JP2017526659A5 - - Google Patents
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- JP2017526659A5 JP2017526659A5 JP2017505447A JP2017505447A JP2017526659A5 JP 2017526659 A5 JP2017526659 A5 JP 2017526659A5 JP 2017505447 A JP2017505447 A JP 2017505447A JP 2017505447 A JP2017505447 A JP 2017505447A JP 2017526659 A5 JP2017526659 A5 JP 2017526659A5
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- JP
- Japan
- Prior art keywords
- alkyl
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- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179600 | 2014-08-01 | ||
| EP14179600.3 | 2014-08-01 | ||
| EP14196083.1 | 2014-12-03 | ||
| EP14196083 | 2014-12-03 | ||
| PCT/EP2015/067572 WO2016016395A1 (en) | 2014-08-01 | 2015-07-30 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526659A JP2017526659A (ja) | 2017-09-14 |
| JP2017526659A5 true JP2017526659A5 (en:Method) | 2018-09-06 |
| JP6609306B2 JP6609306B2 (ja) | 2019-11-20 |
Family
ID=53765202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505447A Expired - Fee Related JP6609306B2 (ja) | 2014-08-01 | 2015-07-30 | ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのその使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US10005785B2 (en:Method) |
| EP (1) | EP3174883B1 (en:Method) |
| JP (1) | JP6609306B2 (en:Method) |
| KR (1) | KR102531680B1 (en:Method) |
| CN (1) | CN107018662B (en:Method) |
| AU (1) | AU2015295313B2 (en:Method) |
| BR (1) | BR112017001861A2 (en:Method) |
| CA (1) | CA2954094C (en:Method) |
| CL (1) | CL2017000249A1 (en:Method) |
| CY (1) | CY1121123T1 (en:Method) |
| DK (1) | DK3174883T3 (en:Method) |
| EA (1) | EA033052B1 (en:Method) |
| ES (1) | ES2705425T3 (en:Method) |
| HR (1) | HRP20182114T1 (en:Method) |
| HU (1) | HUE041777T2 (en:Method) |
| IL (1) | IL250303A0 (en:Method) |
| JO (1) | JOP20150177B1 (en:Method) |
| LT (1) | LT3174883T (en:Method) |
| ME (1) | ME03341B (en:Method) |
| MX (1) | MX370182B (en:Method) |
| NZ (1) | NZ728025A (en:Method) |
| PH (1) | PH12017500170B1 (en:Method) |
| PL (1) | PL3174883T3 (en:Method) |
| PT (1) | PT3174883T (en:Method) |
| RS (1) | RS58215B1 (en:Method) |
| SG (1) | SG11201700637WA (en:Method) |
| SI (1) | SI3174883T1 (en:Method) |
| SM (1) | SMT201900013T1 (en:Method) |
| TW (1) | TWI688566B (en:Method) |
| WO (1) | WO2016016395A1 (en:Method) |
| ZA (1) | ZA201700758B (en:Method) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20150177B1 (ar) * | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| ES2727158T3 (es) | 2014-12-03 | 2019-10-14 | Janssen Pharmaceutica Nv | Ligandos para PET de mGluR2 radiomarcados |
| JP6689856B2 (ja) * | 2014-12-03 | 2020-04-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用 |
| PL3389727T3 (pl) | 2015-12-18 | 2021-02-08 | Janssen Pharmaceutica Nv | RADIOZNAKOWANE LIGANDY mGluR2/3 DO PET |
| WO2017103179A1 (en) * | 2015-12-18 | 2017-06-22 | Janssen Pharmaceutica Nv | Radiolabelled mglur2/3 pet ligands |
| JP2020011902A (ja) * | 2016-10-26 | 2020-01-23 | 大日本住友製薬株式会社 | 縮環ピロール誘導体およびその医薬用途 |
| CA3082976A1 (en) | 2017-11-24 | 2019-05-31 | Sumitomo Dainippon Pharma Co., Ltd. | 6,7-dihydropyrazolo[1,5-a]pyrazinone derivative and medical use thereof |
| WO2024008909A1 (en) | 2022-07-08 | 2024-01-11 | Janssen Pharmaceutica Nv | Inhibitors of coronavirus |
| WO2025146502A1 (en) | 2024-01-05 | 2025-07-10 | Janssen Pharmaceutica Nv | Coronavirus inhibiting compounds |
Family Cites Families (48)
