HUE041777T2 - 6,7-Dihidropirazol[1,5-A]pirazin-4(5H)-on vegyületek és azok alkalmazása mint mglu2 receptorok negatív allosztérikus modulátorai - Google Patents
6,7-Dihidropirazol[1,5-A]pirazin-4(5H)-on vegyületek és azok alkalmazása mint mglu2 receptorok negatív allosztérikus modulátoraiInfo
- Publication number
- HUE041777T2 HUE041777T2 HUE15744915A HUE15744915A HUE041777T2 HU E041777 T2 HUE041777 T2 HU E041777T2 HU E15744915 A HUE15744915 A HU E15744915A HU E15744915 A HUE15744915 A HU E15744915A HU E041777 T2 HUE041777 T2 HU E041777T2
- Authority
- HU
- Hungary
- Prior art keywords
- dihydropyrazolo
- pyrazin
- compounds
- allosteric modulators
- negative allosteric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14179600 | 2014-08-01 | ||
EP14196083 | 2014-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE041777T2 true HUE041777T2 (hu) | 2019-05-28 |
Family
ID=53765202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE15744915A HUE041777T2 (hu) | 2014-08-01 | 2015-07-30 | 6,7-Dihidropirazol[1,5-A]pirazin-4(5H)-on vegyületek és azok alkalmazása mint mglu2 receptorok negatív allosztérikus modulátorai |
Country Status (30)
Country | Link |
---|---|
US (2) | US10005785B2 (hu) |
EP (1) | EP3174883B1 (hu) |
JP (1) | JP6609306B2 (hu) |
KR (1) | KR102531680B1 (hu) |
CN (1) | CN107018662B (hu) |
AU (1) | AU2015295313B2 (hu) |
BR (1) | BR112017001861A2 (hu) |
CA (1) | CA2954094C (hu) |
CL (1) | CL2017000249A1 (hu) |
CY (1) | CY1121123T1 (hu) |
DK (1) | DK3174883T3 (hu) |
EA (1) | EA033052B1 (hu) |
ES (1) | ES2705425T3 (hu) |
HR (1) | HRP20182114T1 (hu) |
HU (1) | HUE041777T2 (hu) |
IL (1) | IL250303A0 (hu) |
JO (1) | JOP20150177B1 (hu) |
LT (1) | LT3174883T (hu) |
ME (1) | ME03341B (hu) |
MX (1) | MX370182B (hu) |
NZ (1) | NZ728025A (hu) |
PH (1) | PH12017500170B1 (hu) |
PL (1) | PL3174883T3 (hu) |
PT (1) | PT3174883T (hu) |
RS (1) | RS58215B1 (hu) |
SG (1) | SG11201700637WA (hu) |
SI (1) | SI3174883T1 (hu) |
TW (1) | TWI688566B (hu) |
WO (1) | WO2016016395A1 (hu) |
ZA (1) | ZA201700758B (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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JOP20150177B1 (ar) * | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
CA2967153A1 (en) * | 2014-12-03 | 2016-06-09 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo[1,5-.alpha.]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
EP3389727B1 (en) | 2015-12-18 | 2020-08-12 | Janssen Pharmaceutica NV | Radiolabelled mglur2/3 pet ligands |
JP6929285B2 (ja) * | 2015-12-18 | 2021-09-01 | ヤンセン ファーマシューティカ エヌ.ベー. | 放射性標識mGluR2/3PETリガンド |
JP2020011902A (ja) * | 2016-10-26 | 2020-01-23 | 大日本住友製薬株式会社 | 縮環ピロール誘導体およびその医薬用途 |
CN111601811B (zh) | 2017-11-24 | 2023-05-05 | 住友制药株式会社 | 6,7-二氢吡唑并[1,5-a]吡嗪酮衍生物和其医药用途 |
WO2024008909A1 (en) | 2022-07-08 | 2024-01-11 | Janssen Pharmaceutica Nv | Inhibitors of coronavirus |
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JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
JOP20150177B1 (ar) * | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
