SG11201701633SA - Spirocyclic inhibitors of cathepsin c - Google Patents
Spirocyclic inhibitors of cathepsin cInfo
- Publication number
- SG11201701633SA SG11201701633SA SG11201701633SA SG11201701633SA SG11201701633SA SG 11201701633S A SG11201701633S A SG 11201701633SA SG 11201701633S A SG11201701633S A SG 11201701633SA SG 11201701633S A SG11201701633S A SG 11201701633SA SG 11201701633S A SG11201701633S A SG 11201701633SA
- Authority
- SG
- Singapore
- Prior art keywords
- cathepsin
- spirocyclic
- inhibitors
- spirocyclic inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14184613 | 2014-09-12 | ||
| PCT/EP2015/070449 WO2016038007A1 (en) | 2014-09-12 | 2015-09-08 | Spirocyclic inhibitors of cathepsin c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201701633SA true SG11201701633SA (en) | 2017-03-30 |
Family
ID=51535355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201701633SA SG11201701633SA (en) | 2014-09-12 | 2015-09-08 | Spirocyclic inhibitors of cathepsin c |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US9540373B2 (en) |
| EP (2) | EP3191487B1 (en) |
| JP (2) | JP2017526716A (en) |
| KR (1) | KR102510588B1 (en) |
| CN (2) | CN107074870B (en) |
| AP (1) | AP2017009733A0 (en) |
| AU (1) | AU2015314355B2 (en) |
| BR (1) | BR112017003433B1 (en) |
| CA (1) | CA2960916C (en) |
| CL (1) | CL2017000432A1 (en) |
| CO (1) | CO2017002268A2 (en) |
| CY (1) | CY1123033T1 (en) |
| DK (1) | DK3191487T3 (en) |
| EA (1) | EA031376B1 (en) |
| ES (1) | ES2749009T3 (en) |
| HK (1) | HK1255362A1 (en) |
| HR (1) | HRP20191756T1 (en) |
| HU (1) | HUE047208T2 (en) |
| IL (1) | IL250262B (en) |
| LT (1) | LT3191487T (en) |
| MX (2) | MX367316B (en) |
| MY (1) | MY188382A (en) |
| NZ (1) | NZ728684A (en) |
| PE (1) | PE20170438A1 (en) |
| PH (1) | PH12017500453B1 (en) |
| PL (1) | PL3191487T3 (en) |
| PT (1) | PT3191487T (en) |
| RS (1) | RS59444B1 (en) |
| SA (1) | SA517381064B1 (en) |
| SG (1) | SG11201701633SA (en) |
| SI (1) | SI3191487T1 (en) |
| TW (1) | TWI687424B (en) |
| UA (1) | UA118610C2 (en) |
| WO (1) | WO2016038007A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9018227B2 (en) | 2010-03-19 | 2015-04-28 | Indiana State University | Nicotinic acetylcholine receptor agonists |
| NO2699580T3 (en) | 2014-01-24 | 2018-02-24 | ||
| WO2016016242A1 (en) * | 2014-08-01 | 2016-02-04 | Boehringer Ingelheim International Gmbh | Substituted oxetanes and their use as inhibitors of cathepsin c |
| SI3191487T1 (en) * | 2014-09-12 | 2019-12-31 | Boehringer Ingelheim International Gmbh | Spirocyclic inhibitors of cathepsin c |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| EP3749326A4 (en) * | 2018-02-07 | 2021-11-03 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating anca associated vasculitides |
| MA52424A (en) | 2018-03-01 | 2021-01-06 | Astrazeneca Ab | PHARMACEUTICAL COMPOSITIONS CONTAINING (2S) - ((1S) -1-CYANO-2- [4- (3-METHYL-2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-5-YL) PHENYL] ETHYL) -1,4-OXAZEPANE-2-CARBOXAMIDE |
| US11998553B2 (en) | 2018-07-17 | 2024-06-04 | Insmed Incorporated | Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis |
