JP2017532037A5 - - Google Patents
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- JP2017532037A5 JP2017532037A5 JP2017518907A JP2017518907A JP2017532037A5 JP 2017532037 A5 JP2017532037 A5 JP 2017532037A5 JP 2017518907 A JP2017518907 A JP 2017518907A JP 2017518907 A JP2017518907 A JP 2017518907A JP 2017532037 A5 JP2017532037 A5 JP 2017532037A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062431P | 2014-10-10 | 2014-10-10 | |
| US62/062,431 | 2014-10-10 | ||
| PCT/US2015/054490 WO2016057667A1 (en) | 2014-10-10 | 2015-10-07 | Humanized anti-ox40 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020187650A Division JP2021036887A (ja) | 2014-10-10 | 2020-11-11 | ヒト化抗ox40抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532037A JP2017532037A (ja) | 2017-11-02 |
| JP2017532037A5 true JP2017532037A5 (enExample) | 2018-11-15 |
| JP6794348B2 JP6794348B2 (ja) | 2020-12-09 |
Family
ID=55130798
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518907A Active JP6794348B2 (ja) | 2014-10-10 | 2015-10-07 | ヒト化抗ox40抗体及びその使用 |
| JP2020187650A Withdrawn JP2021036887A (ja) | 2014-10-10 | 2020-11-11 | ヒト化抗ox40抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020187650A Withdrawn JP2021036887A (ja) | 2014-10-10 | 2020-11-11 | ヒト化抗ox40抗体及びその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9738723B2 (enExample) |
| EP (1) | EP3204422B1 (enExample) |
| JP (2) | JP6794348B2 (enExample) |
| KR (1) | KR20170064550A (enExample) |
| CN (1) | CN107074953A (enExample) |
| AR (1) | AR102239A1 (enExample) |
| AU (1) | AU2015328090A1 (enExample) |
| BR (1) | BR112017007170A2 (enExample) |
| CA (1) | CA2963798A1 (enExample) |
| CL (1) | CL2017000885A1 (enExample) |
| CO (1) | CO2017004516A2 (enExample) |
| ES (1) | ES2914177T3 (enExample) |
| GB (1) | GB2536324A (enExample) |
| IL (1) | IL251537A0 (enExample) |
| MX (1) | MX2017004715A (enExample) |
| RU (1) | RU2709742C2 (enExample) |
| SG (1) | SG11201702826XA (enExample) |
| TW (1) | TW201619200A (enExample) |
| WO (1) | WO2016057667A1 (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160006168A (ko) | 2013-03-18 | 2016-01-18 | 바이오서오엑스 프로덕스 비.브이. | 인간화 항-cd134(ox40) 항체 및 이의 용도 |
| EP3083687A2 (en) * | 2013-12-17 | 2016-10-26 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| MX2016012779A (es) | 2014-03-31 | 2017-04-27 | Genentech Inc | Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40. |
| CA3224830A1 (en) * | 2015-01-08 | 2016-07-14 | Biontech Ag | Agonistic tnf receptor binding agents |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| CN115109158A (zh) | 2015-05-07 | 2022-09-27 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
| US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| PT3303396T (pt) | 2015-05-29 | 2023-01-30 | Bristol Myers Squibb Co | Anticorpos contra ox40 e utilizações dos mesmos |
| PE20240096A1 (es) | 2015-10-02 | 2024-01-18 | Hoffmann La Roche | Anticuerpos biespecificos especificos para un receptor de tnf coestimulador |
| CN108137684B (zh) | 2015-10-15 | 2022-03-08 | 苏州丁孚靶点生物技术有限公司 | 抗ox40抗体及其应用 |
| CN116063542A (zh) | 2015-12-02 | 2023-05-05 | 阿吉纳斯公司 | 抗体和其使用方法 |
| IL321475A (en) | 2016-05-06 | 2025-08-01 | Medimmune Llc | Bispecific binding proteins and their uses |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| CN109311993B (zh) | 2016-06-20 | 2022-12-20 | F-星治疗有限公司 | Lag-3结合元件 |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| US20190330374A1 (en) * | 2016-07-20 | 2019-10-31 | Igm Biosciences, Inc. | Multimeric ox40 binding molecules and uses thereof |
| WO2018027204A1 (en) | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
| AU2017359467A1 (en) | 2016-11-09 | 2019-05-02 | Agenus Inc. | Anti-OX40 antibodies, anti-GITR antibodies, and methods of use thereof |
