PL3415616T3 - Sposób odmładzania komórek - Google Patents
Sposób odmładzania komórekInfo
- Publication number
- PL3415616T3 PL3415616T3 PL18183987.9T PL18183987T PL3415616T3 PL 3415616 T3 PL3415616 T3 PL 3415616T3 PL 18183987 T PL18183987 T PL 18183987T PL 3415616 T3 PL3415616 T3 PL 3415616T3
- Authority
- PL
- Poland
- Prior art keywords
- rejuvenation method
- cell rejuvenation
- cell
- rejuvenation
- Prior art date
Links
- 230000003716 rejuvenation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11161771 | 2011-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3415616T3 true PL3415616T3 (pl) | 2024-10-14 |
Family
ID=45094314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18183987.9T PL3415616T3 (pl) | 2011-04-08 | 2012-04-10 | Sposób odmładzania komórek |
| PL12712670T PL2694642T3 (pl) | 2011-04-08 | 2012-04-10 | Sposób odmładzania komórek |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12712670T PL2694642T3 (pl) | 2011-04-08 | 2012-04-10 | Sposób odmładzania komórek |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9476031B2 (pl) |
| EP (3) | EP2694642B8 (pl) |
| JP (3) | JP6584776B2 (pl) |
| CN (1) | CN103562376B (pl) |
| ES (2) | ES2991402T3 (pl) |
| PL (2) | PL3415616T3 (pl) |
| WO (1) | WO2012136841A1 (pl) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140051600A1 (en) * | 2012-08-16 | 2014-02-20 | Mandala Biosciences Llc | SUPERCENTENARIAN INDUCED PLURIPOTENT STEM (sciPS) CELLS AND METHODS OF MAKING AND USING THEREOF |
| WO2014172507A1 (en) * | 2013-04-16 | 2014-10-23 | Memorial Sloan-Kettering Cancer Center | Age-modified cells and methods for making age-modified cells |
| CA2963934C (en) | 2014-10-06 | 2023-05-09 | Memorial Sloan-Kettering Cancer Center | Method to reduce oncogenic potential of induced pluripotent stem cells from aged donors |
| EP3209680B1 (en) * | 2014-10-21 | 2019-04-17 | Consiglio Nazionale delle Ricerche | New methods and agents for cellular reprogramming |
| WO2016185481A2 (en) | 2015-05-20 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Method of targeting senescent cells |
| CN105061594B (zh) * | 2015-07-16 | 2019-03-19 | 中国人民解放军第二军医大学 | 一种抗人Oct4单克隆抗体及其制备与应用 |
| US20180245051A1 (en) * | 2015-11-02 | 2018-08-30 | Orig3N, Inc. | Methods for generating induced pluripotent stem cells via cell cycle synchronization |
| CN108348556A (zh) * | 2015-11-02 | 2018-07-31 | 欧瑞3恩公司 | 细胞周期阻滞提高产生诱导多能干细胞的效率 |
| WO2018148409A1 (en) * | 2017-02-08 | 2018-08-16 | Orig3N, Inc. | Systems, methods, and apparatus for induced pluripotent stem cell isolation and combinatorial production |
| WO2019166702A1 (fr) | 2018-02-28 | 2019-09-06 | Hagalife | Utilisation d'un procédé d'irradiation flash pour augmenter la longévité et/ou pour retarder les effets du vieillissement chez les mammifères |
| EP3764795A4 (en) * | 2018-03-13 | 2022-05-11 | The Board Of Trustees Of The Leland Stanford Junior University | TRANSIENT CELLULAR REPROGRAMMING TO REVERSE CELLULAR AGING |
| CN110628821B (zh) * | 2018-06-25 | 2022-02-18 | 首都医科大学宣武医院 | 一种细胞模型及其制备方法、应用 |
| JP7241483B2 (ja) * | 2018-07-23 | 2023-03-17 | 株式会社ノエビア | 皮膚用組成物 |
| US12274733B2 (en) | 2018-09-28 | 2025-04-15 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| CN113453702A (zh) | 2018-09-28 | 2021-09-28 | 哈佛大学的校长及成员们 | 细胞重编程以逆转衰老并促进组织和组织再生 |
| WO2020206187A1 (en) * | 2019-04-02 | 2020-10-08 | Centagen, Inc | Engineered system of stem cell rejuvenation to treat aging and disease |
| GB201909975D0 (en) * | 2019-07-11 | 2019-08-28 | Babraham Inst | Novel reprogramming method |
| IL275186A (en) | 2020-06-07 | 2022-01-01 | Yeda Res & Dev | Human antibodies against grp94 and uses |
| CN116348592A (zh) * | 2020-10-02 | 2023-06-27 | 菲特治疗公司 | 诱导性多能干细胞的改善的重编程、维持和保存 |
| IL302744A (en) * | 2020-11-24 | 2023-07-01 | Lyell Immunopharma Inc | Methods for production, total preparations and methods of using regenerated T cells |
| CN116157529A (zh) * | 2020-12-22 | 2023-05-23 | 中国科学院动物研究所 | 鉴定和/或调节衰老的方法 |
