UY38338A - INHIBIDORES DE LA INTERACCIÓN PROTEÍNA-PROTEÍNA KEAP1-Nrf2 - Google Patents

INHIBIDORES DE LA INTERACCIÓN PROTEÍNA-PROTEÍNA KEAP1-Nrf2

Info

Publication number
UY38338A
UY38338A UY0001038338A UY38338A UY38338A UY 38338 A UY38338 A UY 38338A UY 0001038338 A UY0001038338 A UY 0001038338A UY 38338 A UY38338 A UY 38338A UY 38338 A UY38338 A UY 38338A
Authority
UY
Uruguay
Prior art keywords
protein
keap1
inhibitors
nrf2
methods
Prior art date
Application number
UY0001038338A
Other languages
English (en)
Inventor
D Venable Jennifer
Jianmei Wei
Kent Barbay J
Wenying Chai
C Hirst Gavin
T Nishimura Rachel
Y Shih Amy
D Kreutter Kevin
A Kummer David
Hariharan Venkatesan
J Mcclure Kelly
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY38338A publication Critical patent/UY38338A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos de sultam, composiciones farmacéuticas que los contienen, métodos para elaborarlos y métodos para usarlos que incluyen métodos para tratar estados de enfermedad, trastornos y afecciones asociados con la interacción de KEAP1-Nrf2, tal como inflamación intestinal, que incluye enfermedad de Crohn y colitis ulcerante.
UY0001038338A 2018-08-20 2019-08-19 INHIBIDORES DE LA INTERACCIÓN PROTEÍNA-PROTEÍNA KEAP1-Nrf2 UY38338A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862719978P 2018-08-20 2018-08-20
US201962801433P 2019-02-05 2019-02-05
US201962823450P 2019-03-25 2019-03-25
US201962875737P 2019-07-18 2019-07-18
US201962881639P 2019-08-01 2019-08-01

Publications (1)

Publication Number Publication Date
UY38338A true UY38338A (es) 2020-02-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038338A UY38338A (es) 2018-08-20 2019-08-19 INHIBIDORES DE LA INTERACCIÓN PROTEÍNA-PROTEÍNA KEAP1-Nrf2

Country Status (28)

Country Link
US (3) US10947252B2 (es)
EP (2) EP4364804A3 (es)
JP (2) JP7212763B2 (es)
KR (2) KR102590310B1 (es)
CN (1) CN112930347B (es)
AU (3) AU2019326368B2 (es)
BR (1) BR112021002979A2 (es)
CA (1) CA3108534A1 (es)
CL (1) CL2021000426A1 (es)
CO (1) CO2021002670A2 (es)
CR (1) CR20210087A (es)
DK (1) DK3833662T3 (es)
EC (1) ECSP21016032A (es)
ES (1) ES2974026T3 (es)
FI (1) FI3833662T3 (es)
HU (1) HUE065501T2 (es)
IL (2) IL280950B2 (es)
JO (1) JOP20210030A1 (es)
MX (1) MX2021002060A (es)
PE (1) PE20211205A1 (es)
PH (1) PH12021500012A1 (es)
PL (1) PL3833662T3 (es)
PT (1) PT3833662T (es)
SG (1) SG11202101613XA (es)
TW (2) TW202309020A (es)
UA (1) UA126950C2 (es)
UY (1) UY38338A (es)
WO (1) WO2020041169A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3833662T3 (da) 2018-08-20 2024-02-26 Janssen Pharmaceutica Nv Inhibitorer af protein-protein-interaktionen mellem KEAP-1-NRF2-
AU2020283361A1 (en) 2019-05-31 2022-01-20 Ube Corporation Benzotriazole derivative
US20230107927A1 (en) 2020-02-28 2023-04-06 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
WO2022145459A1 (ja) * 2020-12-28 2022-07-07 千寿製薬株式会社 Ｎｒｆ２活性化化合物
CN112661655B (zh) * 2020-12-29 2022-02-18 江苏云朴医药新材料科技有限公司 一种1-氨甲基-1-环丙醇类化合物及其合成方法
WO2023210741A1 (ja) * 2022-04-28 2023-11-02 第一三共株式会社 ベンゾトリアゾール化合物
TW202400017A (zh) 2022-04-28 2024-01-01 日商日本農藥股份有限公司 具肟基之含氮雜環化合物及含有該化合物之農園藝用除草劑、以及彼等之使用方法
CN115925606B (zh) * 2023-01-05 2023-10-13 宁夏医科大学 一种5-（3-（磺酰胺基）苯基）-1h-吡咯-2-羧酸衍生物及其制备方法和应用
CN116003397B (zh) * 2023-03-24 2023-06-16 凯思凯旭(上海)医药科技有限公司 一种苯并多元环噻唑啉酰胺类化合物及其应用

