JP2017526716A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017526716A5 JP2017526716A5 JP2017513658A JP2017513658A JP2017526716A5 JP 2017526716 A5 JP2017526716 A5 JP 2017526716A5 JP 2017513658 A JP2017513658 A JP 2017513658A JP 2017513658 A JP2017513658 A JP 2017513658A JP 2017526716 A5 JP2017526716 A5 JP 2017526716A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- compound
- pharmaceutically acceptable
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- QMBZVWHMCQUVTP-DSYKOEDSSA-N C[C@H]1N[C@H]2C[C@@H]1CC2 Chemical compound C[C@H]1N[C@H]2C[C@@H]1CC2 QMBZVWHMCQUVTP-DSYKOEDSSA-N 0.000 description 2
- 0 *C1(CC2)NCC2CC1 Chemical compound *C1(CC2)NCC2CC1 0.000 description 1
- QOQFIGTUFLXDFE-UHFFFAOYSA-N CC1(CC2)NCC2CC1 Chemical compound CC1(CC2)NCC2CC1 QOQFIGTUFLXDFE-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14184613 | 2014-09-12 | ||
| EP14184613.9 | 2014-09-12 | ||
| PCT/EP2015/070449 WO2016038007A1 (en) | 2014-09-12 | 2015-09-08 | Spirocyclic inhibitors of cathepsin c |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246001A Division JP6360961B2 (ja) | 2014-09-12 | 2017-12-22 | カテプシンｃのスピロ環状阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017526716A JP2017526716A (ja) | 2017-09-14 |
| JP2017526716A5 true JP2017526716A5 (enExample) | 2017-10-26 |
Family
ID=51535355
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513658A Ceased JP2017526716A (ja) | 2014-09-12 | 2015-09-08 | カテプシンｃのスピロ環状阻害剤 |
| JP2017246001A Active JP6360961B2 (ja) | 2014-09-12 | 2017-12-22 | カテプシンｃのスピロ環状阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246001A Active JP6360961B2 (ja) | 2014-09-12 | 2017-12-22 | カテプシンｃのスピロ環状阻害剤 |
Country Status (34)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011116282A2 (en) | 2010-03-19 | 2011-09-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nicotinic acetylcholine receptor agonists |
| NO2699580T3 (enExample) | 2014-01-24 | 2018-02-24 | ||
| JP6529575B2 (ja) * | 2014-08-01 | 2019-06-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換オキセタンおよびそれらのカテプシンｃの阻害薬としての使用 |
| CN108047240B (zh) * | 2014-09-12 | 2020-08-04 | 勃林格殷格翰国际有限公司 | 组织蛋白酶c的螺环化合物抑制剂 |
| MA47106A (fr) | 2016-12-21 | 2019-10-30 | Amgen Inc | Formulations d'anticorps anti-tnf alpha |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| KR20200118103A (ko) * | 2018-02-07 | 2020-10-14 | 인스메드 인코포레이티드 | Anca 관련 혈관염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드 |
| HRP20250115T1 (hr) | 2018-03-01 | 2025-05-23 | Astrazeneca Ab | Farmaceutski pripravci koji sadrže (2s)-{(1s)-1-cijano-2-[4-(3-metil-2-okso-2,3-dihidro-1,3-benzoksazol-5-il)fenil]etil} -1,4-oksazepan-2-karboksamid |
| CA3106269A1 (en) | 2018-07-17 | 2020-01-23 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis |
| CN110256429B (zh) * | 2019-06-17 | 2021-06-22 | 广东药科大学 | 一种具有螺环结构的氨基嘧啶类化合物及其制备方法和应用 |
| CN110257504A (zh) * | 2019-06-30 | 2019-09-20 | 中南大学 | 一种难治性哮喘检测标记物的筛选方法及其应用 |
| EP4182700A4 (en) | 2020-07-20 | 2024-11-13 | Insmed Incorporated | METHODS FOR EXTRACTING NEUTROPHIL SERINE PROTEASES AND TREATMENT OF DIPETIDYL PEPTIDASE-1-MEDIATED DISEASES |
| CN114106005B (zh) * | 2020-08-26 | 2025-08-01 | 西藏海思科制药有限公司 | 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途 |
| EP4247490A2 (en) * | 2020-11-17 | 2023-09-27 | Vertex Pharmaceuticals Incorporated | Solid forms of 4-(5-(4-fluorophenyl)-6-tetrahydro-2h-pyran-4-yl)- 1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid |
| CN114591315A (zh) * | 2020-12-04 | 2022-06-07 | 瑞石生物医药有限公司 | 一种组织蛋白酶c小分子抑制剂 |
| CA3199568A1 (en) * | 2020-12-04 | 2022-06-09 | Reistone Biopharma Company Limited | Small molecule inhibitor of cathepsin c and medicinal use thereof |
| WO2023243601A1 (ja) * | 2022-06-13 | 2023-12-21 | モジュラス株式会社 | アザシクロアルキルカルボニル環状アミン化合物 |
