JP2017513524A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017513524A5 JP2017513524A5 JP2017505717A JP2017505717A JP2017513524A5 JP 2017513524 A5 JP2017513524 A5 JP 2017513524A5 JP 2017505717 A JP2017505717 A JP 2017505717A JP 2017505717 A JP2017505717 A JP 2017505717A JP 2017513524 A5 JP2017513524 A5 JP 2017513524A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- streptavidin
- analog
- avidin
- biotin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010090804 Streptavidin Proteins 0.000 claims 23
- 239000003153 chemical reaction reagent Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 20
- 108090001008 Avidin Proteins 0.000 claims 19
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 229960002685 biotin Drugs 0.000 claims 9
- 235000020958 biotin Nutrition 0.000 claims 9
- 239000011616 biotin Substances 0.000 claims 9
- 150000001615 biotins Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 230000002441 reversible effect Effects 0.000 claims 3
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102000000584 Calmodulin Human genes 0.000 claims 2
- 108010041952 Calmodulin Proteins 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 229910001428 transition metal ion Inorganic materials 0.000 claims 2
- 108010028230 Trp-Ser- His-Pro-Gln-Phe-Glu-Lys Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020076705A JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980506P | 2014-04-16 | 2014-04-16 | |
| US61/980,506 | 2014-04-16 | ||
| PCT/EP2015/058339 WO2015158868A2 (en) | 2014-04-16 | 2015-04-16 | Methods, kits and apparatus for expanding a population of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076705A Division JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513524A JP2017513524A (ja) | 2017-06-01 |
| JP2017513524A5 true JP2017513524A5 (show.php) | 2018-05-31 |
| JP6696969B2 JP6696969B2 (ja) | 2020-05-20 |
Family
ID=53052805
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505717A Active JP6696969B2 (ja) | 2014-04-16 | 2015-04-16 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2020076705A Active JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2023024443A Pending JP2023062124A (ja) | 2014-04-16 | 2023-02-20 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2024225388A Pending JP2025060756A (ja) | 2014-04-16 | 2024-12-20 | 細胞の集団を拡大する方法、キット、及び装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076705A Active JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2023024443A Pending JP2023062124A (ja) | 2014-04-16 | 2023-02-20 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2024225388A Pending JP2025060756A (ja) | 2014-04-16 | 2024-12-20 | 細胞の集団を拡大する方法、キット、及び装置 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11274278B2 (show.php) |
| EP (2) | EP3132247B1 (show.php) |
| JP (4) | JP6696969B2 (show.php) |
| KR (2) | KR102459384B1 (show.php) |
| CN (3) | CN111961647A (show.php) |
| AU (2) | AU2015248786B2 (show.php) |
| BR (1) | BR112016024072B1 (show.php) |
| CA (2) | CA3176848A1 (show.php) |
| CY (1) | CY1124717T1 (show.php) |
| DK (1) | DK3132247T3 (show.php) |
| ES (1) | ES2892927T3 (show.php) |
| HR (1) | HRP20211430T1 (show.php) |
| HU (1) | HUE056852T2 (show.php) |
| IL (3) | IL293587B2 (show.php) |
| LT (1) | LT3132247T (show.php) |
| MX (2) | MX380519B (show.php) |
| MY (1) | MY184699A (show.php) |
| PH (2) | PH12016502017B1 (show.php) |
| PL (1) | PL3132247T3 (show.php) |
| PT (1) | PT3132247T (show.php) |
| RS (1) | RS62471B1 (show.php) |
| RU (2) | RU2020133435A (show.php) |
| SA (3) | SA516380090B1 (show.php) |
| SG (2) | SG10201808491UA (show.php) |
