|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4702907A
(en)
|
1983-08-09 |
1987-10-27 |
Cornell Research Foundation, Inc. |
Process for inducing selective immunosuppression of antibodies
|
|
US4747825A
(en)
|
1984-06-29 |
1988-05-31 |
Ferring Laboratories, Inc. |
Apparatus and methodology for pulsed administration of growth promoting agents
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
IT1178786B
(it)
|
1984-12-21 |
1987-09-16 |
Assorenti |
Analoghi retro-inverso parzialmente modificati della neurotensina
|
|
US4948592A
(en)
|
1986-05-09 |
1990-08-14 |
Alza Corporation |
Pulsed drug delivery
|
|
US4723958A
(en)
|
1986-05-23 |
1988-02-09 |
Merck & Co., Inc. |
Pulsatile drug delivery system
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US4965251A
(en)
|
1987-04-03 |
1990-10-23 |
The Board Of Regents Of The University Of Washington |
Pulse treatment of hemoglobinopathies with erythropoietin
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
AU649217B2
(en)
|
1988-11-18 |
1994-05-19 |
Regents Of The University Of California, The |
Method for site-specifically incorporating unnatural amino acids into proteins
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
US5705732A
(en)
|
1989-06-12 |
1998-01-06 |
Oklahoma Medical Research Foundation |
Universal donor cells
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
US5585362A
(en)
|
1989-08-22 |
1996-12-17 |
The Regents Of The University Of Michigan |
Adenovirus vectors for gene therapy
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
CA2109528A1
(en)
|
1991-05-01 |
1992-11-02 |
Gregory A. Prince |
A method for treating infectious respiratory diseases
|
|
US5474771A
(en)
|
1991-11-15 |
1995-12-12 |
The Trustees Of Columbia University In The City Of New York |
Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
DE69331778T2
(de)
|
1992-01-08 |
2002-11-14 |
The General Hospital Corp., Boston |
Induzierte toleranz gegen transplantate
|
|
US6916654B1
(en)
|
1992-06-29 |
2005-07-12 |
Oklahoma Medical Research Foundation |
Universal donor cells
|
|
US5397703A
(en)
|
1992-07-09 |
1995-03-14 |
Cetus Oncology Corporation |
Method for generation of antibodies to cell surface molecules
|
|
HUT71860A
(en)
|
1992-08-27 |
1996-02-28 |
Deakin Res Ltd |
Retro-, inverso-, and retro-inverso synthetic peptide analogues
|
|
US5350674A
(en)
|
1992-09-04 |
1994-09-27 |
Becton, Dickinson And Company |
Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
|
|
US5403590A
(en)
|
1992-12-21 |
1995-04-04 |
New England Deaconess Hospital Corporation |
Method of pulsatile drug infusion
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
US5849991A
(en)
|
1994-01-27 |
1998-12-15 |
Bresatch Limited |
Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
|
|
US5683693A
(en)
|
1994-04-25 |
1997-11-04 |
Trustees Of Dartmouth College |
Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US6156306A
(en)
|
1994-08-17 |
2000-12-05 |
Albert Einstein College Of Medicine Of Yeshiva University |
Pancreatic β-cells for allogeneic transplantation without immunosuppression
|
|
US5770201A
(en)
|
1994-12-23 |
1998-06-23 |
Rijsuniversiteit Te Leiden |
HA-2 antigenic peptide
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
JPH11510698A
(ja)
*
|
1995-08-04 |
1999-09-21 |
ザ ジェネラル ホスピタル コーポレイション |
トランスジェニックブタ及びヒトｈｌａ遺伝子を有するブタ細胞
|
|
ATE508733T1
(de)
|
