JP2018510178A5 - - Google Patents

Download PDF

Info

Publication number
JP2018510178A5
JP2018510178A5 JP2017551039A JP2017551039A JP2018510178A5 JP 2018510178 A5 JP2018510178 A5 JP 2018510178A5 JP 2017551039 A JP2017551039 A JP 2017551039A JP 2017551039 A JP2017551039 A JP 2017551039A JP 2018510178 A5 JP2018510178 A5 JP 2018510178A5
Authority
JP
Japan
Prior art keywords
weight
component
configuration
intragranular
extragranular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017551039A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018510178A (ja
JP6929785B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/025235 external-priority patent/WO2016161094A1/en
Publication of JP2018510178A publication Critical patent/JP2018510178A/ja
Publication of JP2018510178A5 publication Critical patent/JP2018510178A5/ja
Priority to JP2021131241A priority Critical patent/JP7270688B2/ja
Application granted granted Critical
Publication of JP6929785B2 publication Critical patent/JP6929785B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017551039A 2015-04-01 2016-03-31 貧血治療のための組成物及び方法 Active JP6929785B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021131241A JP7270688B2 (ja) 2015-04-01 2021-08-11 貧血治療のための組成物及び方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562141420P 2015-04-01 2015-04-01
US62/141,420 2015-04-01
US201562270168P 2015-12-21 2015-12-21
US62/270,168 2015-12-21
PCT/US2016/025235 WO2016161094A1 (en) 2015-04-01 2016-03-31 Compositions and methods for treating anemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021131241A Division JP7270688B2 (ja) 2015-04-01 2021-08-11 貧血治療のための組成物及び方法

Publications (3)

Publication Number Publication Date
JP2018510178A JP2018510178A (ja) 2018-04-12
JP2018510178A5 true JP2018510178A5 (cg-RX-API-DMAC7.html) 2019-05-09
JP6929785B2 JP6929785B2 (ja) 2021-09-01

Family

ID=57006457

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017551039A Active JP6929785B2 (ja) 2015-04-01 2016-03-31 貧血治療のための組成物及び方法
JP2021131241A Active JP7270688B2 (ja) 2015-04-01 2021-08-11 貧血治療のための組成物及び方法
JP2023071337A Active JP7629049B2 (ja) 2015-04-01 2023-04-25 貧血治療のための組成物及び方法
JP2025013506A Pending JP2025069280A (ja) 2015-04-01 2025-01-30 貧血治療のための組成物及び方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021131241A Active JP7270688B2 (ja) 2015-04-01 2021-08-11 貧血治療のための組成物及び方法
JP2023071337A Active JP7629049B2 (ja) 2015-04-01 2023-04-25 貧血治療のための組成物及び方法
JP2025013506A Pending JP2025069280A (ja) 2015-04-01 2025-01-30 貧血治療のための組成物及び方法

Country Status (35)

