JP2018508513A - 軟骨若返りを可能とする小分子 - Google Patents

軟骨若返りを可能とする小分子 Download PDF

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Publication number
JP2018508513A
JP2018508513A JP2017545300A JP2017545300A JP2018508513A JP 2018508513 A JP2018508513 A JP 2018508513A JP 2017545300 A JP2017545300 A JP 2017545300A JP 2017545300 A JP2017545300 A JP 2017545300A JP 2018508513 A JP2018508513 A JP 2018508513A
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substituted
unsubstituted
nhc
nhnr
alkyl
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Japanese (ja)
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JP2018508513A5 (enExample
Inventor
イブセーンコ，デニス
バン・ハンデル，ベンジャミン・ジェイ
ジョン，バルギース
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University of California
University of California, Los Angeles
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University of California, San Diego
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Publication of JP2018508513A publication Critical patent/JP2018508513A/ja
Publication of JP2018508513A5 publication Critical patent/JP2018508513A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017545300A 2015-02-27 2016-02-29 軟骨若返りを可能とする小分子 Pending JP2018508513A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126010P 2015-02-27 2015-02-27
US62/126,010 2015-02-27
PCT/US2016/020126 WO2016138533A2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Publications (2)

Publication Number Publication Date
JP2018508513A true JP2018508513A (ja) 2018-03-29
JP2018508513A5 JP2018508513A5 (enExample) 2019-04-25

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Family Applications (1)

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JP2017545300A Pending JP2018508513A (ja) 2015-02-27 2016-02-29 軟骨若返りを可能とする小分子

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US (2) US11072592B2 (enExample)
EP (1) EP3262040A4 (enExample)
JP (1) JP2018508513A (enExample)
KR (1) KR20170122788A (enExample)
CN (1) CN107531687A (enExample)
AU (1) AU2016224975B2 (enExample)
CA (1) CA2977401A1 (enExample)
WO (1) WO2016138533A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170122788A (ko) 2015-02-27 2017-11-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연골 재생을 가능하게 하는 소분자
EP3493803A4 (en) * 2016-08-05 2020-04-22 The Regents of The University of California GP130 MODULATORS
US10828289B2 (en) 2016-08-26 2020-11-10 The Regents Of The University Of California Hair follicle stem cell activation and hair growth
EP3758700B1 (en) 2018-02-28 2024-07-31 University of Southern California Compositions for modulating inflammatory and degenerative disorders
CN112877283A (zh) * 2021-02-10 2021-06-01 安徽农业大学 一种鸡原代软骨细胞分离培养及鉴定的方法
CN114276999A (zh) * 2022-03-03 2022-04-05 中日友好医院(中日友好临床医学研究所) 黑素瘤细胞株及其制备方法
WO2023205366A1 (en) * 2022-04-20 2023-10-26 Carthronix, Inc. Small molecule modulators of gp130 signaling pathways
WO2026127686A1 (ko) * 2024-12-11 2026-06-18 주식회사 프리모테라 당단백질130 억제제로서 신규한 화합물

Citations (10)

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JP2003525291A (ja) * 2000-03-01 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２，４−二置換チアゾリル誘導体
JP2005501099A (ja) * 2001-08-13 2005-01-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−アミノ−４，５−三置換チアゾリル誘導体
JP2007504282A (ja) * 2003-05-14 2007-03-01 トリーパインズ セラピューティクス， インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
JP2008540537A (ja) * 2005-05-09 2008-11-20 アキリオン ファーマシューティカルズ，インコーポレーテッド チアゾール化合物および使用方法
JP2009513566A (ja) * 2005-09-13 2009-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−アニリン−４−アリール置換チアゾール誘導体
JP2010528019A (ja) * 2007-05-22 2010-08-19 アキリオン ファーマシューティカルズ，インコーポレーテッド ヘテロアリール置換チアゾール
WO2013056679A1 (en) * 2011-10-21 2013-04-25 Beijing Hanmi Pharmaceutical Co., Ltd Novel heteroaryl-amino derivatives
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2014113620A2 (en) * 2013-01-18 2014-07-24 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

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US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
JP2002020286A (ja) * 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd 骨・軟骨疾患治療剤
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
EP1860098B1 (en) * 2005-03-16 2012-11-14 Toyama Chemical Co., Ltd. Novel anthranilic acid derivative or salt thereof
JP2008543754A (ja) 2005-06-09 2008-12-04 メルク エンド カムパニー インコーポレーテッド チェックポイントキナーゼの阻害剤
US20090280483A1 (en) * 2005-11-22 2009-11-12 Toshio Kitamura Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors
EP2007393B1 (en) * 2006-04-07 2013-08-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
US9315449B2 (en) * 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
KR20170122788A (ko) 2015-02-27 2017-11-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연골 재생을 가능하게 하는 소분자

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525291A (ja) * 2000-03-01 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２，４−二置換チアゾリル誘導体
JP2005501099A (ja) * 2001-08-13 2005-01-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−アミノ−４，５−三置換チアゾリル誘導体
JP2007504282A (ja) * 2003-05-14 2007-03-01 トリーパインズ セラピューティクス， インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
JP2008540537A (ja) * 2005-05-09 2008-11-20 アキリオン ファーマシューティカルズ，インコーポレーテッド チアゾール化合物および使用方法
JP2009513566A (ja) * 2005-09-13 2009-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−アニリン−４−アリール置換チアゾール誘導体
JP2010528019A (ja) * 2007-05-22 2010-08-19 アキリオン ファーマシューティカルズ，インコーポレーテッド ヘテロアリール置換チアゾール
WO2013056679A1 (en) * 2011-10-21 2013-04-25 Beijing Hanmi Pharmaceutical Co., Ltd Novel heteroaryl-amino derivatives
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2014113620A2 (en) * 2013-01-18 2014-07-24 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

Non-Patent Citations (1)

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Title
EGYPTIAN JOURNAL OF CHEMISTRY, vol. 25, no. 2, JPN6020003075, 1983, pages 187 - 189, ISSN: 0004564500 *

Also Published As

Publication number Publication date
CN107531687A (zh) 2018-01-02
WO2016138533A3 (en) 2016-12-01
WO2016138533A2 (en) 2016-09-01
US20180244638A1 (en) 2018-08-30
CA2977401A1 (en) 2016-09-01
AU2016224975A1 (en) 2017-09-07
EP3262040A2 (en) 2018-01-03
US11247974B2 (en) 2022-02-15
KR20170122788A (ko) 2017-11-06
US11072592B2 (en) 2021-07-27
EP3262040A4 (en) 2018-09-12
AU2016224975B2 (en) 2020-10-22
US20190169141A1 (en) 2019-06-06

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