JP2017500017A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017500017A5 JP2017500017A5 JP2016532136A JP2016532136A JP2017500017A5 JP 2017500017 A5 JP2017500017 A5 JP 2017500017A5 JP 2016532136 A JP2016532136 A JP 2016532136A JP 2016532136 A JP2016532136 A JP 2016532136A JP 2017500017 A5 JP2017500017 A5 JP 2017500017A5
- Authority
- JP
- Japan
- Prior art keywords
- culture
- cells
- liters
- item
- viable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919629P | 2013-12-20 | 2013-12-20 | |
| US61/919,629 | 2013-12-20 | ||
| PCT/US2014/071701 WO2015095809A1 (en) | 2013-12-20 | 2014-12-19 | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000268A Division JP2020054388A (ja) | 2013-12-20 | 2020-01-06 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017500017A JP2017500017A (ja) | 2017-01-05 |
| JP2017500017A5 true JP2017500017A5 (enExample) | 2018-02-08 |
Family
ID=52347449
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532136A Withdrawn JP2017500017A (ja) | 2013-12-20 | 2014-12-19 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| JP2020000268A Withdrawn JP2020054388A (ja) | 2013-12-20 | 2020-01-06 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| JP2022197095A Pending JP2023022317A (ja) | 2013-12-20 | 2022-12-09 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000268A Withdrawn JP2020054388A (ja) | 2013-12-20 | 2020-01-06 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| JP2022197095A Pending JP2023022317A (ja) | 2013-12-20 | 2022-12-09 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20160289633A1 (enExample) |
| EP (1) | EP3083933B1 (enExample) |
| JP (3) | JP2017500017A (enExample) |
| DK (1) | DK3083933T3 (enExample) |
| WO (1) | WO2015095809A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160289633A1 (en) | 2013-12-20 | 2016-10-06 | Biogen Ma Inc. | Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TW202246486A (zh) * | 2014-06-09 | 2022-12-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN108350415A (zh) * | 2015-11-02 | 2018-07-31 | 阿雷斯贸易股份有限公司 | 调节灌注模式中重组蛋白生产概况的方法 |
| SG11201806310TA (en) | 2016-01-26 | 2018-08-30 | Boehringer Ingelheim Int | Linked perfusion to continuous-flow stirred-tank reactor cell culture system |
| CN115044471B (zh) | 2016-08-27 | 2025-05-27 | 三维生物科技有限公司 | 生物反应器 |
| WO2019055796A1 (en) * | 2017-09-15 | 2019-03-21 | Bristol-Myers Squibb Company | ONLINE BIOMASS CAPACITY MONITORING DURING LARGE SCALE PRODUCTION OF POLYPEPTIDES OF INTEREST |
| IL273549B2 (en) | 2017-10-06 | 2023-10-01 | Lonza Ag | Automated control of cell culture using Raman spectroscopy |
| TW202538049A (zh) | 2017-10-16 | 2025-10-01 | 美商再生元醫藥公司 | 灌注生物反應器及相關使用方法 |
| EP3710139A4 (en) * | 2017-11-13 | 2021-09-08 | Amgen Inc. | PROTEIN PRODUCTS PRODUCTION PROCESSES |
| TWI827570B (zh) * | 2017-12-11 | 2024-01-01 | 美商安進公司 | 雙特異性抗體產品之連續製造製程 |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| CA3098565A1 (en) * | 2018-04-29 | 2019-11-07 | Claire G. ZHANG | Scalable clarification process for recombinant aav production |
| US12071607B2 (en) | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| EP4368699A3 (en) * | 2018-07-03 | 2024-09-11 | Bristol-Myers Squibb Company | Methods of producing recombinant proteins |
| WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
| JP7453151B2 (ja) * | 2018-11-02 | 2024-03-19 | 協和キリン株式会社 | 液体培地の調製方法 |
| EP3914696A4 (en) * | 2019-01-25 | 2022-12-14 | Biogen MA Inc. | SEED CULTIVATION METHOD FOR THE PRODUCTION OF AAV |