Country Link
US (3) US11324734B2 (cg-RX-API-DMAC7.html)
EP (2) EP3277270B1 (cg-RX-API-DMAC7.html)
JP (4) JP6929785B2 (cg-RX-API-DMAC7.html)
KR (3) KR102647879B1 (cg-RX-API-DMAC7.html)
CN (2) CN115607521A (cg-RX-API-DMAC7.html)
AU (3) AU2016243700B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017021097B1 (cg-RX-API-DMAC7.html)
CL (2) CL2017002456A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017011200A2 (cg-RX-API-DMAC7.html)
CR (2) CR20170450A (cg-RX-API-DMAC7.html)
CU (1) CU20170126A7 (cg-RX-API-DMAC7.html)
CY (1) CY1124869T1 (cg-RX-API-DMAC7.html)
DK (1) DK3277270T3 (cg-RX-API-DMAC7.html)
EA (1) EA036920B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP17073209A (cg-RX-API-DMAC7.html)
ES (1) ES2900481T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20211862T1 (cg-RX-API-DMAC7.html)
HU (1) HUE056958T2 (cg-RX-API-DMAC7.html)
IL (3) IL292262B2 (cg-RX-API-DMAC7.html)
LT (1) LT3277270T (cg-RX-API-DMAC7.html)
MA (1) MA41863A (cg-RX-API-DMAC7.html)
MX (3) MX386796B (cg-RX-API-DMAC7.html)
MY (1) MY192705A (cg-RX-API-DMAC7.html)
NZ (1) NZ735973A (cg-RX-API-DMAC7.html)
PE (1) PE20180189A1 (cg-RX-API-DMAC7.html)
PH (1) PH12017501789B1 (cg-RX-API-DMAC7.html)
PL (1) PL3277270T3 (cg-RX-API-DMAC7.html)
PT (1) PT3277270T (cg-RX-API-DMAC7.html)
SA (1) SA517390054B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201707994UA (cg-RX-API-DMAC7.html)
SI (1) SI3277270T1 (cg-RX-API-DMAC7.html)
TW (4) TWI836883B (cg-RX-API-DMAC7.html)
UA (1) UA123308C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016161094A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201706681B (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009000286A (es) 2006-06-26 2009-03-20 Procter & Gamble Inhibidores de prolil hidroxilasa y metodos de uso.
NO2686520T3 (cg-RX-API-DMAC7.html) 2011-06-06 2018-03-17
PT3007695T (pt) 2013-06-13 2024-03-07 Akebia Therapeutics Inc Composições e métodos para tratamento de anemia
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
CN107427503A (zh) 2015-01-23 2017-12-01 阿克比治疗有限公司 2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途
CR20170450A (es) 2015-04-01 2018-04-03 Akebia Therapeutics Inc Composiciones y métodos para el tratamiento de la anemia
JP6864834B2 (ja) 2017-06-14 2021-04-28 ニプロ株式会社 投与量決定プログラムおよび投与量決定装置
WO2019028150A1 (en) 2017-08-01 2019-02-07 Akebia Therapeutics, Inc. COMPOSITIONS FOR USE IN METHODS OF TREATING HEMOGLOBINOPATHIES
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
JP2023501221A (ja) * 2019-10-31 2023-01-18 アケビア セラピューティクス インコーポレイテッド バダデュスタットを使用する治療方法
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
WO2021186356A1 (en) * 2020-03-17 2021-09-23 Cadila Healthcare Limited Formulation comprising hif prolyl hydroxylase inhibitors
US20210353612A1 (en) * 2020-04-29 2021-11-18 BioAge Labs, Inc. Hypoxia-inducible factor prolyl hydroxylase inhibitors for treating aging-related conditions
CA3180509A1 (en) * 2020-06-19 2021-12-23 Sayantan CHATTORAJ Formulation comprising daprodustat
EP4181873A1 (en) 2020-06-19 2023-05-24 Akebia Therapeutics Inc. Modulation of drug-drug interactions of vadadustat
US20220034871A1 (en) * 2020-07-31 2022-02-03 Daiichi Sankyo Company, Limited Methods for administering pexidartinib
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
AU2022206302A1 (en) 2021-01-08 2023-08-17 Akebia Therapeutics, Inc. Therapeutic methods using vadadustat
JP2024510926A (ja) 2021-03-01 2024-03-12 アケビア セラピューティクス インコーポレイテッド バダデュスタットの薬物間相互作用の調節
CN119868550A (zh) * 2023-10-24 2025-04-25 杭州安道药业有限公司 缺氧诱导因子-脯酰胺羟基化酶抑制剂(hif-phi)在罕见贫血中的应用

