JP2018513687A5 - - Google Patents
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- JP2018513687A5 JP2018513687A5 JP2017553189A JP2017553189A JP2018513687A5 JP 2018513687 A5 JP2018513687 A5 JP 2018513687A5 JP 2017553189 A JP2017553189 A JP 2017553189A JP 2017553189 A JP2017553189 A JP 2017553189A JP 2018513687 A5 JP2018513687 A5 JP 2018513687A5
- Authority
- JP
- Japan
- Prior art keywords
- egfr
- cells
- cell
- car
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 114
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 43
- 102000001301 EGF receptor Human genes 0.000 claims description 37
- 108060006698 EGF receptor Proteins 0.000 claims description 37
- 206010028980 Neoplasm Diseases 0.000 claims description 26
- 201000011510 cancer Diseases 0.000 claims description 25
- 239000013598 vector Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- 210000000130 stem cell Anatomy 0.000 claims description 13
- 206010006187 Breast cancer Diseases 0.000 claims description 12
- 208000026310 Breast neoplasm Diseases 0.000 claims description 12
- 230000000139 costimulatory effect Effects 0.000 claims description 12
- 208000005017 glioblastoma Diseases 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 10
- 206010027476 Metastases Diseases 0.000 claims description 10
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 10
- 230000009401 metastasis Effects 0.000 claims description 10
- 230000000174 oncolytic effect Effects 0.000 claims description 9
- 241000283690 Bos taurus Species 0.000 claims description 8
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 8
- 241000700584 Simplexvirus Species 0.000 claims description 8
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 241000699670 Mus sp. Species 0.000 claims description 6
- 210000004556 brain Anatomy 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 239000003550 marker Substances 0.000 claims description 5
- 210000004881 tumor cell Anatomy 0.000 claims description 5
- 241000282472 Canis lupus familiaris Species 0.000 claims description 4
- 241000283086 Equidae Species 0.000 claims description 4
- 241000282326 Felis catus Species 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 4
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 230000010261 cell growth Effects 0.000 claims description 3
- 210000000822 natural killer cell Anatomy 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 206010059282 Metastases to central nervous system Diseases 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 150000001413 amino acids Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 238000007917 intracranial administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 241001529453 unidentified herpesvirus Species 0.000 claims description 2
- 241000282465 Canis Species 0.000 description 4
- 241000283073 Equus caballus Species 0.000 description 4
- 241000282324 Felis Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 210000004962 mammalian cell Anatomy 0.000 description 4
- 210000004102 animal cell Anatomy 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 238000011394 anticancer treatment Methods 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143744P | 2015-04-06 | 2015-04-06 | |
| US62/143,744 | 2015-04-06 | ||
| PCT/US2016/026057 WO2016164370A1 (en) | 2015-04-06 | 2016-04-05 | Egfr-directed car therapy for glioblastoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020115454A Division JP2020156522A (ja) | 2015-04-06 | 2020-07-03 | 神経膠芽腫のためのｅｇｆｒ指向ｃａｒ療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513687A JP2018513687A (ja) | 2018-05-31 |