| CN110256429B (en) * | 2019-06-17 | 2021-06-22 | 广东药科大学 | Aminopyrimidine compound with spiro structure and preparation method and application thereof |
| CN110257504A (en) * | 2019-06-30 | 2019-09-20 | 中南大学 | A kind of refractory asthma detects screening technique and its application of marker |
| CN114106005A (en) * | 2020-08-26 | 2022-03-01 | 四川海思科制药有限公司 | Nitrile derivative as dipeptidyl peptidase 1 inhibitor and application thereof |
| JP7563100B2 (en) | 2020-10-14 | 2024-10-08 | 東亞合成株式会社 | Curable composition for temporary fixing and method for temporary fixing |
| JP7563101B2 (en) | 2020-10-14 | 2024-10-08 | 東亞合成株式会社 | Curable composition for producing peelable adhesive, peelable adhesive, and peeling method |
| CN116157405A (en) * | 2020-12-04 | 2023-05-23 | 瑞石生物医药有限公司 | Cathepsin C small molecule inhibitor and medical application thereof |
| TW202413352A (en) * | 2022-06-13 | 2024-04-01 | 日商模數探索股份有限公司 | Azacycloalkyl carbonyl cyclic amine compound |
| WO2024008680A1 (en) | 2022-07-06 | 2024-01-11 | Chiesi Farmaceutici S.P.A. | Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors |
| WO2024088307A1 (en) * | 2022-10-26 | 2024-05-02 | 上海壹迪生物技术有限公司 | Novel peptidyl nitrile compound and use thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125727A (en) | 1976-10-18 | 1978-11-14 | American Cyanamid Company | Method of preparing imidazoisoindolediones |
| GB8922355D0 (en) | 1989-10-04 | 1989-11-22 | British Telecomm | Sealing gland |
| GEP20012487B (en) | 1998-09-16 | 2001-07-25 | Merab Lomia | Use of Chemical Agent 5-carbarnoyl-5H-Dibenz (b,f) azepin, its Derivatives and Analogues by New Purpose |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| JP4365094B2 (en) | 2001-03-02 | 2009-11-18 | メルク フロスト カナダ リミテツド | Cathepsin cysteine protease inhibitor |
| TW200306189A (en) | 2002-03-21 | 2003-11-16 | Merz Pharma Gmbh & Co Kgaa | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| US20070099958A1 (en) | 2003-06-18 | 2007-05-03 | Prozymex A/S | Protease inhibitors |
| TW200528440A (en) | 2003-10-31 | 2005-09-01 | Fujisawa Pharmaceutical Co | 2-cyanopyrrolidinecarboxamide compound |
| US20060223846A1 (en) | 2005-03-08 | 2006-10-05 | Dyatkin Alexey B | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| DK2032535T3 (en) * | 2006-06-01 | 2012-11-05 | Sanofi Sa | Spiro-cyclic nitriles as protease inhibitors |
| JPWO2008038692A1 (en) | 2006-09-28 | 2010-01-28 | 萬有製薬株式会社 | Diaryl ketimine derivatives |
| JP5240201B2 (en) | 2007-10-12 | 2013-07-17 | 富士通株式会社 | IP telephone automatic test system and method |
| EA201000958A1 (en) | 2007-12-12 | 2010-12-30 | Астразенека Аб | PEPTIDYLNITRILES AND THEIR APPLICATION AS DIPEPTIDYLPEPTIDASE I INHIBITORS |
| AU2010244218B2 (en) | 2009-05-07 | 2012-07-19 | Astrazeneca Ab | Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750 |
| WO2010142985A1 (en) | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
| WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| US8999975B2 (en) | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
| WO2013160418A1 (en) | 2012-04-27 | 2013-10-31 | Glaxo Group Limited | Novel compounds |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| EA026393B1 (en) | 2012-05-22 | 2017-04-28 | Дженентек, Инк. | N-substituted benzamides and their use in the treatment of pain |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| JO3459B1 (en) | 2012-09-09 | 2020-07-05 | H Lundbeck As | Pharmaceutical compositions for treating alzheimer's disease |
