DK3833662T3 - Inhibitorer af protein-protein-interaktionen mellem KEAP-1-NRF2- - Google Patents
Inhibitorer af protein-protein-interaktionen mellem KEAP-1-NRF2- Download PDFInfo
- Publication number
- DK3833662T3 DK3833662T3 DK19773579.8T DK19773579T DK3833662T3 DK 3833662 T3 DK3833662 T3 DK 3833662T3 DK 19773579 T DK19773579 T DK 19773579T DK 3833662 T3 DK3833662 T3 DK 3833662T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- keap
- nrf2
- inhibitors
- interaction
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000004850 protein–protein interaction Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862719978P | 2018-08-20 | 2018-08-20 | |
| US201962801433P | 2019-02-05 | 2019-02-05 | |
| US201962823450P | 2019-03-25 | 2019-03-25 | |
| US201962875737P | 2019-07-18 | 2019-07-18 | |
| US201962881639P | 2019-08-01 | 2019-08-01 | |
| PCT/US2019/047015 WO2020041169A2 (en) | 2018-08-20 | 2019-08-19 | Inhibitors of keap1-nrf2 protein-protein interaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3833662T3 true DK3833662T3 (da) | 2024-02-26 |
Family
ID=69523716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19773579.8T DK3833662T3 (da) | 2018-08-20 | 2019-08-19 | Inhibitorer af protein-protein-interaktionen mellem KEAP-1-NRF2- |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10947252B2 (da) |
| EP (1) | EP3833662B1 (da) |
| JP (2) | JP7212763B2 (da) |
| KR (2) | KR20230146136A (da) |
| CN (1) | CN112930347A (da) |
| AU (3) | AU2019326368B2 (da) |
| BR (1) | BR112021002979A2 (da) |
| CA (1) | CA3108534A1 (da) |
| CL (1) | CL2021000426A1 (da) |
| CO (1) | CO2021002670A2 (da) |
| CR (1) | CR20210087A (da) |
| DK (1) | DK3833662T3 (da) |
| EC (1) | ECSP21016032A (da) |
| FI (1) | FI3833662T3 (da) |
| IL (2) | IL280950B2 (da) |
| JO (1) | JOP20210030A1 (da) |
| MX (1) | MX2021002060A (da) |
| PE (1) | PE20211205A1 (da) |
| PH (1) | PH12021500012A1 (da) |
| PT (1) | PT3833662T (da) |
| SG (1) | SG11202101613XA (da) |
| TW (2) | TWI781342B (da) |
| UA (1) | UA126950C2 (da) |
| UY (1) | UY38338A (da) |
| WO (1) | WO2020041169A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019326368B2 (en) | 2018-08-20 | 2021-11-11 | Janssen Pharmaceutica Nv | Inhibitors of KEAP1-Nrf2 protein-protein interaction |
| WO2020241853A1 (ja) | 2019-05-31 | 2020-12-03 | 宇部興産株式会社 | ベンゾトリアゾール誘導体 |
| US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| EP4273145A1 (en) * | 2020-12-28 | 2023-11-08 | Senju Pharmaceutical Co., Ltd. | Nrf2-activating compound |
| CN112661655B (zh) * | 2020-12-29 | 2022-02-18 | 江苏云朴医药新材料科技有限公司 | 一种1-氨甲基-1-环丙醇类化合物及其合成方法 |
| WO2023210741A1 (ja) * | 2022-04-28 | 2023-11-02 | 第一三共株式会社 | ベンゾトリアゾール化合物 |
| CN115925606B (zh) * | 2023-01-05 | 2023-10-13 | 宁夏医科大学 | 一种5-（3-（磺酰胺基）苯基）-1h-吡咯-2-羧酸衍生物及其制备方法和应用 |
| CN116003397B (zh) * | 2023-03-24 | 2023-06-16 | 凯思凯旭(上海)医药科技有限公司 | 一种苯并多元环噻唑啉酰胺类化合物及其应用 |
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| AU2019326368B2 (en) * | 2018-08-20 | 2021-11-11 | Janssen Pharmaceutica Nv | Inhibitors of KEAP1-Nrf2 protein-protein interaction |
| JP2022508936A (ja) | 2018-10-19 | 2022-01-19 | アクリプス ワン インコーポレイテッド | 神経疾患の治療 |
| WO2020084300A1 (en) | 2018-10-22 | 2020-04-30 | C4X Discovery Limited | Therapeutic compounds |
| UA127872C2 (uk) | 2018-12-05 | 2024-01-31 | Скохія Фарма, Інк. | Макроциклічна сполука та її застосування |
| WO2020132040A1 (en) | 2018-12-20 | 2020-06-25 | President And Fellows Of Harvard College | Compositions and methods for the treatment of degenerative ocular diseases |
| WO2020150446A1 (en) | 2019-01-18 | 2020-07-23 | Rutgers, The State University Of New Jersey | Small molecule direct inhibitors of keap1-nrf2 protein-protein interaction |
| MA54939A (fr) | 2019-02-15 | 2021-12-22 | Glaxosmithkline Ip Dev Ltd | Hydroxypyridoxazépines utilisées en tant qu'activateurs de nrf2 |
| AU2020264773A1 (en) | 2019-04-30 | 2021-10-14 | Sitryx Therapeutics Limited | Itaconic acid derivatives and uses thereof in treating an inflammatory disease or a disease associated with an undesirable immune response |
| WO2020241853A1 (ja) | 2019-05-31 | 2020-12-03 | 宇部興産株式会社 | ベンゾトリアゾール誘導体 |
| CN110256305B (zh) | 2019-07-24 | 2020-05-26 | 中国药科大学 | 一种萘磺酰胺类化合物、制备方法和应用 |
| CN110845435B (zh) | 2019-11-28 | 2021-06-08 | 中国药科大学 | 一种过氧化氢响应型Keap1-Nrf2 PPI抑制剂前药、制备方法及其医药用途 |
| CN111362857B (zh) | 2020-04-23 | 2023-02-28 | 中国药科大学 | 一类具有吲哚啉骨架的化合物、制备方法及其医药用途 |
| CN112321620B (zh) | 2020-11-10 | 2022-03-29 | 中国药科大学 | 一种Keap1-Nrf2 PPI抑制剂前药、制备方法和用途 |
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