JP2017532290A5 - - Google Patents
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- JP2017532290A5 JP2017532290A5 JP2017505793A JP2017505793A JP2017532290A5 JP 2017532290 A5 JP2017532290 A5 JP 2017532290A5 JP 2017505793 A JP2017505793 A JP 2017505793A JP 2017505793 A JP2017505793 A JP 2017505793A JP 2017532290 A5 JP2017532290 A5 JP 2017532290A5
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- 235000001014 amino acid Nutrition 0.000 claims description 38
- 150000001413 amino acids Chemical group 0.000 claims description 38
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 14
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 14
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 14
- 208000034578 Multiple myelomas Diseases 0.000 claims description 11
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000004475 Arginine Substances 0.000 claims description 10
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 10
- 239000004472 Lysine Substances 0.000 claims description 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 10
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 10
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 8
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 8
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 8
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims description 8
- 235000003704 aspartic acid Nutrition 0.000 claims description 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 8
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 235000013922 glutamic acid Nutrition 0.000 claims description 8
- 239000004220 glutamic acid Substances 0.000 claims description 8
- 102000046935 human TNFRSF17 Human genes 0.000 claims description 8
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 6
- 208000021161 Plasma cell disease Diseases 0.000 claims description 5
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 230000001131 transforming effect Effects 0.000 claims description 2
- 210000004180 plasmocyte Anatomy 0.000 description 5
- 210000001185 bone marrow Anatomy 0.000 description 4
- 208000037914 B-cell disorder Diseases 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010061728 Bone lesion Diseases 0.000 description 1
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 description 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 208000025883 type III hypersensitivity disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179705.0A EP2982692A1 (en) | 2014-08-04 | 2014-08-04 | Bispecific antibodies against CD3epsilon and BCMA |
| EP14179705.0 | 2014-08-04 | ||
| PCT/EP2015/067841 WO2016020332A1 (en) | 2014-08-04 | 2015-08-03 | Bispecific antibodies against cd3epsilon and bcma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020082524A Division JP2020122013A (ja) | 2014-08-04 | 2020-05-08 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532290A JP2017532290A (ja) | 2017-11-02 |
| JP2017532290A5 true JP2017532290A5 (OSRAM) | 2019-04-04 |
| JP6703520B2 JP6703520B2 (ja) | 2020-06-03 |
Family
ID=51260770
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505793A Active JP6703520B2 (ja) | 2014-08-04 | 2015-08-03 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
| JP2020082524A Pending JP2020122013A (ja) | 2014-08-04 | 2020-05-08 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020082524A Pending JP2020122013A (ja) | 2014-08-04 | 2020-05-08 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10253104B2 (OSRAM) |
| EP (2) | EP2982692A1 (OSRAM) |
| JP (2) | JP6703520B2 (OSRAM) |
| AU (2) | AU2015299101B2 (OSRAM) |
| CA (1) | CA2955685C (OSRAM) |
| CY (1) | CY1118168T1 (OSRAM) |
| DK (1) | DK2982694T3 (OSRAM) |
| ES (1) | ES2602051T3 (OSRAM) |
| HR (1) | HRP20161211T1 (OSRAM) |
| HU (1) | HUE031076T2 (OSRAM) |
| LT (1) | LT2982694T (OSRAM) |
| MA (1) | MA39266B1 (OSRAM) |
| ME (1) | ME02533B (OSRAM) |
| PL (1) | PL2982694T3 (OSRAM) |
| PT (1) | PT2982694T (OSRAM) |
| RS (1) | RS55410B1 (OSRAM) |
| SG (1) | SG11201700551TA (OSRAM) |
| SI (1) | SI2982694T1 (OSRAM) |
| SM (1) | SMT201600392B (OSRAM) |
| WO (1) | WO2016020332A1 (OSRAM) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| DK2417156T3 (en) | 2009-04-07 | 2015-03-02 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| CN103403025B (zh) | 2011-02-28 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 单价抗原结合蛋白 |
| JP5764677B2 (ja) | 2011-02-28 | 2015-08-19 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗原結合タンパク質 |
| WO2013026839A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| RU2015117393A (ru) | 2012-10-08 | 2016-12-10 | Роше Гликарт Аг | Лишенные fc антитела, содержащие два Fab-фрагмента, и способы их применения |
| PL2953972T3 (pl) * | 2013-02-05 | 2021-03-08 | Engmab Sàrl | Metoda wyboru przeciwciał przeciwko bcma |
| EA201891502A1 (ru) | 2013-02-26 | 2018-12-28 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
| GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
| RU2016115866A (ru) | 2013-10-11 | 2017-11-16 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи |
| MX389442B (es) | 2013-11-11 | 2025-03-20 | Chugai Pharmaceutical Co Ltd | Región variable de anticuerpo modificada que contiene molécula de unión al antígeno. |
| KR102411972B1 (ko) | 2014-08-04 | 2022-06-23 | 에프. 호프만-라 로슈 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| EP3204415B1 (en) * | 2014-10-09 | 2020-06-17 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and ror1 |
| WO2016076345A1 (ja) | 2014-11-11 | 2016-05-19 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子のライブラリ |
| LT3789402T (lt) | 2014-11-20 | 2022-09-26 | F. Hoffmann-La Roche Ag | Kompleksinė terapija, naudojant t ląsteles aktyvinančias bispecifines antigeną surišančias molekules ir pd-1 ašį surišančius antagonistus |
| RS60615B1 (sr) | 2014-11-20 | 2020-08-31 | Hoffmann La Roche | Zajednički laki lanci i postupci upotrebe |
| CN107074955B (zh) | 2014-11-20 | 2021-06-22 | 豪夫迈·罗氏有限公司 | 针对FolR1和CD3的T细胞活化性双特异性抗原结合分子 |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| PL3227332T3 (pl) | 2014-12-03 | 2020-06-15 | F. Hoffmann-La Roche Ag | Wielospecyficzne przeciwciała |
| KR20180029201A (ko) | 2015-05-18 | 2018-03-20 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| EP3150636A1 (en) * | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Tetravalent multispecific antibodies |
| CN107849137B (zh) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | 双特异性抗ceaxcd3 t细胞活化性抗原结合分子 |
| IL257696B2 (en) | 2015-12-09 | 2024-11-01 | Hoffmann La Roche | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| IL311107A (en) | 2016-02-17 | 2024-04-01 | Seagen Inc | BCMA antibodies and their use for the treatment of cancer and immune disorders |
| BR112018016281A2 (pt) * | 2016-03-22 | 2019-01-02 | F. Hoffmann-La Roche Ag | molécula biespecífica ativadora de célula t ativável por protease, polipeptídeo idiotipo-específico, composição farmacêutica, usos da molécula biespecífica e método de tratamento de uma doença em um indivíduo |
| FI3433280T3 (fi) * | 2016-03-22 | 2023-06-06 | Hoffmann La Roche | Proteaasin aktivoimia t-solubispesifisiä molekyylejä |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018060301A1 (en) | 2016-09-30 | 2018-04-05 | F. Hoffmann-La Roche Ag | Bispecific antibodies against cd3 |
| IL302917A (en) | 2016-10-07 | 2023-07-01 | Tcr2 Therapeutics Inc | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| US11124577B2 (en) * | 2016-11-02 | 2021-09-21 | Engmab Sàrl | Bispecific antibody against BCMA and CD3 and an immunological drug for combined use in treating multiple myeloma |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| WO2018144535A1 (en) | 2017-01-31 | 2018-08-09 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
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| CN111107874A (zh) | 2017-09-14 | 2020-05-05 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于癌症的组合治疗 |
| WO2019053613A2 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | POLY THERAPY FOR THE TREATMENT OF CANCER |
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| BR112021023048A2 (pt) | 2019-05-21 | 2022-04-19 | Novartis Ag | Moléculas de ligação a cd19 e usos das mesmas |
| CN111269315B (zh) * | 2019-06-19 | 2022-04-08 | 北京智仁美博生物科技有限公司 | 针对bcma的单克隆抗体 |
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2015
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- 2015-08-03 PL PL15179545T patent/PL2982694T3/pl unknown
- 2015-08-03 LT LTEP15179545.7T patent/LT2982694T/lt unknown
- 2015-08-03 RS RS20160781A patent/RS55410B1/sr unknown
- 2015-08-03 AU AU2015299101A patent/AU2015299101B2/en active Active
- 2015-08-03 US US15/501,620 patent/US10253104B2/en active Active
- 2015-08-03 SG SG11201700551TA patent/SG11201700551TA/en unknown
- 2015-08-03 JP JP2017505793A patent/JP6703520B2/ja active Active
- 2015-08-03 ME MEP-2016-205A patent/ME02533B/me unknown
- 2015-08-03 WO PCT/EP2015/067841 patent/WO2016020332A1/en not_active Ceased
- 2015-08-03 EP EP15179545.7A patent/EP2982694B1/en active Active
- 2015-08-03 PT PT151795457T patent/PT2982694T/pt unknown
- 2015-08-03 CA CA2955685A patent/CA2955685C/en active Active
- 2015-08-03 SI SI201530004A patent/SI2982694T1/sl unknown
- 2015-08-03 DK DK15179545.7T patent/DK2982694T3/en active
- 2015-08-03 ES ES15179545.7T patent/ES2602051T3/es active Active
- 2015-08-03 MA MA39266A patent/MA39266B1/fr unknown
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2016
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- 2016-09-21 HR HRP20161211TT patent/HRP20161211T1/hr unknown
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2020
- 2020-05-08 JP JP2020082524A patent/JP2020122013A/ja active Pending
- 2020-11-20 AU AU2020273347A patent/AU2020273347A1/en not_active Abandoned
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