JP6787892B2 - Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 - Google Patents

Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 Download PDF

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JP6787892B2
JP6787892B2 JP2017527260A JP2017527260A JP6787892B2 JP 6787892 B2 JP6787892 B2 JP 6787892B2 JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017527260 A JP2017527260 A JP 2017527260A JP 6787892 B2 JP6787892 B2 JP 6787892B2
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methyl
mmol
pyrazole
pyrimidine
phenyl
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JP2017536369A5 (enExample
JP2017536369A (ja
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ヨラン−ルブラン カトリーヌ
ヨラン−ルブラン カトリーヌ
ジョーンズ レイナルド
ジョーンズ レイナルド
チョ ウォン アニー
チョ ウォン アニー
グエン ガン
グエン ガン
エル．ジョンソン テレサ
エル．ジョンソン テレサ
セレステ ディゼルム リズベス
セレステ ディゼルム リズベス
パンダ カウシク
パンダ カウシク
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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JP2017527260A 2014-11-20 2015-11-19 Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 Active JP6787892B2 (ja)

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US201462082231P 2014-11-20 2014-11-20
US62/082,231 2014-11-20
PCT/US2015/061463 WO2016081679A1 (en) 2014-11-20 2015-11-19 Heteroaryl compounds as irak inhibitors and uses thereof

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SG11201707752SA (en) 2015-04-22 2017-11-29 Rigel Pharmaceuticals Inc Pyrazole compounds and method for making and using the compounds
WO2017144633A1 (en) * 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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