PL2734538T5 - Sposób odwracalnego barwienia komórki docelowej - Google Patents
Sposób odwracalnego barwienia komórki docelowejInfo
- Publication number
- PL2734538T5 PL2734538T5 PL12747985.5T PL12747985T PL2734538T5 PL 2734538 T5 PL2734538 T5 PL 2734538T5 PL 12747985 T PL12747985 T PL 12747985T PL 2734538 T5 PL2734538 T5 PL 2734538T5
- Authority
- PL
- Poland
- Prior art keywords
- target cell
- reversible staining
- staining
- reversible
- target
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508943P | 2011-07-18 | 2011-07-18 | |
| PCT/EP2012/063969 WO2013011011A2 (en) | 2011-07-18 | 2012-07-17 | Method of reversibly staining a target cell |
| EP12747985.5A EP2734538B2 (en) | 2011-07-18 | 2012-07-17 | Method of reversibly staining a target cell |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL2734538T3 PL2734538T3 (pl) | 2018-10-31 |
| PL2734538T5 true PL2734538T5 (pl) | 2025-11-12 |
Family
ID=46682800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12747985.5T PL2734538T5 (pl) | 2011-07-18 | 2012-07-17 | Sposób odwracalnego barwienia komórki docelowej |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9023604B2 (pl) |
| EP (2) | EP2734538B2 (pl) |
| JP (2) | JP6310388B2 (pl) |
| CN (2) | CN103797028B (pl) |
| ES (1) | ES2682750T5 (pl) |
| PL (1) | PL2734538T5 (pl) |
| PT (1) | PT2734538T (pl) |
| SI (1) | SI2734538T2 (pl) |
| TR (1) | TR201811128T4 (pl) |
| WO (1) | WO2013011011A2 (pl) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2734538T (pt) * | 2011-07-18 | 2018-08-02 | Iba Gmbh | Processo para corar, de forma reversível, uma célula-alvo |
| WO2013124474A2 (en) | 2012-02-23 | 2013-08-29 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| PT3524617T (pt) | 2013-03-15 | 2023-07-12 | Gladiator Biosciences Inc | Domínios gla como agentes terapêuticos |
| EP3132247B1 (en) | 2014-04-16 | 2021-08-18 | Juno Therapeutics GmbH | Methods, kits and apparatus for expanding a population of cells |
| ES2995052T3 (en) | 2014-04-23 | 2025-02-05 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| JP6661544B2 (ja) * | 2014-04-24 | 2020-03-11 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子改変したｔ細胞の自動生成法 |
| CA2945414C (en) | 2014-04-30 | 2023-05-09 | Iba Gmbh | Method of isolating a target cell |
| EP3037820A1 (en) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| US11867696B2 (en) * | 2015-02-06 | 2024-01-09 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| EP3365453A2 (en) * | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| IL258844B2 (en) | 2015-10-22 | 2024-03-01 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| EP3365678A1 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods for culturing cells and kits and apparatus for same |
| JP7165060B2 (ja) * | 2016-06-28 | 2022-11-02 | テクニッシェ ウニヴェルズィテート ミュンヘン | 受容体－リガンドｋｏｆｆ速度を分析するための可逆的細胞標識および不可逆的細胞標識の組み合わせ |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| EP3336545A1 (en) | 2016-12-13 | 2018-06-20 | Miltenyi Biotec GmbH | Reversible labeling of antigens in biological specimens |
| EP3336546B1 (en) | 2016-12-13 | 2020-07-01 | Miltenyi Biotec B.V. & Co. KG | Reversible cell labelling with conjugates having two releasable binding sites |
