JP2015521167A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015521167A5 JP2015521167A5 JP2015509257A JP2015509257A JP2015521167A5 JP 2015521167 A5 JP2015521167 A5 JP 2015521167A5 JP 2015509257 A JP2015509257 A JP 2015509257A JP 2015509257 A JP2015509257 A JP 2015509257A JP 2015521167 A5 JP2015521167 A5 JP 2015521167A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- alkyl
- group
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 5
- 206010016654 Fibrosis Diseases 0.000 claims 4
- 102100027159 Membrane primary amine oxidase Human genes 0.000 claims 4
- 101710132836 Membrane primary amine oxidase Proteins 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Chemical group 0.000 claims 2
- 230000007882 cirrhosis Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 1
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 229910052740 iodine Chemical group 0.000 claims 1
- 239000011630 iodine Chemical group 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- -1 salt (E) -4- (2- (aminomethyl) -3-fluoroallyloxy) -N-tert-butylbenzamide hydrochloride Chemical class 0.000 claims 1
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261641814P | 2012-05-02 | 2012-05-02 | |
| US61/641,814 | 2012-05-02 | ||
| PCT/AU2013/000356 WO2013163675A1 (en) | 2012-05-02 | 2013-04-05 | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019542A Division JP6602802B2 (ja) | 2012-05-02 | 2017-02-06 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521167A JP2015521167A (ja) | 2015-07-27 |
| JP2015521167A5 true JP2015521167A5 (enExample) | 2016-10-06 |
| JP6182595B2 JP6182595B2 (ja) | 2017-08-16 |
Family
ID=49514094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509257A Active JP6182595B2 (ja) | 2012-05-02 | 2013-04-05 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
| JP2017019542A Expired - Fee Related JP6602802B2 (ja) | 2012-05-02 | 2017-02-06 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
| JP2019185763A Withdrawn JP2020019810A (ja) | 2012-05-02 | 2019-10-09 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019542A Expired - Fee Related JP6602802B2 (ja) | 2012-05-02 | 2017-02-06 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
| JP2019185763A Withdrawn JP2020019810A (ja) | 2012-05-02 | 2019-10-09 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9302986B2 (enExample) |
| EP (2) | EP3438087A1 (enExample) |
| JP (3) | JP6182595B2 (enExample) |
| KR (2) | KR20200030126A (enExample) |
| CN (2) | CN107266332B (enExample) |
| AU (2) | AU2013255103B2 (enExample) |
| BR (1) | BR112014027406B1 (enExample) |
| CA (2) | CA2871793C (enExample) |
| CY (1) | CY1120334T1 (enExample) |
| DK (1) | DK2844637T5 (enExample) |
| ES (1) | ES2668300T3 (enExample) |
| HR (1) | HRP20180953T1 (enExample) |
| HU (1) | HUE038437T2 (enExample) |
| LT (1) | LT2844637T (enExample) |
| ME (1) | ME03063B (enExample) |
| MX (2) | MX360634B (enExample) |
| NO (1) | NO2842608T3 (enExample) |
| PL (1) | PL2844637T3 (enExample) |
| PT (1) | PT2844637T (enExample) |
| RS (1) | RS57086B1 (enExample) |
| SG (2) | SG10201707020TA (enExample) |
| SI (1) | SI2844637T1 (enExample) |
| TR (1) | TR201807453T4 (enExample) |
| WO (1) | WO2013163675A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20180953T1 (hr) * | 2012-05-02 | 2018-07-27 | Boehringer Ingelheim International Gmbh | Supstituirani 3-haloalilaminski inhibitori za ssao i njihove uporabe |
| GB201304526D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| JP2018076236A (ja) * | 2015-06-05 | 2018-05-17 | 株式会社アールテック・ウエノ | がんを処置するための医薬組成物 |
| HK1256174A1 (zh) | 2015-12-07 | 2019-09-13 | Benevolentai Cambridge Limited | 用於治疗疼痛的 vap-1 抑制剂 |
