DK1263759T3 - Azainodoler - Google Patents
AzainodolerInfo
- Publication number
- DK1263759T3 DK1263759T3 DK00985695.6T DK00985695T DK1263759T3 DK 1263759 T3 DK1263759 T3 DK 1263759T3 DK 00985695 T DK00985695 T DK 00985695T DK 1263759 T3 DK1263759 T3 DK 1263759T3
- Authority
- DK
- Denmark
- Prior art keywords
- ny3y4
- compounds
- halo
- heteroaryl
- cyano
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
The invention is directed to compositions containing physiologically active compounds of general formula (I) wherein R1 is aryl or heteroaryl; R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8,-C(=O)-NY3Y4,-CO2R8,-NY3Y4,-N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7, -N(R6)-SO2-R7,-N(R6)-SO2-NY3Y4 and one or more halogen atoms; R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR5 or -C(=O)-NY3Y; and X1 represents N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)-R7, C-SO2-NY3Y4, C-N(R8)-SO2-R7, C-alkenyl, C-alkynyl or C-NO2; and their produgs, and pharmaceutically acceptable salts and solvates of such compounds and their produgs, as well as to novel compounds within the scope of fomula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9930698.7A GB9930698D0 (en) | 1999-12-24 | 1999-12-24 | Chemical compounds |
US21581800P | 2000-07-05 | 2000-07-05 | |
PCT/GB2000/004993 WO2001047922A2 (en) | 1999-12-24 | 2000-12-27 | Azaindoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1263759T3 true DK1263759T3 (en) | 2011-01-10 |
Family
ID=10867079
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00985695.6T DK1263759T3 (en) | 1999-12-24 | 2000-12-27 | Azainodoler |
DK08162392.8T DK1990343T3 (en) | 1999-12-24 | 2000-12-27 | azaindoles |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08162392.8T DK1990343T3 (en) | 1999-12-24 | 2000-12-27 | azaindoles |
Country Status (12)
Country | Link |
---|---|
JP (1) | JP4871474B2 (en) |
AT (2) | ATE552258T1 (en) |
DE (1) | DE60044946D1 (en) |
DK (2) | DK1263759T3 (en) |
ES (2) | ES2348861T3 (en) |
GB (1) | GB9930698D0 (en) |
ME (1) | MEP49908A (en) |
PL (1) | PL218884B1 (en) |
PT (2) | PT1990343E (en) |
RS (2) | RS20100123A (en) |
UA (1) | UA76410C2 (en) |
ZA (1) | ZA200204126B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
EP1962830B1 (en) * | 2005-12-23 | 2013-03-27 | GlaxoSmithKline LLC | Azaindole inhibitors of aurora kinases |
CL2007002617A1 (en) * | 2006-09-11 | 2008-05-16 | Sanofi Aventis | COMPOUNDS DERIVED FROM PIRROLO [2,3-B] PIRAZIN-6-ILO; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT INFLAMMATION OF THE ARTICULATIONS, Rheumatoid Arthritis, TUMORS, LYMPHOMA OF THE CELLS OF THE MANTO. |
JP5274805B2 (en) * | 2006-09-20 | 2013-08-28 | 三菱化学株式会社 | Method for producing fluorinated aromatic compound |
ES2464458T3 (en) * | 2008-12-05 | 2014-06-02 | F. Hoffmann-La Roche Ag | Pyrrolopyrazinyl ureas as kinase inhibitors |
WO2011023696A1 (en) * | 2009-08-26 | 2011-03-03 | Nycomed Gmbh | Methylpyrrolopyridinecarboxamides |
US9796708B2 (en) * | 2013-03-14 | 2017-10-24 | Abbvie Inc. | Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9903330A2 (en) * | 1996-11-19 | 2000-03-28 | Amgen Inc. | Aryl and heteroaryl substituted fused pyrrole derivatives, as antiinflammatory agents containing the same |
WO1998047899A1 (en) * | 1997-04-24 | 1998-10-29 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
BR9812944A (en) * | 1997-10-20 | 2000-08-08 | Hoffmann La Roche | Bicyclic kinase inhibitors |
-
1999
- 1999-12-24 GB GBGB9930698.7A patent/GB9930698D0/en not_active Ceased
-
2000
- 2000-12-27 UA UA2002076056A patent/UA76410C2/en unknown
- 2000-12-27 DK DK00985695.6T patent/DK1263759T3/en active
- 2000-12-27 ES ES00985695T patent/ES2348861T3/en not_active Expired - Lifetime
- 2000-12-27 JP JP2001549392A patent/JP4871474B2/en not_active Expired - Fee Related
- 2000-12-27 DE DE60044946T patent/DE60044946D1/en not_active Expired - Lifetime
- 2000-12-27 AT AT08162392T patent/ATE552258T1/en active
- 2000-12-27 RS RSP-2010/0123A patent/RS20100123A/en unknown
- 2000-12-27 PT PT08162392T patent/PT1990343E/en unknown
- 2000-12-27 PL PL386205A patent/PL218884B1/en unknown
- 2000-12-27 PT PT00985695T patent/PT1263759E/en unknown
- 2000-12-27 DK DK08162392.8T patent/DK1990343T3/en active
- 2000-12-27 AT AT00985695T patent/ATE480537T1/en active
- 2000-12-27 ME MEP-499/08A patent/MEP49908A/en unknown
- 2000-12-27 ES ES08162392T patent/ES2382759T3/en not_active Expired - Lifetime
- 2000-12-27 RS YUP-462/02A patent/RS51303B/en unknown
-
2002
- 2002-05-23 ZA ZA200204126A patent/ZA200204126B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE552258T1 (en) | 2012-04-15 |
RS51303B (en) | 2010-12-31 |
JP2003519144A (en) | 2003-06-17 |
DE60044946D1 (en) | 2010-10-21 |
MEP49908A (en) | 2011-02-10 |
UA76410C2 (en) | 2006-08-15 |
PL218884B1 (en) | 2015-02-27 |
PT1990343E (en) | 2012-05-22 |
GB9930698D0 (en) | 2000-02-16 |
JP4871474B2 (en) | 2012-02-08 |
ES2348861T3 (en) | 2010-12-16 |
YU46202A (en) | 2005-06-10 |
ATE480537T1 (en) | 2010-09-15 |
PT1263759E (en) | 2010-11-02 |
DK1990343T3 (en) | 2012-07-23 |
ES2382759T3 (en) | 2012-06-13 |
RS20100123A (en) | 2010-12-31 |
ZA200204126B (en) | 2003-08-25 |
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