JP2017532302A5 - - Google Patents
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- JP2017532302A5 JP2017532302A5 JP2017512684A JP2017512684A JP2017532302A5 JP 2017532302 A5 JP2017532302 A5 JP 2017532302A5 JP 2017512684 A JP2017512684 A JP 2017512684A JP 2017512684 A JP2017512684 A JP 2017512684A JP 2017532302 A5 JP2017532302 A5 JP 2017532302A5
- Authority
- JP
- Japan
- Prior art keywords
- tev
- utr
- sequence
- human
- gaopt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 108020004705 Codon Proteins 0.000 description 2
- 241000723792 Tobacco etch virus Species 0.000 description 2
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 101000899111 Homo sapiens Hemoglobin subunit beta Proteins 0.000 description 1
- 101001063991 Homo sapiens Leptin Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 102000049953 human LEP Human genes 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046487P | 2014-09-05 | 2014-09-05 | |
| US62/046,487 | 2014-09-05 | ||
| PCT/US2015/048535 WO2016037053A1 (en) | 2014-09-05 | 2015-09-04 | Lipids and lipid compositions for the delivery of active agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532302A JP2017532302A (ja) | 2017-11-02 |
| JP2017532302A5 true JP2017532302A5 (enExample) | 2018-10-18 |
| JP6731912B2 JP6731912B2 (ja) | 2020-07-29 |
Family
ID=54256820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512684A Active JP6731912B2 (ja) | 2014-09-05 | 2015-09-04 | 活性物質の送達用の脂質および脂質組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10125092B2 (enExample) |
| EP (1) | EP3188760B1 (enExample) |
| JP (1) | JP6731912B2 (enExample) |
| CN (1) | CN107072946B (enExample) |
| ES (1) | ES2969956T3 (enExample) |
| WO (1) | WO2016037053A1 (enExample) |
Families Citing this family (82)
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| US10227588B2 (en) | 2013-10-04 | 2019-03-12 | Novartis Ag | 3′end caps for RNAi agents for use in RNA interference |
| EP3052627B1 (en) | 2013-10-04 | 2018-08-22 | Novartis AG | Novel formats for organic compounds for use in rna interference |
| EP3052107B1 (en) | 2013-10-04 | 2018-05-02 | Novartis AG | Organic compounds to treat hepatitis b virus |
| HRP20220070T1 (hr) | 2014-04-23 | 2022-04-01 | Modernatx, Inc. | Cjepiva nukleinske kiseline |
| ES2969956T3 (es) * | 2014-09-05 | 2024-05-23 | Novartis Ag | Lípidos y composiciones lipídicas para el suministro de agentes activos |
| KR102630720B1 (ko) | 2015-08-28 | 2024-01-29 | 세키스이 메디칼 가부시키가이샤 | 벤질 화합물 |
| WO2017070613A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| TWI773666B (zh) * | 2016-03-30 | 2022-08-11 | 美商英特利亞醫療公司 | Crispr/cas 組分之脂質奈米粒子調配物 |
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| JP2019528312A (ja) * | 2016-08-07 | 2019-10-10 | ノバルティス アーゲー | ｍＲＮＡ媒介性の免疫化方法 |
| EP3518966A1 (en) | 2016-09-29 | 2019-08-07 | GlaxoSmithKline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
| GB201616904D0 (en) | 2016-10-05 | 2016-11-16 | Glaxosmithkline Biologicals Sa | Vaccine |
| MA46584A (fr) | 2016-10-21 | 2019-08-28 | Modernatx Inc | Vaccin contre le cytomégalovirus humain |
| WO2018091540A1 (en) | 2016-11-17 | 2018-05-24 | Glaxosmithkline Biologicals Sa | Zika viral antigen constructs |
| MA47787A (fr) | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
| JP2020521781A (ja) | 2017-05-30 | 2020-07-27 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | リポソームに内包されたｒｎａを製造する方法 |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| WO2019016680A1 (en) | 2017-07-17 | 2019-01-24 | Glaxosmithkline Biologicals Sa | ANTIGEN CONSTRUCTS OF LYSSAVIRUS |
| US11744801B2 (en) | 2017-08-31 | 2023-09-05 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| EP3461497A1 (en) | 2017-09-27 | 2019-04-03 | GlaxoSmithKline Biologicals S.A. | Viral antigens |
