CA2977401A1 - Small molecules that enable cartilage rejuvenation - Google Patents

Small molecules that enable cartilage rejuvenation Download PDF

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Publication number
CA2977401A1
CA2977401A1 CA2977401A CA2977401A CA2977401A1 CA 2977401 A1 CA2977401 A1 CA 2977401A1 CA 2977401 A CA2977401 A CA 2977401A CA 2977401 A CA2977401 A CA 2977401A CA 2977401 A1 CA2977401 A1 CA 2977401A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
nhc
halogen
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2977401A
Other languages
English (en)
French (fr)
Inventor
Denis EVSEENKO
Benjamin J. Van Handel
Varghese John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CA2977401A1 publication Critical patent/CA2977401A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2977401A 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvenation Abandoned CA2977401A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126010P 2015-02-27 2015-02-27
US62/126,010 2015-02-27
PCT/US2016/020126 WO2016138533A2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Publications (1)

Publication Number Publication Date
CA2977401A1 true CA2977401A1 (en) 2016-09-01

Family

ID=56789264

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2977401A Abandoned CA2977401A1 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvenation

Country Status (8)

Country Link
US (2) US11072592B2 (enExample)
EP (1) EP3262040A4 (enExample)
JP (1) JP2018508513A (enExample)
KR (1) KR20170122788A (enExample)
CN (1) CN107531687A (enExample)
AU (1) AU2016224975B2 (enExample)
CA (1) CA2977401A1 (enExample)
WO (1) WO2016138533A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531687A (zh) 2015-02-27 2018-01-02 加利福尼亚大学董事会 能够实现软骨复壮的小分子
WO2018027193A1 (en) 2016-08-05 2018-02-08 The Regents Of The University Of California Gp130 modulators
KR20190058494A (ko) 2016-08-26 2019-05-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 모낭 줄기 세포 활성화 및 모발 성장
CA3090545A1 (en) 2018-02-28 2019-09-06 University Of Southern California Compositions and methods for modulating inflammatory and degenerative disorder
CN112877283A (zh) * 2021-02-10 2021-06-01 安徽农业大学 一种鸡原代软骨细胞分离培养及鉴定的方法
CN114276999A (zh) * 2022-03-03 2022-04-05 中日友好医院(中日友好临床医学研究所) 黑素瘤细胞株及其制备方法
EP4511378A4 (en) * 2022-04-20 2026-03-11 Carthronix Inc GP130 Small Molecule Modulators for Signaling Channels

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US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
ATE414079T1 (de) 2000-03-01 2008-11-15 Janssen Pharmaceutica Nv 2,4-disubstituierte thiazolyl derivate
JP2002020286A (ja) 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd 骨・軟骨疾患治療剤
EA007717B1 (ru) * 2001-08-13 2006-12-29 Янссен Фармацевтика Н.В. 2-амино-4,5-тризамещенные производные тиазолила
EP1628666B1 (en) * 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Compouds and uses thereof in modulating amyloid beta
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
DK1860098T3 (da) * 2005-03-16 2012-12-17 Toyama Chemical Co Ltd Nyt anthranilsyrderivat eller salt deraf
SG159561A1 (en) * 2005-05-09 2010-03-30 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use
JP2008543754A (ja) 2005-06-09 2008-12-04 メルク エンド カムパニー インコーポレーテッド チェックポイントキナーゼの阻害剤
NZ566036A (en) * 2005-09-13 2010-06-25 Janssen Pharmaceutica Nv 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor
JP4882076B2 (ja) * 2005-11-22 2012-02-22 国立大学法人 東京大学 インターロイキン−６（ｉｌ−６）シグナル伝達阻害剤スクリーニング方法
EP2007393B1 (en) 2006-04-07 2013-08-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
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US9315449B2 (en) * 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
WO2013056679A1 (en) * 2011-10-21 2013-04-25 Beijing Hanmi Pharmaceutical Co., Ltd Novel heteroaryl-amino derivatives
CN103130792B (zh) * 2011-11-30 2016-05-04 正大天晴药业集团股份有限公司 一种2-氨基噻唑类化合物
WO2014113620A2 (en) 2013-01-18 2014-07-24 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
US20150045353A1 (en) 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators, methods for preparation and delivery thereof
CN107531687A (zh) 2015-02-27 2018-01-02 加利福尼亚大学董事会 能够实现软骨复壮的小分子

Also Published As

Publication number Publication date
US20190169141A1 (en) 2019-06-06
US11247974B2 (en) 2022-02-15
KR20170122788A (ko) 2017-11-06
US11072592B2 (en) 2021-07-27
US20180244638A1 (en) 2018-08-30
JP2018508513A (ja) 2018-03-29
EP3262040A2 (en) 2018-01-03
WO2016138533A3 (en) 2016-12-01
AU2016224975B2 (en) 2020-10-22
WO2016138533A2 (en) 2016-09-01
EP3262040A4 (en) 2018-09-12
CN107531687A (zh) 2018-01-02
AU2016224975A1 (en) 2017-09-07

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220525