JP2018508513A5 - - Google Patents
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- Publication number
- JP2018508513A5 JP2018508513A5 JP2017545300A JP2017545300A JP2018508513A5 JP 2018508513 A5 JP2018508513 A5 JP 2018508513A5 JP 2017545300 A JP2017545300 A JP 2017545300A JP 2017545300 A JP2017545300 A JP 2017545300A JP 2018508513 A5 JP2018508513 A5 JP 2018508513A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- nhc
- alkyl
- nhnr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126010P | 2015-02-27 | 2015-02-27 | |
| US62/126,010 | 2015-02-27 | ||
| PCT/US2016/020126 WO2016138533A2 (en) | 2015-02-27 | 2016-02-29 | Small molecules that enable cartilage rejuvanation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018508513A JP2018508513A (ja) | 2018-03-29 |
| JP2018508513A5 true JP2018508513A5 (enExample) | 2019-04-25 |
Family
ID=56789264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545300A Pending JP2018508513A (ja) | 2015-02-27 | 2016-02-29 | 軟骨若返りを可能とする小分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11072592B2 (enExample) |
| EP (1) | EP3262040A4 (enExample) |
| JP (1) | JP2018508513A (enExample) |
| KR (1) | KR20170122788A (enExample) |
| CN (1) | CN107531687A (enExample) |
| AU (1) | AU2016224975B2 (enExample) |
| CA (1) | CA2977401A1 (enExample) |
| WO (1) | WO2016138533A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170122788A (ko) | 2015-02-27 | 2017-11-06 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 연골 재생을 가능하게 하는 소분자 |
| EP3493803A4 (en) * | 2016-08-05 | 2020-04-22 | The Regents of The University of California | GP130 MODULATORS |
| US10828289B2 (en) | 2016-08-26 | 2020-11-10 | The Regents Of The University Of California | Hair follicle stem cell activation and hair growth |
| EP3758700B1 (en) | 2018-02-28 | 2024-07-31 | University of Southern California | Compositions for modulating inflammatory and degenerative disorders |
| CN112877283A (zh) * | 2021-02-10 | 2021-06-01 | 安徽农业大学 | 一种鸡原代软骨细胞分离培养及鉴定的方法 |
| CN114276999A (zh) * | 2022-03-03 | 2022-04-05 | 中日友好医院(中日友好临床医学研究所) | 黑素瘤细胞株及其制备方法 |
| WO2023205366A1 (en) * | 2022-04-20 | 2023-10-26 | Carthronix, Inc. | Small molecule modulators of gp130 signaling pathways |
| WO2026127686A1 (ko) * | 2024-12-11 | 2026-06-18 | 주식회사 프리모테라 | 당단백질130 억제제로서 신규한 화합물 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| CA2397661C (en) | 2000-03-01 | 2012-01-03 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
| JP2002020286A (ja) * | 2000-06-30 | 2002-01-23 | Sumitomo Pharmaceut Co Ltd | 骨・軟骨疾患治療剤 |
| HUP0401748A3 (en) * | 2001-08-13 | 2011-03-28 | Janssen Pharmaceutica Nv | 2-amino-4,5-trisubstituted thiazolyl derivatives, process for their preparation and pharmaceutical compositions containing them |
| CN102584813B (zh) * | 2003-05-14 | 2016-07-06 | Ngc药物公司 | 化合物及其在调节淀粉样蛋白β中的用途 |
| WO2005033288A2 (en) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| EP1860098B1 (en) * | 2005-03-16 | 2012-11-14 | Toyama Chemical Co., Ltd. | Novel anthranilic acid derivative or salt thereof |
| AU2006244203B2 (en) * | 2005-05-09 | 2012-05-03 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
| JP2008543754A (ja) | 2005-06-09 | 2008-12-04 | メルク エンド カムパニー インコーポレーテッド | チェックポイントキナーゼの阻害剤 |
| AU2006290814B2 (en) * | 2005-09-13 | 2012-06-07 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
| US20090280483A1 (en) * | 2005-11-22 | 2009-11-12 | Toshio Kitamura | Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors |
| EP2007393B1 (en) * | 2006-04-07 | 2013-08-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers |
| EA200901573A1 (ru) * | 2007-05-22 | 2010-04-30 | Ачиллион Фармасьютикалз, Инк. | Гетероарилзамещенные тиазолы |
| US9315449B2 (en) * | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| CN103059014B (zh) | 2011-10-21 | 2016-05-18 | 北京韩美药品有限公司 | 新型杂芳基氨基衍生物 |
| CN103130792B (zh) * | 2011-11-30 | 2016-05-04 | 正大天晴药业集团股份有限公司 | 一种2-氨基噻唑类化合物 |
| ES2684776T3 (es) * | 2013-01-18 | 2018-10-04 | Bristol-Myers Squibb Company | Ftalazinonas e isoquinolinonas como inhibidores de ROCK |
| US20150045353A1 (en) * | 2013-08-09 | 2015-02-12 | Neurogenetic Pharmaceuticals, Inc. | Formulations containing gamma secretase modulators, methods for preparation and delivery thereof |
| KR20170122788A (ko) | 2015-02-27 | 2017-11-06 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 연골 재생을 가능하게 하는 소분자 |
-
2016
- 2016-02-29 KR KR1020177027191A patent/KR20170122788A/ko not_active Withdrawn
- 2016-02-29 EP EP16756554.8A patent/EP3262040A4/en not_active Withdrawn
- 2016-02-29 JP JP2017545300A patent/JP2018508513A/ja active Pending
- 2016-02-29 US US15/553,353 patent/US11072592B2/en active Active
- 2016-02-29 CA CA2977401A patent/CA2977401A1/en not_active Abandoned
- 2016-02-29 CN CN201680024174.9A patent/CN107531687A/zh active Pending
- 2016-02-29 WO PCT/US2016/020126 patent/WO2016138533A2/en not_active Ceased
- 2016-02-29 AU AU2016224975A patent/AU2016224975B2/en active Active
-
2018
- 2018-12-07 US US16/213,958 patent/US11247974B2/en active Active
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