CN107108561B - 用作irak抑制剂的杂芳基化合物及其用途 - Google Patents

用作irak抑制剂的杂芳基化合物及其用途 Download PDF

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Publication number
CN107108561B
CN107108561B CN201580073060.9A CN201580073060A CN107108561B CN 107108561 B CN107108561 B CN 107108561B CN 201580073060 A CN201580073060 A CN 201580073060A CN 107108561 B CN107108561 B CN 107108561B
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methyl
pyrazol
mmol
phenyl
pyrimidin
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CN107108561A (zh
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C·乔兰德-勒布伦
R·琼斯
A·C·温
N·恩古耶
T·L·约翰逊
L·C·德赛尔姆
K·潘达
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Merck Patent GmbH
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Merck Patent GmbH
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CN201580073060.9A 2014-11-20 2015-11-19 用作irak抑制剂的杂芳基化合物及其用途 Expired - Fee Related CN107108561B (zh)

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US201462082231P 2014-11-20 2014-11-20
US62/082,231 2014-11-20
PCT/US2015/061463 WO2016081679A1 (en) 2014-11-20 2015-11-19 Heteroaryl compounds as irak inhibitors and uses thereof

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PL3286181T3 (pl) 2015-04-22 2021-08-02 Rigel Pharmaceuticals, Inc. Związki pirazolowe oraz sposób wytwarzania i zastosowania tych związków
MX2018010192A (es) * 2016-02-25 2019-01-31 Asceneuron S A Inhibidores de glucosidasa.
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US10414753B2 (en) 2016-10-26 2019-09-17 Rigel Pharmaceuticals, Inc. Amide compounds and method for making and using
US10370367B2 (en) 2016-10-26 2019-08-06 Rigel Pharmaceuticals, Inc. IRAK inhibitors and method for making and using
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