JP2018517731A5 - - Google Patents
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- Publication number
- JP2018517731A5 JP2018517731A5 JP2017564886A JP2017564886A JP2018517731A5 JP 2018517731 A5 JP2018517731 A5 JP 2018517731A5 JP 2017564886 A JP2017564886 A JP 2017564886A JP 2017564886 A JP2017564886 A JP 2017564886A JP 2018517731 A5 JP2018517731 A5 JP 2018517731A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- disease
- unsubstituted
- substituted
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562175510P | 2015-06-15 | 2015-06-15 | |
| US62/175,510 | 2015-06-15 | ||
| PCT/CN2016/085806 WO2016202253A1 (en) | 2015-06-15 | 2016-06-15 | Nrf2 regulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018517731A JP2018517731A (ja) | 2018-07-05 |
| JP2018517731A5 true JP2018517731A5 (enExample) | 2020-11-12 |
| JP6789995B2 JP6789995B2 (ja) | 2020-11-25 |
Family
ID=57545504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564886A Active JP6789995B2 (ja) | 2015-06-15 | 2016-06-15 | Ｎｒｆ２レギュレーター |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US10604509B2 (enExample) |
| EP (2) | EP3307739B1 (enExample) |
| JP (1) | JP6789995B2 (enExample) |
| KR (1) | KR102675041B1 (enExample) |
| CN (1) | CN108112251B (enExample) |
| AU (1) | AU2016279388B2 (enExample) |
| CA (1) | CA2988338C (enExample) |
| CL (1) | CL2017003226A1 (enExample) |
| CO (1) | CO2017012995A2 (enExample) |
| CY (1) | CY1123853T1 (enExample) |
| DK (2) | DK3782996T3 (enExample) |
| DO (1) | DOP2017000298A (enExample) |
| EA (1) | EA035864B1 (enExample) |
| ES (2) | ES2980945T3 (enExample) |
| FI (1) | FI3782996T3 (enExample) |
| HR (2) | HRP20240666T1 (enExample) |
| HU (2) | HUE052919T2 (enExample) |
| IL (1) | IL256297B (enExample) |
| LT (2) | LT3307739T (enExample) |
| MA (1) | MA52309B1 (enExample) |
| MX (1) | MX375352B (enExample) |
| MY (1) | MY207356A (enExample) |
| PE (1) | PE20180799A1 (enExample) |
| PH (1) | PH12017502255B1 (enExample) |
| PL (2) | PL3782996T3 (enExample) |
| PT (2) | PT3782996T (enExample) |
| RS (2) | RS61302B1 (enExample) |
| SI (2) | SI3307739T1 (enExample) |
| SM (1) | SMT202400207T1 (enExample) |
| WO (1) | WO2016202253A1 (enExample) |
| ZA (1) | ZA201708145B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108137557B (zh) | 2015-06-15 | 2021-09-07 | 葛兰素史密斯克莱知识产权发展有限公司 | Nrf2调节剂 |
| WO2017060855A1 (en) * | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as nrf2 regulators |
| WO2017060854A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as nrf2 regulators |
| JP2020502129A (ja) * | 2016-12-14 | 2020-01-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２アクチベーターとしての３−オキソ−１，４−ジアゼピニル化合物 |
| ES2901617T3 (es) | 2016-12-14 | 2022-03-23 | Glaxosmithkline Ip Dev Ltd | Bisarilamidas como reguladores de NRF2 |
| US11117905B2 (en) | 2016-12-14 | 2021-09-14 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl heterocycles as NRF2 activators |
| AU2017376900A1 (en) * | 2016-12-15 | 2019-05-23 | Glaxosmithkline Intellectual Property Development Limited | NRF2 compounds |
| US11059816B2 (en) | 2016-12-15 | 2021-07-13 | Glaxosmithkline Intellectual Property Development Limited | Ether linked triazoles as NRF2 activators |
| MX2019013645A (es) * | 2017-05-17 | 2020-09-17 | Denali Therapeutics Inc | Inhibidores de quinasa y usos de los mismos. |
| WO2019116231A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
| EP3773536A4 (en) * | 2018-04-06 | 2022-01-05 | The Board of Trustees of the University of Illinois | 1,4-SUBSTITUTES OF ISOQUINOLINE USED AS PROTEIN-PROTEIN INTERACTION INHIBITORS BETWEEN KEAP1 / NRF2 |
| MX2021002060A (es) | 2018-08-20 | 2021-07-21 | Janssen Pharmaceutica Nv | Inhibidores de la interacción proteína-proteína keap1-nrf2. |
| CA3121952C (en) | 2018-12-05 | 2025-05-13 | Scohia Pharma, Inc. | MACROCYCLICAL COMPOUND AND ITS USES |