| EP3555267B1 (en) | 2016-12-16 | 2021-08-04 | Diagnologix, LLC | Buoyancy enabled separation method and system |
| CA3050085A1 (en) | 2017-01-20 | 2018-07-26 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| EP4647493A3 (en) | 2017-04-27 | 2026-01-14 | Juno Therapeutics, Inc. | Oligomeric particle reagents and methods of use thereof |
| ES3009018T3 (en) | 2017-07-29 | 2025-03-25 | Juno Therapeutics Inc | Reagents for expanding cells expressing recombinant receptors |
| WO2019032927A1 (en) | 2017-08-09 | 2019-02-14 | Juno Therapeutics, Inc. | METHODS FOR PRODUCING GENETICALLY MODIFIED CELL COMPOSITIONS AND COMPOSITIONS THEREOF |
| PE20201462A1 (es) * | 2017-09-05 | 2020-12-17 | Gladiator Biosciences Inc | Metodo de direccionamiento de exosomas |
| WO2019089855A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| WO2019113557A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| CN116148467A (zh) * | 2017-12-12 | 2023-05-23 | 清华大学 | 检测翻译后修饰蛋白质与其配体间相互作用的成套试剂 |
| CA3108657A1 (en) | 2018-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| WO2020048876A1 (en) | 2018-09-03 | 2020-03-12 | Technische Universitaet Muenchen | A double peptide tag combining reversibility and flexible functionalization |
| JP7504891B2 (ja) | 2018-09-11 | 2024-06-24 | ジュノー セラピューティクス インコーポレイテッド | 操作された細胞組成物のマススペクトロメトリー分析のための方法 |
| US12522660B2 (en) | 2018-10-31 | 2026-01-13 | C3S2 Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| CA3117720A1 (en) | 2018-11-06 | 2020-05-14 | Juno Therapeutics, Inc. | Process for producing genetically engineered t cells |
| CN113677995A (zh) | 2019-04-23 | 2021-11-19 | 美天施生物科技有限两合公司 | 使用具有用于增加荧光亮度的接头和酶促可释放荧光部分的缀合物的可逆细胞检测 |
| US20220220504A1 (en) | 2019-05-28 | 2022-07-14 | Miltenyi Biotec B.V. & Co. KG | Method for Generation of Genetically Modified T Cells |
| CA3139965A1 (en) | 2019-06-07 | 2020-12-10 | Ivie AIFUWA | Automated t cell culture |
| US12444491B2 (en) | 2019-08-30 | 2025-10-14 | Juno Therapeutics, Inc. | Machine learning methods for classifying cells |
| US20220315894A1 (en) | 2019-09-11 | 2022-10-06 | Miltenyi Biotec B.V. & Co. KG | Method for Transduction of T Cells in the Presence of Malignant Cells |
| IL292319B2 (en) | 2019-10-30 | 2026-01-01 | C3S2 Gmbh | Cell selection and/or stimulation devices and methods of use |
| US20230090117A1 (en) | 2020-01-28 | 2023-03-23 | Juno Therapeutics, Inc. | Methods for t cell transduction |
| MX2022009830A (es) | 2020-02-12 | 2022-10-28 | Juno Therapeutics Inc | Composiciones de celulas t que expresan receptores de antigenos quimericos dirigidos a bcma y metodos y usos de las mismas. |
| IL295384A (en) | 2020-02-12 | 2022-10-01 | Juno Therapeutics Inc | Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
| JP2023526278A (ja) | 2020-05-13 | 2023-06-21 | ジュノー セラピューティクス インコーポレイテッド | 組み換え受容体を発現しているドナーバッチ細胞を産生するための方法 |
| WO2021261451A1 (ja) | 2020-06-24 | 2021-12-30 | 旭化成メディカル株式会社 | タンパク質含有溶液の評価方法 |
| EP4204809A1 (en) | 2020-08-27 | 2023-07-05 | Miltenyi Biotec B.V. & Co. KG | Releasable reagents for cell separation |