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655679A (en) 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
US3703582A (en) 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
US3894920A (en) 1971-12-21 1975-07-15 Sagami Chem Res Process for preparing alkyl-substituted 3,6-dihydro-o-dioxin derivatives
US4016287A (en) 1972-07-17 1977-04-05 Boehringer Ingelheim Gmbh Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof
CA1261335A (en) 1984-08-29 1989-09-26 Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee Ethylenediamine monoamide derivatives
CN1023479C (zh) 1985-09-27 1994-01-12 弗·哈夫曼-拉罗切有限公司 乙二胺的单酰胺衍生物的制备方法
TW219933B (cg-RX-API-DMAC7.html) 1990-02-26 1994-02-01 Lilly Co Eli
US5405613A (en) 1991-12-11 1995-04-11 Creative Nutrition Canada Corp. Vitamin/mineral composition
TW352384B (en) 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4219158A1 (de) 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE59401923D1 (de) 1993-11-02 1997-04-10 Hoechst Ag Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
EP0650961B1 (de) 1993-11-02 1997-03-05 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
TW406076B (en) 1993-12-30 2000-09-21 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
DE4410423A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carbonsäureamide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4410480A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carbonsäureesteramide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5789426A (en) 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
IL135495A (en) 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
JPH09221476A (ja) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
WO1997041103A1 (de) 1996-04-30 1997-11-06 Hoechst Aktiengesellschaft 3-alkoxypyridin-2-carbonsäureamidester, ihre herstellung und ihre verwendung als arzneimittel
DE19620041A1 (de) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE19650215A1 (de) 1996-12-04 1998-06-10 Hoechst Ag 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1024134A4 (en) 1997-10-09 2003-05-14 Ono Pharmaceutical Co DERIVATIVES OF AMINOBUTANIC ACID
DE19746287A1 (de) 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
JP4495339B2 (ja) 1998-03-23 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド ピペリジニルおよびn−アミジノピペリジニル誘導体
US6159379A (en) 1999-05-04 2000-12-12 Baker Hughes Incorporated Organic ammonium salts for the removal of water soluble organics in produced water
JP2001048786A (ja) 1999-08-05 2001-02-20 Yamanouchi Pharmaceut Co Ltd 三環式ヘテロアリール誘導体
DK1265608T3 (da) 2000-03-22 2008-12-08 Pharmacia & Upjohn Co Llc Oxazolidinon tabletformulering
US6589758B1 (en) 2000-05-19 2003-07-08 Amgen Inc. Crystal of a kinase-ligand complex and methods of use
US6849718B2 (en) 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
JP4590157B2 (ja) 2001-03-21 2010-12-01 アイシス イノヴェイション リミテッド アッセイ、方法および手段
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
US6566088B1 (en) 2001-10-04 2003-05-20 Board Of Regents, The University Of Texas System Prolyl-4-hydroxylases
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
ES2686625T3 (es) 2001-12-06 2018-10-18 Fibrogen, Inc. Métodos para el tratamiento o prevención de la anemia
WO2003097040A1 (en) 2002-05-17 2003-11-27 Celgene Corporation Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
AU2003265674B2 (en) 2002-08-29 2008-12-11 Merck & Co., Inc. N-biarylmethyl aminocycloalkanecarboxamide derivatives
EP1554394B1 (en) 2002-10-16 2009-12-16 Isis Innovation Limited Screening methods using a structural model of FIH
CA2506799A1 (en) 2002-11-21 2004-06-10 Eli Lilly And Company Mixed lineage kinase modulators
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US7183287B2 (en) 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
KR100932169B1 (ko) 2003-06-06 2009-12-16 피브로겐, 인크. 질소-함유 헤테로아릴 화합물 및 내인성 적혈구생성소의증가에서의 그들의 사용
US20060251638A1 (en) 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
GB0314129D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
JPWO2005108370A1 (ja) 2004-04-16 2008-03-21 味の素株式会社 ベンゼン化合物
ES2332798T3 (es) 2004-05-28 2010-02-12 Fibrogen, Inc. Ensayo de actividad de la prolil hidroxilasa de hif.
EP1771418A2 (en) 2004-05-31 2007-04-11 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
CA2573185A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
TW200616969A (en) 2004-09-17 2006-06-01 Tanabe Seiyaku Co Imidazole compound
DE05815688T1 (de) * 2005-01-27 2008-06-26 Alembic Ltd. Levetiracetam-formulierung mit verlängerter freisetzung
US20080213404A1 (en) 2005-02-04 2008-09-04 Johnson Randall S Hif Modulating Compounds and Methods of Use Thereof
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
CN101849943A (zh) 2005-06-06 2010-10-06 菲布罗根公司 使用HIFα稳定剂的改进的贫血治疗
EP1919463B9 (en) 2005-06-15 2011-02-02 Fibrogen, Inc. Use of hif 1alfa modulators for treatment of cancer
WO2007033216A2 (en) 2005-09-12 2007-03-22 Beth Israel Deaconess Medical Center Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
WO2007038571A2 (en) 2005-09-26 2007-04-05 Smithkline Beecham Corporation Prolyl hydroxylase antagonists
US20090176726A1 (en) 2005-10-11 2009-07-09 Fisher David E Methods for treating mitf-related disorders
US7728130B2 (en) 2005-12-09 2010-06-01 Amgen Inc. Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity
GB2453819A (en) 2006-01-09 2009-04-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses
WO2007082899A1 (en) 2006-01-17 2007-07-26 Vib Vzw Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration
JP4801451B2 (ja) 2006-01-19 2011-10-26 株式会社日立ハイテクノロジーズ 走査電子顕微鏡等に用いる電子銃の制御装置及び制御方法
TW200738709A (en) 2006-01-19 2007-10-16 Osi Pharm Inc Fused heterobicyclic kinase inhibitors
