JP2017535552A - アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法 - Google Patents

アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法 Download PDF

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JP2017535552A
JP2017535552A JP2017526493A JP2017526493A JP2017535552A JP 2017535552 A JP2017535552 A JP 2017535552A JP 2017526493 A JP2017526493 A JP 2017526493A JP 2017526493 A JP2017526493 A JP 2017526493A JP 2017535552 A JP2017535552 A JP 2017535552A
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double
rnai agent
nucleotides
stranded rnai
nucleotide
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JP2017535552A5 (https=
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ケビン・フィッツジェラルド
ウィリアム・クアーベス
ジェイムズ・バトラー
ステファニー・ウィリアムズ
アビゲイル・リーボウ
グレゴリー・ヒンクル
マルティン・マイアー
スチュアート・ミルスタイン
サティアナラヤーナ・クチマンチ
ムティア・マノハラン
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Alnylam Pharmaceuticals Inc
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JP2017526493A 2014-11-17 2015-11-17 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法 Pending JP2017535552A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080941P 2014-11-17 2014-11-17
US62/080,941 2014-11-17
US201562136159P 2015-03-20 2015-03-20
US62/136,159 2015-03-20
PCT/US2015/061065 WO2016081444A1 (en) 2014-11-17 2015-11-17 Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof

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JP2020083294A Division JP2020141685A (ja) 2014-11-17 2020-05-11 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法

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JP2017535552A true JP2017535552A (ja) 2017-11-30
JP2017535552A5 JP2017535552A5 (https=) 2018-12-27

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JP2017526493A Pending JP2017535552A (ja) 2014-11-17 2015-11-17 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2020083294A Pending JP2020141685A (ja) 2014-11-17 2020-05-11 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2023077186A Active JP7516613B2 (ja) 2014-11-17 2023-05-09 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2024107357A Active JP7778857B2 (ja) 2014-11-17 2024-07-03 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2025197843A Pending JP2026048670A (ja) 2014-11-17 2025-11-19 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法

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JP2023077186A Active JP7516613B2 (ja) 2014-11-17 2023-05-09 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2024107357A Active JP7778857B2 (ja) 2014-11-17 2024-07-03 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2025197843A Pending JP2026048670A (ja) 2014-11-17 2025-11-19 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法

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US (7) US10407679B2 (https=)
EP (1) EP3221451A1 (https=)
JP (5) JP2017535552A (https=)
CN (2) CN113846101A (https=)
AU (3) AU2015350120B2 (https=)
CA (1) CA2968114A1 (https=)
HK (1) HK1244843A1 (https=)
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Cited By (7)

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JP2021503929A (ja) * 2017-12-01 2021-02-15 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドＳｕｚｈｏｕ Ｒｉｂｏ Ｌｉｆｅ Ｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
JP2021509402A (ja) * 2017-12-29 2021-03-25 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドＳｕｚｈｏｕ Ｒｉｂｏ Ｌｉｆｅ Ｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． 複合体及びその調製方法と使用
JP2022501059A (ja) * 2018-09-30 2022-01-06 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. ｓｉＲＮＡ複合体及びその調製方法と使用
JP2022506503A (ja) * 2018-11-09 2022-01-17 アルニラム ファーマスーティカルズ インコーポレイテッド 修飾二重鎖オリゴヌクレオチド
JP2022515503A (ja) * 2018-12-28 2022-02-18 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
JP2022543136A (ja) * 2019-08-05 2022-10-07 アローヘッド ファーマシューティカルズ インコーポレイテッド Ａｐｏｃ３関連疾患および障害の処置のための方法
JP2025520796A (ja) * 2022-06-27 2025-07-03 大睿生物 アポリポタンパク質Ｃ３発現を阻害するｓｉＲＮＡ

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RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
SI3366775T2 (sl) * 2011-11-18 2025-12-31 Alnylam Pharmaceuticals, Inc. Modificirana sredstva RNAI
CN113057959B (zh) 2014-02-11 2024-07-16 阿尔尼拉姆医药品有限公司 己酮糖激酶（KHK）iRNA组合物及其使用方法
JP2017535552A (ja) 2014-11-17 2017-11-30 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
CN110234998A (zh) * 2016-07-21 2019-09-13 克利夫兰心脏实验室公司 Hdl相关蛋白质生物标记物组的检测
WO2018104499A1 (en) * 2016-12-08 2018-06-14 Juntti Berggren Lisa Methods for treating and limiting development of obesity and fatty liver disorders
JP2020522510A (ja) 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
CA3065523A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
CN120330183A (zh) * 2017-06-02 2025-07-18 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
KR20240161202A (ko) * 2017-09-11 2024-11-12 애로우헤드 파마슈티컬스 인코포레이티드 아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물
WO2019105404A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
DK3719128T3 (da) * 2017-12-01 2025-03-03 Suzhou Ribo Life Science Co Ltd Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf
CA3083970A1 (en) * 2017-12-01 2019-06-06 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
CN110945131B (zh) * 2017-12-01 2024-05-28 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN110944675B9 (zh) * 2017-12-01 2024-08-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
EP3719126B1 (en) 2017-12-01 2025-01-01 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
EP3728593A1 (en) * 2017-12-18 2020-10-28 Alnylam Pharmaceuticals, Inc. High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
SG11202009877XA (en) 2018-04-12 2020-11-27 Wave Life Sciences Ltd Oligonucleotide compositions and methods of use thereof
US12391942B2 (en) 2018-05-11 2025-08-19 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
TWI851574B (zh) * 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
JP7625512B2 (ja) 2018-08-13 2025-02-03 アルナイラム ファーマシューティカルズ， インコーポレイテッド Ｂ型肝炎ウイルス（ＨＢＶ）ｄｓＲＮＡ物質組成物およびその使用方法
WO2020038377A1 (zh) 2018-08-21 2020-02-27 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
US20210332367A1 (en) * 2018-09-18 2021-10-28 Alnylam Pharmaceuticals, Inc. KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
KR102769565B1 (ko) 2018-09-19 2025-02-20 애로우헤드 파마슈티컬스 인코포레이티드 17베타-HSD 유형 13- (HSD17B13)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법
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