| CN112285083B (zh) * | 2020-10-28 | 2022-01-07 | 上海睿钰生物科技有限公司 | 一种细胞杀伤效力的评价方法 |
| KR20240018454A (ko) | 2021-05-06 | 2024-02-13 | 주노 테라퓨틱스 게엠베하 | T 세포의 자극 및 형질도입 방법 |
| WO2023147510A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Chromatography arrays and related methods and kits |
| EP4227423A1 (en) | 2022-02-09 | 2023-08-16 | Technische Universität München | Means and methods for identifying high affinity t-cells |
| EP4514944A1 (en) | 2022-04-28 | 2025-03-05 | Bio-ReCell Ltd. | Method for separating target cells |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| JP2026501122A (ja) | 2022-12-09 | 2026-01-14 | ジュノー セラピューティクス インコーポレイテッド | ホログラフィックイメージングを使用して細胞表現型を予測するための機械学習方法 |
| CN121002052A (zh) | 2023-02-03 | 2025-11-21 | C3S2 有限公司 | 用于非病毒生产工程化免疫细胞的方法 |
| CN121127253A (zh) | 2023-02-28 | 2025-12-12 | 朱诺治疗学股份有限公司 | 治疗系统性自身免疫性疾病的细胞疗法 |
| WO2025049253A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Bridged cycle‑based inhibitors of dna‑dependent protein kinase and compositions and application in gene editing |
| WO2025049250A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 6,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049254A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Pyrazolopyridine based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049247A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 5,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025083196A1 (en) | 2023-10-18 | 2025-04-24 | Tq Therapeutics Gmbh | A method of manufacturing a cellular therapy product and respective kits and devices |
| WO2025160395A1 (en) | 2024-01-25 | 2025-07-31 | Juno Therapeutics, Inc. | Use of bridged cycle-based inhibitors of dna-dependent protein kinase in combination of dna polymerase theta inhibitor and compositions and application in gene editing |
| WO2025179188A1 (en) | 2024-02-22 | 2025-08-28 | Juno Therapeutics, Inc. | Pyrazole-based inhibitors of dna-dependent protein kinase and compositions and applications in gene editing |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| EP1227321A1 (en) * | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| PL217752B1 (pl) * | 2001-08-23 | 2014-08-29 | Genmab As | Izolowane ludzkie przeciwciało monoklonalne wobec IL-15 lub jego fragment wiążący antygen i związane z nimi hybrydoma, kompozycja farmaceutyczna oraz zastosowania medyczne |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| JP4517081B2 (ja) * | 2005-12-22 | 2010-08-04 | 独立行政法人産業技術総合研究所 | 免疫センサ用デバイス |
| JP4953390B2 (ja) * | 2006-11-02 | 2012-06-13 | 国立大学法人 鹿児島大学 | ＩｇＧ結合性ペプチド |
| CN101587043B (zh) * | 2008-05-20 | 2013-10-02 | 北京莱尔生物医药科技有限公司 | 从生物体液样本中富集与检测稀有细胞的整合方法 |
| WO2010017103A2 (en) | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
| PT2734538T (pt) * | 2011-07-18 | 2018-08-02 | Iba Gmbh | Processo para corar, de forma reversível, uma célula-alvo |
-
2012
- 2012-07-17 PT PT127479855T patent/PT2734538T/pt unknown
- 2012-07-17 PL PL12747985.5T patent/PL2734538T5/pl unknown
- 2012-07-17 CN CN201280045377.8A patent/CN103797028B/zh active Active
- 2012-07-17 ES ES12747985T patent/ES2682750T5/es active Active