ITMI20060179A1 (it) 2006-02-02 2007-08-03 Abiogen Pharma Spa Procedimento per la risoluzione di miscele racemiche e complesso diastereoisomerico di un agente risolvente e di unantiomero di interesse
US7625927B2 (en) 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
AR059733A1 (es) 2006-03-07 2008-04-23 Smithkline Beecham Corp Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion
ES2288117B1 (es) 2006-05-08 2008-12-01 Combino Pharm, S.L. Composicion farmaceutica solida de gabapentina.
US20090176825A1 (en) 2006-05-16 2009-07-09 Fitch Duke M Prolyl hydroxylase inhibitors
AR061570A1 (es) 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto de glicina sustituido en el n heteroaromatico composicion farmaceutica que lo comprende, su uso para preparar un medicamento, procedimientos para preparar dicha composicion farmaceutica y para preparar el compuesto
MX2009000286A (es) 2006-06-26 2009-03-20 Procter & Gamble Inhibidores de prolil hidroxilasa y metodos de uso.
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
TW200845994A (en) 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: prolyl hydroxylase inhibitors
JP2008201711A (ja) * 2007-02-20 2008-09-04 Ss Pharmaceut Co Ltd システイン臭が低減された固形製剤
CN101663037A (zh) 2007-04-18 2010-03-03 默克公司 新的1,8-二氮杂萘化合物
ES2446418T3 (es) 2007-04-18 2014-03-07 Amgen, Inc Derivados de indanona que inhiben la prolil hidroxilasa
ES2389063T3 (es) 2007-05-04 2012-10-22 Amgen, Inc Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa
WO2008144266A1 (en) 2007-05-16 2008-11-27 Merck & Co., Inc. Spiroindalones
RU2009146851A (ru) 2007-05-18 2011-06-27 Байер Шеринг Фарма Акциенгезельшафт (DE) Гетероарил-замещенные пиразольные производные, которые могут использоваться для лечения гиперпролиферативных нарушений и заболеваний, связанных с ангиогенезом
EP2186528B1 (en) 2007-08-06 2014-03-19 Senju Pharmaceutical Co., Ltd. Pharmaceutical containing hif-1 alpha and hif-2 alpha expression inhibitor
TW200908984A (en) 2007-08-07 2009-03-01 Piramal Life Sciences Ltd Pyridyl derivatives, their preparation and use
CN101815718A (zh) 2007-08-10 2010-08-25 克里斯捷诺米有限公司 吡啶衍生物及其用法
WO2009035534A2 (en) 2007-09-07 2009-03-19 The Cleveland Clinic Foundation Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif)
WO2009039321A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009039323A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009043093A1 (en) 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Hif inhibition
WO2009049112A1 (en) 2007-10-10 2009-04-16 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009067790A1 (en) 2007-11-26 2009-06-04 Uti Limited Partnership STIMULATION OF HYPOXIA INDUCIBLE FACTOR -1 ALPHA (HIF-1α) FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE (CDAD), FOR INTESTINAL MOTILITY AND FOR DETECTING INFECTION
AU2008331480A1 (en) 2007-11-30 2009-06-11 Glaxosmithkline Llc Prolyl hydroxylase inhibitors
EA201000920A1 (ru) 2007-11-30 2011-02-28 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Ингибиторы пролилгидроксилазы
US8269008B2 (en) 2007-12-03 2012-09-18 Fibrogen, Inc. Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions
US20100298324A1 (en) 2007-12-19 2010-11-25 Smith Kline Beecham Corporation Prolyl Hydroxylase Inhibitors
WO2009086592A1 (en) 2008-01-04 2009-07-16 Garvan Institute Of Medical Research Method of increasing metabolism
US8952160B2 (en) 2008-01-11 2015-02-10 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
JP5380465B2 (ja) 2008-03-03 2014-01-08 アイアールエム・リミテッド・ライアビリティ・カンパニー Tlr活性モジュレーターとしての化合物および組成物
WO2010010017A1 (en) 2008-07-23 2010-01-28 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
NZ591394A (en) 2008-09-15 2013-03-28 Kasina Laila Innova Pharmaceuticals Private Ltd Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
HRP20130846T1 (hr) 2009-03-31 2013-11-22 Kissei Pharmaceutical Co., Ltd. Derivati indolizina i njihova uporaba u medicinske svrhe
PL2496236T4 (pl) 2009-11-06 2015-11-30 Aerpio Therapeutics Inc Inhibitory hydroksylazy prolilowej
JO2978B1 (en) 2009-12-21 2016-03-15 ايلي ليلي اند كومباني MGLU2 aids
CN103429239A (zh) 2011-01-13 2013-12-04 菲布罗根有限公司 增加网织红细胞血红蛋白含量的方法
CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
NO2686520T3 (cg-RX-API-DMAC7.html) 2011-06-06 2018-03-17
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
US9206134B2 (en) 2011-07-22 2015-12-08 Beijing Betta Pharmaceuticals Co. Ltd. Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
US20140309256A1 (en) 2011-11-09 2014-10-16 Fibrogen, Inc. Therapeutic Method
JP2015537013A (ja) 2012-11-19 2015-12-24 アサンタ・アー/エス 速崩性錠剤
JP2016519684A (ja) * 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び/又は副作用を低減するための方法および組成物
RS60464B1 (sr) * 2013-06-06 2020-07-31 Fibrogen Inc Farmaceutske formulacije inhibitora hif hidroksilaze
PT3007695T (pt) * 2013-06-13 2024-03-07 Akebia Therapeutics Inc Composições e métodos para tratamento de anemia
RU2016109125A (ru) 2013-08-16 2017-09-22 Огайо Стейт Инновейшн Фаундейшн Композиции и способы модуляции метилирования днк
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
WO2015112831A1 (en) 2014-01-23 2015-07-30 Akebia Therapeutics, Inc. Compositions and methods for treating ocular diseases
US10617716B2 (en) 2014-12-16 2020-04-14 Urgo Us, Inc. Hypochlorous acid formulations and methods for treating skin conditions
CN107427503A (zh) 2015-01-23 2017-12-01 阿克比治疗有限公司 2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途
WO2016153996A1 (en) 2015-03-20 2016-09-29 Akebia Therapeutics, Inc. Deuterium-enriched hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors
CR20170450A (es) 2015-04-01 2018-04-03 Akebia Therapeutics Inc Composiciones y métodos para el tratamiento de la anemia

