JP2017536369A5 - - Google Patents
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- JP2017536369A5 JP2017536369A5 JP2017527260A JP2017527260A JP2017536369A5 JP 2017536369 A5 JP2017536369 A5 JP 2017536369A5 JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017536369 A5 JP2017536369 A5 JP 2017536369A5
- Authority
- JP
- Japan
- Prior art keywords
- nrc
- compound according
- sulfur
- nitrogen
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462082231P | 2014-11-20 | 2014-11-20 | |
| US62/082,231 | 2014-11-20 | ||
| PCT/US2015/061463 WO2016081679A1 (en) | 2014-11-20 | 2015-11-19 | Heteroaryl compounds as irak inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536369A JP2017536369A (ja) | 2017-12-07 |
| JP2017536369A5 true JP2017536369A5 (enExample) | 2018-12-20 |
| JP6787892B2 JP6787892B2 (ja) | 2020-11-18 |
Family
ID=54705914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527260A Active JP6787892B2 (ja) | 2014-11-20 | 2015-11-19 | Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9790221B2 (enExample) |
| EP (1) | EP3221306B1 (enExample) |
| JP (1) | JP6787892B2 (enExample) |
| KR (2) | KR20170086057A (enExample) |
| CN (1) | CN107108561B (enExample) |
| AR (1) | AR103138A1 (enExample) |
| AU (1) | AU2015349899B9 (enExample) |
| CA (1) | CA2964982C (enExample) |
| DK (1) | DK3221306T3 (enExample) |
| ES (1) | ES2772133T3 (enExample) |
| HR (1) | HRP20200179T1 (enExample) |
| HU (1) | HUE047586T2 (enExample) |
| IL (1) | IL252346B (enExample) |
| LT (1) | LT3221306T (enExample) |
| MX (1) | MX375625B (enExample) |
| NZ (1) | NZ730728A (enExample) |
| PL (1) | PL3221306T3 (enExample) |
| PT (1) | PT3221306T (enExample) |
| RS (1) | RS59974B1 (enExample) |
| RU (1) | RU2743718C2 (enExample) |
| SG (1) | SG11201702741SA (enExample) |
| SI (1) | SI3221306T1 (enExample) |
| WO (1) | WO2016081679A1 (enExample) |
| ZA (1) | ZA201702402B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201707752SA (en) | 2015-04-22 | 2017-11-29 | Rigel Pharmaceuticals Inc | Pyrazole compounds and method for making and using the compounds |
| WO2017144633A1 (en) * | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Glycosidase inhibitors |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| EP3532465B1 (en) | 2016-10-26 | 2023-03-01 | Rigel Pharmaceuticals, Inc. | Pyrazole amide compounds as irak inhibitors |
| DK3532470T3 (da) | 2016-10-26 | 2023-02-20 | Rigel Pharmaceuticals Inc | Oxazolderivater til anvendelse som irak-hæmmere og fremgangsmåde til fremstilling deraf |
| WO2018098367A1 (en) * | 2016-11-22 | 2018-05-31 | Dana-Farber Cancer Institute, Inc. | Inhibitors of interleukin-1 receptor-associated kinases and uses thereof |
| NZ755447A (en) * | 2017-02-01 | 2023-05-26 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| US11053225B2 (en) * | 2017-05-02 | 2021-07-06 | Korea Research Institute Of Chemical Technology | Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient |
| BR112020000122A2 (pt) * | 2017-07-03 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | derivados da n-(3-(2-(4-clorofenóxi)acetamido)biciclo[1.1.1] pentan-1-il)-2-ciclobutano-1-carboxamida e compostos relacionados como inibidores do atf4 para tratamento contra o câncer e outras doenças |
| MA49858A (fr) * | 2017-08-09 | 2021-04-28 | Denali Therapeutics Inc | Composés, compositions et procédés |
| DK3676297T3 (da) | 2017-09-01 | 2023-08-14 | Denali Therapeutics Inc | Forbindelser, sammensætninger og fremgangsmåder |
| WO2019060742A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc | AGENTS FOR DEGRADING PROTEINS AND USES THEREOF |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| TWI727392B (zh) | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| MA54959A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| MX2021015995A (es) | 2019-06-28 | 2022-03-11 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| AU2020335903A1 (en) | 2019-08-30 | 2022-03-24 | Rigel Pharmaceuticals, Inc. | Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations |
| US12551564B2 (en) | 2019-12-10 | 2026-02-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| CN115052627A (zh) | 2019-12-17 | 2022-09-13 | 凯麦拉医疗公司 | Irak降解剂和其用途 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| CA3202360A1 (en) | 2020-12-30 | 2022-07-07 | Nello Mainolfi | Irak degraders and uses thereof |