| EP3414226A4 (en) * | 2016-02-12 | 2019-12-18 | Pharmaxis Ltd. | INDOL AND AZAINDOL HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYLOXIDASES AND USES THEREOF |
| WO2018027892A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
| BR112019005930A2 (pt) * | 2016-10-19 | 2019-06-11 | Boehringer Ingelheim Int | combinações compreendendo um inibidor de ssao/vap-1 e um inibidor de sglt2, e usos das mesmas |
| US20200087390A1 (en) | 2016-12-21 | 2020-03-19 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN108341752B (zh) * | 2017-01-21 | 2022-12-23 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| WO2018148856A1 (en) * | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
| PH12019501980B1 (en) * | 2017-03-01 | 2023-05-31 | Boehringer Ingelheim Int | Transition metal-catalyzed protodecarboxylation of alpha-halo-acrylic acid derivatives |
| JP2020508996A (ja) * | 2017-03-02 | 2020-03-26 | ファーマクシス リミテッド | リシルオキシダーゼのハロアリルアミンピラゾール誘導体阻害剤およびその使用 |
| CN110352188B (zh) * | 2017-04-28 | 2022-11-29 | 四川科伦博泰生物医药股份有限公司 | 氟代烯丙胺衍生物及其用途 |
| EP3630084A1 (en) | 2017-05-31 | 2020-04-08 | Boehringer Ingelheim International GmbH | Pharmaceutical composition and pharmaceutical dosage form comprising (e)-4-(2-(aminomethyl)-3-fluoroallyloxy)-n-tert-butylbenzamide, process for their preparation, methods for treating and uses thereof |
| GB201709136D0 (en) * | 2017-06-08 | 2017-07-26 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| KR102187608B1 (ko) * | 2017-06-20 | 2020-12-08 | 산동 단홍 파머수티컬 컴퍼니., 리미티드. | Ssao 억제제 |
| CN109251166B (zh) * | 2017-07-13 | 2021-11-05 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| WO2019024924A1 (zh) * | 2017-08-04 | 2019-02-07 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| CN109810041B (zh) | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 |
| CN109988109B (zh) | 2017-12-29 | 2020-12-29 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其用途 |
| CN109988106B (zh) * | 2017-12-29 | 2023-03-31 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| EP3768690B1 (en) | 2018-03-22 | 2025-08-27 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| WO2020006177A1 (en) * | 2018-06-29 | 2020-01-02 | Blade Therapeutics, Inc. | Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof |
| KR20200004036A (ko) * | 2018-07-03 | 2020-01-13 | 주식회사유한양행 | (e)-(2-(클로로메틸)-3-플루오로알릴)카바메이트 유도체의 제조방법 |
| KR102780601B1 (ko) * | 2018-08-03 | 2025-03-12 | 파맥시스 엘티디 | 라이실 옥시다제의 할로알릴아민 설폰 유도체 저해제 및 이의 용도 |
| CN110938059A (zh) * | 2018-09-25 | 2020-03-31 | 上海轶诺药业有限公司 | 胺基脲敏感性胺氧化酶抑制剂制备及其应用 |
| WO2020063854A1 (zh) * | 2018-09-27 | 2020-04-02 | 南京明德新药研发有限公司 | 作为vap-1抑制剂的喹啉类衍生物 |
| US11787791B2 (en) | 2018-09-28 | 2023-10-17 | Acucela Inc. | Inhibitors of VAP-1 |
| US12037334B2 (en) | 2018-09-28 | 2024-07-16 | Acucela Inc. | Inhibitors of VAP-1 |
| JP2022504697A (ja) * | 2018-10-24 | 2022-01-13 | メタクリン，インク． | Ｓｓａｏ阻害剤とその使用 |
| WO2020089025A1 (en) | 2018-10-29 | 2020-05-07 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| ES2967359T3 (es) * | 2018-10-29 | 2024-04-29 | Boehringer Ingelheim Int | Derivados piridinil-sulfonamida, composiciones farmacéuticas y usos de los mismos |
| AU2019394947B2 (en) * | 2018-12-05 | 2025-09-11 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of liver disorders |
| US12102646B2 (en) | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| TWI835945B (zh) * | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| WO2020125776A1 (zh) | 2018-12-20 | 2020-06-25 | 山东丹红制药有限公司 | 式(iv)化合物的工艺路线、晶型及其制备方法 |
| UA126997C2 (uk) * | 2019-01-11 | 2023-03-01 | Транстера Саєнсиз (Наньцзин), Інк. | Галоаліламінові сполуки та їх застосування |
| CN113748104B (zh) * | 2019-05-20 | 2024-02-27 | 广东东阳光药业股份有限公司 | 抑制ssao/vap-1的异喹啉酮类化合物及其用途 |