Similar Documents

Publication Publication Date Title
JP2018510178A5 (cg-RX-API-DMAC7.html)
RU2019134558A (ru) Композиции и способы лечения анемии
JP2018514534A5 (cg-RX-API-DMAC7.html)
JP2011516613A (ja) 好ましくはポサコナゾールおよびhpmcasを含む固体分散物中の経口用薬学的組成物
IL305910A (en) Formulation of an oral administration form of }]5-)3-chlorophenyl(-3-hydroxypyridine-2-carbonyl[amino{acetic acid
US20170095453A1 (en) Low Dose Pharmaceutical Composition
JP7246384B2 (ja) 遅延放出デフェリプロン錠剤及びその使用法
BG108221A (bg) Възстановим парентерален състав, съдържащ инхибитор на сох-2
EP3836920A1 (en) Formulations of ag10
JP2023139157A (ja) 抗線維化療法を投与する方法
KR100709528B1 (ko) 혈당콘트롤용 의약조성물
TW201716064A (zh) 供治療癌症之口服投予紫杉醇及P-gp抑制劑的治療性組合
JP2004091473A (ja) 色素沈着改善治療薬
KR20200013719A (ko) 레모글리플로진의 경구 약학적 제제
US20110117070A1 (en) Compositions and methods for treating headache
CN113557016A (zh) 衣壳组装调节剂固体配制品
AU2023397768A1 (en) Stat3 inhibitors for use in the treatment of non-viral liver cancer
KR20200035437A (ko) 레모글리플로진 및 당뇨병 치료제를 포함하는 약제학적 조성물
CA2103666C (en) Products containing verapamil and trandolapril
KR102330953B1 (ko) 소듐-1-[6-(모르폴린-4-일)피리미딘-4-일]-4-(1h-1,2,3-트리아졸-1-일)-1h-피라졸-5-올레이트를 함유하는 제약 투여 형태
KR100709531B1 (ko) 당뇨병성 합병증의 예방 또는 진전저지용 의약조성물
JPWO2020069288A5 (cg-RX-API-DMAC7.html)
JPWO2023018904A5 (cg-RX-API-DMAC7.html)
WO2021053564A1 (en) Pharmaceutical composition comprising remogliflozin or salt or ester thereof and teneligliptin or salt thereof
EP1731170A1 (en) Therapeutic agent for diabetes containing insulin resistance improving agent