MEP49908A - Azaindoles - Google Patents
AzaindolesInfo
- Publication number
- MEP49908A MEP49908A MEP-499/08A MEP49908A MEP49908A ME P49908 A MEP49908 A ME P49908A ME P49908 A MEP49908 A ME P49908A ME P49908 A MEP49908 A ME P49908A
- Authority
- ME
- Montenegro
- Prior art keywords
- ny3y4
- compounds
- halo
- heteroaryl
- cyano
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention is directed to compositions containing physiologically active compounds of general formula (I) wherein R1 is aryl or heteroaryl; R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8,-C(=O)-NY3Y4,-CO2R8,-NY3Y4,-N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7, -N(R6)-SO2-R7,-N(R6)-SO2-NY3Y4 and one or more halogen atoms; R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR5 or -C(=O)-NY3Y; and X1 represents N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)-R7, C-SO2-NY3Y4, C-N(R8)-SO2-R7, C-alkenyl, C-alkynyl or C-NO2; and their produgs, and pharmaceutically acceptable salts and solvates of such compounds and their produgs, as well as to novel compounds within the scope of fomula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930698.7A GB9930698D0 (en) | 1999-12-24 | 1999-12-24 | Chemical compounds |
| US21581800P | 2000-07-05 | 2000-07-05 | |
| YUP-462/02A RS51303B (en) | 1999-12-24 | 2000-12-27 | Azaindoles |
| PCT/GB2000/004993 WO2001047922A2 (en) | 1999-12-24 | 2000-12-27 | Azaindoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP49908A true MEP49908A (en) | 2011-02-10 |
Family
ID=10867079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-499/08A MEP49908A (en) | 1999-12-24 | 2000-12-27 | Azaindoles |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP4871474B2 (en) |
| AT (2) | ATE480537T1 (en) |
| DE (1) | DE60044946D1 (en) |
| DK (2) | DK1263759T3 (en) |
| ES (2) | ES2348861T3 (en) |
| GB (1) | GB9930698D0 (en) |
| ME (1) | MEP49908A (en) |
| PL (1) | PL218884B1 (en) |
| PT (2) | PT1263759E (en) |
| RS (2) | RS51303B (en) |
| UA (1) | UA76410C2 (en) |
| ZA (1) | ZA200204126B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| BRPI0620341A2 (en) * | 2005-12-23 | 2011-11-08 | Smithkline Beecham Corparation | aurase kinase inhibitor azaindoles |
| CL2007002617A1 (en) * | 2006-09-11 | 2008-05-16 | Sanofi Aventis | COMPOUNDS DERIVED FROM PIRROLO [2,3-B] PIRAZIN-6-ILO; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT INFLAMMATION OF THE ARTICULATIONS, Rheumatoid Arthritis, TUMORS, LYMPHOMA OF THE CELLS OF THE MANTO. |
| JP5274805B2 (en) * | 2006-09-20 | 2013-08-28 | 三菱化学株式会社 | Method for producing fluorinated aromatic compound |
| ES2464458T3 (en) * | 2008-12-05 | 2014-06-02 | F. Hoffmann-La Roche Ag | Pyrrolopyrazinyl ureas as kinase inhibitors |
| CA2771939A1 (en) * | 2009-08-26 | 2011-03-03 | Nycomed Gmbh | Methylpyrrolopyridinecarboxamides |
| AU2014231567A1 (en) * | 2013-03-14 | 2015-10-01 | Abbvie Inc. | Pyrrolo[2,3-b]pyridine CDK9 kinase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0948495T3 (en) * | 1996-11-19 | 2004-06-01 | Amgen Inc | Aryl- and heteroaryl-substituted condensed pyrrole as anti-inflammatory agents |
| WO1998047899A1 (en) * | 1997-04-24 | 1998-10-29 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| ID27124A (en) * | 1997-10-20 | 2001-03-01 | Hoffmann La Roche | DISCLAIMER OF BUSINESS KINASE |
-
1999
- 1999-12-24 GB GBGB9930698.7A patent/GB9930698D0/en not_active Ceased
-
2000
- 2000-12-27 JP JP2001549392A patent/JP4871474B2/en not_active Expired - Fee Related
- 2000-12-27 PT PT00985695T patent/PT1263759E/en unknown
- 2000-12-27 AT AT00985695T patent/ATE480537T1/en active
- 2000-12-27 DK DK00985695.6T patent/DK1263759T3/en active
- 2000-12-27 UA UA2002076056A patent/UA76410C2/en unknown
- 2000-12-27 PT PT08162392T patent/PT1990343E/en unknown
- 2000-12-27 DE DE60044946T patent/DE60044946D1/en not_active Expired - Lifetime
- 2000-12-27 DK DK08162392.8T patent/DK1990343T3/en active
- 2000-12-27 RS YUP-462/02A patent/RS51303B/en unknown
- 2000-12-27 RS RSP-2010/0123A patent/RS20100123A/en unknown
- 2000-12-27 ME MEP-499/08A patent/MEP49908A/en unknown
- 2000-12-27 PL PL386205A patent/PL218884B1/en unknown
- 2000-12-27 ES ES00985695T patent/ES2348861T3/en not_active Expired - Lifetime
- 2000-12-27 AT AT08162392T patent/ATE552258T1/en active
- 2000-12-27 ES ES08162392T patent/ES2382759T3/en not_active Expired - Lifetime
-
2002
- 2002-05-23 ZA ZA200204126A patent/ZA200204126B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1990343T3 (en) | 2012-07-23 |
| GB9930698D0 (en) | 2000-02-16 |
| DE60044946D1 (en) | 2010-10-21 |
| PT1263759E (en) | 2010-11-02 |
| ES2382759T3 (en) | 2012-06-13 |
| RS20100123A (en) | 2010-12-31 |
| ES2348861T3 (en) | 2010-12-16 |
| UA76410C2 (en) | 2006-08-15 |
| PL218884B1 (en) | 2015-02-27 |
| ATE480537T1 (en) | 2010-09-15 |
| JP4871474B2 (en) | 2012-02-08 |
| DK1263759T3 (en) | 2011-01-10 |
| ATE552258T1 (en) | 2012-04-15 |
| RS51303B (en) | 2010-12-31 |
| YU46202A (en) | 2005-06-10 |
| ZA200204126B (en) | 2003-08-25 |
| JP2003519144A (en) | 2003-06-17 |
| PT1990343E (en) | 2012-05-22 |
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