JP2017536369A5 - - Google Patents
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- Publication number
- JP2017536369A5 JP2017536369A5 JP2017527260A JP2017527260A JP2017536369A5 JP 2017536369 A5 JP2017536369 A5 JP 2017536369A5 JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017536369 A5 JP2017536369 A5 JP 2017536369A5
- Authority
- JP
- Japan
- Prior art keywords
- nrc
- compound according
- sulfur
- nitrogen
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462082231P | 2014-11-20 | 2014-11-20 | |
| US62/082,231 | 2014-11-20 | ||
| PCT/US2015/061463 WO2016081679A1 (en) | 2014-11-20 | 2015-11-19 | Heteroaryl compounds as irak inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536369A JP2017536369A (ja) | 2017-12-07 |
| JP2017536369A5 true JP2017536369A5 (enExample) | 2018-12-20 |
| JP6787892B2 JP6787892B2 (ja) | 2020-11-18 |
Family
ID=54705914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527260A Active JP6787892B2 (ja) | 2014-11-20 | 2015-11-19 | Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9790221B2 (enExample) |
| EP (1) | EP3221306B1 (enExample) |
| JP (1) | JP6787892B2 (enExample) |
| KR (2) | KR102683518B1 (enExample) |
| CN (1) | CN107108561B (enExample) |
| AR (1) | AR103138A1 (enExample) |
| AU (1) | AU2015349899B9 (enExample) |
| CA (1) | CA2964982C (enExample) |
| DK (1) | DK3221306T3 (enExample) |
| ES (1) | ES2772133T3 (enExample) |
| HR (1) | HRP20200179T1 (enExample) |
| HU (1) | HUE047586T2 (enExample) |
| IL (1) | IL252346B (enExample) |
| LT (1) | LT3221306T (enExample) |
| MX (1) | MX375625B (enExample) |
| NZ (1) | NZ730728A (enExample) |
| PL (1) | PL3221306T3 (enExample) |
| PT (1) | PT3221306T (enExample) |
| RS (1) | RS59974B1 (enExample) |
| RU (1) | RU2743718C2 (enExample) |
| SG (1) | SG11201702741SA (enExample) |
| SI (1) | SI3221306T1 (enExample) |
| WO (1) | WO2016081679A1 (enExample) |
| ZA (1) | ZA201702402B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3286181T (pt) | 2015-04-22 | 2021-04-05 | Rigel Pharmaceuticals Inc | Compostos de pirazol e método para preparar e usar os compostos |
| US11612599B2 (en) * | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| ES2939232T3 (es) | 2016-10-26 | 2023-04-20 | Rigel Pharmaceuticals Inc | Derivados de oxazol para uso como inhibidores de IRAK y método para su preparación |
| ES2946001T3 (es) | 2016-10-26 | 2023-07-11 | Rigel Pharmaceuticals Inc | Compuestos de pirazol amida como inhibidores de IRAK |
| CA3042731A1 (en) * | 2016-11-22 | 2018-05-31 | Dana-Farber Cancer Institute, Inc. | Inhibitors of interleukin-1 receptor-associated kinases and uses thereof |
| NZ755447A (en) * | 2017-02-01 | 2023-05-26 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer |
| TWI733982B (zh) | 2017-02-16 | 2021-07-21 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒衍生物 |
| EP3620457A4 (en) * | 2017-05-02 | 2021-01-06 | Korea Research Institute of Chemical Technology | PYRIMIDE-DERIVATIVE COMPOUND, OPTICAL ISOMER THEREOF, OR PHARMACEUTICAL SALT THEREOF AND COMPOSITION FOR THE PREVENTION OR TREATMENT OF TYRO-3 RELATED DISEASES THEREOF AS ACTIVE SUBSTANCE |
| CA3068753A1 (en) * | 2017-07-03 | 2019-01-10 | Glaxosmithkline Intellectual Property Development Limited | N-(3-(2-(4-chlorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-2-cyclobutane-1-carboxamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases |
| CR20200054A (es) | 2017-08-09 | 2020-03-21 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| HUE062446T2 (hu) | 2017-09-01 | 2023-11-28 | Denali Therapeutics Inc | Vegyületek, készítmények és eljárások |
| JP7366031B2 (ja) | 2017-09-22 | 2023-10-20 | カイメラ セラピューティクス， インコーポレイテッド | タンパク質分解剤およびそれらの使用 |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
| EP3817822A4 (en) | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| TWI727392B (zh) * | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| MA54959A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| EP3923935A4 (en) | 2019-02-13 | 2022-10-26 | Denali Therapeutics Inc. | COMPOUNDS, COMPOSITIONS AND METHODS |
| BR112021026517A2 (pt) | 2019-06-28 | 2022-05-10 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| PH12022550466A1 (en) | 2019-08-30 | 2023-03-06 | Rigel Pharmaceuticals Inc | Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations |
| EP4072591A4 (en) | 2019-12-10 | 2024-06-05 | Kymera Therapeutics, Inc. | IRAQ DEGRADER AND USES THEREOF |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| WO2022147465A1 (en) | 2020-12-30 | 2022-07-07 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| TW202245788A (zh) | 2021-02-15 | 2022-12-01 | 美商凱麥拉醫療公司 | Irak4降解劑及其用途 |