ES2707525T3 (es) | 2014-08-01 | 2019-04-03 | Janssen Pharmaceutica Nv | Compuestos de 6,7-dihidropirazolo[1,5-a]pirazin-4(5H)-ona y su uso como moduladores alostéricos negativos de receptores de mGlu2 |
CA2954222C (en) | 2014-08-01 | 2022-11-29 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
JO3601B1 (ar) | 2014-08-01 | 2020-07-05 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
CA2967153A1 (en) | 2014-12-03 | 2016-06-09 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo[1,5-.alpha.]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
JP6929285B2 (ja) | 2015-12-18 | 2021-09-01 | ヤンセン ファーマシューティカ エヌ.ベー. | 放射性標識mGluR2/3PETリガンド |
EP3389727B1 (en) | 2015-12-18 | 2020-08-12 | Janssen Pharmaceutica NV | Radiolabelled mglur2/3 pet ligands |
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2015
- 2015-07-27 JO JOP/2015/0177A patent/JOP20150177B1/ar active
- 2015-07-30 EP EP15744915.8A patent/EP3174883B1/en active Active
- 2015-07-30 RS RS20190054A patent/RS58215B1/sr unknown
- 2015-07-30 PT PT15744915T patent/PT3174883T/pt unknown
- 2015-07-30 BR BR112017001861A patent/BR112017001861A2/pt not_active Application Discontinuation
- 2015-07-30 WO PCT/EP2015/067572 patent/WO2016016395A1/en active Application Filing
- 2015-07-30 HU HUE15744915A patent/HUE041777T2/hu unknown
- 2015-07-30 ES ES15744915T patent/ES2705425T3/es active Active
- 2015-07-30 KR KR1020177004410A patent/KR102531680B1/ko active IP Right Grant
- 2015-07-30 MX MX2017001454A patent/MX370182B/es active IP Right Grant
- 2015-07-30 LT LTEP15744915.8T patent/LT3174883T/lt unknown
- 2015-07-30 TW TW104124698A patent/TWI688566B/zh not_active IP Right Cessation
- 2015-07-30 PL PL15744915T patent/PL3174883T3/pl unknown
- 2015-07-30 AU AU2015295313A patent/AU2015295313B2/en active Active
- 2015-07-30 CN CN201580041305.XA patent/CN107018662B/zh active Active
- 2015-07-30 DK DK15744915.8T patent/DK3174883T3/en active
- 2015-07-30 EA EA201692544A patent/EA033052B1/ru unknown
- 2015-07-30 US US15/500,319 patent/US10005785B2/en active Active
- 2015-07-30 NZ NZ728025A patent/NZ728025A/en not_active IP Right Cessation
- 2015-07-30 SI SI201530532T patent/SI3174883T1/sl unknown
- 2015-07-30 JP JP2017505447A patent/JP6609306B2/ja active Active
- 2015-07-30 CA CA2954094A patent/CA2954094C/en active Active
- 2015-07-30 ME MEP-2019-9A patent/ME03341B/me unknown
- 2015-07-30 SG SG11201700637WA patent/SG11201700637WA/en unknown
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2017
- 2017-01-26 IL IL250303A patent/IL250303A0/en active IP Right Grant
- 2017-01-27 PH PH12017500170A patent/PH12017500170B1/en unknown
- 2017-01-31 ZA ZA2017/00758A patent/ZA201700758B/en unknown
- 2017-01-31 CL CL2017000249A patent/CL2017000249A1/es unknown
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2018
- 2018-05-10 US US15/976,223 patent/US10519162B2/en active Active
- 2018-12-13 HR HRP20182114TT patent/HRP20182114T1/hr unknown
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2019
- 2019-01-15 CY CY191100040T patent/CY1121123T1/el unknown
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