| SI (1) | SI3132247T1 (show.php) |
| SM (1) | SMT202100600T1 (show.php) |
| WO (1) | WO2015158868A2 (show.php) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| US11274278B2 (en) * | 2014-04-16 | 2022-03-15 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| BR112016024579A2 (pt) | 2014-04-23 | 2017-10-10 | Juno Therapeutics Inc | métodos para isolamento, cultura e engenharia genética de populações de célula imune para terapia adotiva |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MX395154B (es) | 2015-10-22 | 2025-03-25 | Juno Therapeutics Gmbh | Métodos, kits, agentes y aparatos para transducción. |
| EP3192810A1 (en) | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN107129988A (zh) * | 2016-02-29 | 2017-09-05 | 广西医科大学 | 一种特异性结合cd3的核酸适配体及其筛选方法和应用 |
| KR102570250B1 (ko) * | 2016-06-02 | 2023-08-29 | 클로토 테라퓨틱스, 아이엔씨. | 치료학적 재조합 클로토 단백질 및 이를 수반하는 조성물 및 방법 |
| KR20230107408A (ko) | 2016-07-29 | 2023-07-14 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항-cd19 항체에 대한 항-이디오타입 항체 |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| CA3045338A1 (en) * | 2016-12-05 | 2018-06-14 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| EP3656841A1 (en) * | 2017-03-31 | 2020-05-27 | Terumo BCT, Inc. | Cell expansion |
| US11624046B2 (en) * | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) * | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| SG11201909931PA (en) * | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| CN111936158A (zh) * | 2017-12-15 | 2020-11-13 | 艾丽塔生物治疗剂公司 | Cd19变体 |
| CN107904278B (zh) * | 2017-12-25 | 2021-07-20 | 北昊干细胞与再生医学研究院有限公司 | 检测药物对细胞增殖影响的方法 |
| US11149244B2 (en) * | 2018-04-04 | 2021-10-19 | Southwest Research Institute | Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy |
| WO2019217512A1 (en) * | 2018-05-08 | 2019-11-14 | Life Technologies Corporation | Compositions and methods for culturing and expanding cells |
| CN112912103B (zh) * | 2018-05-21 | 2025-08-29 | 广州邦定生物技术有限公司 | 多价蛋白质复合物 |
| IL280659B2 (en) | 2018-08-09 | 2024-11-01 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| WO2020053300A1 (en) | 2018-09-11 | 2020-03-19 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved anti-flt3 antigen binding proteins |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
| US11447731B2 (en) * | 2018-09-24 | 2022-09-20 | Southwest Research Institute | Three-dimensional bioreactors |
| EP3874024A1 (en) * | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| KR20200132147A (ko) * | 2019-05-15 | 2020-11-25 | 의료법인 성광의료재단 | 자연 살해 세포의 배양용 조성물 및 이를 이용한 방법 |
| US20220241702A1 (en) * | 2019-05-24 | 2022-08-04 | Sol Bio Corporation | Affinity isolation system and method using switch-like binding reaction |
| EP3980530A1 (en) * | 2019-06-07 | 2022-04-13 | Juno Therapeutics, Inc. | Automated t cell culture |
| BR112022008023A2 (pt) | 2019-10-30 | 2022-07-12 | Juno Therapeutics Gmbh | Dispositivos de seleção e/ou estimulação de células e métodos de uso |
| EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| WO2021113776A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods |
| WO2021113780A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods |
| AU2021213439B2 (en) | 2020-01-31 | 2023-01-05 | Cell.Copedia GmbH | Methods of isolating a biological entity |
| CN115768443A (zh) | 2020-02-12 | 2023-03-07 | 朱诺治疗学股份有限公司 | Cd19定向嵌合抗原受体t细胞组合物和方法及其用途 |
| JP2023519099A (ja) | 2020-02-12 | 2023-05-10 | ジュノー セラピューティクス インコーポレイテッド | Ｂｃｍａ指向性キメラ抗原受容体ｔ細胞組成物ならびにその方法および使用 |
| US12378521B2 (en) | 2020-04-15 | 2025-08-05 | Amgen Inc. | Method for enhancing production of genetically engineered autologous T cells |
