JP2017504311A5 - - Google Patents
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- JP2017504311A5 JP2017504311A5 JP2016538000A JP2016538000A JP2017504311A5 JP 2017504311 A5 JP2017504311 A5 JP 2017504311A5 JP 2016538000 A JP2016538000 A JP 2016538000A JP 2016538000 A JP2016538000 A JP 2016538000A JP 2017504311 A5 JP2017504311 A5 JP 2017504311A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- rpe
- culturing
- days
- cultured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 62
- 238000000034 method Methods 0.000 claims 31
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 24
- 239000003112 inhibitor Substances 0.000 claims 13
- 238000012258 culturing Methods 0.000 claims 12
- 239000012190 activator Substances 0.000 claims 8
- 230000037361 pathway Effects 0.000 claims 8
- -1 4- (piperazin-1-yl) phenyl Chemical group 0.000 claims 3
- FHYUGAJXYORMHI-UHFFFAOYSA-N SB 431542 Chemical compound C1=CC(C(=O)N)=CC=C1C1=NC(C=2C=C3OCOC3=CC=2)=C(C=2N=CC=CC=2)N1 FHYUGAJXYORMHI-UHFFFAOYSA-N 0.000 claims 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 3
- 238000010899 nucleation Methods 0.000 claims 3
- 238000011536 re-plating Methods 0.000 claims 3
- 239000002356 single layer Substances 0.000 claims 3
- IHLVSLOZUHKNMQ-UHFFFAOYSA-N 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine Chemical compound C=1C=C2C(C=3C(=NN4CCCC4=3)C=3N=CC=CC=3)=CC=NC2=CC=1OCCN1CCOCC1 IHLVSLOZUHKNMQ-UHFFFAOYSA-N 0.000 claims 2
- 102000005606 Activins Human genes 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 2
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 2
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 2
- IBCXZJCWDGCXQT-UHFFFAOYSA-N LY 364947 Chemical compound C=1C=NC2=CC=CC=C2C=1C1=CNN=C1C1=CC=CC=N1 IBCXZJCWDGCXQT-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- WGZOTBUYUFBEPZ-UHFFFAOYSA-N SB 505124 Chemical compound CC1=CC=CC(C2=C(N=C(N2)C(C)(C)C)C=2C=C3OCOC3=CC=2)=N1 WGZOTBUYUFBEPZ-UHFFFAOYSA-N 0.000 claims 2
- 239000000488 activin Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000004114 suspension culture Methods 0.000 claims 2
- LBPKYPYHDKKRFS-UHFFFAOYSA-N 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- Chemical compound CC1=CC=CC(C2=C(C=NN2)C=2N=C3C=CC=NC3=CC=2)=N1 LBPKYPYHDKKRFS-UHFFFAOYSA-N 0.000 claims 1
- BERLXWPRSBJFHO-UHFFFAOYSA-N 2-(5-chloro-2-fluorophenyl)-n-pyridin-4-ylpteridin-4-amine Chemical compound FC1=CC=C(Cl)C=C1C1=NC(NC=2C=CN=CC=2)=C(N=CC=N2)C2=N1 BERLXWPRSBJFHO-UHFFFAOYSA-N 0.000 claims 1
- JONFDFIXMPXTRH-UHFFFAOYSA-N 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine Chemical compound CC1=CC=CC(C=2N=C3C=CC=CC3=C(NC=3C=CN=CC=3)N=2)=N1 JONFDFIXMPXTRH-UHFFFAOYSA-N 0.000 claims 1
- VRQZQTWWFHBPNK-UHFFFAOYSA-N 2-[4-methyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridine Chemical compound C=1C2=CN=CC=C2SC=1C1=C(C)C=NN1C1=CC=CC(C)=N1 VRQZQTWWFHBPNK-UHFFFAOYSA-N 0.000 claims 1
- ROHZDDHEDXKZQL-UHFFFAOYSA-N 2-methyl-5-[6-(3-methylphenyl)-7H-imidazo[1,2-a]imidazol-5-yl]benzotriazole Chemical compound CN1N=C2C(=N1)C=CC(=C2)C2=C(N=C1N2C=CN1)C=1C=C(C=CC1)C ROHZDDHEDXKZQL-UHFFFAOYSA-N 0.000 claims 1
- HIJMSZGHKQPPJS-UHFFFAOYSA-N 3-(6-methylpyridin-2-yl)-n-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide Chemical compound CC1=CC=CC(C=2C(=CN(N=2)C(=S)NC=2C=CC=CC=2)C=2C3=CC=CC=C3N=CC=2)=N1 HIJMSZGHKQPPJS-UHFFFAOYSA-N 0.000 claims 1
- QNZSQJBDZIOEAN-UHFFFAOYSA-N 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]phenol Chemical compound CC1=CC=CC(C=2C(=C3CCCN3N=2)C=2C=CC(O)=CC=2)=N1 QNZSQJBDZIOEAN-UHFFFAOYSA-N 0.000 claims 1