| EP4551554A1 (en) | 2022-07-06 | 2025-05-14 | Chiesi Farmaceutici S.p.A. | Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors |
| CN119948034A (zh) * | 2022-10-26 | 2025-05-06 | 上海壹迪生物技术有限公司 | 一种新型肽基腈类化合物及其应用 |
| EP4646265A1 (en) | 2023-01-06 | 2025-11-12 | Insmed Incorporated | Novel, reversible dpp1 inhibitors and uses thereof |
| WO2025214464A1 (en) * | 2024-04-12 | 2025-10-16 | Insmed Incorporated | Crystalline forms of (s) -n- (1-cyano-2- (2-fluoro-4- (1' - (oxetan-3-yl) -3h-spiro [isobenzofuran-1, 4' -piperidin] -6-yl) phenyl) ethyl) -2-azabicyclo [2.2.2] octane-1-carboxamide |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125727A (en) | 1976-10-18 | 1978-11-14 | American Cyanamid Company | Method of preparing imidazoisoindolediones |
| GB8922355D0 (en) | 1989-10-04 | 1989-11-22 | British Telecomm | Sealing gland |
| GEP20012487B (en) | 1998-09-16 | 2001-07-25 | Merab Lomia | Use of Chemical Agent 5-carbarnoyl-5H-Dibenz (b,f) azepin, its Derivatives and Analogues by New Purpose |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| WO2002069901A2 (en) | 2001-03-02 | 2002-09-12 | Merck Frosst Canada & Co. | Cathepsin cysteine protease inhibitors |
| TW200306189A (en) | 2002-03-21 | 2003-11-16 | Merz Pharma Gmbh & Co Kgaa | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| JP2006527704A (ja) | 2003-06-18 | 2006-12-07 | プロザイメックス・アクティーゼルスカブ | プロテアーゼ阻害剤 |
| TW200528440A (en) | 2003-10-31 | 2005-09-01 | Fujisawa Pharmaceutical Co | 2-cyanopyrrolidinecarboxamide compound |
| US20060223846A1 (en) | 2005-03-08 | 2006-10-05 | Dyatkin Alexey B | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| MX2008014800A (es) * | 2006-06-01 | 2008-12-02 | Sanofi Aventis | Nitrilos espirociclicos como inhibidores de proteasa. |
| WO2008038692A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| JP5240201B2 (ja) | 2007-10-12 | 2013-07-17 | 富士通株式会社 | Ｉｐ電話自動試験システム及び方法 |
| WO2009074829A1 (en) | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors |
| EA201190235A1 (ru) | 2009-05-07 | 2012-05-30 | Астразенека Аб | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 |
| WO2010142985A1 (en) | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
| WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| US8999975B2 (en) | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
| CN104379559B (zh) | 2012-04-27 | 2016-11-09 | 葛兰素集团有限公司 | 化合物 |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| CN104718188B (zh) | 2012-05-22 | 2018-08-21 | 基因泰克公司 | N-取代的苯甲酰胺类及其在治疗疼痛中的用途 |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| EP2900666B1 (en) | 2012-09-28 | 2020-11-04 | Cancer Research Technology Limited | Azaquinazoline inhibitors of atypical protein kinase c |
| JP2015533134A (ja) * | 2012-10-09 | 2015-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 錠剤の機械的安定性に適切な少なくとも１種の水和物形成活性物質及び／又はアジュバントを含有する機械的に安定な錠剤、特にアルギニン含有錠剤の製造における選択的に水分調整された打錠材料の使用 |
| SG10201705989YA (en) | 2012-10-15 | 2017-08-30 | Epizyme Inc | Substituted benzene compounds |
| ME02794B (me) | 2012-10-16 | 2018-01-20 | Janssen Pharmaceutica Nv | Metilen vezani hinolinil modulatori ror-gama-t |
| US9181271B2 (en) | 2012-11-01 | 2015-11-10 | Incyte Holdings Corporation | Tricyclic fused thiophene derivatives as JAK inhibitors |
| US9233974B2 (en) | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
| ES2718495T3 (es) | 2012-12-21 | 2019-07-02 | Celgene Quanticel Res Inc | Inhibidores de la histona desmetilasa |
| PE20151280A1 (es) | 2012-12-21 | 2015-09-12 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasas y sus indicaciones |
| EA201591051A1 (ru) | 2013-02-08 | 2016-06-30 | Селджен Авиломикс Рисерч, Инк. | Ингибиторы erk и варианты их применения |
| WO2014140075A1 (en) * | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