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2614110A1 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
WO2007008652A2 (en) 2005-07-08 2007-01-18 The University Of North Carolina At Chapel Hill Methods and compositions directed to dj-1 as regulator of the anti-oxidant transcription factor nrf2
US8022246B2 (en) 2006-10-10 2011-09-20 The Burnham Institute For Medical Research Neuroprotective compositions and methods
WO2011156889A1 (en) 2010-06-14 2011-12-22 Trt Pharma Inc. Novel modulators of nrf2 and uses thereof
US10828378B2 (en) 2011-01-21 2020-11-10 Riken Nucleic acid construct for expression of oxidative stress indicator and use thereof
US9075070B2 (en) 2011-02-09 2015-07-07 Rutgers, The State University Of New Jersey HTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction
WO2012116362A2 (en) 2011-02-25 2012-08-30 The Johns Hopkins University Chalcone derivatives as nrf2 activators
JP2013028575A (ja) 2011-07-29 2013-02-07 Toray Ind Inc Ｋｅａｐ１タンパク質結合化合物、該Ｋｅａｐ１タンパク質結合化合物とＫｅａｐ１タンパク質の複合体の結晶及びその製造方法
US20140256767A1 (en) 2011-10-31 2014-09-11 The Broad Institute, Inc. Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators
ME02926B (me) 2012-04-27 2018-04-20 Reata Pharmaceuticals Inc 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu
US10054583B2 (en) 2012-10-10 2018-08-21 Temple University Of The Commonwealth System Of Higher Education Nuclear factor-erythroid 2 related factor 2 (NRF2) biosensors and modulators of NRF2
WO2014148455A1 (ja) 2013-03-19 2014-09-25 第一三共株式会社 テルペノイド誘導体
TW201936625A (zh) 2013-04-24 2019-09-16 美商艾伯維有限公司 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法
WO2014197818A2 (en) 2013-06-07 2014-12-11 The General Hospital Corporation Small molecule activators of nrf2 pathway
EP3777980B1 (en) 2013-10-29 2023-12-06 President and Fellows of Harvard College Nuclear factor erythroid 2-like 2 (nrf2) for use in treatment of age-related macular degeneration
CA2934216C (en) * 2013-12-18 2021-03-16 Glaxosmithkline Intellectual Property Development Limited Substitued phenyl or benzyl propanote derivatives and pharmaceutical compositiions thereof useful as nrf2 regulators
WO2015127094A1 (en) 2014-02-19 2015-08-27 University Of Florida Research Foundation, Inc. Delivery of nrf2 as therapy for protection against reactive oxygen species
EP3192875B1 (en) 2014-09-10 2019-12-18 Daiichi Sankyo Company, Limited Sustained-release pharmaceutical composition for treating and preventing ophthalmic diseases
ES2570452B1 (es) 2014-10-15 2017-04-19 Fundación Para La Investigación Biomédida Del Hospital Universitario De La Princesa Compuestos derivados de acrilato de 3-Alquilamino-1H-Indolilo y su uso en el tratamiento de enfermedades neurodegenerativas
US20160120158A1 (en) 2014-11-03 2016-05-05 The Johns Hopkins University Compositions and methods for the study and treatment of acute kidney injury
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
CN104825443B (zh) 2015-04-27 2017-10-24 广东省中医院 青蒿烯的抗氧化应用
MX2017016405A (es) 2015-06-15 2018-05-22 Glaxosmithkline Ip Dev Ltd Reguladores de nrf2.
CA2988373A1 (en) 2015-06-15 2016-12-22 Glaxosmithkline Intellectual Property Development Limited Nrf2 regulators
WO2017031223A1 (en) 2015-08-18 2017-02-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Activators of nrf2-dependent photoprotection and related uses thereof
WO2017060854A1 (en) 2015-10-06 2017-04-13 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as nrf2 regulators
EP3371167A1 (en) 2015-10-06 2018-09-12 GlaxoSmithKline Intellectual Property Development Limited Arylcyclohexyl pyrazoles as nrf2 regulators
CN105566241B (zh) 2016-01-18 2018-05-25 中国药科大学 1-磺酰胺基-4-芳氧基类化合物、制备方法及其医药用途
EP3429690A4 (en) 2016-03-16 2019-10-23 Ionis Pharmaceuticals, Inc. METHOD FOR MODULATING KEAP1
