JP2017205118A5 - - Google Patents

Download PDF

Info

Publication number
JP2017205118A5
JP2017205118A5 JP2017126314A JP2017126314A JP2017205118A5 JP 2017205118 A5 JP2017205118 A5 JP 2017205118A5 JP 2017126314 A JP2017126314 A JP 2017126314A JP 2017126314 A JP2017126314 A JP 2017126314A JP 2017205118 A5 JP2017205118 A5 JP 2017205118A5
Authority
JP
Japan
Prior art keywords
tdp
antibody
binding fragment
disease
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017126314A
Other languages
English (en)
Japanese (ja)
Other versions
JP6417451B2 (ja
JP2017205118A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2017205118A publication Critical patent/JP2017205118A/ja
Publication of JP2017205118A5 publication Critical patent/JP2017205118A5/ja
Application granted granted Critical
Publication of JP6417451B2 publication Critical patent/JP6417451B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017126314A 2011-10-28 2017-06-28 Tdp−43に特異的な結合分子 Expired - Fee Related JP6417451B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161553113P 2011-10-28 2011-10-28
US61/553,113 2011-10-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2014537750A Division JP6240611B2 (ja) 2011-10-28 2012-10-26 Tdp−43に特異的な結合分子

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018174683A Division JP6652609B2 (ja) 2011-10-28 2018-09-19 Tdp−43に特異的な結合分子

Publications (3)

Publication Number Publication Date
JP2017205118A JP2017205118A (ja) 2017-11-24
JP2017205118A5 true JP2017205118A5 (https=) 2018-01-18
JP6417451B2 JP6417451B2 (ja) 2018-11-07

Family

ID=47720540

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014537750A Expired - Fee Related JP6240611B2 (ja) 2011-10-28 2012-10-26 Tdp−43に特異的な結合分子
JP2017126314A Expired - Fee Related JP6417451B2 (ja) 2011-10-28 2017-06-28 Tdp−43に特異的な結合分子
JP2018174683A Expired - Fee Related JP6652609B2 (ja) 2011-10-28 2018-09-19 Tdp−43に特異的な結合分子

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2014537750A Expired - Fee Related JP6240611B2 (ja) 2011-10-28 2012-10-26 Tdp−43に特異的な結合分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018174683A Expired - Fee Related JP6652609B2 (ja) 2011-10-28 2018-09-19 Tdp−43に特異的な結合分子

Country Status (18)