| GEP201706699B (en) | 2013-03-14 | 2017-07-10 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| JO3383B1 (ar) | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| EP2970252B1 (en) * | 2013-03-14 | 2020-06-03 | Boehringer Ingelheim International GmbH | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
| TWI644671B (zh) | 2013-03-14 | 2018-12-21 | 比利時商健生藥品公司 | Ｐ２ｘ７調節劑 |
| BR112015022588A2 (pt) | 2013-03-14 | 2017-07-18 | Newlink Genetics Corp | composto, composição farmacêutica, e, método para tratamento de imunossupressão em um indivíduo |
| US10596332B2 (en) * | 2014-04-29 | 2020-03-24 | Shl Medical Ag | Device for adjusting needle insertion depth |
| EP3164272A1 (en) | 2014-07-03 | 2017-05-10 | Bridgestone Americas Tire Operations, LLC | Sidewall decoration on rim guard |
| TW201625591A (zh) | 2014-09-12 | 2016-07-16 | 美國禮來大藥廠 | 吖丁啶基氧苯基吡咯啶化合物 |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| CN108047240B (zh) * | 2014-09-12 | 2020-08-04 | 勃林格殷格翰国际有限公司 | 组织蛋白酶c的螺环化合物抑制剂 |
| ES2705623T3 (es) | 2014-09-12 | 2019-03-26 | Glaxosmithkline Ip No 2 Ltd | Derivados de tetrahidroquinolina como inhibidores del bromodominio |
-
2015
- 2015-09-08 CN CN201810030066.3A patent/CN108047240B/zh active Active
- 2015-09-08 PT PT157575234T patent/PT3191487T/pt unknown
- 2015-09-08 WO PCT/EP2015/070449 patent/WO2016038007A1/en not_active Ceased
- 2015-09-08 AP AP2017009733A patent/AP2017009733A0/en unknown
- 2015-09-08 KR KR1020177009993A patent/KR102510588B1/ko active Active
- 2015-09-08 EP EP15757523.4A patent/EP3191487B1/en active Active
- 2015-09-08 MY MYPI2017000213A patent/MY188382A/en unknown
- 2015-09-08 PL PL15757523T patent/PL3191487T3/pl unknown
- 2015-09-08 BR BR112017003433-6A patent/BR112017003433B1/pt active IP Right Grant
- 2015-09-08 SG SG11201701633SA patent/SG11201701633SA/en unknown
- 2015-09-08 DK DK15757523T patent/DK3191487T3/da active
- 2015-09-08 UA UAA201703350A patent/UA118610C2/uk unknown
- 2015-09-08 AU AU2015314355A patent/AU2015314355B2/en active Active
- 2015-09-08 LT LTEP15757523.4T patent/LT3191487T/lt unknown
- 2015-09-08 MX MX2017003156A patent/MX367316B/es active IP Right Grant
- 2015-09-08 HU HUE15757523A patent/HUE047208T2/hu unknown
- 2015-09-08 EP EP19155235.5A patent/EP3511331A1/en not_active Withdrawn
- 2015-09-08 PE PE2017000400A patent/PE20170438A1/es unknown
- 2015-09-08 RS RSP20191350 patent/RS59444B1/sr unknown
- 2015-09-08 ES ES15757523T patent/ES2749009T3/es active Active
- 2015-09-08 HR HRP20191756TT patent/HRP20191756T1/hr unknown
- 2015-09-08 MX MX2019009695A patent/MX378099B/es unknown
- 2015-09-08 CN CN201580048467.6A patent/CN107074870B/zh active Active
- 2015-09-08 SI SI201530977T patent/SI3191487T1/sl unknown
- 2015-09-08 JP JP2017513658A patent/JP2017526716A/ja not_active Ceased
- 2015-09-08 CA CA2960916A patent/CA2960916C/en active Active
- 2015-09-08 NZ NZ728684A patent/NZ728684A/en unknown
- 2015-09-08 EA EA201790576A patent/EA031376B1/ru not_active IP Right Cessation
- 2015-09-10 US US14/849,710 patent/US9540373B2/en not_active Ceased
- 2015-09-11 TW TW104130165A patent/TWI687424B/zh active
-
2016
- 2016-11-29 US US15/362,949 patent/US9879026B2/en active Active
-
2017
- 2017-01-24 IL IL250262A patent/IL250262B/en active IP Right Grant
- 2017-02-23 CL CL2017000432A patent/CL2017000432A1/es unknown
- 2017-03-07 CO CONC2017/0002268A patent/CO2017002268A2/es unknown
- 2017-03-09 SA SA517381064A patent/SA517381064B1/ar unknown
- 2017-03-10 PH PH12017500453A patent/PH12017500453B1/en unknown
- 2017-11-30 US US15/827,433 patent/USRE47636E1/en active Active
- 2017-12-22 JP JP2017246001A patent/JP6360961B2/ja active Active
-
2018
- 2018-11-14 HK HK18114501.3A patent/HK1255362A1/zh unknown
-
2019
- 2019-11-06 CY CY20191101154T patent/CY1123033T1/el unknown