| CA3145738A1 (en) * | 2019-07-25 | 2021-01-28 | Pharmaxis Ltd. | Difluorohaloallylamine sulfone derivative inhibitors of lysyl oxidases, methods of preparation, and uses thereof |
| EP4051669A4 (en) * | 2019-10-29 | 2023-12-13 | Eccogene (Shanghai) Co., Ltd. | SSAO INHIBITORS AND THEIR USE |
| CN114728925B (zh) * | 2019-11-28 | 2023-12-08 | 广东东阳光药业股份有限公司 | 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途 |
| US20230127498A1 (en) * | 2020-03-25 | 2023-04-27 | Terns, Inc. | Treatment of respiratory disorders |
| CN111654920B (zh) * | 2020-06-02 | 2022-03-11 | 重庆邮电大学 | 一种分布式能效子载波功率分配方法 |
| JP7665122B2 (ja) * | 2020-06-26 | 2025-04-21 | シンタラ リミテッド | ハロアリルアミン系二重アミンオキシダーゼ阻害剤 |
| AU2021332217A1 (en) | 2020-08-25 | 2023-05-11 | Eli Lilly And Company | Polymorphs of an ssao inhibitor |
| CN114621189B (zh) * | 2020-12-14 | 2024-01-02 | 上海拓界生物医药科技有限公司 | 一种内酰胺类衍生物及其用途 |
| CN114621243B (zh) * | 2020-12-14 | 2024-03-01 | 上海拓界生物医药科技有限公司 | 一种磺酰胺类衍生物及其用途 |
| CN114621190B (zh) * | 2020-12-14 | 2023-12-05 | 上海拓界生物医药科技有限公司 | 一种烯丙基胺类衍生物及其用途 |
| WO2024044813A1 (en) * | 2022-08-29 | 2024-03-07 | Pharmaxis Ltd. | Novel selective inhibitors of lysyl oxidases |
| WO2024240633A1 (en) | 2023-05-24 | 2024-11-28 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment and/or prevention of renal diseases and/or hypertension in non-human mammals comprising one or more sglt-2 inhibitors and telmisartan |
| WO2025107036A1 (en) * | 2023-11-23 | 2025-05-30 | Syntara Limited | Dual inhibitors of amine oxidases and peroxidases, and uses thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4454158A (en) | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4699928A (en) | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
| ZA855101B (en) * | 1984-07-13 | 1986-05-28 | Merrell Dow Pharma | Fluoroallylaine derivatives |
| US4650907A (en) | 1985-12-05 | 1987-03-17 | Merrell Dow Pharmaceuticals Inc. | Nonaromatic fluoroallylamine MAO inhibitors |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US6010715A (en) | 1992-04-01 | 2000-01-04 | Bertek, Inc. | Transdermal patch incorporating a polymer film incorporated with an active agent |
| US6024975A (en) | 1992-04-08 | 2000-02-15 | Americare International Diagnostics, Inc. | Method of transdermally administering high molecular weight drugs with a polymer skin enhancer |
| US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
| US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
| US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
| US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
| US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US5983134A (en) | 1995-04-23 | 1999-11-09 | Electromagnetic Bracing Systems Inc. | Electrophoretic cuff apparatus drug delivery system |
| US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
| US6167301A (en) | 1995-08-29 | 2000-12-26 | Flower; Ronald J. | Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit |
| US6039975A (en) | 1995-10-17 | 2000-03-21 | Hoffman-La Roche Inc. | Colon targeted delivery system |
| TW345603B (en) | 1996-05-29 | 1998-11-21 | Gmundner Fertigteile Gmbh | A noise control device for tracks |
| US5985317A (en) | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
| NZ334914A (en) | 1996-10-01 | 2000-09-29 | Stanford Res Inst Int | Taste-masked microcapsule compositions and methods of manufacture using a phase seperation-coacervation technique |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| KR100719273B1 (ko) | 1997-10-28 | 2007-05-18 | 반도 카가쿠 가부시키가이샤 | 피부 패치 시트 및 그것을 위한 베이스 시트의 제조 방법 |
| US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
| US6271359B1 (en) | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
| AU2003259965A1 (en) | 2002-08-20 | 2004-03-11 | Neurogenetics, Inc. | Methods and compositions for modulating amyloid beta |