- CDOVNWNANFFLFJ-UHFFFAOYSA-N 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline Chemical compound C1CNCCN1C1=CC=C(C2=CN3N=CC(=C3N=C2)C=2C3=CC=CC=C3N=CC=2)C=C1 CDOVNWNANFFLFJ-UHFFFAOYSA-N 0.000 claims 1
- WKHRIIQNWCIMKB-UHFFFAOYSA-N 6-methyl-2-phenyl-3h-thieno[2,3-d]pyrimidin-4-one Chemical compound S1C(C)=CC(C(N2)=O)=C1N=C2C1=CC=CC=C1 WKHRIIQNWCIMKB-UHFFFAOYSA-N 0.000 claims 1
- 102100034134 Activin receptor type-1B Human genes 0.000 claims 1
- 102100034135 Activin receptor type-1C Human genes 0.000 claims 1
- 102100025423 Bone morphogenetic protein receptor type-1A Human genes 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 101000799140 Homo sapiens Activin receptor type-1 Proteins 0.000 claims 1
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims 1
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 claims 1
- 101000934638 Homo sapiens Bone morphogenetic protein receptor type-1A Proteins 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- XHBVYDAKJHETMP-UHFFFAOYSA-N dorsomorphin Chemical class C=1C=C(C2=CN3N=CC(=C3N=C2)C=2C=CN=CC=2)C=CC=1OCCN1CCCCC1 XHBVYDAKJHETMP-UHFFFAOYSA-N 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 102000045246 noggin Human genes 0.000 claims 1
- 108700007229 noggin Proteins 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914445P | 2013-12-11 | 2013-12-11 | |
| US61/914,445 | 2013-12-11 | ||
| PCT/IB2014/066703 WO2015087231A1 (en) | 2013-12-11 | 2014-12-08 | Method for producing retinal pigment epithelial cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017504311A JP2017504311A (ja) | 2017-02-09 |
| JP2017504311A5 true JP2017504311A5 (https=) | 2018-01-25 |
Family
ID=52446403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538000A Pending JP2017504311A (ja) | 2013-12-11 | 2014-12-08 | 網膜色素上皮細胞を生成する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20150159134A1 (https=) |
| EP (1) | EP3080248A1 (https=) |
| JP (1) | JP2017504311A (https=) |
| KR (1) | KR101871084B1 (https=) |
| CN (1) | CN105814194A (https=) |
| AR (1) | AR098693A1 (https=) |
| AU (1) | AU2014363032A1 (https=) |
| BR (1) | BR112016012129A8 (https=) |
| CA (1) | CA2933083A1 (https=) |
| HK (1) | HK1221734A1 (https=) |
| IL (1) | IL245594A0 (https=) |
| MX (1) | MX2016007671A (https=) |
| TW (2) | TW201823451A (https=) |
| WO (1) | WO2015087231A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL281453B (en) | 2009-11-17 | 2022-07-01 | Astellas Inst For Regenerative Medicine | Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells |
| EP3221318B1 (en) * | 2014-11-21 | 2021-08-25 | Rigel Pharmaceuticals, Inc. | Fused imidazole derivatives as tgf-beta inhibitors |
| EP3240612B1 (en) * | 2014-12-30 | 2020-12-23 | Cell Cure Neurosciences Ltd. | Methods of treating retinal diseases |
| CA2972575A1 (en) * | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Rpe cell populations and methods of generating same |
| EP3916085A1 (en) * | 2014-12-30 | 2021-12-01 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
| CN108290855A (zh) | 2015-07-01 | 2018-07-17 | 西北大学 | 被取代的喹唑啉化合物及其调节葡糖脑苷脂酶活性的用途 |
| US11066642B2 (en) | 2015-08-05 | 2021-07-20 | Cell Cure Neurosciences Ltd | Preparation of retinal pigment epithelium cells |
| AU2016318774B2 (en) * | 2015-09-08 | 2022-08-18 | FUJIFILM Cellular Dynamics, Inc. | MACS-based purification of stem cell-derived retinal pigment epithelium |