- 2012-07-17 EP EP12747985.5A patent/EP2734538B2/en active Active
- 2012-07-17 TR TR2018/11128T patent/TR201811128T4/tr unknown
- 2012-07-17 US US14/234,463 patent/US9023604B2/en active Active
- 2012-07-17 CN CN201710565030.0A patent/CN107843730B/zh active Active
- 2012-07-17 EP EP18168713.8A patent/EP3418295B1/en active Active
- 2012-07-17 JP JP2014520636A patent/JP6310388B2/ja active Active
- 2012-07-17 SI SI201231352T patent/SI2734538T2/sl unknown
- 2012-07-17 WO PCT/EP2012/063969 patent/WO2013011011A2/en not_active Ceased
-
2015
- 2015-04-24 US US14/696,284 patent/US9188589B2/en active Active
-
2018
- 2018-03-16 JP JP2018048668A patent/JP6770989B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2734538A2 (en) | 2014-05-28 |
| JP2014529361A (ja) | 2014-11-06 |
| ES2682750T5 (en) | 2025-02-04 |
| US20140295458A1 (en) | 2014-10-02 |
| CN107843730B (zh) | 2021-08-20 |
| PT2734538T (pt) | 2018-08-02 |
| ES2682750T3 (es) | 2018-09-21 |
| SI2734538T1 (sl) | 2018-09-28 |
| US20150301046A1 (en) | 2015-10-22 |
| JP6770989B2 (ja) | 2020-10-21 |
| EP2734538B1 (en) | 2018-05-02 |
| US9188589B2 (en) | 2015-11-17 |
| EP3418295B1 (en) | 2020-09-02 |
| CN103797028A (zh) | 2014-05-14 |
| WO2013011011A3 (en) | 2013-05-02 |
| CN107843730A (zh) | 2018-03-27 |
| WO2013011011A2 (en) | 2013-01-24 |
| CN103797028B (zh) | 2017-08-25 |
| SI2734538T2 (sl) | 2024-10-30 |
| TR201811128T4 (tr) | 2018-08-27 |
| US9023604B2 (en) | 2015-05-05 |
| JP2018119982A (ja) | 2018-08-02 |
| EP2734538B2 (en) | 2024-07-03 |
| EP3418295A1 (en) | 2018-12-26 |
| JP6310388B2 (ja) | 2018-04-11 |
| HK1258907A1 (en) | 2019-11-22 |
| PL2734538T3 (pl) | 2018-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2734538T5 (pl) | Sposób odwracalnego barwienia komórki docelowej | |
| PL3415616T3 (pl) | Sposób odmładzania komórek | |
| HUE041929T2 (hu) | Eljárás szaruhártya endotél sejtek irányított differenciálására | |
| HUE037174T2 (hu) | Tenyésztõ tápközeg õssejtekhez | |
| HUE040455T2 (hu) | T-sejt aktiválás inhibitorai | |
| DK2837680T3 (da) | Mammaliacellekultur | |
| HUE039165T2 (hu) | Eljárás intrapredikciós mód származtatására | |
| DK3432580T3 (da) | Fremgangsmåde til at udlede bevægelsesinformation | |
| DK3330370T3 (da) | Fremgangsmåde til dyrkning af cho-celler | |
| EP2681306A4 (en) | CELL CULTURE SYSTEM | |
| DK2751387T3 (da) | Selvsuspenderende proppanter til hydraulisk frakturering | |
| DK2755963T3 (da) | Nye dihydroquinolin-2-on-derivater | |
| DK2732131T3 (da) | Positioneringsfremgangsmåde | |
| PL2744768T3 (pl) | Sposób wytwarzania klinkieru zawierającego ternezyt | |
| DK2569129T3 (da) | Fremgangsmåde til styring af en automatiseret arbejdscelle | |
| EP2734529A4 (en) | BTK INHIBITORS | |
| EP2788470A4 (en) | CLOSED BIOREACTORS | |
| IL245535B (en) | Method of engrafting cells from solid tissues | |
| PL2776455T3 (pl) | Rodopsyny kanałowe do kontroli optycznej komórek | |
| DK3104003T3 (da) | Nacellekonstruktion til en vindmølle | |
| BR112014009795A2 (pt) | método | |
| BR112014007958A2 (pt) | método | |
| EP2751846A4 (en) | SOLAR CELL | |
| BR112014001765A2 (pt) | método | |
| BR112014001237A2 (pt) | método |