CN105753795B (zh) * 2016-04-29 2018-04-13 济南大学 一种具有1,2,3‑三氮唑结构片段的生物碱化合物及其用途
DK3471733T3 (da) 2016-06-15 2024-10-14 Targa Biomedical Inc Reagenser, sammensætninger og fremgangsmåder til forbedring af cellers, vævs og organers levedygtighed og funktion
WO2018089386A1 (en) 2016-11-11 2018-05-17 The Broad Institute, Inc. Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
CN108779108A (zh) 2016-12-06 2018-11-09 葛兰素史密斯克莱知识产权发展有限公司 3-(2,3-二氢-1h-茚-5-基)丙酸衍生物和它们作为nrf2调节剂的用途
WO2018109641A1 (en) 2016-12-12 2018-06-21 Glaxosmithkline Intellectual Property Development Limited 3-carboxylic acid pyrroles as nrf2 regulators
JP2020500918A (ja) 2016-12-12 2020-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーターとしてのｎ−アリールピラゾール
US11078216B2 (en) 2016-12-14 2021-08-03 Glaxosmithkline Intellectual Property Development Limited Bisaryl amides as NRF2 activators
US20220002272A1 (en) 2016-12-14 2022-01-06 Glaxosmithkline Intellectual Property Development Limited Bisaryl lactams as nrf2 activators
US11117905B2 (en) 2016-12-14 2021-09-14 Glaxosmithkline Intellectual Property Development Limited Bisaryl heterocycles as NRF2 activators
JP7110197B2 (ja) 2016-12-15 2022-08-01 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｎｒｆ２アクチベーター
JP2020502152A (ja) 2016-12-15 2020-01-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２アクチベーターとしてのエーテル結合トリアゾール
US20190389836A1 (en) 2017-01-30 2019-12-26 Biogen Ma Inc. Nrf2 activator
US10786471B2 (en) * 2017-02-06 2020-09-29 Massachusetts Institute Of Technology Methods and products related to glutaminase inhibitors
JP2020097526A (ja) 2017-03-28 2020-06-25 武田薬品工業株式会社 複素環化合物
CN107033100B (zh) 2017-05-24 2019-03-01 济南大学 一种苯并噻唑衍生物、制备方法及其医药用途
CN107236813A (zh) 2017-07-02 2017-10-10 东北林业大学 一种指示Nrf2‑Keap1相互作用的BiFC细胞内检测方法及系统
CN107881195B (zh) 2017-10-26 2021-08-27 深圳市第三人民医院 一种双基因共表达质粒pIRES2-Nrf2-DKK1及其制备方法和应用
WO2019122265A1 (en) 2017-12-22 2019-06-27 Medimmune Limited Small molecule modulators of the btb domain of keap1
CA3095908A1 (en) 2018-04-06 2019-10-10 The Board Of Trustees Of The University Of Illinois 1,4-substituted isoquinoline inhibitors of keap1/nrf2 protein-protein interaction
WO2019224667A1 (en) 2018-05-23 2019-11-28 Glaxosmithkline Intellectual Property Development Limited Indanes as nrf2 activators
CN110724669A (zh) 2018-06-29 2020-01-24 李陶 一种Nrf2基因修饰的脐带间充质干细胞及其制备方法与应用
CN108752245A (zh) 2018-07-16 2018-11-06 宁夏医科大学 萘磺酰胺乙酰胺类化合物及其应用和药物组合物
DK3833662T3 (da) * 2018-08-20 2024-02-26 Janssen Pharmaceutica Nv Inhibitorer af protein-protein-interaktionen mellem KEAP-1-NRF2-
KR20210102208A (ko) 2018-10-19 2021-08-19 아클립스 원, 인크. 신경계 질환의 치료
PT3870578T (pt) 2018-10-22 2023-11-15 C4X Discovery Ltd Compostos terapêuticos
CN113164468A (zh) 2018-12-05 2021-07-23 思可海雅药品公司 大环化合物及其用途
US20220088222A1 (en) 2018-12-20 2022-03-24 President And Fellows Of Harvard College Compositions and methods for the treatment of degenerative ocular diseases
WO2020150446A1 (en) 2019-01-18 2020-07-23 Rutgers, The State University Of New Jersey Small molecule direct inhibitors of keap1-nrf2 protein-protein interaction
JP2022520442A (ja) 2019-02-15 2022-03-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｎｒｆ２活性剤としてのヒドロキシピリドキシアゼピン
BR112021021301A2 (pt) 2019-04-30 2022-01-18 Sitryx Therapeutics Ltd Derivados de ácido itacônico e usos dos mesmos no tratamento de uma doença inflamatória ou de uma doença associada a uma resposta imune indesejável
AU2020283361A1 (en) 2019-05-31 2022-01-20 Ube Corporation Benzotriazole derivative
CN110256305B (zh) 2019-07-24 2020-05-26 中国药科大学 一种萘磺酰胺类化合物、制备方法和应用
CN110845435B (zh) 2019-11-28 2021-06-08 中国药科大学 一种过氧化氢响应型Keap1-Nrf2 PPI抑制剂前药、制备方法及其医药用途
CN111362857B (zh) 2020-04-23 2023-02-28 中国药科大学 一类具有吲哚啉骨架的化合物、制备方法及其医药用途
CN112321620B (zh) 2020-11-10 2022-03-29 中国药科大学 一种Keap1-Nrf2 PPI抑制剂前药、制备方法和用途

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