| US12241086B2 (en) | 2020-04-15 | 2025-03-04 | Amgen Inc. | Process for generating genetically engineered autologous T cells |
| WO2022029660A1 (en) | 2020-08-05 | 2022-02-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ジュノー セラピューティクス インコーポレイテッド | 改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| AU2022241654A1 (en) | 2021-03-22 | 2023-09-28 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| US20250283037A1 (en) | 2021-05-06 | 2025-09-11 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| WO2023001833A1 (en) | 2021-07-19 | 2023-01-26 | Repairon Immuno Gmbh | Method of producing a population of immune cells from pluripotent stem cells |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| EP4630782A1 (en) | 2022-12-09 | 2025-10-15 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| JP2026504491A (ja) | 2023-02-03 | 2026-02-05 | ツェー３エス２ ゲーエムベーハー | 操作された免疫細胞の非ウイルス的製造のための方法 |
| TW202502363A (zh) | 2023-02-28 | 2025-01-16 | 美商奇諾治療有限公司 | 用於治療全身性自體免疫疾病之細胞療法 |
| KR20250169631A (ko) | 2023-04-18 | 2025-12-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 평가하기 위한 세포독성 검정 |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| CN117448255B (zh) * | 2023-09-28 | 2024-12-31 | 深圳市龙华区人民医院 | S2饲养细胞、制备方法及其应用 |
| WO2025109111A1 (en) * | 2023-11-22 | 2025-05-30 | Immudex Aps | Immune cell activating multimers |
| KR102824339B1 (ko) * | 2024-07-01 | 2025-06-26 | 현대자동차주식회사 | 배터리 제어 장치 및 그 방법 |
| WO2026020055A2 (en) | 2024-07-18 | 2026-01-22 | Juno Therapeutics, Inc. | Methods for assessing exosomes in a cell composition and related uses |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| JP2624470B2 (ja) | 1984-10-02 | 1997-06-25 | バイオジェン インコーポレイテッド | ストレプトアビジン様ポリペプチドの製造 |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| PT700430E (pt) | 1993-06-04 | 2005-07-29 | Univ Michigan | Processo para estimular selectivamente a proliferacao das celulas t |
| WO1996023879A1 (en) | 1995-01-30 | 1996-08-08 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| WO1996024606A1 (en) | 1995-02-09 | 1996-08-15 | University Of Washington | Modified-affinity streptavidin |
| EP0856055A1 (en) | 1995-04-11 | 1998-08-05 | Trustees Of Boston University | Streptavidin mutants |
| DE19641876B4 (de) * | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| JP2001514524A (ja) | 1997-03-14 | 2001-09-11 | トラスティーズ オブ ボストン ユニバーシティー | マルチフレイバーストレプトアビジン |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| US6664042B1 (en) | 1999-01-26 | 2003-12-16 | Cornell Research Foundation, Inc. | Determining viral load in double negative T cells |
| CA2640956C (en) * | 1999-02-03 | 2012-07-03 | Amgen Inc. | B7rp-1 polypeptides |
| JP4523169B2 (ja) | 1999-02-04 | 2010-08-11 | プルリステム リミテッド | 造血幹細胞および／または前駆細胞を維持および増加するための方法および装置 |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| EP1630171B1 (de) | 2002-03-01 | 2007-08-15 | Volker A. Erdmann | Streptavidin-Bindungspeptid |
| US7754155B2 (en) | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
| AU2003234194A1 (en) | 2002-04-23 | 2003-11-10 | Meir Strahilevitz | Methods and devices for targeting a site in a mammal and for removing species from a mammal |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| CA2500392C (en) | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| WO2004096975A2 (en) | 2003-05-02 | 2004-11-11 | Insception Bioscience, Inc. | Apparatus and methods for amplification of blood stem cell numbers |
| DE60334250D1 (de) * | 2003-05-08 | 2010-10-28 | Life Technologies Corp | Erzeugung und isolierung antigenspezifischer t-zellen |