1996-03-04 |
2011-05-15 |
Penn State Res Found |
Materialien und verfahren zur steigerung der zellulären internalisierung
|
|
EP0892643B2
(en)
|
1996-03-20 |
2009-09-02 |
Bristol-Myers Squibb Company |
Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
WO1997047321A1
(en)
*
|
1996-06-14 |
1997-12-18 |
The Johns Hopkins University School Of Medicine |
Use of chimeric vaccinia virus complement control proteins to inhibit complement
|
|
US6339069B1
(en)
|
1996-10-15 |
2002-01-15 |
Elan Pharmaceuticalstechnologies, Inc. |
Peptide-lipid conjugates, liposomes and lipsomal drug delivery
|
|
CA2277801C
(en)
|
1997-01-16 |
2002-10-15 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US6103489A
(en)
|
1997-03-21 |
2000-08-15 |
University Of Hawaii |
Cell-free protein synthesis system with protein translocation and processing
|
|
WO1998042838A1
(en)
|
1997-03-25 |
1998-10-01 |
Morphogenesis, Inc. |
Universal stem cells
|
|
BR9809641A
(pt)
|
1997-05-17 |
2000-07-11 |
Biogen Inc |
Uso de um interruptor de ligação cd40:cd154 para evitar respostas imunes inadaptadas, particularmente rejeição a enxerto
|
|
CA2303268A1
(en)
|
1997-06-13 |
1998-12-17 |
Scott Walsh |
Therapeutic nanospheres
|
|
US6825395B1
(en)
*
|
1997-07-14 |
2004-11-30 |
Nippon Meat Packers, Inc. |
Transgenic non-human mammals expressing the human complement inhibitor (DAF/CD55)
|
|
US6521448B1
(en)
*
|
1997-08-19 |
2003-02-18 |
Diacrin, Inc. |
Porcine MHC class I genes and uses thereof
|
|
AU748443B2
(en)
|
1998-02-04 |
2002-06-06 |
General Hospital Corporation, The |
Costimulatory blockade and mixed chimerism in transplantation
|
|
US6051228A
(en)
|
1998-02-19 |
2000-04-18 |
Bristol-Myers Squibb Co. |
Antibodies against human CD40
|
|
US6365185B1
(en)
|
1998-03-26 |
2002-04-02 |
University Of Cincinnati |
Self-destructing, controlled release peroral drug delivery system
|
|
WO1999066903A2
(en)
|
1998-06-24 |
1999-12-29 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
DE19853487A1
(de)
|
1998-11-19 |
2000-05-25 |
Fumapharm Ag Muri |
Verwendung von Dialkylfumaraten
|
|
WO2000037102A2
(en)
*
|
1998-12-19 |
2000-06-29 |
Ml Laboratories Plc |
Improvement of tolerance to a xenograft
|
|
CA2361191A1
(en)
|
1999-02-03 |
2000-08-10 |
The Children's Medical Center Corporation |
Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site
|
|
US20020012660A1
(en)
|
1999-03-04 |
2002-01-31 |
Alan Colman |
Method of preparing a somatic cells for nuclear transfer
|
|
WO2001015521A1
(en)
|
1999-08-31 |
2001-03-08 |
Genencor International, Inc. |
Transgenic mammal capable of facilitating production of donor-specific functional immunity
|
|
CN1377225A
(zh)
*
|
1999-09-13 |
2002-10-30 |
马萨诸塞大学 |
使用来自分化细胞的供体细胞或细胞核克隆猪以及多能猪的生成
|
|
HK1047109A1
(zh)
|
1999-10-15 |
2003-02-07 |
University Of Massachusetts |
作为指定基因干预工具的rna干预轨迹基因
|
|
US6326193B1
(en)
|
1999-11-05 |
2001-12-04 |
Cambria Biosciences, Llc |
Insect control agent
|
|
KR100417566B1
(ko)
|
1999-11-19 |
2004-02-05 |
한국생명공학연구원 |
체세포 핵치환 복제수정란의 대량생산방법
|
|
CA2392615A1
(en)
|
1999-12-06 |
2001-06-07 |
The General Hospital Corporation |
Pancreatic stem cells and their use in transplantation
|
|
US20020006403A1
(en)
|
1999-12-14 |
2002-01-17 |
Xue-Zhong Yu |
CD28-specific antibody compositions for use in methods of immunosuppression
|
|
GB9930616D0
(en)
|
1999-12-24 |
2000-02-16 |
Mathilda & Terence Kennedy Ins |