| EP3504242B1 (en) | 2016-12-15 | 2020-06-24 | AbbVie Biotherapeutics Inc. | Anti-ox40 antibodies and their uses |
| CN110291108A (zh) | 2016-12-19 | 2019-09-27 | 格兰马克药品股份有限公司 | 新型tnfr激动剂及其用途 |
| CN110573528B (zh) * | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| PL3612234T3 (pl) | 2017-04-20 | 2024-09-02 | Adc Therapeutics Sa | Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek |
| BR112019021680A2 (pt) | 2017-04-20 | 2020-05-12 | Adc Therapeutics Sa | Terapia de combinação com conjugado anticorpo-fármaco anti-cd25?? |
| CN111542544A (zh) * | 2017-11-01 | 2020-08-14 | 百时美施贵宝公司 | 用于治疗癌症的免疫刺激性激动性抗体 |
| WO2019100320A1 (en) * | 2017-11-24 | 2019-05-31 | Eucure (Beijing) Biopharma Co., Ltd | Anti-ox40 antibodies and uses thereof |
| CA3082036C (en) | 2017-12-29 | 2025-06-17 | Ap Biosciences, Inc. | MONOSPACTIC AND BISPACTIC PROTEINS WITH IMMUNE CHECKPOINT REGULATION ROLE FOR CANCER TREATMENT |
| CN108218990B (zh) | 2017-12-29 | 2021-03-02 | 南京优迈生物科技有限公司 | 分离的抗体或其抗原结合片段及其在肿瘤治疗中的应用 |
| CN111393529B (zh) * | 2018-01-29 | 2022-02-22 | 康源博创生物科技(北京)有限公司 | 与ox40l非竞争结合的抗ox40抗体 |
| BR112020018539A2 (pt) | 2018-03-23 | 2020-12-29 | Bristol-Myers Squibb Company | Anticorpos contra mica e/ou micb e usos dos mesmos |
| CN111936507B (zh) * | 2018-03-23 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | Ox40抗原多肽及其用途 |
| JP7611700B2 (ja) | 2018-03-27 | 2025-01-10 | ブリストル-マイヤーズ スクイブ カンパニー | 紫外線シグナルを使用した力価のリアルタイムモニタリング |
| AU2019264712A1 (en) | 2018-05-11 | 2021-01-07 | Wuxi Biologics (Shanghai) Co., Ltd. | Fully human antibodies against OX40, method for preparing same, and use thereof |
| EP3797123A4 (en) * | 2018-05-23 | 2022-03-02 | BeiGene, Ltd. | ANTI-OX40 ANTIBODIES AND METHODS OF USE |
| SG11202010469QA (en) | 2018-05-23 | 2020-11-27 | Adc Therapeutics Sa | Molecular adjuvant |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| ES3006183T3 (en) | 2018-07-12 | 2025-03-17 | Invox Pharma Ltd | Antibody molecules that bind pd-l1 and cd137 |
| AU2019301206B2 (en) | 2018-07-12 | 2025-10-30 | Invox Pharma Limited | Antibody molecules that bind CD137 and OX40 |
| US20210277135A1 (en) | 2018-07-13 | 2021-09-09 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a method of treating a cancer or a solid tumor |
| CN111040034B (zh) * | 2018-10-12 | 2022-08-30 | 广东旋玉健康生物科技有限公司 | 一种抗人cd358的单克隆抗体及其用途 |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| US12269890B2 (en) | 2018-11-26 | 2025-04-08 | Nanjing GenScript Biotech Co., Ltd. | Humanized anti-human OX40 monoclonal antibody, preparation method therefor and use thereof |
| WO2020119789A1 (en) * | 2018-12-14 | 2020-06-18 | Wuxi Biologics (Shanghai) Co., Ltd. | Fully human antibodies against ox40, method for preparing the same, and use thereof |
| JP7346576B2 (ja) | 2018-12-25 | 2023-09-19 | ハンクス バイオファーマシューティクス,インコーポレイテッド | 抗ox40モノクローナル抗体とその応用 |
| US10442866B1 (en) * | 2019-01-23 | 2019-10-15 | Beijing Mabworks Biotech Co. Ltd | Antibodies binding OX40 and uses thereof |
| US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| AU2020227824B2 (en) | 2019-02-27 | 2025-07-10 | Ionis Pharmaceuticals, Inc. | Modulators of MALAT1 expression |
| JP7744829B2 (ja) * | 2019-03-25 | 2025-09-26 | オハイオ・ステイト・イノベーション・ファウンデーション | 組み合わせ免疫調節及びその使用 |
| EP3973274A1 (en) | 2019-05-23 | 2022-03-30 | Bristol-Myers Squibb Company | Methods of monitoring cell culture media |
| US20220363760A1 (en) | 2019-05-30 | 2022-11-17 | Bristol-Myers Squibb Company | Multi-tumor gene signature for suitability to immuno-oncology therapy |
| JP2022534982A (ja) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| WO2020243570A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| EP4061850A4 (en) * | 2019-11-21 | 2024-03-20 | BeiGene, Ltd. | Methods of cancer treatment using anti-ox40 antibodies in combination with anti-pd1 or anti-pdl1 antibodies |