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| EP0756200B1 (en) | 1995-07-26 | 1999-11-10 | Konica Corporation | Silver halide color photographic light-sensitive material |
| US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
| DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
| US6754375B1 (en) | 1999-07-16 | 2004-06-22 | Packard Bioscience Company | Method and system for interactively developing at least one grid pattern and computer-readable storage medium having a program for executing the method |
| US6831074B2 (en) | 2001-03-16 | 2004-12-14 | Pfizer Inc | Pharmaceutically active compounds |
| US20030114448A1 (en) | 2001-05-31 | 2003-06-19 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| WO2005061507A1 (en) | 2003-12-16 | 2005-07-07 | Pfizer Products Inc. | Bicyclic pyrazol-4-one cannabinoid receptor ligands and uses thereof |
| WO2006030847A1 (ja) | 2004-09-17 | 2006-03-23 | Dainippon Sumitomo Pharma Co., Ltd. | 新規二環性ピラゾール誘導体 |
| DE102004054665A1 (de) | 2004-11-12 | 2006-05-18 | Bayer Cropscience Gmbh | Substituierte bi- und tricyclische Pyrazol-Derivate Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
| WO2008001115A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea |
| US20110206607A1 (en) | 2007-05-10 | 2011-08-25 | Roger Olsson | Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors |
| EP2085390A1 (en) | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors |
| US9446995B2 (en) | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| KR101673621B1 (ko) | 2008-03-24 | 2016-11-07 | 노파르티스 아게 | 아릴술폰아미드-계 매트릭스 메탈로프로테아제 억제제 |
| WO2009130232A1 (en) | 2008-04-24 | 2009-10-29 | Glaxo Group Limited | Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors |
| JPWO2010024258A1 (ja) | 2008-08-29 | 2012-01-26 | 塩野義製薬株式会社 | Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体 |
| SG176021A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| WO2012035078A1 (en) | 2010-09-16 | 2012-03-22 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
| AU2011328196A1 (en) | 2010-11-08 | 2013-05-02 | Janssen Pharmaceuticals, Inc. | Radiolabelled mGluR2 PET ligands |
| AU2011343477A1 (en) | 2010-12-17 | 2013-07-04 | Vanderbilt University | Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| TWI565709B (zh) | 2011-07-19 | 2017-01-11 | 英菲尼提製藥股份有限公司 | 雜環化合物及其用途 |
| US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9278960B2 (en) | 2011-11-03 | 2016-03-08 | Merck Sharp & Dohme Corp. | Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use |
| WO2013077059A1 (ja) | 2011-11-25 | 2013-05-30 | 日本電気株式会社 | セル識別子割当方法、基地局、保守サーバ、移動通信システム |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US20130281397A1 (en) | 2012-04-19 | 2013-10-24 | Rvx Therapeutics Inc. | Treatment of diseases by epigenetic regulation |
| EP2666775A1 (en) | 2012-05-21 | 2013-11-27 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| US20130345204A1 (en) * | 2012-06-20 | 2013-12-26 | Vanderbilt University | Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors |
| RU2015101532A (ru) * | 2012-06-20 | 2016-08-20 | Вандербилт Юниверсити | Замещенные бициклические алкокси-пиразольные аналоги в качестве аллостерических модуляторов рецепторов mglur5 |
| US20130345205A1 (en) * | 2012-06-20 | 2013-12-26 | Vanderbilt University | Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors |
| WO2014064028A1 (en) | 2012-10-23 | 2014-05-01 | F. Hoffmann-La Roche Ag | Mglu2/3 antagonists for the treatment of autistic disorders |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| US10385054B2 (en) | 2013-06-27 | 2019-08-20 | Janssen Sciences Ireland Unlimited Company | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
| HUE062265T2 (hu) | 2013-06-27 | 2023-10-28 | Pfizer | Heteroaromás vegyületek és azok alkalmazása dopamin D1 ligandumokként |
| CN107001373B (zh) | 2014-08-01 | 2020-01-07 | 詹森药业有限公司 | 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途 |
| JOP20150177B1 (ar) * | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JP6517340B2 (ja) | 2014-08-01 | 2019-05-22 | ヤンセン ファーマシューティカ エヌ．ベー． | ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用 |
| JO3601B1 (ar) | 2014-08-01 | 2020-07-05 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JP6689856B2 (ja) | 2014-12-03 | 2020-04-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用 |
| ES2727158T3 (es) | 2014-12-03 | 2019-10-14 | Janssen Pharmaceutica Nv | Ligandos para PET de mGluR2 radiomarcados |
| WO2017103179A1 (en) | 2015-12-18 | 2017-06-22 | Janssen Pharmaceutica Nv | Radiolabelled mglur2/3 pet ligands |
| PL3389727T3 (pl) | 2015-12-18 | 2021-02-08 | Janssen Pharmaceutica Nv | RADIOZNAKOWANE LIGANDY mGluR2/3 DO PET |
-
2015
- 2015-07-27 JO JOP/2015/0177A patent/JOP20150177B1/ar active
- 2015-07-30 EP EP15744915.8A patent/EP3174883B1/en active Active
- 2015-07-30 PT PT15744915T patent/PT3174883T/pt unknown
- 2015-07-30 ME MEP-2019-9A patent/ME03341B/me unknown
- 2015-07-30 SI SI201530532T patent/SI3174883T1/sl unknown
- 2015-07-30 AU AU2015295313A patent/AU2015295313B2/en not_active Ceased
- 2015-07-30 TW TW104124698A patent/TWI688566B/zh not_active IP Right Cessation
- 2015-07-30 LT LTEP15744915.8T patent/LT3174883T/lt unknown
- 2015-07-30 HR HRP20182114TT patent/HRP20182114T1/hr unknown
- 2015-07-30 JP JP2017505447A patent/JP6609306B2/ja not_active Expired - Fee Related
- 2015-07-30 US US15/500,319 patent/US10005785B2/en active Active
- 2015-07-30 CN CN201580041305.XA patent/CN107018662B/zh active Active
- 2015-07-30 ES ES15744915T patent/ES2705425T3/es active Active
- 2015-07-30 WO PCT/EP2015/067572 patent/WO2016016395A1/en not_active Ceased
- 2015-07-30 SG SG11201700637WA patent/SG11201700637WA/en unknown
- 2015-07-30 CA CA2954094A patent/CA2954094C/en active Active
- 2015-07-30 NZ NZ728025A patent/NZ728025A/en not_active IP Right Cessation
- 2015-07-30 BR BR112017001861A patent/BR112017001861A2/pt not_active Application Discontinuation
- 2015-07-30 PL PL15744915T patent/PL3174883T3/pl unknown
- 2015-07-30 HU HUE15744915A patent/HUE041777T2/hu unknown
- 2015-07-30 DK DK15744915.8T patent/DK3174883T3/en active
- 2015-07-30 MX MX2017001454A patent/MX370182B/es active IP Right Grant
- 2015-07-30 EA EA201692544A patent/EA033052B1/ru unknown
- 2015-07-30 RS RS20190054A patent/RS58215B1/sr unknown
- 2015-07-30 KR KR1020177004410A patent/KR102531680B1/ko active Active
- 2015-07-30 SM SM20190013T patent/SMT201900013T1/it unknown
-
2017
- 2017-01-26 IL IL250303A patent/IL250303A0/en active IP Right Grant
- 2017-01-27 PH PH12017500170A patent/PH12017500170B1/en unknown
- 2017-01-31 CL CL2017000249A patent/CL2017000249A1/es unknown
- 2017-01-31 ZA ZA2017/00758A patent/ZA201700758B/en unknown
-
2018
- 2018-05-10 US US15/976,223 patent/US10519162B2/en active Active
-
2019
- 2019-01-15 CY CY191100040T patent/CY1121123T1/el unknown
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