Activation and inhibition of the immune system
|
|
WO2001056603A1
(en)
|
2000-02-01 |
2001-08-09 |
Tanox, Inc. |
Cd40-binding apc-activating molecules
|
|
US20010051156A1
(en)
|
2000-04-28 |
2001-12-13 |
Defu Zeng |
Methods for inhibition of polyclonal B cell activation and immunoglobulin class switching to pathogenic autoantibodies by blocking CD1-mediated interactions
|
|
AU2001275474A1
(en)
|
2000-06-12 |
2001-12-24 |
Akkadix Corporation |
Materials and methods for the control of nematodes
|
|
EP1322383B9
(en)
|
2000-10-02 |
2006-09-06 |
Chiron Corporation |
Methods of therapy for b-cell malignancies using antagonist anti-cd40 antibodies
|
|
AU2001297523B2
(en)
|
2000-11-17 |
2007-01-18 |
Sab, Llc |
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
|
|
AR033022A1
(es)
|
2001-03-30 |
2003-12-03 |
Dow Agrosciences Llc |
Genes biosinteticos para la produccion de insecticida de butenilespinosina
|
|
CA2658221C
(en)
|
2001-04-27 |
2012-11-27 |
Kyowa Kirin Co., Ltd. |
Anti-cd40 monoclonal antibody
|
|
US7166278B2
(en)
|
2001-04-30 |
2007-01-23 |
Rbc Biotechnology, Inc. |
Modified organs and cells for xenotransplantation
|
|
US7780993B2
(en)
|
2001-09-07 |
2010-08-24 |
Yeda Research And Development Co. Ltd. |
Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
|
|
AU2002350039A1
(en)
|
2001-10-29 |
2003-05-12 |
Renovis, Inc. |
Method for isolating cell-type specific mrnas
|
|
AU2002357110A1
(en)
|
2001-12-07 |
2003-07-09 |
The Ohio State University Research Foundation |
Apoptotic ebv-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
|
|
US20030118568A1
(en)
|
2001-12-18 |
2003-06-26 |
Board Of Trustees Of The University Of Arkansas |
Viral stealth technology to prevent T cell-mediated rejection of xenografts
|
|
US7115796B2
(en)
|
2002-05-06 |
2006-10-03 |
Animal Technology Institute |
Transgenic pig containing heat shock protein 70 transgene
|
|
FR2840307B1
(fr)
|
2002-05-30 |
2006-07-07 |
Centre Nat Rech Scient |
Nouvelles molecules multimeriques, leur procede de preparation, et leur utilisation pour la preparation de medicaments
|
|
US7580532B2
(en)
|
2002-08-06 |
2009-08-25 |
Lg Electronics Inc. |
Multi-channel pulse width modulation apparatus
|
|
DK1534819T3
(da)
|
2002-08-21 |
2010-04-19 |
Revivicor Inc |
Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase
|
|
IL165425A0
(en)
|
2004-11-28 |
2006-01-15 |
Yeda Res & Dev |
Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
|
|
EP1460088A1
(en)
|
2003-03-21 |
2004-09-22 |
Biotest AG |
Humanized anti-CD4 antibody with immunosuppressive properties
|
|
WO2005006949A2
(en)
|
2003-07-07 |
2005-01-27 |
Wagner David H |
Methods for predicting development of auto-immune diseases and treatment of same
|
|
ATE447412T1
(de)
|
2003-11-04 |
2009-11-15 |
Novartis Vaccines & Diagnostic |
Antagonist-anti-cd40-monoklonale antikörper und anwendungsverfahren
|
|
US8277810B2
(en)
|
2003-11-04 |
2012-10-02 |
Novartis Vaccines & Diagnostics, Inc. |
Antagonist anti-CD40 antibodies
|
|
CN1922316B
(zh)
|
2003-12-25 |
2011-03-23 |
协和发酵麒麟株式会社 |
抗cd40抗体突变体
|
|
US20080318837A1
(en)
|
2003-12-26 |
2008-12-25 |
Nastech Pharmaceutical Company Inc. |
Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
|
|
AU2005223617A1
(en)
|
2004-03-17 |
2005-09-29 |
Revivicor, Inc. |
Tissue products from animals lacking functional alpha 1,3 galactosyl transferase
