JP2017522340A5 - - Google Patents

Download PDF

Info

Publication number
JP2017522340A5
JP2017522340A5 JP2017504775A JP2017504775A JP2017522340A5 JP 2017522340 A5 JP2017522340 A5 JP 2017522340A5 JP 2017504775 A JP2017504775 A JP 2017504775A JP 2017504775 A JP2017504775 A JP 2017504775A JP 2017522340 A5 JP2017522340 A5 JP 2017522340A5
Authority
JP
Japan
Prior art keywords
alkyl
group
disorders
het
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017504775A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017522340A (ja
JP6662846B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2015/067530 external-priority patent/WO2016016380A1/en
Publication of JP2017522340A publication Critical patent/JP2017522340A/ja
Publication of JP2017522340A5 publication Critical patent/JP2017522340A5/ja
Application granted granted Critical
Publication of JP6662846B2 publication Critical patent/JP6662846B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017504775A 2014-08-01 2015-07-30 ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用 Expired - Fee Related JP6662846B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14179598.9 2014-08-01
EP14179598 2014-08-01
PCT/EP2015/067530 WO2016016380A1 (en) 2014-08-01 2015-07-30 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Publications (3)

Publication Number Publication Date
JP2017522340A JP2017522340A (ja) 2017-08-10
JP2017522340A5 true JP2017522340A5 (en:Method) 2018-08-23
JP6662846B2 JP6662846B2 (ja) 2020-03-11

Family

ID=51257437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017504775A Expired - Fee Related JP6662846B2 (ja) 2014-08-01 2015-07-30 ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用

Country Status (34)

Country Link
US (3) US10005786B2 (en:Method)
EP (1) EP3177623B1 (en:Method)
JP (1) JP6662846B2 (en:Method)
KR (1) KR102531689B1 (en:Method)
CN (1) CN106573936B (en:Method)
AR (1) AR101392A1 (en:Method)
AU (1) AU2015295298B2 (en:Method)
BR (1) BR112017001726A2 (en:Method)
CA (1) CA2954093C (en:Method)
CL (1) CL2017000192A1 (en:Method)
CY (1) CY1121649T1 (en:Method)
DK (1) DK3177623T3 (en:Method)
EA (1) EA031087B1 (en:Method)
ES (1) ES2708215T3 (en:Method)
HR (1) HRP20181997T1 (en:Method)
HU (1) HUE042871T2 (en:Method)
IL (1) IL250298A0 (en:Method)
JO (1) JOP20150179B1 (en:Method)
LT (1) LT3177623T (en:Method)
MA (1) MA39582B1 (en:Method)
ME (1) ME03320B (en:Method)
MX (1) MX376289B (en:Method)
NZ (1) NZ728122A (en:Method)
PH (1) PH12017500161B1 (en:Method)
PL (1) PL3177623T3 (en:Method)
PT (1) PT3177623T (en:Method)
RS (1) RS58279B1 (en:Method)
SG (1) SG11201700638YA (en:Method)
SI (1) SI3177623T1 (en:Method)
SM (1) SMT201900038T1 (en:Method)
TR (1) TR201901074T4 (en:Method)
TW (1) TWI696624B (en:Method)
WO (1) WO2016016380A1 (en:Method)
ZA (1) ZA201700759B (en:Method)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
PH12021552653A1 (en) 2014-01-21 2023-07-17 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150179B1 (ar) * 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
ES2727158T3 (es) 2014-12-03 2019-10-14 Janssen Pharmaceutica Nv Ligandos para PET de mGluR2 radiomarcados
JP6689856B2 (ja) 2014-12-03 2020-04-28 ヤンセン ファーマシューティカ エヌ．ベー． ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用
PL3389727T3 (pl) 2015-12-18 2021-02-08 Janssen Pharmaceutica Nv RADIOZNAKOWANE LIGANDY mGluR2/3 DO PET
WO2017103179A1 (en) 2015-12-18 2017-06-22 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
JP2020011902A (ja) * 2016-10-26 2020-01-23 大日本住友製薬株式会社 縮環ピロール誘導体およびその医薬用途
CN107298682B (zh) * 2017-06-29 2019-03-01 天津药明康德新药开发有限公司 一种4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-甲酸乙酯的合成方法
CA3082976A1 (en) 2017-11-24 2019-05-31 Sumitomo Dainippon Pharma Co., Ltd. 6,7-dihydropyrazolo[1,5-a]pyrazinone derivative and medical use thereof
EP3743429A1 (en) * 2018-01-26 2020-12-02 RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. TRIAZOLE, IMIDAZOLE AND PYRROLE CONDENSED PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF mGlu5 RECEPTORS
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0756200B1 (en) 1995-07-26 1999-11-10 Konica Corporation Silver halide color photographic light-sensitive material
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
US6482821B2 (en) 1996-12-20 2002-11-19 Hoechst Aktiengellschaft Vitronectin receptor antagonists, their preparation and their use
US6754375B1 (en) 1999-07-16 2004-06-22 Packard Bioscience Company Method and system for interactively developing at least one grid pattern and computer-readable storage medium having a program for executing the method
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
US20030114448A1 (en) 2001-05-31 2003-06-19 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
WO2005061507A1 (en) 2003-12-16 2005-07-07 Pfizer Products Inc. Bicyclic pyrazol-4-one cannabinoid receptor ligands and uses thereof
DE602005004287T2 (de) * 2004-06-21 2008-12-24 F. Hoffmann-La Roche Ag Pyrrazolopyrimidinderivate
WO2006030847A1 (ja) 2004-09-17 2006-03-23 Dainippon Sumitomo Pharma Co., Ltd. 新規二環性ピラゾール誘導体
DE102004054665A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte bi- und tricyclische Pyrazol-Derivate Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
EP1851225B1 (en) 2005-02-11 2011-06-15 F. Hoffmann-La Roche AG Pyrazolo-pyrimidine derivatives as mglur2 antagonists
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
WO2007084314A2 (en) 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
WO2008001115A2 (en) 2006-06-29 2008-01-03 Astex Therapeutics Limited Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea
US20110206607A1 (en) 2007-05-10 2011-08-25 Roger Olsson Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors
EP2085390A1 (en) 2008-01-31 2009-08-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
KR101673621B1 (ko) 2008-03-24 2016-11-07 노파르티스 아게 아릴술폰아미드-계 매트릭스 메탈로프로테아제 억제제
JPWO2010024258A1 (ja) 2008-08-29 2012-01-26 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176021A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
WO2012035078A1 (en) 2010-09-16 2012-03-22 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
AU2011328196A1 (en) 2010-11-08 2013-05-02 Janssen Pharmaceuticals, Inc. Radiolabelled mGluR2 PET ligands
AU2011343477A1 (en) * 2010-12-17 2013-07-04 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
WO2012172093A1 (en) 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
TWI565709B (zh) 2011-07-19 2017-01-11 英菲尼提製藥股份有限公司 雜環化合物及其用途
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9278960B2 (en) * 2011-11-03 2016-03-08 Merck Sharp & Dohme Corp. Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
WO2013077059A1 (ja) 2011-11-25 2013-05-30 日本電気株式会社 セル識別子割当方法、基地局、保守サーバ、移動通信システム
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US20130281397A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
EP2666775A1 (en) 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
US20130345205A1 (en) * 2012-06-20 2013-12-26 Vanderbilt University Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
RU2015101532A (ru) * 2012-06-20 2016-08-20 Вандербилт Юниверсити Замещенные бициклические алкокси-пиразольные аналоги в качестве аллостерических модуляторов рецепторов mglur5
US20130345204A1 (en) 2012-06-20 2013-12-26 Vanderbilt University Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
WO2014064028A1 (en) * 2012-10-23 2014-05-01 F. Hoffmann-La Roche Ag Mglu2/3 antagonists for the treatment of autistic disorders
CN103772686B (zh) 2012-10-26 2015-01-07 苏州雷纳药物研发有限公司 一种两亲性嵌段共聚物及其制备方法、以及该共聚物与抗肿瘤药物形成的胶束载药系统
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JP6517340B2 (ja) 2014-08-01 2019-05-22 ヤンセン ファーマシューティカ エヌ．ベー． ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JO3601B1 (ar) 2014-08-01 2020-07-05 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150179B1 (ar) * 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
CN107001373B (zh) 2014-08-01 2020-01-07 詹森药业有限公司 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途
JP6689856B2 (ja) 2014-12-03 2020-04-28 ヤンセン ファーマシューティカ エヌ．ベー． ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用
ES2727158T3 (es) 2014-12-03 2019-10-14 Janssen Pharmaceutica Nv Ligandos para PET de mGluR2 radiomarcados
WO2017103179A1 (en) 2015-12-18 2017-06-22 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
PL3389727T3 (pl) 2015-12-18 2021-02-08 Janssen Pharmaceutica Nv RADIOZNAKOWANE LIGANDY mGluR2/3 DO PET

