JP2015521167A5 - - Google Patents
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- JP2015521167A5 JP2015521167A5 JP2015509257A JP2015509257A JP2015521167A5 JP 2015521167 A5 JP2015521167 A5 JP 2015521167A5 JP 2015509257 A JP2015509257 A JP 2015509257A JP 2015509257 A JP2015509257 A JP 2015509257A JP 2015521167 A5 JP2015521167 A5 JP 2015521167A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- alkyl
- group
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 5
- 206010016654 Fibrosis Diseases 0.000 claims 4
- 102100027159 Membrane primary amine oxidase Human genes 0.000 claims 4
- 101710132836 Membrane primary amine oxidase Proteins 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Chemical group 0.000 claims 2
- 230000007882 cirrhosis Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 1
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 229910052740 iodine Chemical group 0.000 claims 1
- 239000011630 iodine Chemical group 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- -1 salt (E) -4- (2- (aminomethyl) -3-fluoroallyloxy) -N-tert-butylbenzamide hydrochloride Chemical class 0.000 claims 1
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261641814P | 2012-05-02 | 2012-05-02 | |
| US61/641,814 | 2012-05-02 | ||
| PCT/AU2013/000356 WO2013163675A1 (en) | 2012-05-02 | 2013-04-05 | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019542A Division JP6602802B2 (ja) | 2012-05-02 | 2017-02-06 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521167A JP2015521167A (ja) | 2015-07-27 |
| JP2015521167A5 true JP2015521167A5 (enExample) | 2016-10-06 |
| JP6182595B2 JP6182595B2 (ja) | 2017-08-16 |
Family
ID=49514094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509257A Active JP6182595B2 (ja) | 2012-05-02 | 2013-04-05 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
| JP2017019542A Expired - Fee Related JP6602802B2 (ja) | 2012-05-02 | 2017-02-06 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
| JP2019185763A Withdrawn JP2020019810A (ja) | 2012-05-02 | 2019-10-09 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019542A Expired - Fee Related JP6602802B2 (ja) | 2012-05-02 | 2017-02-06 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
| JP2019185763A Withdrawn JP2020019810A (ja) | 2012-05-02 | 2019-10-09 | Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9302986B2 (enExample) |
| EP (2) | EP3438087A1 (enExample) |
| JP (3) | JP6182595B2 (enExample) |
| KR (2) | KR20200030126A (enExample) |
| CN (2) | CN104520268B (enExample) |
| AU (2) | AU2013255103B2 (enExample) |
| BR (1) | BR112014027406B1 (enExample) |
| CA (2) | CA3086105A1 (enExample) |
| CY (1) | CY1120334T1 (enExample) |
| DK (1) | DK2844637T5 (enExample) |
| ES (1) | ES2668300T3 (enExample) |
| HR (1) | HRP20180953T1 (enExample) |
| HU (1) | HUE038437T2 (enExample) |
| LT (1) | LT2844637T (enExample) |
| ME (1) | ME03063B (enExample) |
| MX (2) | MX360634B (enExample) |
| NO (1) | NO2842608T3 (enExample) |
| PL (1) | PL2844637T3 (enExample) |
| PT (1) | PT2844637T (enExample) |
| RS (1) | RS57086B1 (enExample) |
| SG (2) | SG10201707020TA (enExample) |
| SI (1) | SI2844637T1 (enExample) |
| TR (1) | TR201807453T4 (enExample) |
| WO (1) | WO2013163675A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2844637T5 (en) * | 2012-05-02 | 2018-08-13 | Boehringer Ingelheim Int | SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS BY SSAO AND USES THEREOF |
| GB201304526D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| JP2018076236A (ja) * | 2015-06-05 | 2018-05-17 | 株式会社アールテック・ウエノ | がんを処置するための医薬組成物 |
| EP3386494A1 (en) | 2015-12-07 | 2018-10-17 | Benevolentai Cambridge Limited | Vap-1 inhibitors for treating pain |
| KR102742235B1 (ko) * | 2016-02-12 | 2024-12-13 | 파맥시스 엘티디 | 라이실 옥시다제의 할로알릴아민 인돌 및 아자인돌 유도체 억제제 및 이의 용도 |
| WO2018027892A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
| JP2019531320A (ja) | 2016-10-19 | 2019-10-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｓａｏ／ｖａｐ−１阻害剤とｓｇｌｔ２阻害剤とを含む組合せ、その使用 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN108341752B (zh) * | 2017-01-21 | 2022-12-23 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| WO2018148856A1 (en) | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
| DK3589606T3 (da) * | 2017-03-01 | 2024-01-02 | Boehringer Ingelheim Int | Overgangsmetal-katalyseret protodecarboxylering af alfa-halo-akrylsyrederivater |
