AU2016224975B2 - Small molecules that enable cartilage rejuvanation - Google Patents

Small molecules that enable cartilage rejuvanation Download PDF

Info

Publication number
AU2016224975B2
AU2016224975B2 AU2016224975A AU2016224975A AU2016224975B2 AU 2016224975 B2 AU2016224975 B2 AU 2016224975B2 AU 2016224975 A AU2016224975 A AU 2016224975A AU 2016224975 A AU2016224975 A AU 2016224975A AU 2016224975 B2 AU2016224975 B2 AU 2016224975B2
Authority
AU
Australia
Prior art keywords
substituted
unsubstituted
nhc
membered
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016224975A
Other languages
English (en)
Other versions
AU2016224975A1 (en
Inventor
Denis EVSEENKO
Varghese John
Benjamin J. Van Handel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California, San Diego
Original Assignee
University of California Berkeley
University of California, San Diego
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California, San Diego filed Critical University of California Berkeley
Publication of AU2016224975A1 publication Critical patent/AU2016224975A1/en
Application granted granted Critical
Publication of AU2016224975B2 publication Critical patent/AU2016224975B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016224975A 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation Active AU2016224975B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126010P 2015-02-27 2015-02-27
US62/126,010 2015-02-27
PCT/US2016/020126 WO2016138533A2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Publications (2)

Publication Number Publication Date
AU2016224975A1 AU2016224975A1 (en) 2017-09-07
AU2016224975B2 true AU2016224975B2 (en) 2020-10-22

Family

ID=56789264

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016224975A Active AU2016224975B2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Country Status (8)

Country Link
US (2) US11072592B2 (enExample)
EP (1) EP3262040A4 (enExample)
JP (1) JP2018508513A (enExample)
KR (1) KR20170122788A (enExample)
CN (1) CN107531687A (enExample)
AU (1) AU2016224975B2 (enExample)
CA (1) CA2977401A1 (enExample)
WO (1) WO2016138533A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170122788A (ko) 2015-02-27 2017-11-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연골 재생을 가능하게 하는 소분자
EP3493803A4 (en) * 2016-08-05 2020-04-22 The Regents of The University of California GP130 MODULATORS
US10828289B2 (en) 2016-08-26 2020-11-10 The Regents Of The University Of California Hair follicle stem cell activation and hair growth
EP3758700B1 (en) 2018-02-28 2024-07-31 University of Southern California Compositions for modulating inflammatory and degenerative disorders
CN112877283A (zh) * 2021-02-10 2021-06-01 安徽农业大学 一种鸡原代软骨细胞分离培养及鉴定的方法
CN114276999A (zh) * 2022-03-03 2022-04-05 中日友好医院(中日友好临床医学研究所) 黑素瘤细胞株及其制备方法
WO2023205366A1 (en) * 2022-04-20 2023-10-26 Carthronix, Inc. Small molecule modulators of gp130 signaling pathways
WO2026127686A1 (ko) * 2024-12-11 2026-06-18 주식회사 프리모테라 당단백질130 억제제로서 신규한 화합물

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015773A2 (en) * 2001-08-13 2003-02-27 Janssen Pharmaceutica N.V. 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases
WO2004110350A2 (en) * 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
WO2006122011A2 (en) * 2005-05-09 2006-11-16 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
WO2007031440A2 (en) * 2005-09-13 2007-03-22 Janssen Pharmaceutica N.V. 2-aniline-4-aryl substituted thiazole derivatives
WO2008147557A2 (en) * 2007-05-22 2008-12-04 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles and their use as antiviral agents
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
CA2397661C (en) 2000-03-01 2012-01-03 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
JP2002020286A (ja) * 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd 骨・軟骨疾患治療剤
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
EP1860098B1 (en) * 2005-03-16 2012-11-14 Toyama Chemical Co., Ltd. Novel anthranilic acid derivative or salt thereof
JP2008543754A (ja) 2005-06-09 2008-12-04 メルク エンド カムパニー インコーポレーテッド チェックポイントキナーゼの阻害剤
US20090280483A1 (en) * 2005-11-22 2009-11-12 Toshio Kitamura Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors
EP2007393B1 (en) * 2006-04-07 2013-08-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
US9315449B2 (en) * 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
CN103059014B (zh) 2011-10-21 2016-05-18 北京韩美药品有限公司 新型杂芳基氨基衍生物
ES2684776T3 (es) * 2013-01-18 2018-10-04 Bristol-Myers Squibb Company Ftalazinonas e isoquinolinonas como inhibidores de ROCK
KR20170122788A (ko) 2015-02-27 2017-11-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연골 재생을 가능하게 하는 소분자

