HK1255362A1 - 組織蛋白酶c的螺環化合物抑制劑 - Google Patents

組織蛋白酶c的螺環化合物抑制劑

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Publication number
HK1255362A1
HK1255362A1 HK18114501.3A HK18114501A HK1255362A1 HK 1255362 A1 HK1255362 A1 HK 1255362A1 HK 18114501 A HK18114501 A HK 18114501A HK 1255362 A1 HK1255362 A1 HK 1255362A1
Authority
HK
Hong Kong
Prior art keywords
cathepsin
spirocyclic
inhibitors
spirocyclic inhibitors
Prior art date
Application number
HK18114501.3A
Other languages
English (en)
Inventor
V‧文頓亞克
M‧格勞爾特
M‧格倫德爾
A‧波奇
Original Assignee
勃林格殷格翰國際有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 勃林格殷格翰國際有限公司 filed Critical 勃林格殷格翰國際有限公司
Publication of HK1255362A1 publication Critical patent/HK1255362A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK18114501.3A 2014-09-12 2018-11-14 組織蛋白酶c的螺環化合物抑制劑 HK1255362A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14184613 2014-09-12

Publications (1)

Publication Number Publication Date
HK1255362A1 true HK1255362A1 (zh) 2019-08-16

Family

ID=51535355

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114501.3A HK1255362A1 (zh) 2014-09-12 2018-11-14 組織蛋白酶c的螺環化合物抑制劑

Country Status (34)

Country Link
US (3) US9540373B2 (zh)
EP (2) EP3511331A1 (zh)
JP (2) JP2017526716A (zh)
KR (1) KR102510588B1 (zh)
CN (2) CN108047240B (zh)
AP (1) AP2017009733A0 (zh)
AU (1) AU2015314355B2 (zh)
BR (1) BR112017003433B1 (zh)
CA (1) CA2960916C (zh)
CL (1) CL2017000432A1 (zh)
CO (1) CO2017002268A2 (zh)
CY (1) CY1123033T1 (zh)
DK (1) DK3191487T3 (zh)
EA (1) EA031376B1 (zh)
ES (1) ES2749009T3 (zh)
HK (1) HK1255362A1 (zh)
HR (1) HRP20191756T1 (zh)
HU (1) HUE047208T2 (zh)
IL (1) IL250262B (zh)
LT (1) LT3191487T (zh)
MX (2) MX367316B (zh)
MY (1) MY188382A (zh)
NZ (1) NZ728684A (zh)
PE (1) PE20170438A1 (zh)
PH (1) PH12017500453B1 (zh)
PL (1) PL3191487T3 (zh)
PT (1) PT3191487T (zh)
RS (1) RS59444B1 (zh)
SA (1) SA517381064B1 (zh)
SG (1) SG11201701633SA (zh)
SI (1) SI3191487T1 (zh)
TW (1) TWI687424B (zh)
UA (1) UA118610C2 (zh)
WO (1) WO2016038007A1 (zh)

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CN110256429B (zh) * 2019-06-17 2021-06-22 广东药科大学 一种具有螺环结构的氨基嘧啶类化合物及其制备方法和应用
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CN114106005A (zh) * 2020-08-26 2022-03-01 四川海思科制药有限公司 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途
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SI3191487T1 (sl) 2019-12-31
LT3191487T (lt) 2019-10-10
JP2018044011A (ja) 2018-03-22
US20160075704A1 (en) 2016-03-17
PH12017500453A1 (en) 2017-07-31
UA118610C2 (uk) 2019-02-11
MX2019009695A (es) 2019-10-07
JP6360961B2 (ja) 2018-07-18
US9540373B2 (en) 2017-01-10
KR102510588B1 (ko) 2023-03-17
RS59444B1 (sr) 2019-11-29
CA2960916A1 (en) 2016-03-17
CL2017000432A1 (es) 2017-10-20
CO2017002268A2 (es) 2017-06-20
USRE47636E1 (en) 2019-10-08
NZ728684A (en) 2022-09-30
WO2016038007A1 (en) 2016-03-17
MX2017003156A (es) 2017-05-23
CN108047240B (zh) 2020-08-04
KR20170054489A (ko) 2017-05-17
MX367316B (es) 2019-08-15
CN108047240A (zh) 2018-05-18
AU2015314355A1 (en) 2017-02-16
CA2960916C (en) 2023-03-07
PT3191487T (pt) 2019-11-18
TW201625647A (zh) 2016-07-16
SA517381064B1 (ar) 2021-02-07
EP3191487B1 (en) 2019-08-07
EA031376B1 (ru) 2018-12-28
PH12017500453B1 (en) 2017-07-31
EA201790576A1 (ru) 2017-08-31
MY188382A (en) 2021-12-07
US20170073352A1 (en) 2017-03-16
ES2749009T3 (es) 2020-03-18
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