| MA54676A (fr) | 2018-01-29 | 2021-11-17 | Modernatx Inc | Vaccins à base d'arn contre le vrs |
| CN113164584A (zh) | 2018-08-17 | 2021-07-23 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物及其用途 |
| CN109260174B (zh) * | 2018-09-04 | 2021-10-15 | 中山大学 | 一种治疗性蛋白纳米颗粒的高通量制备方法 |
| US12151029B2 (en) | 2018-09-19 | 2024-11-26 | Modernatx, Inc. | PEG lipids and uses thereof |
| MA53652A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg de haute pureté et leurs utilisations |
| CN113271926A (zh) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| DK3646854T3 (da) * | 2018-10-30 | 2022-09-26 | Polyplus Transfection | Sammensætninger til transfektion af mRNA i en celle og anvendelser deraf |
| CN119285480A (zh) | 2018-12-05 | 2025-01-10 | 英特利亚治疗股份有限公司 | 改性的胺脂质 |
| US20220062409A1 (en) * | 2018-12-14 | 2022-03-03 | Glaxosmithkline Biologicals Sa | Heterologous prime boost vaccine compositions and methods |
| BR112021017637A8 (pt) * | 2019-03-08 | 2022-08-16 | Massachusetts Inst Technology | Vírus oncolítico sintético, composição farmacêutica, e, método para tratar câncer |
| BR112022000710A2 (pt) | 2019-07-21 | 2022-03-22 | Glaxosmithkline Biologicals Sa | Vacina viral terapêutica |
| WO2021038508A1 (en) | 2019-08-30 | 2021-03-04 | Glaxosmithkline Biologicals Sa | Jet mixing lipid nanoparticle manufacturing process |
| BR112022009429A2 (pt) * | 2019-11-15 | 2022-08-09 | Daiichi Sankyo Co Ltd | Vacina de partícula lipídica de ácido nucleico encapsulando o mrna de hpv |
| US12435035B2 (en) | 2020-01-09 | 2025-10-07 | Guide Therapeutics, Llc | Nanomaterials |
| US20240269266A1 (en) * | 2020-04-14 | 2024-08-15 | The Regents Of The University Of California | Broad-spectrum multi-antigen pan-coronavirus vaccine |
| EP4135761A1 (en) | 2020-04-16 | 2023-02-22 | GlaxoSmithKline Biologicals S.A. | Sars cov-2 spike protein construct |
| EP4161570A1 (en) | 2020-06-05 | 2023-04-12 | GlaxoSmithKline Biologicals S.A. | Modified betacoronavirus spike proteins |
| WO2022002783A1 (en) | 2020-06-29 | 2022-01-06 | Glaxosmithkline Biologicals Sa | Adjuvants |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| US20240301006A1 (en) | 2020-12-23 | 2024-09-12 | Glaxosmithkline Biologicals Sa | Self-amplifying messenger rna |
| EP4281080A4 (en) | 2021-01-20 | 2025-09-24 | Beam Therapeutics Inc | NANOMATERIALS COMPRISING A BIODEGRADABLE ELEMENT |
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| CA3203742A1 (en) * | 2021-01-20 | 2022-07-28 | Beam Therapeutics Inc. | Nanomaterials |
| MX2023009195A (es) * | 2021-02-05 | 2023-12-08 | Immorna Hangzhou Biotechnology Co Ltd | Molecula lipida ionizable, metodo de preparacion de la misma, y aplicacion de la misma en la preparacion de nanoparticula lipida. |
| CN112961065B (zh) * | 2021-02-05 | 2023-03-14 | 嘉晨西海(杭州)生物技术有限公司 | 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用 |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20240181038A1 (en) | 2021-03-26 | 2024-06-06 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
| JPWO2022244815A1 (enExample) * | 2021-05-19 | 2022-11-24 | ||
| EP4346894A1 (en) | 2021-05-24 | 2024-04-10 | GlaxoSmithKline Biologicals S.A. | Adjuvants |
| EP4352247A1 (en) | 2021-06-09 | 2024-04-17 | GlaxoSmithKline Biologicals s.a. | Release assay for determining potency of self-amplifying rna drug product and methods for using |
| EP4387596A1 (en) | 2021-08-16 | 2024-06-26 | GlaxoSmithKline Biologicals SA | Low-dose lyophilized rna vaccines and methods for preparing and using the same |
| US20240350410A1 (en) | 2021-08-16 | 2024-10-24 | Glaxosmithkline Biologicals Sa | Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof |
| WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| CA3229889A1 (en) | 2021-09-03 | 2023-03-09 | Glaxosmithkline Biologicals Sa | Substitution of nucleotide bases in self-amplifying messenger ribonucleic acids |