| JP2018513687A5 true JP2018513687A5 (enExample) | 2019-05-16 |
| JP6879932B2 JP6879932B2 (ja) | 2021-06-02 |
Family
ID=57073323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553189A Expired - Fee Related JP6879932B2 (ja) | 2015-04-06 | 2016-04-05 | 神経膠芽腫のためのｅｇｆｒ指向ｃａｒ療法 |
| JP2020115454A Pending JP2020156522A (ja) | 2015-04-06 | 2020-07-03 | 神経膠芽腫のためのｅｇｆｒ指向ｃａｒ療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020115454A Pending JP2020156522A (ja) | 2015-04-06 | 2020-07-03 | 神経膠芽腫のためのｅｇｆｒ指向ｃａｒ療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11045543B2 (enExample) |
| EP (1) | EP3280437A4 (enExample) |
| JP (2) | JP6879932B2 (enExample) |
| KR (1) | KR20180012749A (enExample) |
| CN (1) | CN108367057B (enExample) |
| AU (1) | AU2016246457B2 (enExample) |
| CA (1) | CA2981979A1 (enExample) |
| HK (1) | HK1250918A1 (enExample) |
| WO (1) | WO2016164370A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| JP7085990B2 (ja) * | 2015-10-13 | 2022-06-17 | シティ・オブ・ホープ | クロロトキシンドメインを含むキメラ抗原レセプター |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| CN107354199A (zh) * | 2017-07-04 | 2017-11-17 | 武汉波睿达生物科技有限公司 | 一种检测靶向cd30的cart细胞中car表达的荧光定量试剂盒 |
| CN107759701B (zh) * | 2017-10-27 | 2021-07-02 | 杭州优善生物科技有限公司 | 嵌合抗原受体、其修饰的NK细胞、编码DNA、mRNA、表达载体、制备方法和应用 |
| CN109836497A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向egfr的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN108315305B (zh) * | 2017-12-26 | 2020-11-06 | 沣潮医药科技（上海）有限公司 | 携带嵌合抗原受体的免疫细胞外泌体的制备方法及其应用 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| CN109568351B (zh) * | 2018-11-30 | 2020-02-21 | 武汉波睿达生物科技有限公司 | 溶瘤病毒和car-t联合应用针对实体肿瘤的治疗 |
| CN111378046B (zh) * | 2018-12-27 | 2024-03-15 | 上海细胞治疗集团有限公司 | 一种免疫效应细胞转换受体 |
| MX2021009785A (es) * | 2019-02-14 | 2021-09-08 | Res Institute At Nationwide Children´S Hospital | Uso de particulas de membrana plasmatica, liposomas y exosomas para evaluar la potencia de celulas inmunitarias. |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| CN110592024A (zh) * | 2019-09-12 | 2019-12-20 | 广东食品药品职业学院 | 以tEGFR与CD19为双靶点的CAR-NK细胞制备方法及其应用 |
| CN110845623B (zh) * | 2019-10-11 | 2021-07-09 | 厦门大学 | 一种egfr特异性嵌合抗原受体及其应用 |
| WO2021142835A1 (zh) * | 2020-01-19 | 2021-07-22 | 北京卡替医疗技术有限公司 | 一种提升免疫细胞功能的增强受体 |
| WO2021150936A1 (en) * | 2020-01-22 | 2021-07-29 | City Of Hope | Oncolytic virus compositions including il-15 complex and methods for the treatment of cancer |
| WO2021159035A1 (en) | 2020-02-07 | 2021-08-12 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
| CN111925448B (zh) * | 2020-08-03 | 2022-06-21 | 山东大学 | 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用 |
| JP2023541253A (ja) * | 2020-09-10 | 2023-09-29 | ムスタング バイオ，インコーポレイテッド | 癌標的のｃａｒ－ｔ細胞を含む併用療法と、それを癌治療に使用する方法 |
| US20240307539A1 (en) * | 2020-09-30 | 2024-09-19 | Institute Of Zoology, Chinese Academy Of Science | Egfr-targeting chimeric antigen receptor |
| WO2023034758A1 (en) * | 2021-08-30 | 2023-03-09 | Cytoimmune Therapeutics, Inc. | Methods and compositions for cell expansion |
| US20260216334A1 (en) * | 2023-01-11 | 2026-07-30 | The Trustees Of The University Of Pennsylvania | Hydrogels for intratumoral delivery of cellular immunotherapies |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1266014A2 (en) | 2000-03-24 | 2002-12-18 | Peter Kufer | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| WO2003082200A2 (en) | 2002-03-27 | 2003-10-09 | Baylor College Of Medicine | Potent oncolytic herpes simplex virus for cancer therapy |
| JP3803790B2 (ja) * | 2003-02-17 | 2006-08-02 | 株式会社東北テクノアーチ | 新規なダイアボディ型二重特異性抗体 |