| EP3953449A1 (en) * | 2019-04-11 | 2022-02-16 | Merck Patent GmbH | Cell culture media comprising keto acids |
| WO2021008571A1 (zh) * | 2019-07-16 | 2021-01-21 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| US20220315887A1 (en) * | 2019-08-01 | 2022-10-06 | Bristol-Myers Squibb Company | Methods of improving protein productivity in fed-batch cell cultures |
| JP2023503849A (ja) | 2019-11-15 | 2023-02-01 | ロンザ リミテッド | 接種物を生産するためのプロセスおよびシステム |
| CA3201327A1 (en) * | 2020-12-08 | 2022-06-16 | Partner Therapeutics, Inc. | Manufacture of granulocyte macrophage-colony stimulating factor |
| BR112023017717A2 (pt) | 2021-05-03 | 2024-01-09 | Boehringer Ingelheim Int | Método para produção de espesolimabe |
| WO2023114901A2 (en) | 2021-12-15 | 2023-06-22 | Oxford Biomedica Solutions Llc | Methods and compositions for the production of adeno-associated virus |
| EP4490278A1 (en) * | 2022-03-07 | 2025-01-15 | Ultragenyx Pharmaceutical Inc. | Modified batch aav production systems and methods |
| JP2025529258A (ja) * | 2022-09-06 | 2025-09-04 | アムジェン インコーポレイテッド | リーン灌流細胞培養法 |
| WO2026033566A2 (en) | 2024-08-09 | 2026-02-12 | Omnibrx Biotechnologies Private Limited | A multistage bioreactor system and method thereof |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| DE69233769D1 (de) | 1991-03-01 | 2009-09-24 | Dyax Corp | Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| CA2225189C (en) | 1997-03-06 | 2010-05-25 | Queen's University At Kingston | Canine factor viii gene, protein and methods of use |
| AU2002226028A1 (en) | 2000-11-14 | 2002-05-27 | Board Of Regents, Unversity Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
| ES2276853T3 (es) | 2000-12-20 | 2007-07-01 | Bayer Pharmaceuticals Corporation | Dispositivo y procedimiento para expansion en serie de semillas de celulas de mamifero. |
| MXPA04001982A (es) | 2001-09-04 | 2004-06-07 | Merck Patent Gmbh | Factor ix modificado. |
| ATE503998T1 (de) | 2002-02-21 | 2011-04-15 | Tokyo Gas Co Ltd | Testagentien zur beurteilung der pharmakologischen wirkung eines arzneistoffs sowie verfahren und reagentien zum screening eines arzneistoffs mit ausgezeichneter verabreichungswirkung und/oder geringer nebenwirkung aus enzyme, enzyminhibitoren oder rezeptorliganden umfassenden arzneistoffen und/oder prodrugs davon |
| EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US20050079574A1 (en) | 2003-01-16 | 2005-04-14 | Genentech, Inc. | Synthetic antibody phage libraries |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| CN104388324A (zh) * | 2004-03-05 | 2015-03-04 | 帝斯曼知识产权资产管理有限公司 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US8383388B2 (en) | 2006-06-19 | 2013-02-26 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| BRPI0716762A2 (pt) * | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
| US7700734B2 (en) | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
| AU2008311973B2 (en) | 2007-10-15 | 2013-10-03 | Cangene Corporation | Human Factor IX variants with an extended half life |
| WO2009140015A2 (en) | 2008-04-16 | 2009-11-19 | Bayer Healthcare Llc | Site-directed modification of factor ix |
| RU2010146387A (ru) | 2008-04-16 | 2012-05-27 | БАЙЕР ХЕЛСКЕР ЛЛСи (US) | Модифицированные полипептиды фактора ix и их применение |
| EP2811017A2 (en) | 2008-04-21 | 2014-12-10 | Novo Nordisk Health Care AG | Hyperglycosylated human coagulation factor IX |
| KR20110016899A (ko) * | 2008-04-23 | 2011-02-18 | 심포젠 에이/에스 | 폴리클로날 단백질을 제조하는 방법 |
| KR101648765B1 (ko) * | 2008-06-13 | 2016-08-17 | 센토코 오르토 바이오테크 인코포레이티드 | 포유류 세포 배양에서 고 생존 세포 밀도를 얻는 방법 |
