JP2017504311A5 - - Google Patents
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- JP2017504311A5 JP2017504311A5 JP2016538000A JP2016538000A JP2017504311A5 JP 2017504311 A5 JP2017504311 A5 JP 2017504311A5 JP 2016538000 A JP2016538000 A JP 2016538000A JP 2016538000 A JP2016538000 A JP 2016538000A JP 2017504311 A5 JP2017504311 A5 JP 2017504311A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- rpe
- culturing
- days
- cultured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 62
- 238000000034 method Methods 0.000 claims 31
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 24
- 239000003112 inhibitor Substances 0.000 claims 13
- 238000012258 culturing Methods 0.000 claims 12
- 239000012190 activator Substances 0.000 claims 8
- 230000037361 pathway Effects 0.000 claims 8
- -1 4- (piperazin-1-yl) phenyl Chemical group 0.000 claims 3
- FHYUGAJXYORMHI-UHFFFAOYSA-N SB 431542 Chemical compound C1=CC(C(=O)N)=CC=C1C1=NC(C=2C=C3OCOC3=CC=2)=C(C=2N=CC=CC=2)N1 FHYUGAJXYORMHI-UHFFFAOYSA-N 0.000 claims 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 3
- 238000010899 nucleation Methods 0.000 claims 3
- 238000011536 re-plating Methods 0.000 claims 3
- 239000002356 single layer Substances 0.000 claims 3
- IHLVSLOZUHKNMQ-UHFFFAOYSA-N 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine Chemical compound C=1C=C2C(C=3C(=NN4CCCC4=3)C=3N=CC=CC=3)=CC=NC2=CC=1OCCN1CCOCC1 IHLVSLOZUHKNMQ-UHFFFAOYSA-N 0.000 claims 2
- 102000005606 Activins Human genes 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 2
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 2
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 2
- IBCXZJCWDGCXQT-UHFFFAOYSA-N LY 364947 Chemical compound C=1C=NC2=CC=CC=C2C=1C1=CNN=C1C1=CC=CC=N1 IBCXZJCWDGCXQT-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- WGZOTBUYUFBEPZ-UHFFFAOYSA-N SB 505124 Chemical compound CC1=CC=CC(C2=C(N=C(N2)C(C)(C)C)C=2C=C3OCOC3=CC=2)=N1 WGZOTBUYUFBEPZ-UHFFFAOYSA-N 0.000 claims 2
- 239000000488 activin Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000004114 suspension culture Methods 0.000 claims 2
- LBPKYPYHDKKRFS-UHFFFAOYSA-N 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- Chemical compound CC1=CC=CC(C2=C(C=NN2)C=2N=C3C=CC=NC3=CC=2)=N1 LBPKYPYHDKKRFS-UHFFFAOYSA-N 0.000 claims 1
- BERLXWPRSBJFHO-UHFFFAOYSA-N 2-(5-chloro-2-fluorophenyl)-n-pyridin-4-ylpteridin-4-amine Chemical compound FC1=CC=C(Cl)C=C1C1=NC(NC=2C=CN=CC=2)=C(N=CC=N2)C2=N1 BERLXWPRSBJFHO-UHFFFAOYSA-N 0.000 claims 1
- JONFDFIXMPXTRH-UHFFFAOYSA-N 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine Chemical compound CC1=CC=CC(C=2N=C3C=CC=CC3=C(NC=3C=CN=CC=3)N=2)=N1 JONFDFIXMPXTRH-UHFFFAOYSA-N 0.000 claims 1
- VRQZQTWWFHBPNK-UHFFFAOYSA-N 2-[4-methyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridine Chemical compound C=1C2=CN=CC=C2SC=1C1=C(C)C=NN1C1=CC=CC(C)=N1 VRQZQTWWFHBPNK-UHFFFAOYSA-N 0.000 claims 1
- ROHZDDHEDXKZQL-UHFFFAOYSA-N 2-methyl-5-[6-(3-methylphenyl)-7H-imidazo[1,2-a]imidazol-5-yl]benzotriazole Chemical compound CN1N=C2C(=N1)C=CC(=C2)C2=C(N=C1N2C=CN1)C=1C=C(C=CC1)C ROHZDDHEDXKZQL-UHFFFAOYSA-N 0.000 claims 1
- HIJMSZGHKQPPJS-UHFFFAOYSA-N 3-(6-methylpyridin-2-yl)-n-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide Chemical compound CC1=CC=CC(C=2C(=CN(N=2)C(=S)NC=2C=CC=CC=2)C=2C3=CC=CC=C3N=CC=2)=N1 HIJMSZGHKQPPJS-UHFFFAOYSA-N 0.000 claims 1