| SG11201801770VA (en) | 2015-09-08 | 2018-04-27 | Sumitomo Dainippon Pharma Co Ltd | Method for producing retinal pigment epithelial cells |
| DK3347456T3 (da) * | 2015-09-08 | 2024-02-19 | Us Health | Fremgangsmåde til reproducerbar differentiering af retinale pigmentepitelceller af klinisk kvalitet |
| US10947502B2 (en) | 2015-10-20 | 2021-03-16 | FUJIFILM Cellular Dynamics, Inc. | Methods for directed differentiation of pluripotent stem cells to immune cells |
| US20180362925A1 (en) * | 2015-12-04 | 2018-12-20 | Bond University Ltd | Methods for differentiating cells |
| CN106344932B (zh) * | 2016-08-26 | 2019-12-27 | 首都医科大学附属北京同仁医院 | 一种用于提高视网膜退行性疾病基因治疗效果的组合物及其应用 |
| JP2020501543A (ja) | 2016-12-07 | 2020-01-23 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 網膜色素上皮移植のためのフィブリン支持体を用いた方法及び材料 |
| CN110520139A (zh) * | 2017-02-08 | 2019-11-29 | 哈达西特医疗研究服务和开发有限公司 | 用于治疗视网膜疾病的感光细胞 |
| WO2018164240A1 (ja) | 2017-03-08 | 2018-09-13 | 大日本住友製薬株式会社 | 網膜色素上皮細胞の製造方法 |
| CN106906178A (zh) * | 2017-04-07 | 2017-06-30 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 培养上皮细胞的组合物及其保持上皮样细胞形态中的应用 |
| SG11201909331UA (en) | 2017-04-18 | 2019-11-28 | Fujifilm Cellular Dynamics Inc | Antigen-specific immune effector cells |
| KR102624998B1 (ko) * | 2017-06-05 | 2024-01-12 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 줄기 세포의 배양, 증식 및 분화를 위한 방법 및 물질 |
| EP3687580A1 (en) * | 2017-09-27 | 2020-08-05 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising active cells |
| IL263217B (en) | 2017-11-24 | 2022-06-01 | Juul Labs Inc | Puff sensing and power circuitry for vaporizer devices |
| CN109957545A (zh) | 2017-12-26 | 2019-07-02 | 江苏艾尔康生物医药科技有限公司 | 一种消化rpe细胞的方法 |
| WO2019130061A2 (en) | 2017-12-29 | 2019-07-04 | Cell Cure Neurosciences Ltd. | Retinal pigment epithelium cell compositions |
| WO2020003219A1 (en) * | 2018-06-29 | 2020-01-02 | Oat & Iil India Laboratories Private Limited | Substituted pyrazole derivatives as insecticides and fungicides |
| EP3969570A1 (en) * | 2019-05-15 | 2022-03-23 | Novo Nordisk A/S | Methods for obtaining eye field progenitor cells from human pluripotent stem cells |
| WO2021014515A1 (ja) * | 2019-07-19 | 2021-01-28 | 東京エレクトロン株式会社 | 細胞の分化状態の評価方法 |
| EP4008350A4 (en) | 2019-07-26 | 2023-06-14 | Saitama Medical University | ANTIBODY RECOGNIZING THE EXTRACELLULAR REGION OF ALK2/ACVR1 |
| CN113699097B (zh) * | 2021-09-08 | 2023-06-09 | 湖南光琇高新生命科技有限公司 | 视网膜色素上皮细胞的制备方法 |
| CN120905148B (zh) * | 2025-10-11 | 2026-01-06 | 中国人民解放军陆军军医大学第一附属医院 | 一种基于ChR2和GCaMP5G双转染hESC构建起搏细胞制备视网膜类器官的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SG49267A1 (en) | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
| US6045791A (en) | 1992-03-06 | 2000-04-04 | Photogenesis, Inc. | Retinal pigment epithelium transplantation |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5941250A (en) | 1996-11-21 | 1999-08-24 | University Of Louisville Research Foundation Inc. | Retinal tissue implantation method |
| CN1720055A (zh) | 2002-10-04 | 2006-01-11 | 组织技术公司 | 视网膜上皮细胞在羊膜上的培养和移植 |
| EP2929782A1 (en) | 2004-01-23 | 2015-10-14 | Ocata Therapeutics, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| US7838727B2 (en) | 2004-11-04 | 2010-11-23 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| EP2128244A4 (en) | 2007-01-18 | 2012-05-09 | Riken | PROCESS FOR INDUCTION / DIFFERENTIATION TO A PHOTOREZEPTORZELLE |
| JP5813321B2 (ja) | 2007-03-23 | 2015-11-17 | ウィスコンシン アラムニ リサーチ ファンデーション | 体細胞の再プログラム化 |