| TWI608013B (en) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | Glucagon analogues |
| AU2013323360B2 (en) | 2012-09-28 | 2017-09-07 | Cancer Research Technology Limited | Azaquinazoline inhibitors of atypical protein kinase C |
| JP2015533134A (en) * | 2012-10-09 | 2015-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Selective moisture-adjustable tableting material in the manufacture of mechanically stable tablets, in particular arginine-containing tablets, containing at least one hydrate-forming active substance and / or adjuvant suitable for the mechanical stability of the tablets Use of |
| EP2906538A4 (en) | 2012-10-15 | 2016-05-11 | Epizyme Inc | Substituted benzene compounds |
| ME02794B (en) | 2012-10-16 | 2018-01-20 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| PE20151141A1 (en) | 2012-11-01 | 2015-08-06 | Incyte Corp | FUSED TRICYCLIC DERIVATIVES OF THIOPHENE AS JAK INHIBITORS |
| PT2935248T (en) | 2012-12-21 | 2018-04-05 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| US9233974B2 (en) | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
| EA028774B1 (en) | 2012-12-21 | 2017-12-29 | Квонтисел Фармасьютикалс, Инк. | Histone demethylase inhibitors |
| SG11201505850WA (en) | 2013-02-08 | 2015-08-28 | Celgene Avilomics Res Inc | Erk inhibitors and uses thereof |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8877775B2 (en) * | 2013-03-14 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
| PE20151727A1 (en) * | 2013-03-14 | 2015-12-17 | Boehringer Ingelheim Int | 2-AZA-BICYCLE ACID [2.2.1] HEPTANE-3-CARBOXYL (BENZYL-CYAN-METHYL) -AMIDES SUBSTITUTED, CATEPSIN C INHIBITORS |
| JO3773B1 (en) | 2013-03-14 | 2021-01-31 | Janssen Pharmaceutica Nv | P2x7 modulators |
| CA2903979A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| AR095426A1 (en) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | TRIPEPTIDE INHIBITORS OF PROTEASA EPOXYCETONE |
| JO3383B1 (en) | 2013-03-14 | 2019-03-13 | Lilly Co Eli | CDC7 Inhibitors |
| SG11201507255QA (en) | 2013-03-14 | 2015-10-29 | Newlink Genetics Corp | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| KR101886550B1 (en) * | 2014-04-29 | 2018-08-07 | 케어베이 유럽 리미티드 | Device for adjusting needle insertion depth |
| CN106660409A (en) | 2014-07-03 | 2017-05-10 | 普利司通美国轮胎运营有限责任公司 | Sidewall decoration on rim guard |
| TW201625591A (en) | 2014-09-12 | 2016-07-16 | 美國禮來大藥廠 | Azetidinyloxyphenylpyrrolidine compounds |
| SI3191487T1 (en) * | 2014-09-12 | 2019-12-31 | Boehringer Ingelheim International Gmbh | Spirocyclic inhibitors of cathepsin c |
| UY36294A (en) | 2014-09-12 | 2016-04-29 | Novartis Ag | COMPOUNDS AND COMPOSITIONS AS QUINASA INHIBITORS |
| CA2958159A1 (en) | 2014-09-12 | 2016-03-17 | Glaxosmithkline Intellectual Property (No. 2) Limited | Tetrahydroquinoline derivatives as bromodomain inhibitors |
-
2015
- 2015-09-08 SI SI201530977T patent/SI3191487T1/en unknown
- 2015-09-08 NZ NZ728684A patent/NZ728684A/en unknown
- 2015-09-08 DK DK15757523T patent/DK3191487T3/en active