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
EP1810979B1
(en)
|
2004-09-22 |
2012-06-20 |
Kyowa Hakko Kirin Co., Ltd. |
STABILIZED HUMAN IgG4 ANTIBODIES
|
|
US20060148080A1
(en)
*
|
2004-12-30 |
2006-07-06 |
Paul Diamond |
Methods for supporting and producing human cells and tissues in non-human mammal hosts
|
|
US8889365B2
(en)
|
2005-03-16 |
2014-11-18 |
Rutgers, The State University Of New Jersey |
Methods and kit for detecting breast cancer
|
|
DK2341149T3
(en)
|
2005-08-26 |
2017-02-27 |
Dupont Nutrition Biosci Aps |
Use of CRISPR-associated genes (Cas)
|
|
US7659252B2
(en)
|
2005-09-15 |
2010-02-09 |
Novomed Technologies, Inc. (Shanghai) |
Transdermal delivery peptides and method of use thereof
|
|
WO2007053661A2
(en)
|
2005-11-01 |
2007-05-10 |
Novartis Ag |
Uses of anti-cd40 antibodies
|
|
AU2006337093B2
(en)
|
2005-12-22 |
2013-03-14 |
Opko Pharmaceuticals, Llc. |
Compositions and methods for regulating complement system
|
|
US20070237826A1
(en)
|
2006-04-05 |
2007-10-11 |
Rao Kollipara K |
Polymerized solid lipid nanoparticles for oral or mucosal delivery of therapeutic proteins and peptides
|
|
AR060487A1
(es)
|
2006-04-21 |
2008-06-18 |
Xoma Technology Ltd |
Composiciones farmaceuticas de antagonistas del anticuerpo anti- cd40
|
|
WO2007124751A2
(en)
|
2006-05-01 |
2007-11-08 |
Aarhus Universitet |
An animal model and a method for producing an animal model
|
|
EP1854810A1
(en)
|
2006-05-09 |
2007-11-14 |
PanGenetics B.V. |
Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody
|
|
DK2426220T3
(en)
|
2006-05-19 |
2016-09-26 |
Dupont Nutrition Biosci Aps |
Labeled microorganisms, and methods for labeling
|
|
US9006510B2
(en)
|
2006-06-29 |
2015-04-14 |
Mayo Foundation For Medical Education And Research |
Genetically modified heart valve xenografts
|
|
DK2134846T3
(en)
|
2007-03-07 |
2018-11-26 |
Univ Aarhus |
Transgenic swine as a model for Alzheimer's disease
|
|
US7750449B2
(en)
|
2007-03-13 |
2010-07-06 |
Micron Technology, Inc. |
Packaged semiconductor components having substantially rigid support members and methods of packaging semiconductor components
|
|
AU2008233256B2
(en)
|
2007-03-28 |
2013-06-27 |
The Curators Of The University Of Missouri |
Transgenic animal models of disease
|
|
MX2010005099A
(es)
|
2007-11-09 |
2010-05-27 |
Novartis Ag |
Usos de anticuerpos anti-cd40.
|
|
EP2067785A1
(en)
|
2007-12-03 |
2009-06-10 |
Fresenius Medical Care Deutschland GmbH |
Human CD154-binding synthetic peptide and uses thereof
|
|
EP2077329A1
(en)
|
2008-01-04 |
2009-07-08 |
MWM Biomodels GmbH |
Transgenic pig with altered incretin function
|
|
CA2712989C
(en)
|
2008-01-23 |
2015-10-27 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
WO2010008562A2
(en)
|
2008-07-16 |
2010-01-21 |
Recombinetics |
Methods and materials for producing transgenic animals
|
|
WO2010011961A2
(en)
|
2008-07-25 |
2010-01-28 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic rnai-like system and methods of use
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
|
EP2184297A1
(en)
|
2008-11-07 |
2010-05-12 |
Hla-G Technologies |
HLA-G polypeptides and pharmaceutical uses thereof
|
|
US8709400B2
(en)
|
2009-07-27 |
2014-04-29 |
Washington University |
Inducement of organogenetic tolerance for pancreatic xenotransplant
|
|
ES2767881T3
(es)
*
|
2009-08-14 |
2020-06-18 |
Revivicor Inc |
