PL2694642T3 - Sposób odmładzania komórek - Google Patents

Sposób odmładzania komórek

Info

Publication number
PL2694642T3
PL2694642T3 PL12712670T PL12712670T PL2694642T3 PL 2694642 T3 PL2694642 T3 PL 2694642T3 PL 12712670 T PL12712670 T PL 12712670T PL 12712670 T PL12712670 T PL 12712670T PL 2694642 T3 PL2694642 T3 PL 2694642T3
Authority
PL
Poland
Prior art keywords
rejuvenating cells
rejuvenating
cells
Prior art date
Application number
PL12712670T
Other languages
English (en)
Inventor
Alexandre PRIEUR
Ollivier MILHAVET
Jean-Marc Lemaitre
Laure LAPASSET
Original Assignee
Institut National De La Santé Et De La Recherche Médicale (Inserm)
Centre National De La Recherche Scientifique (C.N.R.S.)
Université De Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National De La Santé Et De La Recherche Médicale (Inserm), Centre National De La Recherche Scientifique (C.N.R.S.), Université De Montpellier filed Critical Institut National De La Santé Et De La Recherche Médicale (Inserm)
Publication of PL2694642T3 publication Critical patent/PL2694642T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/605—Nanog
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/608—Lin28
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL12712670T 2011-04-08 2012-04-10 Sposób odmładzania komórek PL2694642T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11161771 2011-04-08
PCT/EP2012/056409 WO2012136841A1 (en) 2011-04-08 2012-04-10 Method for rejuvenating cells
EP12712670.4A EP2694642B8 (en) 2011-04-08 2012-04-10 Method for rejuvenating cells

Publications (1)

Publication Number Publication Date
PL2694642T3 true PL2694642T3 (pl) 2019-01-31

Family

ID=45094314

Family Applications (2)

Application Number Title Priority Date Filing Date
PL18183987.9T PL3415616T3 (pl) 2011-04-08 2012-04-10 Sposób odmładzania komórek
PL12712670T PL2694642T3 (pl) 2011-04-08 2012-04-10 Sposób odmładzania komórek

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL18183987.9T PL3415616T3 (pl) 2011-04-08 2012-04-10 Sposób odmładzania komórek

Country Status (7)

Country Link
US (4) US9476031B2 (pl)
EP (3) EP2694642B8 (pl)
JP (3) JP6584776B2 (pl)
CN (1) CN103562376B (pl)
ES (2) ES2991402T3 (pl)
PL (2) PL3415616T3 (pl)
WO (1) WO2012136841A1 (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140051600A1 (en) * 2012-08-16 2014-02-20 Mandala Biosciences Llc SUPERCENTENARIAN INDUCED PLURIPOTENT STEM (sciPS) CELLS AND METHODS OF MAKING AND USING THEREOF
WO2014172507A1 (en) * 2013-04-16 2014-10-23 Memorial Sloan-Kettering Cancer Center Age-modified cells and methods for making age-modified cells
CA2963934C (en) 2014-10-06 2023-05-09 Memorial Sloan-Kettering Cancer Center Method to reduce oncogenic potential of induced pluripotent stem cells from aged donors
EP3209680B1 (en) * 2014-10-21 2019-04-17 Consiglio Nazionale delle Ricerche New methods and agents for cellular reprogramming
WO2016185481A2 (en) 2015-05-20 2016-11-24 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
CN105061594B (zh) * 2015-07-16 2019-03-19 中国人民解放军第二军医大学 一种抗人Oct4单克隆抗体及其制备与应用
US20180245051A1 (en) * 2015-11-02 2018-08-30 Orig3N, Inc. Methods for generating induced pluripotent stem cells via cell cycle synchronization
CN108348556A (zh) * 2015-11-02 2018-07-31 欧瑞3恩公司 细胞周期阻滞提高产生诱导多能干细胞的效率
WO2018148409A1 (en) * 2017-02-08 2018-08-16 Orig3N, Inc. Systems, methods, and apparatus for induced pluripotent stem cell isolation and combinatorial production
WO2019166702A1 (fr) 2018-02-28 2019-09-06 Hagalife Utilisation d'un procédé d'irradiation flash pour augmenter la longévité et/ou pour retarder les effets du vieillissement chez les mammifères
EP3764795A4 (en) * 2018-03-13 2022-05-11 The Board Of Trustees Of The Leland Stanford Junior University TRANSIENT CELLULAR REPROGRAMMING TO REVERSE CELLULAR AGING
CN110628821B (zh) * 2018-06-25 2022-02-18 首都医科大学宣武医院 一种细胞模型及其制备方法、应用
JP7241483B2 (ja) * 2018-07-23 2023-03-17 株式会社ノエビア 皮膚用組成物
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
CN113453702A (zh) 2018-09-28 2021-09-28 哈佛大学的校长及成员们 细胞重编程以逆转衰老并促进组织和组织再生
WO2020206187A1 (en) * 2019-04-02 2020-10-08 Centagen, Inc Engineered system of stem cell rejuvenation to treat aging and disease
GB201909975D0 (en) * 2019-07-11 2019-08-28 Babraham Inst Novel reprogramming method
IL275186A (en) 2020-06-07 2022-01-01 Yeda Res & Dev Human antibodies against grp94 and uses
CN116348592A (zh) * 2020-10-02 2023-06-27 菲特治疗公司 诱导性多能干细胞的改善的重编程、维持和保存
IL302744A (en) * 2020-11-24 2023-07-01 Lyell Immunopharma Inc Methods for production, total preparations and methods of using regenerated T cells
CN116157529A (zh) * 2020-12-22 2023-05-23 中国科学院动物研究所 鉴定和/或调节衰老的方法
WO2023288287A2 (en) * 2021-07-15 2023-01-19 Turn Biotechnologies, Inc. Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment
WO2023205406A1 (en) * 2022-04-21 2023-10-26 Restoration Biologics Llc Nutritional or dietary supplement to enhance regenerative medicine therapies
IL319222A (en) 2022-09-06 2025-04-01 Max Planck Gesellschaft Zur F?Rderung Der Wss E V Engineering SOX/OCT heterodimerization to induce high-level developmental initiation
CN115607689A (zh) * 2022-10-13 2023-01-17 呈诺再生医学科技(北京)有限公司 Klf7基因在制备逆转细胞衰老的药物中的应用
US12252518B2 (en) 2023-01-06 2025-03-18 Life Biosciences, Inc. Methods of treating non-arteritic anterior ischemic optic neuropathy
CN119265241A (zh) * 2023-06-30 2025-01-07 深圳菁童生命科学有限公司 一种无相分离转录因子介导启始阶段重编程使细胞年轻化的方法
WO2025011625A1 (zh) * 2023-07-11 2025-01-16 南京瑞初医药有限公司 组合物及其使用方法
WO2025166291A1 (en) * 2024-02-01 2025-08-07 Immorta Bio, Inc. Systemic means of dedifferentiation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508079A (ja) * 1999-09-07 2003-03-04 アドバンスド セル テクノロジー、インコーポレイテッド 老年期体細胞からクローン化された動物中の細胞寿命のテロメア回復と延長
CN101356270B (zh) 2005-12-13 2014-02-12 国立大学法人京都大学 核重新编程因子
EP2096169B1 (en) * 2007-10-31 2020-11-18 Kyoto University Nuclear reprogramming method
WO2009115295A1 (en) 2008-03-17 2009-09-24 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination
DK2322611T3 (en) * 2008-07-16 2016-09-05 Ip Pharma Co Ltd A process for producing reprogrammed cells using chromosomally non-integrated viral vector
WO2010042490A1 (en) 2008-10-06 2010-04-15 Boston Medical Center Corporation A single lentiviral vector system for induced pluripotent (ips) stem cells derivation
KR101764437B1 (ko) * 2009-03-20 2017-08-02 메소블라스트, 아이엔씨. 재프로그램된 다분화능 세포의 생성 방법
CN102625837B (zh) 2009-08-07 2015-01-14 国立大学法人京都大学 有效建立诱导的多能干细胞的方法