| WO2023288287A2 (en) * | 2021-07-15 | 2023-01-19 | Turn Biotechnologies, Inc. | Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment |
| WO2023205406A1 (en) * | 2022-04-21 | 2023-10-26 | Restoration Biologics Llc | Nutritional or dietary supplement to enhance regenerative medicine therapies |
| IL319222A (en) | 2022-09-06 | 2025-04-01 | Max Planck Gesellschaft Zur F?Rderung Der Wss E V | Engineering SOX/OCT heterodimerization to induce high-level developmental initiation |
| CN115607689A (zh) * | 2022-10-13 | 2023-01-17 | 呈诺再生医学科技(北京)有限公司 | Klf7基因在制备逆转细胞衰老的药物中的应用 |
| US12252518B2 (en) | 2023-01-06 | 2025-03-18 | Life Biosciences, Inc. | Methods of treating non-arteritic anterior ischemic optic neuropathy |
| CN119265241A (zh) * | 2023-06-30 | 2025-01-07 | 深圳菁童生命科学有限公司 | 一种无相分离转录因子介导启始阶段重编程使细胞年轻化的方法 |
| WO2025011625A1 (zh) * | 2023-07-11 | 2025-01-16 | 南京瑞初医药有限公司 | 组合物及其使用方法 |
| WO2025166291A1 (en) * | 2024-02-01 | 2025-08-07 | Immorta Bio, Inc. | Systemic means of dedifferentiation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003508079A (ja) * | 1999-09-07 | 2003-03-04 | アドバンスド セル テクノロジー、インコーポレイテッド | 老年期体細胞からクローン化された動物中の細胞寿命のテロメア回復と延長 |
| CN101356270B (zh) | 2005-12-13 | 2014-02-12 | 国立大学法人京都大学 | 核重新编程因子 |
| EP2096169B1 (en) * | 2007-10-31 | 2020-11-18 | Kyoto University | Nuclear reprogramming method |
| WO2009115295A1 (en) | 2008-03-17 | 2009-09-24 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination |
| DK2322611T3 (en) * | 2008-07-16 | 2016-09-05 | Ip Pharma Co Ltd | A process for producing reprogrammed cells using chromosomally non-integrated viral vector |
| WO2010042490A1 (en) | 2008-10-06 | 2010-04-15 | Boston Medical Center Corporation | A single lentiviral vector system for induced pluripotent (ips) stem cells derivation |
| KR101764437B1 (ko) * | 2009-03-20 | 2017-08-02 | 메소블라스트, 아이엔씨. | 재프로그램된 다분화능 세포의 생성 방법 |
| CN102625837B (zh) | 2009-08-07 | 2015-01-14 | 国立大学法人京都大学 | 有效建立诱导的多能干细胞的方法 |
-
2012
- 2012-04-10 ES ES18183987T patent/ES2991402T3/es active Active
- 2012-04-10 EP EP12712670.4A patent/EP2694642B8/en active Active
- 2012-04-10 PL PL18183987.9T patent/PL3415616T3/pl unknown
- 2012-04-10 EP EP18183987.9A patent/EP3415616B1/en active Active
- 2012-04-10 CN CN201280024987.XA patent/CN103562376B/zh active Active
- 2012-04-10 US US14/009,662 patent/US9476031B2/en active Active
- 2012-04-10 PL PL12712670T patent/PL2694642T3/pl unknown
- 2012-04-10 ES ES12712670T patent/ES2695550T3/es active Active
- 2012-04-10 WO PCT/EP2012/056409 patent/WO2012136841A1/en not_active Ceased
- 2012-04-10 JP JP2014503172A patent/JP6584776B2/ja active Active
- 2012-04-10 EP EP24167906.7A patent/EP4382171A3/en active Pending
-
2016
- 2016-09-12 US US15/262,031 patent/US20160376560A1/en not_active Abandoned
-
2017
- 2017-03-29 JP JP2017065056A patent/JP2017140040A/ja active Pending
-
2018
- 2018-07-06 US US16/028,532 patent/US20180312813A1/en not_active Abandoned
-
2019
- 2019-05-22 JP JP2019095883A patent/JP7051748B2/ja active Active
- 2019-12-05 US US16/704,064 patent/US11414649B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103562376B (zh) | 2017-12-29 |
| JP6584776B2 (ja) | 2019-10-02 |
| EP2694642B8 (en) | 2018-10-17 |
| EP3415616A1 (en) | 2018-12-19 |
| JP2014511689A (ja) | 2014-05-19 |
| US20200095556A1 (en) | 2020-03-26 |
| US9476031B2 (en) | 2016-10-25 |
| EP2694642B1 (en) | 2018-08-15 |
| CN103562376A (zh) | 2014-02-05 |
| ES2695550T3 (es) | 2019-01-09 |
| JP2017140040A (ja) | 2017-08-17 |
| US20180312813A1 (en) | 2018-11-01 |
| US20140056860A1 (en) | 2014-02-27 |
| EP4382171A2 (en) | 2024-06-12 |
| ES2991402T3 (es) | 2024-12-03 |
| US20160376560A1 (en) | 2016-12-29 |
| EP2694642A1 (en) | 2014-02-12 |
| JP7051748B2 (ja) | 2022-04-11 |
| WO2012136841A1 (en) | 2012-10-11 |
| PL2694642T3 (pl) | 2019-01-31 |
| EP3415616B1 (en) | 2024-05-22 |
| JP2019151660A (ja) | 2019-09-12 |
| US11414649B2 (en) | 2022-08-16 |
| EP4382171A3 (en) | 2024-10-09 |
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