RS20100123A - Azaindoli - Google Patents
AzaindoliInfo
- Publication number
- RS20100123A RS20100123A RSP-2010/0123A RSP20100123A RS20100123A RS 20100123 A RS20100123 A RS 20100123A RS P20100123 A RSP20100123 A RS P20100123A RS 20100123 A RS20100123 A RS 20100123A
- Authority
- RS
- Serbia
- Prior art keywords
- ny3y4
- compounds
- halo
- heteroaryl
- cyano
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ovaj pronalazak se odnosi na preparate koji sadrže fiziološki aktivna jedinjenja opšte formule (I):gde je R1 aril ili heteroaril; R2 je vodonik, acil, cijano, halo, niži alkenil ili niži alkil, po izboru supstituisan sa supstituentom koji se bira između cijano, heteroaril, heterocikloalkil, -Z1R8, -C(=O)-NY3Y4, -CO2R8, -NY3Y4, -N(R6)-C(=O)-R7, -N(R6)-C= O)-NY3Y4, -N(R6)-C(=O)-OR7, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, i jedan ili više atoma halogena; R3 je vodonik, aril, cijano, halo, heteroaril, niži alkil, -C(=O)-OR5 ili -C(=O)-NY3Y4; a X1 je N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)-R7, C-SO2-NY3Y4, C-N(R8)-SO2-R7, C-alkenil, C-alkinil ili C-NO2; i njihovi prolekovi, i farmaceutski prihvatljive soli, i solvati tih jedinjenja i njihovih prolekova, kao i na nova jedinjenja unutar obima formule (I).Ova jedinjenja i preparati imaju vredna farmaceutska svojstva, a naročito sposobnost da inhibiraju protein kinaze.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930698.7A GB9930698D0 (en) | 1999-12-24 | 1999-12-24 | Chemical compounds |
| US21581800P | 2000-07-05 | 2000-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS20100123A true RS20100123A (sr) | 2010-12-31 |
Family
ID=10867079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-462/02A RS51303B (sr) | 1999-12-24 | 2000-12-27 | Azaindoli |
| RSP-2010/0123A RS20100123A (sr) | 1999-12-24 | 2000-12-27 | Azaindoli |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-462/02A RS51303B (sr) | 1999-12-24 | 2000-12-27 | Azaindoli |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP4871474B2 (sr) |
| AT (2) | ATE552258T1 (sr) |
| DE (1) | DE60044946D1 (sr) |
| DK (2) | DK1263759T3 (sr) |
| ES (2) | ES2382759T3 (sr) |
| GB (1) | GB9930698D0 (sr) |
| ME (1) | MEP49908A (sr) |
| PL (1) | PL218884B1 (sr) |
| PT (2) | PT1990343E (sr) |
| RS (2) | RS51303B (sr) |
| UA (1) | UA76410C2 (sr) |
| ZA (1) | ZA200204126B (sr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| KR20080083680A (ko) * | 2005-12-23 | 2008-09-18 | 스미스클라인 비참 코포레이션 | 오로라 키나제의 아자인돌 억제제 |
| CL2007002617A1 (es) * | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
| JP5274805B2 (ja) * | 2006-09-20 | 2013-08-28 | 三菱化学株式会社 | フッ素化芳香族化合物の製造方法 |
| JP5431495B2 (ja) * | 2008-12-05 | 2014-03-05 | エフ．ホフマン−ラ ロシュ アーゲー | ピロロピラジニル尿素キナーゼ阻害薬 |
| JP2013503132A (ja) * | 2009-08-26 | 2013-01-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | メチルピロロピリジンカルボキサミド |
| EP2970264A1 (en) * | 2013-03-14 | 2016-01-20 | AbbVie Inc. | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022457A1 (en) * | 1996-11-19 | 1998-05-28 | Amgen Inc. | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents |
| AU7132998A (en) * | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| AU745579B2 (en) * | 1997-10-20 | 2002-03-21 | F. Hoffmann-La Roche Ag | Bicyclic kinase inhibitors |
-
1999
- 1999-12-24 GB GBGB9930698.7A patent/GB9930698D0/en not_active Ceased
-
2000
- 2000-12-27 PT PT08162392T patent/PT1990343E/pt unknown
- 2000-12-27 PL PL386205A patent/PL218884B1/pl unknown
- 2000-12-27 ME MEP-499/08A patent/MEP49908A/xx unknown
- 2000-12-27 RS YUP-462/02A patent/RS51303B/sr unknown
- 2000-12-27 AT AT08162392T patent/ATE552258T1/de active
- 2000-12-27 UA UA2002076056A patent/UA76410C2/uk unknown
- 2000-12-27 DK DK00985695.6T patent/DK1263759T3/da active
- 2000-12-27 JP JP2001549392A patent/JP4871474B2/ja not_active Expired - Fee Related
- 2000-12-27 DE DE60044946T patent/DE60044946D1/de not_active Expired - Lifetime
- 2000-12-27 PT PT00985695T patent/PT1263759E/pt unknown
- 2000-12-27 ES ES08162392T patent/ES2382759T3/es not_active Expired - Lifetime
- 2000-12-27 RS RSP-2010/0123A patent/RS20100123A/sr unknown
- 2000-12-27 ES ES00985695T patent/ES2348861T3/es not_active Expired - Lifetime
- 2000-12-27 DK DK08162392.8T patent/DK1990343T3/da active
- 2000-12-27 AT AT00985695T patent/ATE480537T1/de active
-
2002
- 2002-05-23 ZA ZA200204126A patent/ZA200204126B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4871474B2 (ja) | 2012-02-08 |
| GB9930698D0 (en) | 2000-02-16 |
| UA76410C2 (en) | 2006-08-15 |
| ES2382759T3 (es) | 2012-06-13 |
| MEP49908A (en) | 2011-02-10 |
| ES2348861T3 (es) | 2010-12-16 |
| ATE552258T1 (de) | 2012-04-15 |
| JP2003519144A (ja) | 2003-06-17 |
| ATE480537T1 (de) | 2010-09-15 |
| DK1263759T3 (da) | 2011-01-10 |
| ZA200204126B (en) | 2003-08-25 |
| DE60044946D1 (de) | 2010-10-21 |
| PL218884B1 (pl) | 2015-02-27 |
| PT1263759E (pt) | 2010-11-02 |
| RS51303B (sr) | 2010-12-31 |
| DK1990343T3 (da) | 2012-07-23 |
| PT1990343E (pt) | 2012-05-22 |
| YU46202A (sh) | 2005-06-10 |
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