| BR112012013502A2 (pt) | 2009-12-06 | 2017-01-10 | Biogen Idec Hemophilia Inc | "polipeptídeos quiméricos e híbridos de fator viii-fc, e métodos de uso dos mesmos". |
| CA2787942A1 (en) * | 2010-01-25 | 2011-07-28 | Ventria Bioscience | Methods & compositions for improving protein production |
| US9611310B2 (en) | 2010-07-09 | 2017-04-04 | Bioverativ Therapeutics Inc. | Systems for factor VIII processing and methods thereof |
| ES2739503T3 (es) | 2010-07-09 | 2020-01-31 | Bioverativ Therapeutics Inc | Moléculas de cadena simple procesables y polipéptidos producidos usándolas |
| SG10201913700SA (en) | 2010-07-09 | 2020-03-30 | Bioverativ Therapeutics Inc | Factor ix polypeptides and methods of use thereof |
| EP2686415B1 (en) | 2011-03-18 | 2017-11-15 | GE Healthcare Bio-Sciences AB | Flexible bag for cultivation of cells |
| CA2838695C (en) * | 2011-07-01 | 2017-02-14 | Amgen Inc. | Mammalian cell culture |
| US20160289633A1 (en) | 2013-12-20 | 2016-10-06 | Biogen Ma Inc. | Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality |
-
2014
- 2014-12-19 US US15/038,698 patent/US20160289633A1/en not_active Abandoned
- 2014-12-19 WO PCT/US2014/071701 patent/WO2015095809A1/en not_active Ceased
- 2014-12-19 DK DK14827357.6T patent/DK3083933T3/da active
- 2014-12-19 EP EP14827357.6A patent/EP3083933B1/en active Active
- 2014-12-19 JP JP2016532136A patent/JP2017500017A/ja not_active Withdrawn
-
2020
- 2020-01-06 JP JP2020000268A patent/JP2020054388A/ja not_active Withdrawn
-
2022
- 2022-12-09 JP JP2022197095A patent/JP2023022317A/ja active Pending
-
2025
- 2025-01-17 US US19/027,281 patent/US20250382568A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017500017A5 (enExample) | ||
| KR101644954B1 (ko) | 배양 동안 락테이트의 축적을 감소시키는 방법 및 폴리펩타이드를 생산하는 방법 | |
| US11912739B2 (en) | Sterile chromatography and manufacturing processes | |
| KR101591671B1 (ko) | 항체의 이질성을 감소시키는 방법 및 그 항체의 제조방법 | |
| US11808766B2 (en) | Method for generating high affinity antibodies | |
| US9908932B2 (en) | Methods of shifting an isoelectric profile of a protein product and uses thereof | |
| CN104245922B (zh) | 絮凝方法 | |
| SI2904092T1 (en) | Ingredients and procedures for the production of glycoproteins | |
| IL262923B2 (en) | Direct selection of cells expressing high levels of heteromeric proteins using intergenic glutamine synthetase complementation vectors | |
| JP2015508056A5 (enExample) | ||
| CN105378071A (zh) | 用于产生稳定转染细胞的方法和组合物 | |
| JP6108170B2 (ja) | 細胞培養用培地 | |
| HRP20250491T1 (hr) | Upotreba monensina za regulaciju glikozilacije rekombinantnih proteina | |
| US20160108357A1 (en) | Methods of culturing a cell | |
| JP3020300B2 (ja) | 動物細胞培養用組成物、培養方法および生理活性物質の製造法 | |
| CN104854125A (zh) | 在不存在全能核酸酶的情况下分离synagis*的方法 | |
| Aalilouch et al. | Monoclonal antibody production using hybridoma technology: advances, challenges and applications | |
| KR20200083564A (ko) | 단백질 산물을 제조하는 방법 | |
| Pörtner et al. | Cell culture technology | |
| AU2017393059B2 (en) | Method for producing corneal epithelial cell mass | |
| RU2786078C2 (ru) | Способы стерильной хроматографии и производства | |
| Bodeus et al. | In Vitro Production of Rat Monoclonal Antibodies | |
| US11254964B1 (en) | Cell culture methods for increased cell viability | |
| Dewan | Evaluation of Zinc Compounds and LongTM R3 IGF-I as Alternatives for Insulin in Serum-free Media to Support Growth and Productivity of an Sp2/0 Cell Line | |
| CN120137879A (zh) | 一种高效率正确表达具有非对称结构抗体的细胞培养方法 |