| AU2018226610A1 (en) * | 2017-03-02 | 2019-09-05 | Pharmaxis Ltd. | Haloallylamine pyrazole derivative inhibitors of lysyl oxidases and uses thereof |
| US20200087248A1 (en) * | 2017-04-28 | 2020-03-19 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Fluoroallylamine Derivative And Use Thereof |
| EP3630084A1 (en) | 2017-05-31 | 2020-04-08 | Boehringer Ingelheim International GmbH | Pharmaceutical composition and pharmaceutical dosage form comprising (e)-4-(2-(aminomethyl)-3-fluoroallyloxy)-n-tert-butylbenzamide, process for their preparation, methods for treating and uses thereof |
| GB201709136D0 (en) * | 2017-06-08 | 2017-07-26 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| PT3626699T (pt) * | 2017-06-20 | 2023-09-21 | Shandong Danhong Pharmaceutical Co Ltd | Inibidor de ssao |
| CN109251166B (zh) * | 2017-07-13 | 2021-11-05 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| CN110914234B (zh) * | 2017-08-04 | 2023-06-23 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| CN109810041B (zh) | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 |
| CN109988109B (zh) * | 2017-12-29 | 2020-12-29 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其用途 |
| CN109988106B (zh) * | 2017-12-29 | 2023-03-31 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| AU2019238090B2 (en) | 2018-03-22 | 2024-08-01 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| US20210238192A1 (en) * | 2018-06-29 | 2021-08-05 | Blade Therapeutics, Inc. | Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof |
| KR20200004036A (ko) * | 2018-07-03 | 2020-01-13 | 주식회사유한양행 | (e)-(2-(클로로메틸)-3-플루오로알릴)카바메이트 유도체의 제조방법 |
| AR115906A1 (es) | 2018-08-03 | 2021-03-10 | Pharmaxis Ltd | Derivados de haloalilamina sulfona como inhibidores de lisil oxidasas |
| CN110938059A (zh) | 2018-09-25 | 2020-03-31 | 上海轶诺药业有限公司 | 胺基脲敏感性胺氧化酶抑制剂制备及其应用 |
| WO2020063854A1 (zh) * | 2018-09-27 | 2020-04-02 | 南京明德新药研发有限公司 | 作为vap-1抑制剂的喹啉类衍生物 |
| AU2019351124A1 (en) * | 2018-09-28 | 2021-05-20 | Acucela Inc. | Inhibitors of VAP-1 |
| JP7515467B2 (ja) * | 2018-09-28 | 2024-07-12 | アキュセラ インコーポレイテッド | Ｖａｐ－１の阻害剤 |
| WO2020086747A2 (en) * | 2018-10-24 | 2020-04-30 | Metacrine, Inc. | Ssao inhibitors and uses thereof |
| CN112955215B (zh) | 2018-10-29 | 2024-05-17 | 勃林格殷格翰国际有限公司 | 吡啶基磺酰胺衍生物、药物组合物及其用途 |
| WO2020089025A1 (en) | 2018-10-29 | 2020-05-07 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| BR112021010916A2 (pt) * | 2018-12-05 | 2021-08-24 | Viking Therapeutics, Inc. | Composições e métodos para tratamento de distúrbios hepáticos |
| US12102646B2 (en) | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| TWI835945B (zh) * | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| EP3901143B1 (en) | 2018-12-20 | 2024-05-29 | Shangdong Danhong Pharmaceutical Co., Ltd. | Process route of compound of formula (iv), crystal form and preparation method therefor |
| PL3892621T3 (pl) * | 2019-01-11 | 2024-11-18 | Transthera Sciences (Nanjing), Inc. | Związki haloalliloaminowe i ich zastosowanie |
| US12258317B2 (en) * | 2019-05-20 | 2025-03-25 | Sunshine Lake Pharma Co., Ltd. | Isoquinolinone compound for inhibiting ssao/vap-1, and use thereof |
| EP4003952A4 (en) * | 2019-07-25 | 2023-08-23 | Pharmaxis Ltd. | DIFLUOROHALOALLYLAMINE SULFONE DERIVATIVE LYSYL OXIDASE INHIBITORS, METHODS FOR THEIR PREPARATION AND THEIR USES |
| CN114901649B (zh) * | 2019-10-29 | 2024-07-23 | 诚益生物(美国)公司 | Ssao抑制剂及其用途 |
| CN114728925B (zh) * | 2019-11-28 | 2023-12-08 | 广东东阳光药业股份有限公司 | 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途 |
| KR20220158022A (ko) * | 2020-03-25 | 2022-11-29 | 테른스, 인크. | 호흡기 장애의 치료 |
| CN111654920B (zh) * | 2020-06-02 | 2022-03-11 | 重庆邮电大学 | 一种分布式能效子载波功率分配方法 |
| CN115916337B (zh) * | 2020-06-26 | 2025-04-15 | 法玛西斯有限公司 | 卤代烯丙基胺双胺氧化酶抑制剂 |
| MX2023002308A (es) | 2020-08-25 | 2023-07-11 | Lilly Co Eli | Polimorfos de un inhibidor de ssao. |
| CN114621189B (zh) * | 2020-12-14 | 2024-01-02 | 上海拓界生物医药科技有限公司 | 一种内酰胺类衍生物及其用途 |
| CN114621190B (zh) * | 2020-12-14 | 2023-12-05 | 上海拓界生物医药科技有限公司 | 一种烯丙基胺类衍生物及其用途 |
| CN114621243B (zh) * | 2020-12-14 | 2024-03-01 | 上海拓界生物医药科技有限公司 | 一种磺酰胺类衍生物及其用途 |
| AU2023331414A1 (en) * | 2022-08-29 | 2025-03-27 | Syntara Limited | Novel selective inhibitors of lysyl oxidases |
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