Cerdos multi-transgénicos para el tratamiento de diabetes
|
|
US8734786B2
(en)
|
2009-09-16 |
2014-05-27 |
Northwestern University |
Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection
|
|
WO2011069037A2
(en)
|
2009-12-03 |
2011-06-09 |
The University Of North Carolina At Charlotte |
Stabilization and storage of biological pharmaceutical compositions
|
|
HUE049849T2
(hu)
|
2010-03-31 |
2020-10-28 |
Boehringer Ingelheim Int |
Anti-CD40 antitestek
|
|
WO2011139488A2
(en)
|
2010-05-06 |
2011-11-10 |
Mayo Foundation For Medical Education And Research |
Methods and materials for reducing cardiac xenograft rejection
|
|
US20130177577A1
(en)
*
|
2010-07-12 |
2013-07-11 |
Dana-Farber Cancer Institute, Inc. |
Nlrc5 as a target to intervene mhc class 1-mediated immune responses
|
|
ES2957957T3
(es)
|
2010-10-19 |
2024-01-30 |
Op T Llc |
Péptidos para modular la actividad de linfocitos T y usos de los mismos
|
|
TWM402396U
(en)
|
2010-11-05 |
2011-04-21 |
Holimay Corp |
Motor mask for the water discharge device for cooling or air-conditioning device
|
|
AR083847A1
(es)
|
2010-11-15 |
2013-03-27 |
Novartis Ag |
Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
|
|
ES2680636T3
(es)
|
2011-02-14 |
2018-09-10 |
Revivicor Inc. |
Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos
|
|
JP5458188B2
(ja)
|
2011-02-17 |
2014-04-02 |
協和発酵キリン株式会社 |
抗ｃｄ４０抗体の高濃度製剤
|
|
TR201909840T4
(tr)
|
2011-03-11 |
2019-07-22 |
Beth Israel Deaconess Medical Ct Inc |
Anti-CD40 antikorları ve kullanımları.
|
|
CA3205636A1
(en)
|
2011-04-20 |
2012-10-26 |
University Of Washington Through Its Center For Commercialization |
Beta-2 microglobulin-deficient cells
|
|
WO2012145632A1
(en)
|
2011-04-21 |
2012-10-26 |
Cerulean Pharma Inc. |
Cyclodextrin-based polymers for therapeutic delivery
|
|
HUE038848T2
(hu)
|
2011-04-21 |
2018-11-28 |
Bristol Myers Squibb Co |
CD40-antagonista antitest polipeptidek
|
|
WO2012164565A1
(en)
|
2011-06-01 |
2012-12-06 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for downregulating prokaryotic genes
|
|
JP2014519340A
(ja)
*
|
2011-06-16 |
2014-08-14 |
カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． |
バイオマーカー組成物および方法
|
|
CN103796681B
(zh)
*
|
2011-06-30 |
2018-07-20 |
建新公司 |
T细胞活化的抑制剂
|
|
KR101307196B1
(ko)
|
2011-07-15 |
2013-09-12 |
국립대학법인 울산과학기술대학교 산학협력단 |
미세 세포 배양 장치
|
|
CN102911270A
(zh)
|
2011-08-05 |
2013-02-06 |
浙江大学 |
一种抑制移植器官慢性排斥反应的抗体的制备及纯化方法
|
|
WO2013063076A1
(en)
|
2011-10-25 |
2013-05-02 |
Indiana University Research & Technology Corporation |
Compositions for and methods of modulating complications, risks and issues with xenotransplantation
|
|
SMT201900478T1
(it)
*
|
2011-10-28 |
2019-09-09 |
Regeneron Pharma |
Topi con complesso maggiore di istocompatibilita' geneticamente modificati
|
|
UA115772C2
(uk)
|
2011-12-16 |
2017-12-26 |
Таргітджин Байотекнолоджиз Лтд |
Композиція програмованого нуклеопротеїнового молекулярного комплексу і спосіб модифікування заданої послідовності нуклеїнової кислоти-мішені
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
FI2838548T3
(fi)
|
2012-04-17 |
2023-10-02 |
Univ Washington Through Its Center For Commercialization |
HLA:n luokan II puutteelliset solut, HLA:n luokan II puutteelliset solut, jotka kykenevät ilmentämään HLA:n luokan II proteiineja, ja niiden käytöt
|
|
CN102851279B
(zh)
|
2012-05-04 |
2013-10-16 |
东北农业大学 |