| US20230011916A1 (en) * | 2019-11-21 | 2023-01-12 | Beigene, Ltd. | Methods of cancer treatment using anti-ox40 antibodies in combination with pi3 kinase delta inhibitors |
| BR112022009265A2 (pt) * | 2019-11-21 | 2022-08-02 | Beigene Ltd | Método de tratamento do câncer e método para aumentar, potencializar ou estimular uma resposta ou função imune |
| CN114729048A (zh) * | 2019-11-21 | 2022-07-08 | 百济神州(北京)生物科技有限公司 | 使用抗ox40抗体与tlr激动剂组合治疗癌症的方法 |
| MX2022006149A (es) * | 2019-11-21 | 2022-06-17 | Beigene Ltd | Metodos de tratamiento del cancer utilizando anticuerpos anti-ox40 en combinacion con anticuerpos anti-tim3. |
| GB201917254D0 (en) | 2019-11-27 | 2020-01-08 | Adc Therapeutics Sa | Combination therapy |
| WO2021111636A1 (ja) * | 2019-12-06 | 2021-06-10 | 大塚製薬株式会社 | 抗gdf15抗体 |
| IL293471A (en) | 2019-12-17 | 2022-08-01 | Amgen Inc | Dual interleukin-2 / tnf receptor agonist for use in medicine |
| CN113429483A (zh) | 2020-03-23 | 2021-09-24 | 百奥泰生物制药股份有限公司 | 一种免疫细胞激活剂的开发及应用 |
| CN115461367A (zh) | 2020-04-17 | 2022-12-09 | 和记黄埔医药(上海)有限公司 | 抗ox40抗体及其用途 |
| JP2023525140A (ja) * | 2020-05-13 | 2023-06-14 | アンセルム(アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル) | Ox40活性化特性を有する組換えタンパク質 |
| WO2022047412A1 (en) | 2020-08-31 | 2022-03-03 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| JP2023544410A (ja) | 2020-10-05 | 2023-10-23 | ブリストル-マイヤーズ スクイブ カンパニー | タンパク質を濃縮するための方法 |
| CN114457022A (zh) * | 2020-10-30 | 2022-05-10 | 未来智人再生医学研究院(广州)有限公司 | 一种表达ox40激活型抗体的多能干细胞及其衍生物与应用 |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| WO2022146947A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| CA3196999A1 (en) | 2020-12-28 | 2022-07-07 | Masano HUANG | Methods of treating tumors |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| US20240317874A1 (en) * | 2021-06-29 | 2024-09-26 | Hifibio (Hk) Limited | Anti-ox40 monoclonal antibody and methods of use thereof |
| CN118488965A (zh) | 2021-12-17 | 2024-08-13 | 上海复宏汉霖生物技术股份有限公司 | 抗ox40抗体、多特异性抗体及其使用方法 |
| EP4448579A1 (en) | 2021-12-17 | 2024-10-23 | Shanghai Henlius Biotech, Inc. | Anti-ox40 antibodies and methods of use |
| WO2023152116A1 (en) | 2022-02-08 | 2023-08-17 | Hookipa Biotech Gmbh | Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines |
| KR20240156411A (ko) | 2022-03-09 | 2024-10-29 | 브리스톨-마이어스 스큅 컴퍼니 | 치료 단백질의 일시적 발현 |
| US20250206775A1 (en) | 2022-03-18 | 2025-06-26 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| CN114591988B (zh) * | 2022-03-30 | 2023-01-13 | 北京贝来生物科技有限公司 | 一种激活肿瘤免疫的基因修饰干细胞制备方法 |
| IL317319A (en) | 2022-06-02 | 2025-01-01 | Bristol Myers Squibb Co | Antibody compounds and methods of using them |
| CN114966061B (zh) * | 2022-07-28 | 2022-10-21 | 中国食品药品检定研究院 | 一种抗ox40抗体的生物活性检测方法 |
| EP4583999A1 (en) | 2022-09-09 | 2025-07-16 | Bristol-Myers Squibb Company | Methods of separating chelator |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| US6242566B1 (en) | 1994-02-10 | 2001-06-05 | Board Of Trustees Of The Leland Stanford Junior University | Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells |
| US6312700B1 (en) | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
| AU7603800A (en) * | 1999-09-24 | 2001-04-24 | Human Genome Sciences, Inc. | 32 human secreted proteins |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| WO2005075514A2 (en) | 2004-03-10 | 2005-08-18 | Lonza Ltd. | Method for producing antibodies |
| CA2581208A1 (en) | 2004-08-30 | 2006-03-09 | Lonza Biologics Plc. | Affinity- plus ion exchange- chromatography for purifying antibodies |
