ZA200204126B - Azaindoles. - Google Patents

Azaindoles.

Info

Publication number
ZA200204126B
ZA200204126B ZA200204126A ZA200204126A ZA200204126B ZA 200204126 B ZA200204126 B ZA 200204126B ZA 200204126 A ZA200204126 A ZA 200204126A ZA 200204126 A ZA200204126 A ZA 200204126A ZA 200204126 B ZA200204126 B ZA 200204126B
Authority
ZA
South Africa
Prior art keywords
ny3y4
compounds
halo
heteroaryl
cyano
Prior art date
Application number
ZA200204126A
Inventor
Paul Joseph Cox
Tahir Nadeem Majid
Justine Yeun Quai Lai
Andrew David Morley
Shelley Amendola
Stephanie Deprets
Chris Edlin
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of ZA200204126B publication Critical patent/ZA200204126B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The invention is directed to compositions containing physiologically active compounds of general formula (I) wherein R1 is aryl or heteroaryl; R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8,-C(=O)-NY3Y4,-CO2R8,-NY3Y4,-N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7, -N(R6)-SO2-R7,-N(R6)-SO2-NY3Y4 and one or more halogen atoms; R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR5 or -C(=O)-NY3Y; and X1 represents N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)-R7, C-SO2-NY3Y4, C-N(R8)-SO2-R7, C-alkenyl, C-alkynyl or C-NO2; and their produgs, and pharmaceutically acceptable salts and solvates of such compounds and their produgs, as well as to novel compounds within the scope of fomula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
ZA200204126A 1999-12-24 2002-05-23 Azaindoles. ZA200204126B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9930698.7A GB9930698D0 (en) 1999-12-24 1999-12-24 Chemical compounds

Publications (1)

Publication Number Publication Date
ZA200204126B true ZA200204126B (en) 2003-08-25

Family

ID=10867079

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200204126A ZA200204126B (en) 1999-12-24 2002-05-23 Azaindoles.

Country Status (12)

Country Link
JP (1) JP4871474B2 (en)
AT (2) ATE552258T1 (en)
DE (1) DE60044946D1 (en)
DK (2) DK1990343T3 (en)
ES (2) ES2382759T3 (en)
GB (1) GB9930698D0 (en)
ME (1) MEP49908A (en)
PL (1) PL218884B1 (en)
PT (2) PT1990343E (en)
RS (2) RS20100123A (en)
UA (1) UA76410C2 (en)
ZA (1) ZA200204126B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
BRPI0620341A2 (en) * 2005-12-23 2011-11-08 Smithkline Beecham Corparation aurase kinase inhibitor azaindoles
CL2007002617A1 (en) * 2006-09-11 2008-05-16 Sanofi Aventis COMPOUNDS DERIVED FROM PIRROLO [2,3-B] PIRAZIN-6-ILO; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT INFLAMMATION OF THE ARTICULATIONS, Rheumatoid Arthritis, TUMORS, LYMPHOMA OF THE CELLS OF THE MANTO.
JP5274805B2 (en) * 2006-09-20 2013-08-28 三菱化学株式会社 Method for producing fluorinated aromatic compound
AU2009324210A1 (en) * 2008-12-05 2010-06-10 F. Hoffmann-La Roche Ag Pyrrolopyrazinyl urea kinase inhibitors
AU2010288553A1 (en) * 2009-08-26 2012-04-12 Takeda Gmbh Methylpyrrolopyridinecarboxamides
MX2015012896A (en) * 2013-03-14 2016-06-02 Abbvie Inc Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9903330A2 (en) * 1996-11-19 2000-03-28 Amgen Inc. Aryl and heteroaryl substituted fused pyrrole derivatives, as antiinflammatory agents containing the same
WO1998047899A1 (en) * 1997-04-24 1998-10-29 Ortho-Mcneil Corporation, Inc. Substituted pyrrolopyridines useful in the treatment of inflammatory diseases
ATE267200T1 (en) * 1997-10-20 2004-06-15 Hoffmann La Roche BICYCLIC KINASE INHIBITORS

Also Published As

Publication number Publication date
YU46202A (en) 2005-06-10
DK1990343T3 (en) 2012-07-23
JP4871474B2 (en) 2012-02-08
ES2348861T3 (en) 2010-12-16
ATE480537T1 (en) 2010-09-15
DK1263759T3 (en) 2011-01-10
JP2003519144A (en) 2003-06-17
ES2382759T3 (en) 2012-06-13
ATE552258T1 (en) 2012-04-15
UA76410C2 (en) 2006-08-15
DE60044946D1 (en) 2010-10-21
PL218884B1 (en) 2015-02-27
PT1990343E (en) 2012-05-22
RS20100123A (en) 2010-12-31
PT1263759E (en) 2010-11-02
MEP49908A (en) 2011-02-10
GB9930698D0 (en) 2000-02-16
RS51303B (en) 2010-12-31

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