猪rosa26特异性整合位点及其应用
|
|
US20140004131A1
(en)
|
2012-05-04 |
2014-01-02 |
Novartis Ag |
Antibody formulation
|
|
US9883939B2
(en)
|
2012-05-08 |
2018-02-06 |
The General Hospital Corporation |
Reducing immunogenicity of xenogeneic transplant tissues
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
KR101329411B1
(ko)
|
2012-05-31 |
2013-11-14 |
주식회사 엘지생활건강 |
피부투과성 펩타이드
|
|
AU2013293270B2
(en)
|
2012-07-25 |
2018-08-16 |
Massachusetts Institute Of Technology |
Inducible DNA binding proteins and genome perturbation tools and applications thereof
|
|
SG11201500799YA
(en)
|
2012-07-31 |
2015-03-30 |
Basil M Hantash |
Hla g-modified cells and methods
|
|
FI2892330T3
(fi)
|
2012-09-07 |
2023-03-25 |
Univ Yale |
Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi
|
|
AU2013335451C1
(en)
|
2012-10-23 |
2024-07-04 |
Toolgen Incorporated |
Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
|
|
US20140115728A1
(en)
|
2012-10-24 |
2014-04-24 |
A. Joseph Tector |
Double knockout (gt/cmah-ko) pigs, organs and tissues
|
|
US20140112958A1
(en)
|
2012-10-24 |
2014-04-24 |
Mwm Biomodels Gmbh |
Pancreatic islets of transgenic LEA29Y animals for treating diabetes
|
|
US20140120152A1
(en)
|
2012-10-31 |
2014-05-01 |
Northwestern University |
Scaffold Delivery of Immune Suppressors and Transplant Material for Control of Transplant Rejection
|
|
PL3360964T3
(pl)
|
2012-12-06 |
2020-03-31 |
Sigma-Aldrich Co. Llc |
Modyfikacja i regulacja genomu oparta na crispr
|
|
WO2014093655A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
IL239344B2
(en)
|
2012-12-12 |
2024-06-01 |
Broad Inst Inc |
Systems engineering, methods and optimal guiding components for sequence manipulation
|
|
CN113355357B
(zh)
|
2012-12-12 |
2024-12-03 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
EP2840140B2
(en)
|
2012-12-12 |
2023-02-22 |
The Broad Institute, Inc. |
Crispr-Cas based method for mutation of prokaryotic cells
|
|
EP3031921B1
(en)
|
2012-12-12 |
2025-03-12 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
DK2931891T3
(da)
|
2012-12-17 |
2019-08-19 |
Harvard College |
Rna-styret modificering af menneskelige genomer
|
|
US10227610B2
(en)
|
2013-02-25 |
2019-03-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
|
CN104046593A
(zh)
|
2013-03-14 |
2014-09-17 |
浙江大学 |
一种低免疫原性的人细胞及其制备方法
|
|
US20160138027A1
(en)
|
2013-03-14 |
2016-05-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
|
|
RU2662932C2
(ru)
|
2013-03-14 |
2018-07-31 |
Карибо Биосайенсиз, Инк. |
Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
CN112301024A
(zh)
|
2013-03-15 |
2021-02-02 |
通用医疗公司 |
使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
EP3003350B1
(en)
*
|
2013-05-27 |
2018-02-21 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Targeted modulation of macrophages
|
|
AU2014273082B2
(en)
|
2013-05-29 |
2018-11-08 |
Cellectis |
A method for producing precise DNA cleavage using Cas9 nickase activity
|
|
JP6195474B2
(ja)
|
2013-05-31 |
2017-09-13 |
ギガフォトン株式会社 |
極端紫外光生成装置及び極端紫外光生成システムにおけるレーザシステムの制御方法
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
MX374532B
(es)
|
2013-06-17 |
2025-03-06 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
|
|
WO2014204723A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
RU2716420C2
(ru)
|
2013-06-17 |
2020-03-11 |
Те Брод Инститьют Инк. |
Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