| WO2022187303A1 (en) | 2021-03-03 | 2022-09-09 | Rigel Pharmaceuticals, Inc. | A method for treating a disease or condition using a pyrazole compound or formulation thereof |
| WO2022217118A1 (en) * | 2021-04-09 | 2022-10-13 | Quanta Therapeutics, Inc. | Pyrimidine based ras modulators and uses thereof |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| EP4422635A4 (en) | 2021-10-29 | 2025-11-26 | Kymera Therapeutics Inc | IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS |
| CN116514769B (zh) * | 2022-01-21 | 2024-02-27 | 中国药科大学 | 4-羟基嘧啶-5-甲酰腙衍生物、制备方法、药物组合物和应用 |
| IL314437A (en) | 2022-01-31 | 2024-09-01 | Kymera Therapeutics Inc | IRAK joints and their uses |
| EP4475956A1 (en) | 2022-02-09 | 2024-12-18 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
| US12384775B2 (en) | 2022-03-23 | 2025-08-12 | Rigel Pharmaceuticals, Inc. | Pyrimid-2-yl-pyrazole compounds as IRAK inhibitors |
| WO2023230190A1 (en) | 2022-05-25 | 2023-11-30 | Quanta Therapeutics, Inc. | Pyrimidine based modulators and uses thereof |
| AU2024234154A1 (en) | 2023-03-15 | 2025-09-25 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
| CN117924102A (zh) * | 2024-01-23 | 2024-04-26 | 成都伊诺达博医药科技有限公司 | 一种微管亲和力调节激酶抑制剂中间体的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090058276A1 (en) | 2007-08-20 | 2009-03-05 | Holliday Bradley J | METAL-CONTAINING POLYMERS and uses thereof |
| JP5402639B2 (ja) * | 2007-10-26 | 2014-01-29 | コニカミノルタ株式会社 | 有機エレクトロルミネッセンス素子、表示装置及び照明装置 |
| SI2307376T1 (sl) | 2008-08-04 | 2016-02-29 | Merck Patent Gmbh | Nove spojine fenilamino izonikotinamida |
| EP2414337B1 (en) * | 2009-04-03 | 2013-05-01 | Cellzome GmbH | Methods for the identification of kinase interacting molecules and for the purification of kinase proteins |
| JP2011098948A (ja) | 2009-06-25 | 2011-05-19 | Yamagata Promotional Organization For Industrial Technology | ビピリジン誘導体及びそれを含む有機エレクトロルミネッセンス素子 |
| WO2011084402A1 (en) * | 2009-12-21 | 2011-07-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| CN102985426B (zh) * | 2010-07-13 | 2015-10-07 | 弗·哈夫曼-拉罗切有限公司 | 作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物 |
| WO2013134415A1 (en) * | 2012-03-07 | 2013-09-12 | Vertex Pharmaceuticals Incorporated | Mannose derivatives for treating bacterial infections |
| WO2013141097A1 (ja) * | 2012-03-22 | 2013-09-26 | コニカミノルタ株式会社 | 透明電極、電子デバイス及び有機エレクトロルミネッセンス素子 |
| SG11201500005SA (en) * | 2012-07-10 | 2015-01-29 | Ares Trading Sa | Pyrimidine pyrazolyl derivatives |
| WO2015106058A1 (en) | 2014-01-09 | 2015-07-16 | Merck Patent Gmbh | Pyrimidine pyrazolyl derivatives and their use as irak inhibitors |
-
2015
- 2015-11-19 ES ES15801650T patent/ES2772133T3/es active Active
- 2015-11-19 SG SG11201702741SA patent/SG11201702741SA/en unknown
- 2015-11-19 HR HRP20200179TT patent/HRP20200179T1/hr unknown
- 2015-11-19 HU HUE15801650A patent/HUE047586T2/hu unknown
- 2015-11-19 EP EP15801650.1A patent/EP3221306B1/en active Active
- 2015-11-19 MX MX2017006266A patent/MX375625B/es active IP Right Grant
- 2015-11-19 WO PCT/US2015/061463 patent/WO2016081679A1/en not_active Ceased
- 2015-11-19 CN CN201580073060.9A patent/CN107108561B/zh not_active Expired - Fee Related
- 2015-11-19 NZ NZ730728A patent/NZ730728A/en not_active IP Right Cessation
- 2015-11-19 PT PT158016501T patent/PT3221306T/pt unknown
- 2015-11-19 US US14/945,610 patent/US9790221B2/en active Active
- 2015-11-19 AU AU2015349899A patent/AU2015349899B9/en active Active
- 2015-11-19 PL PL15801650T patent/PL3221306T3/pl unknown
- 2015-11-19 RS RS20200153A patent/RS59974B1/sr unknown
- 2015-11-19 KR KR1020237038922A patent/KR102683518B1/ko active Active
- 2015-11-19 KR KR1020177015188A patent/KR20170086057A/ko not_active Ceased
- 2015-11-19 DK DK15801650.1T patent/DK3221306T3/da active
- 2015-11-19 LT LTEP15801650.1T patent/LT3221306T/lt unknown
- 2015-11-19 CA CA2964982A patent/CA2964982C/en active Active
- 2015-11-19 RU RU2017120274A patent/RU2743718C2/ru active
- 2015-11-19 JP JP2017527260A patent/JP6787892B2/ja active Active
- 2015-11-19 SI SI201531094T patent/SI3221306T1/sl unknown
- 2015-11-20 AR ARP150103793A patent/AR103138A1/es unknown
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2017
- 2017-04-05 ZA ZA2017/02402A patent/ZA201702402B/en unknown
- 2017-05-17 IL IL252346A patent/IL252346B/en active IP Right Grant
- 2017-09-12 US US15/701,842 patent/US10030013B2/en active Active