| CA3207049A1 (en) | 2021-02-15 | 2022-08-18 | Jared Gollob | Irak4 degraders and uses thereof |
| US12357623B2 (en) | 2021-03-03 | 2025-07-15 | Rigel Pharmaceuticals, Inc. | Method for treating a disease or condition using a pyrazole compound or formulation thereof |
| WO2022217118A1 (en) * | 2021-04-09 | 2022-10-13 | Quanta Therapeutics, Inc. | Pyrimidine based ras modulators and uses thereof |
| KR20240020735A (ko) | 2021-05-07 | 2024-02-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | Cdk2 분해제 및 그 용도 |
| CA3236265A1 (en) | 2021-10-29 | 2023-05-04 | William Leong | Irak4 degraders and synthesis thereof |
| CN116514769B (zh) * | 2022-01-21 | 2024-02-27 | 中国药科大学 | 4-羟基嘧啶-5-甲酰腙衍生物、制备方法、药物组合物和应用 |
| US12091411B2 (en) | 2022-01-31 | 2024-09-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| IL314812A (en) | 2022-02-09 | 2024-10-01 | Quanta Therapeutics Inc | Kras modulators and uses thereof |
| TW202346291A (zh) | 2022-03-23 | 2023-12-01 | 美商雷傑製藥公司 | 作為ｉｒａｋ抑制劑的嘧啶—２—基—吡唑化合物 |
| KR20250034204A (ko) | 2022-05-25 | 2025-03-10 | 콴타 테라퓨틱스, 인크. | 피리미딘 기반 조절인자 및 이의 용도 |
| WO2024192424A1 (en) | 2023-03-15 | 2024-09-19 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090058276A1 (en) | 2007-08-20 | 2009-03-05 | Holliday Bradley J | METAL-CONTAINING POLYMERS and uses thereof |
| WO2009054253A1 (ja) * | 2007-10-26 | 2009-04-30 | Konica Minolta Holdings, Inc. | 有機エレクトロルミネッセンス素子、表示装置及び照明装置 |
| UA107183C2 (uk) | 2008-08-04 | 2014-12-10 | Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань | |
| WO2010112210A1 (en) * | 2009-04-03 | 2010-10-07 | Cellzome Ag | Methods for the identification of kinase interacting molecules and for the purification of kinase proteins |
| JP2011098948A (ja) * | 2009-06-25 | 2011-05-19 | Yamagata Promotional Organization For Industrial Technology | ビピリジン誘導体及びそれを含む有機エレクトロルミネッセンス素子 |
| CA2782885A1 (en) * | 2009-12-21 | 2011-07-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| KR101995013B1 (ko) * | 2010-07-13 | 2019-07-02 | 에프. 호프만-라 로슈 아게 | Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체 |
| US20130261077A1 (en) * | 2012-03-07 | 2013-10-03 | Vertex Pharmaceuticals Incorporated | Mannose derivatives for treating bacterial infections |
| WO2013141097A1 (ja) * | 2012-03-22 | 2013-09-26 | コニカミノルタ株式会社 | 透明電極、電子デバイス及び有機エレクトロルミネッセンス素子 |
| CN104662014B (zh) * | 2012-07-10 | 2017-02-22 | 阿雷斯贸易股份有限公司 | 嘧啶吡唑基衍生物 |
| ES2728403T3 (es) * | 2014-01-09 | 2019-10-24 | Merck Patent Gmbh | Derivados de pirimidin pirazolilo y su uso como inhibidores de IRAK |
-
2015
- 2015-11-19 NZ NZ730728A patent/NZ730728A/en not_active IP Right Cessation
- 2015-11-19 JP JP2017527260A patent/JP6787892B2/ja active Active
- 2015-11-19 PL PL15801650T patent/PL3221306T3/pl unknown
- 2015-11-19 ES ES15801650T patent/ES2772133T3/es active Active
- 2015-11-19 CN CN201580073060.9A patent/CN107108561B/zh not_active Expired - Fee Related
- 2015-11-19 KR KR1020177015188A patent/KR20170086057A/ko not_active Ceased
- 2015-11-19 SI SI201531094T patent/SI3221306T1/sl unknown
- 2015-11-19 RU RU2017120274A patent/RU2743718C2/ru active
- 2015-11-19 AU AU2015349899A patent/AU2015349899B9/en active Active
- 2015-11-19 WO PCT/US2015/061463 patent/WO2016081679A1/en not_active Ceased
- 2015-11-19 DK DK15801650.1T patent/DK3221306T3/da active
- 2015-11-19 HR HRP20200179TT patent/HRP20200179T1/hr unknown
- 2015-11-19 LT LTEP15801650.1T patent/LT3221306T/lt unknown
- 2015-11-19 PT PT158016501T patent/PT3221306T/pt unknown
- 2015-11-19 EP EP15801650.1A patent/EP3221306B1/en active Active
- 2015-11-19 MX MX2017006266A patent/MX375625B/es active IP Right Grant
- 2015-11-19 KR KR1020237038922A patent/KR102683518B1/ko active Active
- 2015-11-19 RS RS20200153A patent/RS59974B1/sr unknown
- 2015-11-19 HU HUE15801650A patent/HUE047586T2/hu unknown
- 2015-11-19 US US14/945,610 patent/US9790221B2/en active Active
- 2015-11-19 SG SG11201702741SA patent/SG11201702741SA/en unknown
- 2015-11-19 CA CA2964982A patent/CA2964982C/en active Active
- 2015-11-20 AR ARP150103793A patent/AR103138A1/es unknown
-
2017
- 2017-04-05 ZA ZA2017/02402A patent/ZA201702402B/en unknown
- 2017-05-17 IL IL252346A patent/IL252346B/en active IP Right Grant
- 2017-09-12 US US15/701,842 patent/US10030013B2/en active Active
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