|
|
CN105683379A
(zh)
|
2013-06-17 |
2016-06-15 |
布罗德研究所有限公司 |
用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
EP3666892A1
(en)
|
2013-07-10 |
2020-06-17 |
President and Fellows of Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
WO2015006774A2
(en)
|
2013-07-12 |
2015-01-15 |
Oms Investments, Inc. |
Plants comprising events pp009-401, pp009-415, and pp009-469, compositions, sequences, and methods for detection thereof
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
CN120574876A
(zh)
|
2013-08-22 |
2025-09-02 |
纳幕尔杜邦公司 |
使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法
|
|
WO2015048577A2
(en)
|
2013-09-27 |
2015-04-02 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
CA2930877A1
(en)
|
2013-11-18 |
2015-05-21 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
JP2016538001A
(ja)
|
2013-11-28 |
2016-12-08 |
ホライズン・ジェノミクス・ゲーエムベーハー |
体細胞半数体ヒト細胞株
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
EP3470089A1
(en)
|
2013-12-12 |
2019-04-17 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
JP2017512481A
(ja)
|
2014-04-08 |
2017-05-25 |
ノースカロライナ ステート ユニバーシティーＮｏｒｔｈ Ｃａｒｏｌｉｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ |
Ｃｒｉｓｐｒ関連遺伝子を用いた、ｒｎａ依存性の転写抑制のための方法および組成物
|
|
TWI530276B
(zh)
|
2014-07-08 |
2016-04-21 |
原相科技股份有限公司 |
具去噪功能之生理偵測模組及其生理偵測方法
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
CA2965550A1
(en)
*
|
2014-10-22 |
2016-04-28 |
Indiana University Research & Technology Corporation |
Triple transgenic pigs suitable for xenograft
|
|
EP3701969A1
(en)
|
2014-10-31 |
2020-09-02 |
NGM Biopharmaceuticals, Inc. |
Compositions and methods of use for treating metabolic disorders
|
|
CN116059378A
(zh)
|
2014-12-10 |
2023-05-05 |
明尼苏达大学董事会 |
用于治疗疾病的遗传修饰的细胞、组织和器官
|
|
CN104789592A
(zh)
|
2015-03-19 |
2015-07-22 |
中国食品药品检定研究院 |
一种制备α-1,3GT基因敲除的非人哺乳动物的方法及应用
|
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
|
CN107810198B
(zh)
|
2015-05-29 |
2021-09-03 |
艾伯维公司 |
抗cd40抗体及其用途
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
US20180172683A1
(en)
|
2015-06-22 |
2018-06-21 |
University Of Southern California |
Methods for analyzing the interaction between a target protein and a ligand
|
|
WO2016210280A1
(en)
|
2015-06-26 |
2016-12-29 |
Indiana University Research & Technology Corporation |
Transgenic pigs with genetic modifications of sla
|
|
BR112018004296B1
(pt)
|
2015-09-04 |
2020-05-05 |
Primatope Therapeutics Inc |
anticorpos anti-cd40 humanizados e usos dos mesmos
|
|
BR112018012235A2
(pt)
|
2015-12-18 |
2018-12-04 |
Sangamo Therapeutics Inc |
rompimento alvejado do receptor de células de mhc
|
|
US9570114B1
(en)
|
2016-01-15 |
2017-02-14 |
HGST Netherlands B.V. |
Laminated film-packed hard disk drive for hermetic sealing
|
|
US20170251646A1
(en)
|
2016-03-01 |
2017-09-07 |
Indiana University Research And Technology Corporation |
Transgenic pigs lacking one or more cellular transport genes
|
|
KR20230110373A
(ko)
|
2016-06-14 |
2023-07-21 |
리전츠 오브 더 유니버스티 오브 미네소타 |
질환을 치료하기 위한 유전적으로 변형된 세포, 조직,및 장기
|
|
JP2020505025A
(ja)
|
2017-01-13 |
2020-02-20 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
免疫工学的な改変をした多能性細胞
|
|
JP2021513367A
(ja)
|
2018-02-12 |
2021-05-27 |
ダイアベーツ−フリー， インコーポレイテッド |
改善されたアンタゴニスト的抗ヒトｃｄ４０モノクローナル抗体
|
|
WO2020102454A1
(en)
|
2018-11-13 |
2020-05-22 |
Regents Of The University Of Minnesota |
Cd40 targeted peptides and uses thereof
|