| WO2023104114A2 (en) * | 2021-12-07 | 2023-06-15 | Immorna (hangzhou) Biotechnology Co., Ltd. | Rna formulations and lipids |
| CN118401547A (zh) * | 2021-12-17 | 2024-07-26 | 嘉晨西海(杭州)生物技术有限公司 | 白细胞介素-12自我复制rna和方法 |
| JP2023130120A (ja) * | 2022-03-07 | 2023-09-20 | スペラファーマ株式会社 | ペプチド合成方法 |
| CN119072464A (zh) * | 2022-03-25 | 2024-12-03 | 赛欧生物医药股份有限公司 | 新型可电离脂质和脂质纳米颗粒以及其使用方法 |
| JP2023181989A (ja) * | 2022-06-13 | 2023-12-25 | 上海臻上医薬科技有限公司 | マイクロニードル注射製剤およびその使用 |
| WO2023242817A2 (en) | 2022-06-18 | 2023-12-21 | Glaxosmithkline Biologicals Sa | Recombinant rna molecules comprising untranslated regions or segments encoding spike protein from the omicron strain of severe acute respiratory coronavirus-2 |
| JP2025528020A (ja) | 2022-07-20 | 2025-08-26 | ビーム セラピューティクス インク． | トリオールを含むナノ材料 |
| KR20250075664A (ko) | 2022-09-26 | 2025-05-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 인플루엔자 바이러스 백신 |
| EP4608812A1 (en) * | 2022-10-28 | 2025-09-03 | Advanced RNA Vaccine (ARV) Technologies, Inc. | Vitamin-based lipids and lipid nanoparticles comprising the same |
| CN120265278A (zh) * | 2022-12-07 | 2025-07-04 | 嘉晨西海(杭州)生物技术有限公司 | 自我复制rna疫苗和使用方法 |
| EP4637812A1 (en) | 2022-12-19 | 2025-10-29 | GlaxoSmithKline Biologicals S.A. | Hepatitis b compositions |
| WO2024160936A1 (en) | 2023-02-03 | 2024-08-08 | Glaxosmithkline Biologicals Sa | Rna formulation |
| GB202302092D0 (en) | 2023-02-14 | 2023-03-29 | Glaxosmithkline Biologicals Sa | Analytical method |
| WO2024187158A1 (en) * | 2023-03-08 | 2024-09-12 | The Regents Of The University Of California | Benzaldehyde acetal acid-degradable amphiphilic lipid and self-assembling peptides |
| WO2024223724A1 (en) | 2023-04-27 | 2024-10-31 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| AU2024260120A1 (en) | 2023-04-27 | 2025-11-06 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025011529A2 (en) | 2023-07-07 | 2025-01-16 | Shanghai Circode Biomed Co., Ltd. | Circular rna vaccines for seasonal flu and methods of uses |
| WO2025045142A1 (en) | 2023-08-29 | 2025-03-06 | Shanghai Circode Biomed Co., Ltd. | Circular rna encoding vegf polypeptides, formulations, and methods of uses |
| WO2025067389A1 (en) * | 2023-09-28 | 2025-04-03 | Immorna (hangzhou) Biotechnology Co., Ltd. | Lipid complex nanoparticle for lung-targeted delivery of nucleic acid therapeutic agent |
| WO2025132839A1 (en) | 2023-12-21 | 2025-06-26 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| CN120227354A (zh) * | 2023-12-29 | 2025-07-01 | 康希诺(上海)生物研发有限公司 | 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途 |
| GB202404607D0 (en) | 2024-03-29 | 2024-05-15 | Glaxosmithkline Biologicals Sa | RNA formulation |
| WO2025229572A1 (en) | 2024-05-01 | 2025-11-06 | Glaxosmithkline Biologicals Sa | Epstein-barr virus antigen-encoding messenger ribonucleic acid and antigen protein vaccines |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
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| US20220062409A1 (en) * | 2018-12-14 | 2022-03-03 | Glaxosmithkline Biologicals Sa | Heterologous prime boost vaccine compositions and methods |
-
2015
- 2015-09-04 ES ES15775528T patent/ES2969956T3/es active Active
- 2015-09-04 JP JP2017512684A patent/JP6731912B2/ja active Active
- 2015-09-04 WO PCT/US2015/048535 patent/WO2016037053A1/en not_active Ceased
- 2015-09-04 US US15/505,282 patent/US10125092B2/en active Active
- 2015-09-04 CN CN201580060043.1A patent/CN107072946B/zh active Active
- 2015-09-04 EP EP15775528.1A patent/EP3188760B1/en active Active
-
2018
- 2018-09-19 US US16/135,116 patent/US10844002B2/en active Active
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