Country Link
US (3) US9587014B2 (https=)
EP (2) EP2771359B1 (https=)
JP (3) JP6240611B2 (https=)
KR (2) KR101961508B1 (https=)
CN (1) CN104159918B (https=)
AU (1) AU2012327211C9 (https=)
BR (1) BR112014010161B1 (https=)
CA (2) CA2853412C (https=)
CL (1) CL2014001074A1 (https=)
EA (1) EA032003B1 (https=)
ES (1) ES2883212T3 (https=)
IL (2) IL232219B (https=)
MX (2) MX357678B (https=)
MY (1) MY167795A (https=)
PH (1) PH12014500940A1 (https=)
SG (1) SG11201401735WA (https=)
WO (1) WO2013061163A2 (https=)
ZA (1) ZA201403680B (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
CA2853412C (en) 2011-10-28 2021-05-04 University Of Zurich Tdp-43 specific binding molecules
CA2914831C (en) * 2013-06-11 2022-10-11 Paul Scherrer Institut Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr
WO2015117088A2 (en) 2014-01-31 2015-08-06 Arizona Board Of Regents On Behalf Of Arizona State University Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein tdp-43
EP4406549A3 (en) 2014-07-29 2025-01-08 Neurimmune Holding AG Human-derived anti-huntingtin (htt) antibodies and uses thereof
CN104497121A (zh) * 2014-08-29 2015-04-08 苏州顺升桥生物科技有限公司 淀粉样蛋白tdp-43及其用途
EP3200825A4 (en) 2014-10-03 2018-03-21 Academia Sinica Antibodies against pathological forms of tdp-43 and uses thereof
WO2016053610A1 (en) * 2014-10-03 2016-04-07 Academia Sinica Antibodies against pathological forms of tdp-43 and uses thereof
TWI592423B (zh) * 2014-10-03 2017-07-21 中央研究院 可辨識致病性tdp-43之抗體及其用途
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
US10509045B2 (en) 2015-05-29 2019-12-17 University Of Florida Research Foundation, Incorporated Methods for diagnosing Huntington's disease
WO2017111166A1 (ja) * 2015-12-25 2017-06-29 国立大学法人東京農工大学 Tdp-43細胞内存在量関連疾患治療剤
DK3430397T3 (da) 2016-03-14 2022-05-02 Biogen Int Neuroscience Gmbh Antistofafhængig cellemedieret fagocytoseassay til pålidelig måling af optagelse af aggregerede proteiner
US10940161B2 (en) 2016-04-04 2021-03-09 University Of Florida Research Foundation, Incorporated Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
US20190330318A1 (en) 2016-07-25 2019-10-31 Biogen Ma Inc. Anti-hspa5 (grp78) antibodies and uses thereof
MA47163A (fr) 2016-12-16 2019-11-06 Biogen Ma Inc Facteur 11 de différenciation de croissance activé protéolytiquement stabilisé
KR102715540B1 (ko) 2017-03-14 2024-10-08 파이브 프라임 테라퓨틱스, 인크. 산성 pH에서 VISTA에 결합하는 항체
WO2018195110A1 (en) 2017-04-17 2018-10-25 University Of Florida Research Foundation, Incorporated Regolation of ran translation by pkr and eif2a-p pathways
CA3064785A1 (en) * 2017-05-30 2018-12-06 The University Of British Columbia Epitopes in the rna recognition motif 1 (rrm1) of tdp-43 and misfolding-selective antibodies thereto
IL272773B2 (en) 2017-08-22 2024-06-01 Biogen Ma Inc Pharmaceutical preparations containing anti-amyloid cell antibodies
JP2020535448A (ja) 2017-09-25 2020-12-03 ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. Ranタンパク質の検出のための免役アッセイ
US11246857B2 (en) * 2017-12-14 2022-02-15 The Johns Hopkins University Anti-fungal inhibitors
WO2019113711A1 (en) 2017-12-14 2019-06-20 University Of Ottawa Exosome packaging and targeted autophagy
EP3735422A1 (en) * 2018-01-05 2020-11-11 AC Immune SA Misfolded tdp-43 binding molecules
US12215142B2 (en) 2018-03-16 2025-02-04 National University Corporation Shiga University Of Medical Science Antibody fragment degrading and removing abnormal TDP-43
BR112020019083A2 (pt) 2018-03-21 2020-12-29 Five Prime Therapeutics, Inc. Anticorpos, ácido nucleico, composições, célula e métodos para preparar um anticorpo, para tratar câncer, para tratar uma doença infecciosa, para tratar uma inflamação, para a identificação de um anticorpo, para melhorar a eficácia antitumoral de um anticorpo, para melhorar a farmacocinética de um anticorpo, para selecionar um anticorpo, para melhorar a eficácia de anticorpos, para isolar anticorpos, para detectar vista em uma amostra e para tratar câncer
TW202019398A (zh) * 2018-06-28 2020-06-01 張翔毓 用於治療或預防構形疾病之方法及藥物篩選方法
BR112021000303A2 (pt) 2018-07-11 2021-04-13 Five Prime Therapeutics, Inc. Anticorpos que se ligam a vista em ph ácido
CN113508135A (zh) 2018-10-29 2021-10-15 比奥根Ma公司 增强血脑屏障转运的人源化和稳定化的fc5变体
AU2019399680A1 (en) * 2018-12-14 2021-07-15 Promis Neurosciences Inc. Antibodies to misfolded TDP-43 and methods of use
KR20220012270A (ko) * 2019-05-23 2022-02-03 에이씨 이뮨 에스.에이. 항-tdp-43 결합 분자 및 이의 용도
JP7850066B2 (ja) * 2019-08-12 2026-04-22 セロシア セラピューティクス プロプライアタリー リミティド 治療のための組成物および方法
WO2021055880A1 (en) 2019-09-20 2021-03-25 University Of Florida Researchfoundation, Incorporated Detection of antibodies against ran proteins from serum and tissue lysates
GB202004863D0 (en) * 2020-04-02 2020-05-20 Univ Oxford Innovation Ltd Method
BR112022021604A2 (pt) 2020-04-28 2022-12-06 Sola Biosciences Llc Composições e métodos para tratamento de proteinopatias associadas à tdp-43
CA3176840A1 (en) * 2020-04-29 2021-11-04 Neil R. Cashman Single chain antibodies and intrabodies to misfolded tdp-43 and methods of use
US20230288432A1 (en) * 2020-07-06 2023-09-14 The Board Of Regents Of The University Of Texas System Tdp-43 biosensor cell lines
EP4196162A1 (en) * 2020-08-14 2023-06-21 AC Immune SA Humanized anti-tdp-43 binding molecules and uses thereof
JP2023551542A (ja) 2020-11-30 2023-12-08 エニグマ バイオインテリジェンス,インコーポレイテッド アルツハイマー病の非侵襲的評価
MX2023008744A (es) 2021-01-29 2023-10-02 Illimis Therapeutics Inc Molecula de fusion que tiene actividad no inflamatoria inductora de la fagocitosis.
CN112920264B (zh) * 2021-02-08 2022-07-05 武汉大学 Tdp-43蛋白的o-糖基化突变体及其应用
JP6961278B1 (ja) * 2021-03-10 2021-11-05 国立研究開発法人量子科学技術研究開発機構 生体試料中のtdp−43を測定する方法及び装置
CA3221254A1 (en) * 2021-05-27 2022-12-01 Mayo Foundation For Medical Education And Research Methods and materials for treating proteinopathies
US20230107901A1 (en) * 2021-10-01 2023-04-06 University Of Utah Research Foundation Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor
CR20240378A (es) 2022-02-16 2024-10-03 Ac Immune Sa Moléculas de unión anti -tdp-43 humanizadas y usos de las mismas
EP4504775A1 (en) * 2022-04-08 2025-02-12 AC Immune SA Anti-tdp-43 binding molecules
WO2023205579A1 (en) * 2022-04-18 2023-10-26 The Regents Of The University Of California Compositions and methods for disrupting pathological aggregates
EP4497826A4 (en) 2022-04-22 2026-03-25 Univ Niigata TDP-43 AGGREGATION SUPPRESSANT AND PHARMACEUTICAL COMPOSITION
WO2024184494A1 (en) 2023-03-08 2024-09-12 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
EP4716540A1 (en) * 2023-06-20 2026-04-01 The Trustees of Dartmouth College Chimeric antigen receptors (cars) targeting tdp43, tregs expressing said cars, and use thereof for the treatment of als, ftd and ad
KR102859015B1 (ko) * 2023-07-20 2025-09-12 충북대학교 산학협력단 c­Abl에 의한 TDP­43의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법
CN116875738A (zh) * 2023-07-24 2023-10-13 山东省农业科学院畜牧兽医研究所 一种鉴定牛tdp-43基因启动子活性区域的方法
AR133828A1 (es) * 2023-09-15 2025-11-05 Prothena Biosciences Ltd Anticuerpos anti-tdp-43 y sus usos
WO2025186332A1 (en) 2024-03-05 2025-09-12 Ac Immune Sa Vectorized anti-tdp-43 antibodies
WO2026013218A1 (en) 2024-07-10 2026-01-15 Ac Immune Sa Anti-tdp-43 vectors, binding molecules and uses thereof
KR20260044274A (ko) * 2024-09-23 2026-04-02 주식회사 피플바이오 Tdp-43에 특이적으로 결합하는 항체 및 이의 용도
CN119331085B (zh) * 2024-10-16 2025-03-14 中国科学院合肥物质科学研究院 沙贝冠状病毒广谱中和抗体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
CA2253633A1 (en) 1997-12-03 1999-06-03 Boehringer Mannheim Corporation Complex specific antibodies, method of preparation and uses thereof
US8354236B2 (en) * 2006-09-29 2013-01-15 The Trustees Of The University Of Pennsylvania Detection of neurodegenerative disease
KR20120017469A (ko) * 2007-01-05 2012-02-28 유니버시티 오브 취리히 질환 특이적 결합 분자 및 표적을 제공하는 방법
WO2008151055A1 (en) 2007-06-01 2008-12-11 Mayo Foundation For Medical Education And Research Diagnosing neurodegenerative diseases
WO2009008529A1 (ja) 2007-07-06 2009-01-15 Tokyo Metropolitan Organization For Medical Research Tdp-43凝集物に特異的に結合する抗体
CA2713871C (en) 2008-02-01 2018-05-22 Washington University In St. Louis Sequences associated with tdp-43 proteinopathies and methods of using the same
AU2009328505B2 (en) 2008-12-19 2014-11-27 Panima Pharmaceuticals Ag Human anti-alpha-synuclein autoantibodies
CN101634656A (zh) 2009-08-21 2010-01-27 武汉三鹰生物技术有限公司 人tdp-43的单抗包被酶标板的制法及elisa检测试剂盒
CA2853412C (en) 2011-10-28 2021-05-04 University Of Zurich Tdp-43 specific binding molecules