- QNZSQJBDZIOEAN-UHFFFAOYSA-N 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]phenol Chemical compound CC1=CC=CC(C=2C(=C3CCCN3N=2)C=2C=CC(O)=CC=2)=N1 QNZSQJBDZIOEAN-UHFFFAOYSA-N 0.000 claims 1
- CDOVNWNANFFLFJ-UHFFFAOYSA-N 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline Chemical compound C1CNCCN1C1=CC=C(C2=CN3N=CC(=C3N=C2)C=2C3=CC=CC=C3N=CC=2)C=C1 CDOVNWNANFFLFJ-UHFFFAOYSA-N 0.000 claims 1
- WKHRIIQNWCIMKB-UHFFFAOYSA-N 6-methyl-2-phenyl-3h-thieno[2,3-d]pyrimidin-4-one Chemical compound S1C(C)=CC(C(N2)=O)=C1N=C2C1=CC=CC=C1 WKHRIIQNWCIMKB-UHFFFAOYSA-N 0.000 claims 1
- 102100034134 Activin receptor type-1B Human genes 0.000 claims 1
- 102100034135 Activin receptor type-1C Human genes 0.000 claims 1
- 102100025423 Bone morphogenetic protein receptor type-1A Human genes 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 101000799140 Homo sapiens Activin receptor type-1 Proteins 0.000 claims 1
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims 1
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 claims 1
- 101000934638 Homo sapiens Bone morphogenetic protein receptor type-1A Proteins 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- XHBVYDAKJHETMP-UHFFFAOYSA-N dorsomorphin Chemical class C=1C=C(C2=CN3N=CC(=C3N=C2)C=2C=CN=CC=2)C=CC=1OCCN1CCCCC1 XHBVYDAKJHETMP-UHFFFAOYSA-N 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 102000045246 noggin Human genes 0.000 claims 1
- 108700007229 noggin Proteins 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914445P | 2013-12-11 | 2013-12-11 | |
| US61/914,445 | 2013-12-11 | ||
| PCT/IB2014/066703 WO2015087231A1 (en) | 2013-12-11 | 2014-12-08 | Method for producing retinal pigment epithelial cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017504311A JP2017504311A (ja) | 2017-02-09 |
| JP2017504311A5 true JP2017504311A5 (https=) | 2018-01-25 |
Family
ID=52446403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538000A Pending JP2017504311A (ja) | 2013-12-11 | 2014-12-08 | 網膜色素上皮細胞を生成する方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP3080248A1 (https=) |
| JP (1) | JP2017504311A (https=) |
| KR (1) | KR101871084B1 (https=) |
| CN (1) | CN105814194A (https=) |
| AR (1) | AR098693A1 (https=) |
| AU (1) | AU2014363032A1 (https=) |
| BR (1) | BR112016012129A8 (https=) |
| CA (1) | CA2933083A1 (https=) |
| HK (1) | HK1221734A1 (https=) |
| IL (1) | IL245594A0 (https=) |
| MX (1) | MX2016007671A (https=) |
| TW (2) | TW201538726A (https=) |
| WO (1) | WO2015087231A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3221318B1 (en) * | 2014-11-21 | 2021-08-25 | Rigel Pharmaceuticals, Inc. | Fused imidazole derivatives as tgf-beta inhibitors |
| KR20170115514A (ko) | 2014-12-30 | 2017-10-17 | 셀 큐어 뉴로사이언시스 리미티드 | Rpe 세포 집단 및 이를 생성하는 방법 |
| WO2016108240A1 (en) * | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
| CN114533761A (zh) * | 2014-12-30 | 2022-05-27 | 细胞治疗神经科学有限公司 | 治疗视网膜疾病的方法 |
| WO2017021973A1 (en) | 2015-08-05 | 2017-02-09 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
| CN114807035B (zh) * | 2015-09-08 | 2024-02-02 | (由卫生与公众服务部部长代表的)美利坚合众国 | 临床级别视网膜色素上皮细胞的可再现的分化方法 |