| EP1690090A1 (en) | 2003-11-20 | 2006-08-16 | Biosensor Applications Sweden AB (Publ) | Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture |
| SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| ATE428931T1 (de) | 2004-06-03 | 2009-05-15 | Meso Scale Technologies Llc | Verfahren zur durchführung von vollbluttests |
| DK1800136T3 (da) | 2004-10-15 | 2012-03-26 | Danisco Us Inc | Kompetitiv differentiel screening |
| WO2006058226A2 (en) * | 2004-11-24 | 2006-06-01 | The Trustees Of Boston University | Modified dimeric streptavidins and uses thereof |
| US20060252087A1 (en) | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US7704708B2 (en) * | 2006-02-13 | 2010-04-27 | Uti Limited Partnership | Monomeric streptavidin muteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| US20090208471A1 (en) | 2006-04-07 | 2009-08-20 | Yun Theodore J | Isolation and Use of Human Regulatory T Cells |
| US20070238169A1 (en) * | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| US20080085532A1 (en) | 2006-09-18 | 2008-04-10 | Jorn Gorlach | Method for determining the immune status of a subject |
| KR101454287B1 (ko) | 2006-10-17 | 2014-11-04 | 온코세라피 사이언스 가부시키가이샤 | Ｍｐｈｏｓｐｈ1 또는 ｄｅｐｄｃ1 폴리펩티드를 발현하는 암에 대한 펩티드 백신 |
| CN105866401A (zh) | 2006-11-02 | 2016-08-17 | 协和梅迪克斯株式会社 | 免疫测定待测组分的方法 |
| US20080255004A1 (en) | 2006-11-15 | 2008-10-16 | Invitrogen Dynal As | Methods of reversibly binding a biotin compound to a support |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| CN101226118B (zh) | 2007-01-19 | 2010-06-16 | 中国医学科学院肿瘤研究所 | 一种兼容免疫荧光分析的细胞化学染色方法及其用途 |
| EP2137308B1 (en) * | 2007-03-26 | 2016-08-03 | Agenus Inc. | Cell surface display, screening and production of proteins of interest |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| CA2697282C (en) | 2007-08-20 | 2018-02-13 | Nextera As | Pvii phage display |
| ATE528077T1 (de) | 2007-12-07 | 2011-10-15 | Miltenyi Biotec Gmbh | Zentrifuge zur trennung einer probe in mindestens zwei komponenten |
| CN107254517A (zh) | 2008-01-18 | 2017-10-17 | 哈佛大学校长及研究员协会 | 在体液中检测疾病或病症标志的方法 |
| ES2666667T3 (es) | 2008-01-29 | 2018-05-07 | Fred Hutchinson Cancer Research Center | Identificación de células T CD8+ que son CD161 hi y/o IL-18R (alfa) hi y tienen una capacidad de evacuación rápida de fármacos |
| CN101446576B (zh) | 2008-12-29 | 2011-06-22 | 江苏省苏微微生物研究有限公司 | 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法 |
| WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
| US20110070581A1 (en) | 2009-04-27 | 2011-03-24 | Amit Gupta | Separation of Leukocytes |
| US20120214187A1 (en) * | 2009-11-02 | 2012-08-23 | Ffina Biolutions, Llc | Method for Enhancing the Sensitivity of Antibody Based Assays |
| US20120321665A1 (en) * | 2009-12-14 | 2012-12-20 | Benaroya Research Institute At Virginia Mason | Compositions and methods for treating airway inflammatory diseases |
| EP2363501A1 (en) | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Method for isolating target cells |
| US9678061B2 (en) | 2010-08-06 | 2017-06-13 | Ludwig-Maximilians-Universität München | Identification of T cell target antigens |
| WO2012058627A2 (en) | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| PL2734538T5 (pl) * | 2011-07-18 | 2025-11-12 | Iba Lifesciences Gmbh | Sposób odwracalnego barwienia komórki docelowej |
| WO2013038272A2 (en) | 2011-09-13 | 2013-03-21 | Uti Limited Partnership | Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| UA114108C2 (uk) * | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| KR20210149195A (ko) | 2012-07-13 | 2021-12-08 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 형질도입된 ｔ 세포의 투여 적합성을 평가하는 방법 |