- 2015-09-08 LT LTEP15757523.4T patent/LT3191487T/en unknown
- 2015-09-08 HU HUE15757523A patent/HUE047208T2/en unknown
- 2015-09-08 BR BR112017003433-6A patent/BR112017003433B1/en active IP Right Grant
- 2015-09-08 PT PT157575234T patent/PT3191487T/en unknown
- 2015-09-08 CA CA2960916A patent/CA2960916C/en active Active
- 2015-09-08 KR KR1020177009993A patent/KR102510588B1/en active IP Right Grant
- 2015-09-08 WO PCT/EP2015/070449 patent/WO2016038007A1/en active Application Filing
- 2015-09-08 ES ES15757523T patent/ES2749009T3/en active Active
- 2015-09-08 EA EA201790576A patent/EA031376B1/en not_active IP Right Cessation
- 2015-09-08 AU AU2015314355A patent/AU2015314355B2/en active Active
- 2015-09-08 RS RSP20191350 patent/RS59444B1/en unknown
- 2015-09-08 CN CN201580048467.6A patent/CN107074870B/en active Active
- 2015-09-08 EP EP15757523.4A patent/EP3191487B1/en active Active
- 2015-09-08 PE PE2017000400A patent/PE20170438A1/en unknown
- 2015-09-08 MX MX2017003156A patent/MX367316B/en active IP Right Grant
- 2015-09-08 SG SG11201701633SA patent/SG11201701633SA/en unknown
- 2015-09-08 JP JP2017513658A patent/JP2017526716A/en not_active Ceased
- 2015-09-08 EP EP19155235.5A patent/EP3511331A1/en not_active Withdrawn
- 2015-09-08 AP AP2017009733A patent/AP2017009733A0/en unknown
- 2015-09-08 UA UAA201703350A patent/UA118610C2/en unknown
- 2015-09-08 PL PL15757523T patent/PL3191487T3/en unknown
- 2015-09-08 CN CN201810030066.3A patent/CN108047240B/en active Active
- 2015-09-08 MY MYPI2017000213A patent/MY188382A/en unknown
- 2015-09-10 US US14/849,710 patent/US9540373B2/en not_active Ceased
- 2015-09-11 TW TW104130165A patent/TWI687424B/en active
-
2016
- 2016-11-29 US US15/362,949 patent/US9879026B2/en active Active
-
2017
- 2017-01-24 IL IL250262A patent/IL250262B/en active IP Right Grant
- 2017-02-23 CL CL2017000432A patent/CL2017000432A1/en unknown
- 2017-03-07 CO CONC2017/0002268A patent/CO2017002268A2/en unknown
- 2017-03-09 SA SA517381064A patent/SA517381064B1/en unknown
- 2017-03-09 MX MX2019009695A patent/MX2019009695A/en unknown
- 2017-03-10 PH PH12017500453A patent/PH12017500453B1/en unknown
- 2017-11-30 US US15/827,433 patent/USRE47636E1/en active Active
- 2017-12-22 JP JP2017246001A patent/JP6360961B2/en active Active
-
2018
- 2018-11-14 HK HK18114501.3A patent/HK1255362A1/en unknown
-
2019
- 2019-09-27 HR HRP20191756TT patent/HRP20191756T1/en unknown
- 2019-11-06 CY CY20191101154T patent/CY1123033T1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1255362A1 (en) | Spirocyclic inhibitors of cathepsin c | |
| IL251584B (en) | Dihydropyrrolopyridine inhibitors of ror-gamma | |
| IL246902A0 (en) | Dihydropyrrolopyridine inhibitors of ror-gamma | |
| ZA201700304B (en) | Spirocycloheptanes as inhibitors of rock | |
| PH12016501922A1 (en) | Substituted spirocyclic inhibitors of autotaxin | |
| IL248505A0 (en) | Inhibitors of lysine specific demethylase-1 | |
| IL249733B (en) | Inhibitors of lysine specific demethylase-1 | |
| IL249881A0 (en) | Inhibitors of lysine specific demethylase-1 | |
| IL249876A0 (en) | Inhibitors of lysine specific demethylase-1 | |
| GB201521059D0 (en) | Inhibitors of metallo-beta-lactamases |