Similar Documents

Publication Publication Date Title
JP2017522340A5 (en:Method)
JP2017526659A5 (en:Method)
JP2017528515A5 (en:Method)
RU2017106489A (ru) 6,7-дигидропиразоло[1,5-а]пиразин-4(5h)-оновые соединения и их применение в качестве отрицательных аллостерических модуляторов рецепторов mglur2
CN107108637B (zh) 三唑并嘧啶化合物及其用途
RU2017123038A (ru) 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2
JP2017523201A5 (en:Method)
RU2017106100A (ru) 6,7-ДИГИДРОПИРАЗОЛО[1,5-α]ПИРАЗИН-4(5Н)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2
CN112409363B (zh) 用于治疗认知损害的苯并二氮杂䓬衍生物、组合物和方法
RU2015135891A (ru) Новые производные пиразола
JP2017523202A5 (en:Method)
CN109963854A (zh) 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
JP2019524872A (ja) 癌の治療に有用なイミダゾピリミジン化合物
CA3080806A1 (en) Modulators of the integrated stress pathway
JP2013526544A5 (en:Method)
ES2798424T3 (es) Compuestos de triazolopiridina y usos de estos
TW201014849A (en) 1,2-disubstituted heterocyclic compounds
JP2013519684A5 (en:Method)
JP2017536399A5 (en:Method)
CA2942817A1 (en) Trka kinase inhibitors, compositions and methods thereof
JP2010523522A5 (en:Method)
RU2013104520A (ru) Пирролопиримидиновые соединения и их применения
JP2015506348A5 (en:Method)
RU2012107101A (ru) Производные пирроло[1,2-в] пиридазина как ингибиторы янус-киназы
JP2013519685A5 (en:Method)