| SI2884999T2 (sl) | 2012-08-20 | 2026-01-30 | Fred Hutchinson Cancer Center | Metoda in sestavki za celično imunoterapijo |
| US10065996B2 (en) | 2012-11-16 | 2018-09-04 | Iba Gmbh | Streptavidin muteins and methods of using them |
| CN103305464B (zh) | 2013-06-05 | 2015-04-15 | 南昌大学 | 直接分离cd4+和cd8+淋巴细胞的方法 |
| US9698876B2 (en) | 2013-07-23 | 2017-07-04 | Telefonaktiebolaget Lm Ericsson (Publ) | Transmission mode allocation in LTE networks |
| JP6942467B2 (ja) | 2013-12-20 | 2021-10-06 | フレッド ハッチンソン キャンサー リサーチ センター | タグ化キメラエフェクター分子およびそのレセプター |
| MX395149B (es) | 2014-04-07 | 2025-03-24 | Novartis Ag | Terapias de combinación que comprenden un receptor quimérico de antígeno cd19 para el cáncer. |
| US11274278B2 (en) | 2014-04-16 | 2022-03-15 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| BR112016024579A2 (pt) | 2014-04-23 | 2017-10-10 | Juno Therapeutics Inc | métodos para isolamento, cultura e engenharia genética de populações de célula imune para terapia adotiva |
| CA2946222C (en) | 2014-04-24 | 2020-12-22 | Miltenyi Biotec Gmbh | Method for automated generation of genetically modified t cells |
| JP6817069B2 (ja) | 2014-04-25 | 2021-01-20 | ブルーバード バイオ， インコーポレイテッド | 養子細胞療法薬を製造するための改善された方法 |
| CA2945414C (en) * | 2014-04-30 | 2023-05-09 | Iba Gmbh | Method of isolating a target cell |
| CN119925616A (zh) | 2015-04-08 | 2025-05-06 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体（car）表达细胞的联合疗法 |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| MX395154B (es) | 2015-10-22 | 2025-03-25 | Juno Therapeutics Gmbh | Métodos, kits, agentes y aparatos para transducción. |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| CA3007262A1 (en) | 2015-12-03 | 2017-06-08 | Lucas James Thompson | Modified chimeric receptors and related compositions and methods |
| SG11201909931PA (en) | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| IL280659B2 (en) | 2018-08-09 | 2024-11-01 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
-
2015
- 2015-04-16 US US15/304,045 patent/US11274278B2/en active Active
- 2015-04-16 MX MX2016013493A patent/MX380519B/es unknown
- 2015-04-16 HR HRP20211430TT patent/HRP20211430T1/hr unknown
- 2015-04-16 PL PL15720620T patent/PL3132247T3/pl unknown
- 2015-04-16 SI SI201531727T patent/SI3132247T1/sl unknown
- 2015-04-16 IL IL293587A patent/IL293587B2/en unknown
- 2015-04-16 HU HUE15720620A patent/HUE056852T2/hu unknown
- 2015-04-16 RU RU2020133435A patent/RU2020133435A/ru unknown
- 2015-04-16 RS RS20211143A patent/RS62471B1/sr unknown
- 2015-04-16 CN CN202010423347.2A patent/CN111961647A/zh active Pending
- 2015-04-16 EP EP15720620.2A patent/EP3132247B1/en active Active
- 2015-04-16 IL IL280738A patent/IL280738B/en unknown
- 2015-04-16 SG SG10201808491UA patent/SG10201808491UA/en unknown
- 2015-04-16 JP JP2017505717A patent/JP6696969B2/ja active Active
- 2015-04-16 KR KR1020167031915A patent/KR102459384B1/ko active Active
- 2015-04-16 WO PCT/EP2015/058339 patent/WO2015158868A2/en not_active Ceased
- 2015-04-16 AU AU2015248786A patent/AU2015248786B2/en active Active
- 2015-04-16 EP EP21191440.3A patent/EP3988920A1/en active Pending
- 2015-04-16 BR BR112016024072-3A patent/BR112016024072B1/pt active IP Right Grant
- 2015-04-16 RU RU2016144724A patent/RU2735640C9/ru active
- 2015-04-16 CA CA3176848A patent/CA3176848A1/en active Pending
- 2015-04-16 SG SG11201608557UA patent/SG11201608557UA/en unknown
- 2015-04-16 CA CA2945889A patent/CA2945889C/en active Active
- 2015-04-16 KR KR1020227036837A patent/KR102714469B1/ko active Active