| JP2005333993A (ja) * | 2005-08-03 | 2005-12-08 | Tohoku Techno Arch Co Ltd | 新規なダイアボディ型二重特異性抗体 |
| US20110052570A1 (en) * | 2005-10-26 | 2011-03-03 | Children's Medical Center Corporation | Method to prognose response to anti-egfr therapeutics |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| CN101952312A (zh) | 2007-07-31 | 2011-01-19 | 米迪缪尼有限公司 | 多特异性表位结合蛋白及其应用 |
| CA2735456C (en) | 2008-08-26 | 2021-11-16 | City Of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| EP3115373B1 (en) | 2010-09-08 | 2019-08-28 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP3459560B1 (en) | 2011-04-08 | 2021-02-24 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| WO2013033008A2 (en) | 2011-08-26 | 2013-03-07 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
| JP6053688B2 (ja) | 2011-10-07 | 2016-12-27 | 国立大学法人三重大学 | キメラ抗原受容体 |
| AU2012340174A1 (en) | 2011-11-16 | 2014-05-29 | Amgen Inc. | Methods of treating epidermal growth factor deletion mutant VIII related disorders |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| EP2817330B1 (en) | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| CN103483452B (zh) * | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| CN103113470B (zh) * | 2013-02-27 | 2015-04-22 | 四川大学 | 靶向人egfr的基因工程化淋巴细胞及其制备方法和用途 |
| CN105339498A (zh) | 2013-03-07 | 2016-02-17 | 贝勒医学院 | 癌症中靶向cd138 |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| DK2992020T3 (da) * | 2013-05-03 | 2020-02-10 | Ohio State Innovation Foundation | Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller |
| BR112015030514A2 (pt) * | 2013-06-04 | 2017-08-29 | Cytomx Therapeutics Inc | Composições e métodos para conjugação de anticorpos ativáveis |
| AU2014337367B2 (en) | 2013-10-15 | 2020-04-30 | The Scripps Research Institute | Peptidic chimeric antigen receptor T cell switches and uses thereof |
| KR102272932B1 (ko) | 2013-10-25 | 2021-07-05 | 싸이오서스 테라퓨틱스 엘티디. | 이종 유전자로 무장된 종양살상 아데노바이러스 |
| CN122399016A (zh) | 2014-03-15 | 2026-07-17 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| AU2015292744C1 (en) | 2014-07-21 | 2021-01-21 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| CN107530424A (zh) | 2015-02-20 | 2018-01-02 | 俄亥俄州国家创新基金会 | 针对nkg2d和肿瘤相关抗原的二价抗体 |
| WO2016154585A1 (en) | 2015-03-26 | 2016-09-29 | Charles Sentman | Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using |
| MX2018005618A (es) | 2015-11-05 | 2018-08-01 | Juno Therapeutics Inc | Receptores quimericos que contienen dominios inductores de traf y composiciones y metodos relacionados. |
| CA3034093A1 (en) | 2016-08-23 | 2018-03-01 | The Regents Of The University Of California | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
-
2016
- 2016-04-05 CN CN201680025143.5A patent/CN108367057B/zh not_active Expired - Fee Related
- 2016-04-05 CA CA2981979A patent/CA2981979A1/en active Pending
- 2016-04-05 US US15/564,166 patent/US11045543B2/en not_active Expired - Fee Related
- 2016-04-05 AU AU2016246457A patent/AU2016246457B2/en not_active Ceased
- 2016-04-05 EP EP16777143.5A patent/EP3280437A4/en not_active Withdrawn
- 2016-04-05 WO PCT/US2016/026057 patent/WO2016164370A1/en not_active Ceased
- 2016-04-05 KR KR1020177031930A patent/KR20180012749A/ko not_active Ceased
- 2016-04-05 HK HK18110330.8A patent/HK1250918A1/zh unknown
- 2016-04-05 JP JP2017553189A patent/JP6879932B2/ja not_active Expired - Fee Related
-
2020
- 2020-07-03 JP JP2020115454A patent/JP2020156522A/ja active Pending
-
2021
- 2021-03-12 US US17/200,322 patent/US20210308261A1/en not_active Abandoned
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