2019-02-15 | 2021-11-12 | Univ Southern California | Composiciones de anticuerpos lym-1 y lym-2 y constructos car mejorados. |
| US20200384029A1 (en) * | 2019-06-07 | 2020-12-10 | The Trustees Of The University Of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| US20240288426A1 (en) * | 2020-01-12 | 2024-08-29 | Vanderbilt University | Human antibodies to crimean congo hemorrhagic fever virus |
| CN116033906A (zh) * | 2020-07-07 | 2023-04-28 | 特默佐梅有限公司 | 脂质体制剂 |
| WO2022081436A1 (en) * | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| CN113156142B (zh) * | 2021-04-16 | 2024-09-27 | 苏州才博医学科技有限公司 | 一种针对异体cart细胞特异性抗体的检测方法 |
| WO2025117530A2 (en) * | 2023-11-27 | 2025-06-05 | The Trustees Of Columbia University In The City Of New York | Tmem106b(120-254) aggregate-binding antibody |
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| ES2816450T3 (es) | 2012-02-22 | 2021-04-05 | Univ Pennsylvania | Uso de CAR basados en ICOS para mejorar la actividad antitumoral y la persistencia del CAR |
| RU2650805C2 (ru) | 2012-04-11 | 2018-04-17 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания в-клеток |
| US20130280220A1 (en) * | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
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| EP2730588A1 (en) | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
| US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| US20140348744A1 (en) * | 2013-05-24 | 2014-11-27 | Jacek K. Pinski | Compositions and methods for regulating cancer-related signaling pathways |
| EP3037819A4 (en) | 2013-08-23 | 2017-03-29 | Fujita Health University | Method of determining resistance to influenza virus |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| AU2016243124A1 (en) | 2015-03-27 | 2017-11-02 | University Of Southern California | CAR T-cell therapy directed to LHR for the treatment of solid tumors |
| US20190031759A1 (en) | 2015-04-30 | 2019-01-31 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
| US20200165342A1 (en) | 2017-02-21 | 2020-05-28 | Eutilex Co., Ltd. | Hla-dr car-t compositions and methods of making and using the same |
-
2016
- 2016-03-25 AU AU2016243124A patent/AU2016243124A1/en not_active Abandoned
- 2016-03-25 US US15/561,967 patent/US11136401B2/en active Active
- 2016-03-25 EP EP16773871.5A patent/EP3273994B1/en not_active Not-in-force
- 2016-03-25 WO PCT/US2016/024354 patent/WO2016160618A2/en not_active Ceased
- 2016-03-25 CN CN201680024480.2A patent/CN107530427A/zh active Pending
- 2016-03-25 CA CA2981142A patent/CA2981142A1/en not_active Abandoned
- 2016-03-25 ES ES16773871T patent/ES2904573T3/es active Active
- 2016-03-25 JP JP2017550493A patent/JP2018518152A/ja active Pending
-
2017
- 2017-09-26 IL IL254701A patent/IL254701A0/en unknown
-
2021
- 2021-08-31 US US17/462,987 patent/US20210403585A1/en not_active Abandoned
-
2024
- 2024-05-20 US US18/669,185 patent/US20250129171A1/en active Pending
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