Similar Documents

Publication Publication Date Title
JP2017205118A5 (https=)
JP2015505665A5 (https=)
HRP20150831T1 (hr) Humana anti-alfa- sinuklein auto-protutijela
JP2014503178A5 (https=)
JP2014528695A5 (https=)
JP2012512634A5 (https=)
JP2016511254A5 (https=)
JP2017522886A5 (https=)
CN109937212A (zh) B7-h3抗体、其抗原结合片段及其医药用途
IL273196B2 (en) Claudin6 antibodies and methods of treating cancer
IL261666B2 (en) Binding proteins and methods of use thereof
JP2020500003A5 (https=)
TWI843040B (zh) 抗N3pGlu類澱粉β抗體及其用途
JP2013116897A5 (https=)
JP2019533426A5 (https=)
JP2021500916A5 (https=)
WO2014028538A2 (en) Multiplexed in situ molecular analyses and programmable molecular probes for regulated signal amplification
HRP20201296T1 (hr) Liječenje transtiretinske (ttr) amiloidoze na bazi antitijela i odgovarajuća antitijela humanog porijekla
JP2018532689A5 (https=)
US10098973B2 (en) Anti-tau antibody and uses thereof
HK1259325A1 (zh) 淀粉样蛋白β中的N-末端表位及其构象选择性抗体
HK1259326A1 (zh) 淀粉样蛋白β中间区域中的表位及其构象选择性抗体
KR101515020B1 (ko) 햅텐 및 이에 결합하는 항체를 레퍼런스 항체로 이용하는 면역학적 측정 방법 및 상기 레퍼런스 항체를 이용한 면역학적 측정장치
JP2021516254A5 (https=)
US20120316085A1 (en) Antibody humanization by framework assembly