| KR20260003355A (ko) | 2015-09-08 | 2026-01-06 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 줄기 세포에서 유래된 망막색소상피의 macs 기반 정제 |
| CN108431211B (zh) | 2015-10-20 | 2026-03-24 | 富士胶片细胞动力公司 | 通过遗传编程的多谱系造血前体细胞产生 |
| EP3384008A4 (en) | 2015-12-04 | 2019-10-02 | Bond University Ltd | Methods of differentiating retinal cells |
| CN106344932B (zh) * | 2016-08-26 | 2019-12-27 | 首都医科大学附属北京同仁医院 | 一种用于提高视网膜退行性疾病基因治疗效果的组合物及其应用 |
| MX2019006576A (es) | 2016-12-07 | 2019-08-21 | Mayo Found Medical Education & Res | Metodos y materiales para usar soportes de fibrina para trasplante de epitelio de pigmento retiniano. |
| CN106906178A (zh) * | 2017-04-07 | 2017-06-30 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 培养上皮细胞的组合物及其保持上皮样细胞形态中的应用 |
| WO2018195175A1 (en) | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| JP7311433B2 (ja) * | 2017-06-05 | 2023-07-19 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 幹細胞を培養し、増殖させ、分化させるための方法及び材料 |
| CN109957545A (zh) | 2017-12-26 | 2019-07-02 | 江苏艾尔康生物医药科技有限公司 | 一种消化rpe细胞的方法 |
| BR112020013238A2 (pt) | 2017-12-29 | 2020-12-01 | Cell Cure Neurosciences Ltd. | composição e método para formular células do epitélio pigmentar da retina bem como uso da dita composição para tratar uma condição retiniana |
| WO2020003219A1 (en) * | 2018-06-29 | 2020-01-02 | Oat & Iil India Laboratories Private Limited | Substituted pyrazole derivatives as insecticides and fungicides |
| JP2022532411A (ja) * | 2019-05-15 | 2022-07-14 | ノヴォ ノルディスク アー／エス | ヒト多能性幹細胞から眼野前駆細胞を得るための方法 |
| CN114450418A (zh) * | 2019-07-19 | 2022-05-06 | 东京毅力科创株式会社 | 细胞的分化状态的评价方法 |
| JP7668013B2 (ja) | 2019-07-26 | 2025-04-24 | 学校法人 埼玉医科大学 | Ａｌｋ２／ａｃｖｒ１の細胞外領域を認識する抗体 |
| CN113699097B (zh) * | 2021-09-08 | 2023-06-09 | 湖南光琇高新生命科技有限公司 | 视网膜色素上皮细胞的制备方法 |
| CN120905148B (zh) * | 2025-10-11 | 2026-01-06 | 中国人民解放军陆军军医大学第一附属医院 | 一种基于ChR2和GCaMP5G双转染hESC构建起搏细胞制备视网膜类器官的方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG49267A1 (en) | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
| US6045791A (en) | 1992-03-06 | 2000-04-04 | Photogenesis, Inc. | Retinal pigment epithelium transplantation |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5941250A (en) | 1996-11-21 | 1999-08-24 | University Of Louisville Research Foundation Inc. | Retinal tissue implantation method |
| WO2004033635A2 (en) | 2002-10-04 | 2004-04-22 | Tissuetech, Inc. | Retinal pigment epithelial cell cultures on amniotic membrane and transplantation |
| BRPI0507074A (pt) | 2004-01-23 | 2007-06-19 | Advanced Cell Tech Inc | modalidades aperfeiçoadas para o tratamento de doenças degenerativas da retina |
| CA3015835A1 (en) | 2004-11-04 | 2006-05-18 | Astellas Institute For Regenerative Medicine | Derivation of embryonic stem cells |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| BRPI0619794B8 (pt) | 2005-12-13 | 2022-06-14 | Univ Kyoto | Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| JP5441099B2 (ja) | 2007-01-18 | 2014-03-12 | 独立行政法人理化学研究所 | 視細胞への分化誘導方法 |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| ES2527444T5 (es) * | 2007-04-18 | 2018-05-17 | Hadasit Medical Research Services & Development Limited | Células del epitelio pigmentario de la retina derivadas de células madre |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| IL292561A (en) | 2007-10-12 | 2022-06-01 | Astellas Inst For Regenerative Medicine | Improved methods of rpe cell production and rpe cell preparations |