| EP2283833A3 (en) | 2004-02-25 | 2013-07-10 | La Jolla Pharmaceutical Co. | Amines and amides for the treatment of diseases |
| CN1921841A (zh) * | 2004-02-25 | 2007-02-28 | 拉卓拉药物公司 | 用于治疗疾病的胺和酰胺类化合物 |
| WO2007005737A2 (en) | 2005-07-01 | 2007-01-11 | Case Western Reserve University | Amine oxidase inhibitors |
| US20070293548A1 (en) | 2006-03-31 | 2007-12-20 | Wang Eric Y | Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases |
| JP2009543871A (ja) | 2006-07-19 | 2009-12-10 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 選択的アンドロゲン受容体調節薬、その類似体及び誘導体とそれらの使用 |
| CA2702885A1 (en) | 2007-10-19 | 2009-04-23 | R-Tech Ueno, Ltd. | Pharmaceutical composition for treatment of cataract |
| US20090170770A1 (en) | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
| AU2008327615B2 (en) * | 2007-11-21 | 2014-08-21 | Pharmaxis Ltd. | Haloallylamine inhibitors of SSAO/VAP-1 and uses therefor |
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| GB201004311D0 (en) * | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| HRP20180953T1 (hr) * | 2012-05-02 | 2018-07-27 | Boehringer Ingelheim International Gmbh | Supstituirani 3-haloalilaminski inhibitori za ssao i njihove uporabe |
-
2013
- 2013-04-05 HR HRP20180953TT patent/HRP20180953T1/hr unknown
- 2013-04-05 US US14/397,931 patent/US9302986B2/en active Active
- 2013-04-05 ME MEP-2018-104A patent/ME03063B/me unknown
- 2013-04-05 CN CN201710329198.1A patent/CN107266332B/zh not_active Expired - Fee Related
- 2013-04-05 MX MX2014013294A patent/MX360634B/es active IP Right Grant
- 2013-04-05 PL PL13784562T patent/PL2844637T3/pl unknown
- 2013-04-05 ES ES13784562.4T patent/ES2668300T3/es active Active
- 2013-04-05 BR BR112014027406-1A patent/BR112014027406B1/pt active IP Right Grant
- 2013-04-05 SG SG10201707020TA patent/SG10201707020TA/en unknown
- 2013-04-05 TR TR2018/07453T patent/TR201807453T4/tr unknown
- 2013-04-05 CN CN201380035139.3A patent/CN104520268B/zh active Active
- 2013-04-05 MX MX2018009129A patent/MX377635B/es unknown
- 2013-04-05 HU HUE13784562A patent/HUE038437T2/hu unknown
- 2013-04-05 PT PT137845624T patent/PT2844637T/pt unknown
- 2013-04-05 WO PCT/AU2013/000356 patent/WO2013163675A1/en not_active Ceased
- 2013-04-05 DK DK13784562.4T patent/DK2844637T5/en active
- 2013-04-05 EP EP18151119.7A patent/EP3438087A1/en not_active Withdrawn
- 2013-04-05 SI SI201331052T patent/SI2844637T1/en unknown
- 2013-04-05 KR KR1020207007076A patent/KR20200030126A/ko not_active Ceased
- 2013-04-05 EP EP13784562.4A patent/EP2844637B1/en active Active
- 2013-04-05 KR KR1020147032073A patent/KR102089935B1/ko active Active
- 2013-04-05 RS RS20180464A patent/RS57086B1/sr unknown
- 2013-04-05 AU AU2013255103A patent/AU2013255103B2/en active Active
- 2013-04-05 JP JP2015509257A patent/JP6182595B2/ja active Active
- 2013-04-05 CA CA2871793A patent/CA2871793C/en active Active
- 2013-04-05 CA CA3086105A patent/CA3086105A1/en not_active Abandoned
- 2013-04-05 LT LTEP13784562.4T patent/LT2844637T/lt unknown
- 2013-04-05 SG SG11201406948PA patent/SG11201406948PA/en unknown
- 2013-04-11 AU AU2013203655A patent/AU2013203655B2/en not_active Ceased
-
2014
- 2014-08-27 NO NO14182515A patent/NO2842608T3/no unknown
-
2016
- 2016-02-26 US US15/054,243 patent/US9815782B2/en active Active
-
2017
- 2017-02-06 JP JP2017019542A patent/JP6602802B2/ja not_active Expired - Fee Related
- 2017-10-05 US US15/725,363 patent/US10160723B2/en not_active Expired - Fee Related
-
2018
- 2018-06-14 CY CY20181100626T patent/CY1120334T1/el unknown
- 2018-11-01 US US16/177,841 patent/US20190071396A1/en not_active Abandoned
-
2019
- 2019-10-09 JP JP2019185763A patent/JP2020019810A/ja not_active Withdrawn