- 2015-04-16 CN CN201580032543.4A patent/CN106414724A/zh active Pending
- 2015-04-16 SM SM20210600T patent/SMT202100600T1/it unknown
- 2015-04-16 MY MYPI2016703777A patent/MY184699A/en unknown
- 2015-04-16 PT PT157206202T patent/PT3132247T/pt unknown
- 2015-04-16 DK DK15720620.2T patent/DK3132247T3/da active
- 2015-04-16 ES ES15720620T patent/ES2892927T3/es active Active
- 2015-04-16 LT LTEPPCT/EP2015/058339T patent/LT3132247T/lt unknown
- 2015-04-16 CN CN202310417528.8A patent/CN116656605A/zh active Pending
-
2016
- 2016-10-11 PH PH12016502017A patent/PH12016502017B1/en unknown
- 2016-10-13 IL IL248360A patent/IL248360B/en active IP Right Grant
- 2016-10-13 MX MX2020014089A patent/MX2020014089A/es unknown
- 2016-10-16 SA SA516380090A patent/SA516380090B1/ar unknown
- 2016-10-16 SA SA520412247A patent/SA520412247B1/ar unknown
- 2016-10-16 SA SA521421882A patent/SA521421882B1/ar unknown
-
2020
- 2020-04-23 JP JP2020076705A patent/JP7762499B2/ja active Active
- 2020-07-01 PH PH12020551028A patent/PH12020551028A1/en unknown
-
2021
- 2021-11-02 CY CY20211100943T patent/CY1124717T1/el unknown
-
2022
- 2022-01-27 AU AU2022200527A patent/AU2022200527B9/en active Active
- 2022-03-11 US US17/693,292 patent/US20220195388A1/en active Pending
-
2023
- 2023-02-20 JP JP2023024443A patent/JP2023062124A/ja active Pending
-
2024
- 2024-12-20 JP JP2024225388A patent/JP2025060756A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017513524A5 (show.php) | ||
| HRP20211430T1 (hr) | Postupci, kompleti i uređaj za ekspanziju populacije stanica | |
| US11913952B2 (en) | Methods for detecting peptide/MHC/TCR binding | |
| US20180284125A1 (en) | Proteomic analysis with nucleic acid identifiers | |
| Uhlmann | The mechanism of sister chromatid cohesion | |
| US8110351B2 (en) | Method for isolating nucleic acids and protein from a single sample | |
| JP2017514481A5 (show.php) | ||
| JP6298456B2 (ja) | アプタマーに基づく多重化アッセイ | |
| Schumacher | Bacterial plasmid partition machinery: a minimalist approach to survival | |
| WO2008140573A3 (en) | Methods for reversibly binding a biotin compound to a support | |
| WO2008028081A3 (en) | Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein | |
| JP2018198599A5 (show.php) | ||
| JP2017536846A5 (show.php) | ||
| JP2018534939A (ja) | ポリメラーゼ複合体の精製 | |
| KR102890413B1 (ko) | 세포 내에서 인 비트로 디스플레이 라이브러리를 스크리닝하는 방법 | |
| Kim et al. | NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics | |
| Fischer et al. | SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells | |
| Peng et al. | The splicing factor PSF is part of a large complex that assembles in the absence of pre-mRNA and contains all 5 snRNPs | |
| Ludwig et al. | High‐throughput single‐cell sequencing of paired TCRα and TCRβ genes for the direct expression‐cloning and functional analysis of murine T‐cell receptors | |
| Cai et al. | Peptoid ligands that bind selectively to phosphoproteins | |
| Wang et al. | Comprehensive analysis of the DNA-binding specificity of an Aspergillus nidulans transcription factor, AmyR, using a bead display system | |
| Noirot-Gros et al. | The beta-propeller protein YxaL increases the processivity of the PcrA helicase | |
| WO2014185802A1 (en) | Dna aptamers binding the histidine tag and their application | |
| EP1400807A3 (en) | Use of novel stem cell markers for isolation of intestinal stem cells, and use of the intestinal stem cells thus obtained for the preparation of a therapeutical composition | |
| Gupta et al. | A complex of DNA gyrase and RNA polymerase fosters transcription in Mycobacterium smegmatis |