| EP2147094B2 (en) * | 2007-04-18 | 2018-02-21 | Hadasit Medical Research Services & Development Limited | Stem cell-derived retinal pigment epithelial cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| DK2209888T3 (da) | 2007-10-12 | 2020-01-20 | Astellas Inst For Regenerative Medicine | Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler |
| GB0806746D0 (en) | 2008-04-14 | 2008-05-14 | Ucl Business Plc | Membrane |
| EP2470645B1 (en) | 2009-08-24 | 2019-06-26 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| IL281453B (en) | 2009-11-17 | 2022-07-01 | Astellas Inst For Regenerative Medicine | Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells |
| ES2542226T3 (es) | 2010-04-28 | 2015-08-03 | Technische Universität Dresden | Método para producir células progenitoras retinianas polarizadas a partir de células madre pluripotentes y su diferenciación para dar células del epitelio pigmentario retiniano |
| DK3578988T3 (da) * | 2010-05-25 | 2025-02-24 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf |
| GB201011313D0 (en) | 2010-07-05 | 2010-08-18 | Ucl Business Plc | Implantation devices, methods and implants |
| EP2593117B1 (en) | 2010-07-12 | 2019-03-20 | University of Southern California | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
| US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| CN102465111A (zh) * | 2010-11-19 | 2012-05-23 | 薛志刚 | 一种体外人胚胎干细胞诱导分化为视网膜色素上皮细胞的试验方法 |
| WO2012099873A1 (en) | 2011-01-18 | 2012-07-26 | Minipums, Llc | Surgical implantation instrument |
| WO2012177968A1 (en) | 2011-06-22 | 2012-12-27 | The Schepens Eye Research Institute, Inc. | A scaffold for subretinal cell transplantation and drug delivery |
| IL287381B2 (en) | 2011-11-14 | 2024-04-01 | Astellas Inst For Regenerative Medicine | Pharmaceutical preparations of human rpe cells and uses thereof |
| US9850463B2 (en) | 2012-02-01 | 2017-12-26 | The Regents Of The University Of California | Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation |
| CN102618488A (zh) * | 2012-03-15 | 2012-08-01 | 中国人民解放军第三军医大学第一附属医院 | 一种制备视网膜色素上皮细胞的方法 |
| US9458428B2 (en) | 2012-06-05 | 2016-10-04 | The Regents Of The University Of California | Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells |
| EP2951290B1 (en) | 2013-02-01 | 2017-11-29 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs) |
-
2014
- 2014-12-08 MX MX2016007671A patent/MX2016007671A/es unknown
- 2014-12-08 CA CA2933083A patent/CA2933083A1/en not_active Abandoned
- 2014-12-08 HK HK16109751.2A patent/HK1221734A1/zh unknown
- 2014-12-08 JP JP2016538000A patent/JP2017504311A/ja active Pending
- 2014-12-08 KR KR1020167018138A patent/KR101871084B1/ko not_active Expired - Fee Related
- 2014-12-08 AU AU2014363032A patent/AU2014363032A1/en not_active Abandoned
- 2014-12-08 CN CN201480067617.3A patent/CN105814194A/zh active Pending
- 2014-12-08 WO PCT/IB2014/066703 patent/WO2015087231A1/en not_active Ceased
- 2014-12-08 BR BR112016012129A patent/BR112016012129A8/pt not_active Application Discontinuation
- 2014-12-08 EP EP14833537.5A patent/EP3080248A1/en not_active Withdrawn
- 2014-12-09 TW TW106131045A patent/TW201823451A/zh unknown
- 2014-12-09 TW TW103142847A patent/TW201538726A/zh unknown
- 2014-12-10 US US14/566,184 patent/US20150159134A1/en not_active Abandoned
- 2014-12-10 AR ARP140104590A patent/AR098693A1/es unknown
-
2016
- 2016-05-10 IL IL245594A patent/IL245594A0/en unknown
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