JP2017532302A5 - - Google Patents
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- JP2017532302A5 JP2017532302A5 JP2017512684A JP2017512684A JP2017532302A5 JP 2017532302 A5 JP2017532302 A5 JP 2017532302A5 JP 2017512684 A JP2017512684 A JP 2017512684A JP 2017512684 A JP2017512684 A JP 2017512684A JP 2017532302 A5 JP2017532302 A5 JP 2017532302A5
- Authority
- JP
- Japan
- Prior art keywords
- tev
- utr
- sequence
- human
- gaopt
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 108020004705 Codon Proteins 0.000 description 2
- 241000723792 Tobacco etch virus Species 0.000 description 2
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 101000899111 Homo sapiens Hemoglobin subunit beta Proteins 0.000 description 1
- 101001063991 Homo sapiens Leptin Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 102000049953 human LEP Human genes 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046487P | 2014-09-05 | 2014-09-05 | |
| US62/046,487 | 2014-09-05 | ||
| PCT/US2015/048535 WO2016037053A1 (en) | 2014-09-05 | 2015-09-04 | Lipids and lipid compositions for the delivery of active agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532302A JP2017532302A (ja) | 2017-11-02 |
| JP2017532302A5 true JP2017532302A5 (enExample) | 2018-10-18 |
| JP6731912B2 JP6731912B2 (ja) | 2020-07-29 |
Family
ID=54256820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512684A Active JP6731912B2 (ja) | 2014-09-05 | 2015-09-04 | 活性物質の送達用の脂質および脂質組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10125092B2 (enExample) |
| EP (1) | EP3188760B1 (enExample) |
| JP (1) | JP6731912B2 (enExample) |
| CN (1) | CN107072946B (enExample) |
| ES (1) | ES2969956T3 (enExample) |
| WO (1) | WO2016037053A1 (enExample) |
Families Citing this family (86)
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| CN105792832B (zh) | 2013-10-04 | 2021-03-23 | 诺华股份有限公司 | 用于治疗乙肝病毒的有机化合物 |
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| WO2015051366A2 (en) | 2013-10-04 | 2015-04-09 | Novartis Ag | Novel formats for organic compounds for use in rna interference |
| RU2021109685A (ru) | 2014-04-23 | 2021-04-13 | МОДЕРНАТиЭкс, ИНК. | Вакцины на основе нуклеиновых кислот |
| ES2969956T3 (es) * | 2014-09-05 | 2024-05-23 | Novartis Ag | Lípidos y composiciones lipídicas para el suministro de agentes activos |
| JP6116782B1 (ja) * | 2015-08-28 | 2017-04-19 | 積水メディカル株式会社 | ベンジル化合物 |
| CA3002922A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| ES2924407T3 (es) | 2015-12-10 | 2022-10-06 | Modernatx Inc | Composiciones y procedimientos para el suministro de agentes terapéuticos |
| SMT202500211T1 (it) * | 2016-03-30 | 2025-07-22 | Intellia Therapeutics Inc | Formulazioni di nanoparticelle lipidiche per componenti crispr/cas |
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| CN109260174B (zh) * | 2018-09-04 | 2021-10-15 | 中山大学 | 一种治疗性蛋白纳米颗粒的高通量制备方法 |
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| CN113966221A (zh) * | 2019-03-08 | 2022-01-21 | 麻省理工学院 | 合成溶瘤lnp复制子rna和用于癌症免疫治疗的用途 |
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| EP4021407A1 (en) | 2019-08-30 | 2022-07-06 | GlaxoSmithKline Biologicals S.A. | Jet mixing lipid nanoparticle manufacturing process |
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| US12558415B2 (en) * | 2020-04-14 | 2026-02-24 | The Regents Of The University Of California | Broad-spectrum multi-antigen pan-coronavirus vaccine |
| EP4135761A1 (en) | 2020-04-16 | 2023-02-22 | GlaxoSmithKline Biologicals S.A. | Sars cov-2 spike protein construct |
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| CN112961065B (zh) * | 2021-02-05 | 2023-03-14 | 嘉晨西海(杭州)生物技术有限公司 | 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用 |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
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| JPWO2022244815A1 (enExample) * | 2021-05-19 | 2022-11-24 | ||
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| EP4352247A1 (en) | 2021-06-09 | 2024-04-17 | GlaxoSmithKline Biologicals s.a. | Release assay for determining potency of self-amplifying rna drug product and methods for using |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
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| CA3240127A1 (en) * | 2021-12-07 | 2023-06-15 | Zihao Wang | Rna formulations and lipids |
| CN118401547A (zh) * | 2021-12-17 | 2024-07-26 | 嘉晨西海(杭州)生物技术有限公司 | 白细胞介素-12自我复制rna和方法 |
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| WO2025067389A1 (en) * | 2023-09-28 | 2025-04-03 | Immorna (hangzhou) Biotechnology Co., Ltd. | Lipid complex nanoparticle for lung-targeted delivery of nucleic acid therapeutic agent |
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| JP2020521781A (ja) * | 2017-05-30 | 2020-07-27 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | リポソームに内包されたｒｎａを製造する方法 |
| CN113194988A (zh) * | 2018-12-14 | 2021-07-30 | 葛兰素史密斯克莱生物公司 | 异源初次免疫加强疫苗组合物及方法 |
-
2015
- 2015-09-04 ES ES15775528T patent/ES2969956T3/es active Active
- 2015-09-04 CN CN201580060043.1A patent/CN107072946B/zh active Active
- 2015-09-04 EP EP15775528.1A patent/EP3188760B1/en active Active
- 2015-09-04 JP JP2017512684A patent/JP6731912B2/ja active Active
- 2015-09-04 WO PCT/US2015/048535 patent/WO2016037053A1/en not_active Ceased
- 2015-09-04 US US15/505,282 patent/US10125092B2/en active Active
-
2018
- 2018-09-19 US US16/135,116 patent/US10844002B2/en active Active
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