| CN113474349B (zh) * | 2019-02-15 | 2024-03-01 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为nrf2活化剂的羟基吡啶并氧氮杂环庚三烯 |
| BR112021023927A2 (pt) * | 2019-05-31 | 2022-02-08 | Ube Industries | Composto, e, composição farmacêutica |
| EP3998262A4 (en) | 2019-07-03 | 2023-07-26 | Senju Pharmaceutical Co., Ltd. | NRF2 ACTIVATING COMPOUND |
| CN110845435B (zh) * | 2019-11-28 | 2021-06-08 | 中国药科大学 | 一种过氧化氢响应型Keap1-Nrf2 PPI抑制剂前药、制备方法及其医药用途 |
| KR102590438B1 (ko) * | 2020-10-16 | 2023-10-18 | 김홍렬 | Pmca 억제제를 포함하는 코로나바이러스 감염 또는 감염 질환의 예방 또는 소독용 조성물 |
| KR102590444B1 (ko) * | 2020-10-16 | 2023-10-18 | 김홍렬 | Pmca 억제제를 포함하는 코로나바이러스 감염 또는 감염 질환의 치료용 조성물 |
| CN114539085B (zh) * | 2020-11-26 | 2023-10-20 | 山东诚创蓝海医药科技有限公司 | 一种脲基衍生物的制备 |
| JP7681044B2 (ja) | 2020-12-28 | 2025-05-21 | 千寿製薬株式会社 | Ｎｒｆ２活性化化合物 |
| WO2023210741A1 (ja) | 2022-04-28 | 2023-11-02 | 第一三共株式会社 | ベンゾトリアゾール化合物 |
| US20250296939A1 (en) | 2022-04-28 | 2025-09-25 | Kyoto Pharmaceutical Industries, Ltd. | Benzothiophene compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CY1308A (en) | 1979-12-06 | 1985-12-06 | Glaxo Group Ltd | Device for dispensing medicaments |
| ATE23272T1 (de) | 1981-07-08 | 1986-11-15 | Draco Ab | Pulverinhalator. |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| ES286422Y (es) | 1982-10-08 | 1986-09-16 | Glaxo Group Limited | Dispositivo para administrar medicamentos a pacientes |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| PT83094B (pt) | 1985-07-30 | 1993-07-30 | Glaxo Group Ltd | Dispositivos proprios para a administracao de medicamentos a pacientes |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| SK280968B6 (sk) | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Balenie medikamentu na použite v inhalačnom prístroji |
| IL99537A (en) | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| US5217994A (en) | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
| WO1993012075A1 (fr) | 1991-12-10 | 1993-06-24 | Shionogi & Co., Ltd. | Derive d'acide hydroxamique a base de sulfonamide aromatique |
| DE4220983A1 (de) * | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate |
| JPH10501222A (ja) | 1994-05-27 | 1998-02-03 | メルク エンド カンパニー インコーポレーテッド | 破骨細胞仲介骨吸収を抑制するための化合物 |
| GB9700226D0 (en) | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
| TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| EP1360173A2 (en) | 2001-01-25 | 2003-11-12 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
| JPWO2002080899A1 (ja) | 2001-03-30 | 2005-01-06 | エーザイ株式会社 | 消化器疾患治療剤 |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| CN110894196A (zh) | 2001-09-21 | 2020-03-20 | 百时美-施贵宝控股爱尔兰无限公司 | 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂 |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| US20040157919A1 (en) | 2002-01-25 | 2004-08-12 | Yong-Qian Wu | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
| WO2004007464A1 (ja) | 2002-07-10 | 2004-01-22 | Sumitomo Pharmaceuticals Co., Ltd. | イミダゾール誘導体 |
| US7589116B2 (en) | 2003-04-03 | 2009-09-15 | Merck & Co. Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
| WO2006044133A1 (en) | 2004-09-24 | 2006-04-27 | Axys Pharmaceuticals, Inc. | Active ketone inhibitors of tryptase |
| WO2006118320A1 (ja) | 2005-04-28 | 2006-11-09 | Takeda Pharmaceutical Company Limited | チエノピリミドン化合物 |
| GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
| WO2008002490A2 (en) | 2006-06-23 | 2008-01-03 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| CN101939053A (zh) | 2007-09-06 | 2011-01-05 | 默沙东公司 | 可溶性的鸟苷酸环化酶活化剂 |
| WO2010005922A1 (en) | 2008-07-07 | 2010-01-14 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same, methods of use for same, and methods for preparing same |
| EP2401265B1 (en) | 2009-02-26 | 2016-09-14 | Merck Sharp & Dohme Corp. | Derivatives of 1-pyri(mid)in-2-yl-pyrazole-4-carboxylic acid which are useful for therapy or prophylaxis of cardiovascular diseases |
| WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| WO2012068589A2 (en) | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2013067036A1 (en) * | 2011-10-31 | 2013-05-10 | Rutgers, The State University Of New Jersey | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
| EP2816023A4 (en) * | 2012-02-13 | 2015-09-09 | Takeda Pharmaceutical | AROMATIC RING CONNECTION |
| WO2013155528A2 (en) | 2012-04-13 | 2013-10-17 | Fasgen, Inc. | Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels |
| US20160046616A1 (en) * | 2013-03-15 | 2016-02-18 | The Johns Hopkins University | Nrf2 small molecule inhibitors for cancer therapy |
| AU2014369153B2 (en) | 2013-12-18 | 2017-09-21 | Astex Therapeutics Limited | Nrf2 regulators |
| JP2018517732A (ja) | 2015-06-15 | 2018-07-05 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーター |
| CN108137557B (zh) | 2015-06-15 | 2021-09-07 | 葛兰素史密斯克莱知识产权发展有限公司 | Nrf2调节剂 |
| WO2017060854A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as nrf2 regulators |
| WO2017060855A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as nrf2 regulators |
-
2016
- 2016-06-15 CA CA2988338A patent/CA2988338C/en active Active
- 2016-06-15 PT PT202002077T patent/PT3782996T/pt unknown
- 2016-06-15 DK DK20200207.7T patent/DK3782996T3/da active
- 2016-06-15 LT LTEP16810994.0T patent/LT3307739T/lt unknown
- 2016-06-15 HU HUE16810994A patent/HUE052919T2/hu unknown
- 2016-06-15 US US15/736,075 patent/US10604509B2/en active Active
- 2016-06-15 PL PL20200207.7T patent/PL3782996T3/pl unknown
- 2016-06-15 SI SI201631036T patent/SI3307739T1/sl unknown
- 2016-06-15 FI FIEP20200207.7T patent/FI3782996T3/fi active
- 2016-06-15 KR KR1020187000828A patent/KR102675041B1/ko active Active
- 2016-06-15 RS RS20210012A patent/RS61302B1/sr unknown
- 2016-06-15 RS RS20240608A patent/RS65562B1/sr unknown
- 2016-06-15 ES ES20200207T patent/ES2980945T3/es active Active
- 2016-06-15 SI SI201631820T patent/SI3782996T1/sl unknown
- 2016-06-15 AU AU2016279388A patent/AU2016279388B2/en active Active
- 2016-06-15 MA MA52309A patent/MA52309B1/fr unknown
- 2016-06-15 EP EP16810994.0A patent/EP3307739B1/en active Active
- 2016-06-15 SM SM20240207T patent/SMT202400207T1/it unknown
- 2016-06-15 DK DK16810994.0T patent/DK3307739T3/da active
- 2016-06-15 PE PE2017002744A patent/PE20180799A1/es unknown
- 2016-06-15 MX MX2017016405A patent/MX375352B/es active IP Right Grant
- 2016-06-15 MY MYPI2017704768A patent/MY207356A/en unknown
- 2016-06-15 PH PH1/2017/502255A patent/PH12017502255B1/en unknown
- 2016-06-15 WO PCT/CN2016/085806 patent/WO2016202253A1/en not_active Ceased
- 2016-06-15 ES ES16810994T patent/ES2841574T3/es active Active
- 2016-06-15 EA EA201890052A patent/EA035864B1/ru not_active IP Right Cessation
- 2016-06-15 HR HRP20240666TT patent/HRP20240666T1/hr unknown
- 2016-06-15 PL PL16810994T patent/PL3307739T3/pl unknown
- 2016-06-15 JP JP2017564886A patent/JP6789995B2/ja active Active
- 2016-06-15 EP EP20200207.7A patent/EP3782996B1/en active Active
- 2016-06-15 PT PT168109940T patent/PT3307739T/pt unknown
- 2016-06-15 HR HRP20202036TT patent/HRP20202036T1/hr unknown
- 2016-06-15 LT LTEP20200207.7T patent/LT3782996T/lt unknown
- 2016-06-15 CN CN201680048338.1A patent/CN108112251B/zh active Active
- 2016-06-15 HU HUE20200207A patent/HUE066668T2/hu unknown
-
2017
- 2017-11-30 ZA ZA2017/08145A patent/ZA201708145B/en unknown
- 2017-12-13 IL IL256297A patent/IL256297B/en active IP Right Grant
- 2017-12-15 CL CL2017003226A patent/CL2017003226A1/es unknown
- 2017-12-15 DO DO2017000298A patent/DOP2017000298A/es unknown
- 2017-12-19 CO CONC2017/0012995A patent/CO2017012995A2/es unknown
-
2019
- 2019-11-06 US US16/675,634 patent/US20200079759A1/en not_active Abandoned
-
2020
- 2020-12-29 CY CY20201101223T patent/CY1123853T1/el unknown
-
2021
- 2021-10-06 US US17/495,115 patent/US20230047296A1/en not_active Abandoned
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