| GB0806746D0 (en) | 2008-04-14 | 2008-05-14 | Ucl Business Plc | Membrane |
| WO2011028524A1 (en) | 2009-08-24 | 2011-03-10 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| US10485829B2 (en) | 2009-11-17 | 2019-11-26 | Astellas Institute For Regenerative Medicine | Methods of producing human RPE cells and pharmaceutical preparations of human RPE cells |
| EP2383333B1 (en) | 2010-04-28 | 2015-05-27 | Technische Universität Dresden | Method for producing polarized retinal progenitor cells from pluripotent stem cells and their differentiation into retinal pigment epithelium cells |
| US9453198B2 (en) * | 2010-05-25 | 2016-09-27 | Memorial Sloan Kettering Cancer Center | Method of nociceptor differentiation of human embryonic stem cells and uses thereof |
| GB201011313D0 (en) | 2010-07-05 | 2010-08-18 | Ucl Business Plc | Implantation devices, methods and implants |
| AU2011279250B2 (en) | 2010-07-12 | 2014-12-04 | California Institute Of Technology | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
| US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| CN102465111A (zh) * | 2010-11-19 | 2012-05-23 | 薛志刚 | 一种体外人胚胎干细胞诱导分化为视网膜色素上皮细胞的试验方法 |
| US10390856B2 (en) | 2011-01-18 | 2019-08-27 | Minipumps, Llc | Surgical implantation instrument |
| WO2012177968A1 (en) | 2011-06-22 | 2012-12-27 | The Schepens Eye Research Institute, Inc. | A scaffold for subretinal cell transplantation and drug delivery |
| TWI719277B (zh) | 2011-11-14 | 2021-02-21 | 美商安斯泰來再生醫藥協會 | 人類rpe細胞之醫藥組合物及其用途 |
| US9850463B2 (en) | 2012-02-01 | 2017-12-26 | The Regents Of The University Of California | Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation |
| CN102618488A (zh) * | 2012-03-15 | 2012-08-01 | 中国人民解放军第三军医大学第一附属医院 | 一种制备视网膜色素上皮细胞的方法 |
| US9458428B2 (en) | 2012-06-05 | 2016-10-04 | The Regents Of The University Of California | Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells |
| EP2951290B1 (en) | 2013-02-01 | 2017-11-29 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs) |
-
2014
- 2014-12-08 CA CA2933083A patent/CA2933083A1/en not_active Abandoned
- 2014-12-08 KR KR1020167018138A patent/KR101871084B1/ko not_active Expired - Fee Related
- 2014-12-08 JP JP2016538000A patent/JP2017504311A/ja active Pending
- 2014-12-08 HK HK16109751.2A patent/HK1221734A1/zh unknown
- 2014-12-08 AU AU2014363032A patent/AU2014363032A1/en not_active Abandoned
- 2014-12-08 WO PCT/IB2014/066703 patent/WO2015087231A1/en not_active Ceased
- 2014-12-08 MX MX2016007671A patent/MX2016007671A/es unknown
- 2014-12-08 CN CN201480067617.3A patent/CN105814194A/zh active Pending
- 2014-12-08 BR BR112016012129A patent/BR112016012129A8/pt not_active Application Discontinuation
- 2014-12-08 EP EP14833537.5A patent/EP3080248A1/en not_active Withdrawn
- 2014-12-09 TW TW103142847A patent/TW201538726A/zh unknown
- 2014-12-09 TW TW106131045A patent/TW201823451A/zh unknown
- 2014-12-10 AR ARP140104590A patent/AR098693A1/es unknown
-
2016
- 2016-05-10 IL IL245594A patent/IL245594A0/en unknown
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