Also Published As

Publication number Publication date
CN103562376B (zh) 2017-12-29
JP6584776B2 (ja) 2019-10-02
EP2694642B8 (en) 2018-10-17
EP3415616A1 (en) 2018-12-19
JP2014511689A (ja) 2014-05-19
US20200095556A1 (en) 2020-03-26
US9476031B2 (en) 2016-10-25
EP2694642B1 (en) 2018-08-15
CN103562376A (zh) 2014-02-05
ES2695550T3 (es) 2019-01-09
JP2017140040A (ja) 2017-08-17
US20180312813A1 (en) 2018-11-01
US20140056860A1 (en) 2014-02-27
EP4382171A2 (en) 2024-06-12
ES2991402T3 (es) 2024-12-03
PL3415616T3 (pl) 2024-10-14
US20160376560A1 (en) 2016-12-29
EP2694642A1 (en) 2014-02-12
JP7051748B2 (ja) 2022-04-11
WO2012136841A1 (en) 2012-10-11
EP3415616B1 (en) 2024-05-22
JP2019151660A (ja) 2019-09-12
US11414649B2 (en) 2022-08-16
EP4382171A3 (en) 2024-10-09

Similar Documents

Publication Publication Date Title
PL2694642T3 (pl) Sposób odmładzania komórek
GB2500163B (en) Method
GB2493207B (en) Method
GB201120527D0 (en) Method
GB201116530D0 (en) Method
GB201117477D0 (en) Method
GB201105436D0 (en) Method
GB201220620D0 (en) Method
GB201212757D0 (en) Method
GB201121301D0 (en) Method
GB201114919D0 (en) Method
GB201114325D0 (en) Method
GB201101219D0 (en) Method
GB201117476D0 (en) Method
GB201117358D0 (en) Method
GB201115783D0 (en) Method
GB201111673D0 (en) Method
GB201111189D0 (en) Method
GB201122297D0 (en) Vaccine - screening method
PL394625A1 (pl) Sposób chlorowodorowania glicerolu
GB201108041D0 (en) Method
PL396508A1 (pl) Sposób otrzymywania elektrolitu cynkowego
GB201119967D0 (en) Method
GB201118964D0 (en) Method
GB201114391D0 (en) Method