| PT1877090E (pt) | 2005-05-06 | 2014-04-15 | Providence Health System | Proteína de fusão trimérica de imunoglobulina-ox40 e métodos de utilização |
| TWI461436B (zh) * | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類cd134(ox40)之人類單株抗體及其製造及使用方法 |
| SG174090A1 (en) * | 2006-08-21 | 2011-09-29 | Hoffmann La Roche | Tumor therapy with an anti-vegf antibody |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| CN101668776A (zh) * | 2007-02-27 | 2010-03-10 | 健泰科生物技术公司 | 拮抗剂ox40抗体及其在炎性和自身免疫疾病的治疗中的用途 |
| AU2008338591B8 (en) * | 2007-12-14 | 2014-02-20 | Bristol-Myers Squibb Company | Binding molecules to the human OX40 receptor |
| EP2275431A3 (en) | 2008-01-18 | 2011-05-25 | Bio-Rad Laboratories, Inc. | Enhanced fractionation of phosphorylated and nonphosphorylated biomolecules by apatite chromotography |
| SI2250279T1 (sl) | 2008-02-08 | 2016-10-28 | Medimmune, Llc | Protitelesa anti-IFNAR1 z zmanjšano afiniteto do FC liganda |
| US8614295B2 (en) * | 2009-02-17 | 2013-12-24 | Ucb Pharma S.A. | Antibody molecules having specificity for human OX40 |
| PT2663579T (pt) | 2011-01-14 | 2017-07-28 | Univ California | Terapêutica de anticorpos contra a proteína r0r-1 e métodos para sua utilização |
| AP2014007415A0 (en) * | 2011-07-11 | 2014-02-28 | Glenmark Pharmaceuticals Sa | Antibodies that bind to OX40 and their uses |
| CN103946238B (zh) * | 2011-08-23 | 2016-10-12 | 德克萨斯州立大学董事会 | 抗ox40抗体及使用其的方法 |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| WO2013119202A1 (en) * | 2012-02-06 | 2013-08-15 | Providence Health & Services - Oregon | Cancer treatment and monitoring methods using ox40 agonists |
| HK1205691A1 (en) * | 2012-03-02 | 2015-12-24 | Providence Health & Services - Oregon | Dual ox40 agonist/il-2 cancer therapy methods |
| CA2905940A1 (en) * | 2013-03-12 | 2014-10-09 | Decimmune Therapeutics, Inc. | Humanized, anti-n2 antibodies |
| KR20160006168A (ko) * | 2013-03-18 | 2016-01-18 | 바이오서오엑스 프로덕스 비.브이. | 인간화 항-cd134(ox40) 항체 및 이의 용도 |
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2015
- 2015-10-01 TW TW104132442A patent/TW201619200A/zh unknown
- 2015-10-07 MX MX2017004715A patent/MX2017004715A/es unknown
- 2015-10-07 BR BR112017007170A patent/BR112017007170A2/pt not_active Application Discontinuation
- 2015-10-07 ES ES15848683T patent/ES2914177T3/es active Active
- 2015-10-07 RU RU2017115662A patent/RU2709742C2/ru active
- 2015-10-07 SG SG11201702826XA patent/SG11201702826XA/en unknown
- 2015-10-07 WO PCT/US2015/054490 patent/WO2016057667A1/en not_active Ceased
- 2015-10-07 US US14/877,547 patent/US9738723B2/en active Active
- 2015-10-07 CN CN201580056175.7A patent/CN107074953A/zh active Pending
- 2015-10-07 JP JP2017518907A patent/JP6794348B2/ja active Active
- 2015-10-07 EP EP15848683.7A patent/EP3204422B1/en active Active
- 2015-10-07 AU AU2015328090A patent/AU2015328090A1/en not_active Abandoned
- 2015-10-07 CA CA2963798A patent/CA2963798A1/en not_active Abandoned
- 2015-10-07 KR KR1020177012413A patent/KR20170064550A/ko not_active Withdrawn
- 2015-10-08 GB GB1517855.1A patent/GB2536324A/en not_active Withdrawn
- 2015-10-09 AR ARP150103284A patent/AR102239A1/es unknown
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2017
- 2017-04-03 IL IL251537A patent/IL251537A0/en unknown
- 2017-04-10 CL CL2017000885A patent/CL2017000885A1/es unknown
- 2017-05-04 CO CONC2017/0004516A patent/CO2017004516A2/es unknown
- 2017-06-28 US US15/635,847 patent/US10150815B2/en active Active
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2018
- 2018-12-10 US US16/215,263 patent/US20190169303A1/en not_active Abandoned
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2020
- 2020-11-11 JP JP2020187650A patent/JP2021036887A/ja not_active Withdrawn
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