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015773A2 (en) * 2001-08-13 2003-02-27 Janssen Pharmaceutica N.V. 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases
WO2004110350A2 (en) * 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
WO2006122011A2 (en) * 2005-05-09 2006-11-16 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
WO2007031440A2 (en) * 2005-09-13 2007-03-22 Janssen Pharmaceutica N.V. 2-aniline-4-aryl substituted thiazole derivatives
WO2008147557A2 (en) * 2007-05-22 2008-12-04 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles and their use as antiviral agents
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

Also Published As

Publication number Publication date
JP2018508513A (ja) 2018-03-29
CN107531687A (zh) 2018-01-02
WO2016138533A3 (en) 2016-12-01
WO2016138533A2 (en) 2016-09-01
US20180244638A1 (en) 2018-08-30
CA2977401A1 (en) 2016-09-01
AU2016224975A1 (en) 2017-09-07
EP3262040A2 (en) 2018-01-03
US11247974B2 (en) 2022-02-15
KR20170122788A (ko) 2017-11-06
US11072592B2 (en) 2021-07-27
EP3262040A4 (en) 2018-09-12
US20190169141A1 (en) 2019-06-06

Similar Documents

Publication Publication Date Title
US11247974B2 (en) Small molecules that enable cartilage rejuvenation
US20220016110A1 (en) Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
Chen et al. Dedifferentiation of lineage-committed cells by a small molecule
TW201843140A (zh) 6-6稠合雙環雜芳基化合物及其作為lats抑制劑之用途
KR20240008354A (ko) 인간 과립구-대식세포 전구체의 확장 방법 및 그의 적용
WO2017110425A1 (ja) 肝疾患治療剤及び肝疾患を治療する方法
Okuno et al. Antifibrotic effects of IL-12-treated natural killer cells on collagen type I regulation in lung fibroblasts
Zhou et al. sEV from 3D‐Cultured MSCs Engineered with miR‐27b‐3p for Treating TMJ‐OA by Suppressing Osteoclastogenesis
WO2022149616A1 (ja) ネフロン前駆細胞を拡大培養するための培地、ネフロン前駆細胞を拡大培養する方法、腎臓オルガノイドの製造方法
TWI627280B (zh) 用於在活體外培養口腔黏膜上皮祖細胞以及口腔黏膜上皮細胞的方法
Wang et al. miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration
CA3034460A1 (en) Hair follicle stem cell activation and hair growth
Wang et al. Effects of TGF-β1 and alginate on the differentiation of rabbit bone marrow-derived mesenchymal stem cells into a chondrocyte cell lineage
Vanorlé et al. UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells
Swiderski et al. The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics
Lin et al. In vivo base editing via single myotrophic adeno-associated viruses in dystrophic mouse muscle and satellite cells.
Yang et al. The mechanism by which miR-let-7b-modified BMSCs mediating Nogo/NgR signaling pathway in the repair of spinal cord injury.
Yin et al. Molecular pathways and immune microenvironment regulation in stem cell therapy for thin endometrium: a comprehensive narrative review
CN121712517A (zh) 用于预防或治疗唾液腺疾病的包含小唾液腺导管中的上皮祖细胞或干细胞的组合物
HK1214143B (en) Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
NZ712630B2 (en) Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
JP2006206543A (ja) 抗癌剤、癌細胞の増殖を抑制する方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)