JP2017169579A5 - - Google Patents
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- JP2017169579A5 JP2017169579A5 JP2017097126A JP2017097126A JP2017169579A5 JP 2017169579 A5 JP2017169579 A5 JP 2017169579A5 JP 2017097126 A JP2017097126 A JP 2017097126A JP 2017097126 A JP2017097126 A JP 2017097126A JP 2017169579 A5 JP2017169579 A5 JP 2017169579A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- antibody
- feeder
- tnfα
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10005602.7A EP2400298B1 (en) | 2010-05-28 | 2010-05-28 | Single B-cell cultivation method and specific antibody production |
| EP10005602.7 | 2010-05-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015138308A Division JP6204415B2 (ja) | 2010-05-28 | 2015-07-10 | 単一ｂ細胞培養法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017169579A JP2017169579A (ja) | 2017-09-28 |
| JP2017169579A5 true JP2017169579A5 (https=) | 2017-11-16 |
| JP6353953B2 JP6353953B2 (ja) | 2018-07-04 |
Family
ID=42396427
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510646A Active JP5779239B2 (ja) | 2010-05-28 | 2011-05-26 | 単一ｂ細胞培養法 |
| JP2015138308A Active JP6204415B2 (ja) | 2010-05-28 | 2015-07-10 | 単一ｂ細胞培養法 |
| JP2017097126A Active JP6353953B2 (ja) | 2010-05-28 | 2017-05-16 | 単一ｂ細胞培養法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510646A Active JP5779239B2 (ja) | 2010-05-28 | 2011-05-26 | 単一ｂ細胞培養法 |
| JP2015138308A Active JP6204415B2 (ja) | 2010-05-28 | 2015-07-10 | 単一ｂ細胞培養法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20130084637A1 (https=) |
| EP (4) | EP2400298B1 (https=) |
| JP (3) | JP5779239B2 (https=) |
| KR (1) | KR101495976B1 (https=) |
| CN (2) | CN105039252B (https=) |
| BR (1) | BR112012025695B1 (https=) |
| CA (2) | CA3008822C (https=) |
| DK (1) | DK2400298T3 (https=) |
| ES (4) | ES2434256T3 (https=) |
| MX (2) | MX345884B (https=) |
| PL (3) | PL2400298T3 (https=) |
| RU (1) | RU2709531C2 (https=) |
| SI (1) | SI2400298T1 (https=) |
| WO (1) | WO2011147903A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2794652B1 (en) | 2011-12-21 | 2017-11-15 | F. Hoffmann-La Roche AG | Rapid method for cloning and expression of cognate antibody variable region gene segments |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| EP2914629A1 (en) | 2012-11-05 | 2015-09-09 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| WO2014152832A1 (en) | 2013-03-14 | 2014-09-25 | Immusoft Corporation | Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors |
| US20160033504A1 (en) * | 2013-03-15 | 2016-02-04 | Alder Biopharmaceuticals, Inc. | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| CN104232577B (zh) * | 2013-06-20 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种获得自身反应性b细胞的方法 |
| AU2014370516B9 (en) * | 2013-12-24 | 2021-07-29 | Kling Biotherapeutics B.V. | Ex vivo antibody production |
| JP7114460B2 (ja) | 2015-06-26 | 2022-08-08 | サノフィ・バイオテクノロジー | モノクローナル抗ＩＬ－１ＲＡｃＰ抗体 |
| WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| CN108884442B (zh) | 2016-03-30 | 2023-06-02 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| CN106222137A (zh) * | 2016-08-24 | 2016-12-14 | 南昌大学 | 一种体外活化人记忆性b细胞成浆细胞的培养方法 |
| WO2018112407A1 (en) | 2016-12-15 | 2018-06-21 | Duke University | Antibodies and methods for depleting regulatory b10 cells and use in combination with immune checkpoint inhibitors |
| EP3562936B1 (en) * | 2017-01-02 | 2024-05-22 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| CN110621773B (zh) | 2017-05-19 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 用于产生胸腺细胞上清液的方法 |
| US12009521B2 (en) * | 2017-11-08 | 2024-06-11 | Sharp Kabushiki Kaisha | Negative electrode for batteries, battery, and method for producing battery |
| WO2019105864A1 (en) | 2017-11-30 | 2019-06-06 | F. Hoffmann-La Roche Ag | B-cell cultivation method |
| CN108588019B (zh) * | 2018-05-03 | 2019-04-02 | 首都医科大学附属北京朝阳医院 | 一种体外诱导初始b细胞分化为调节性b细胞的方法及其培养条件 |
| CN109234232A (zh) * | 2018-09-30 | 2019-01-18 | 杭州华安单抗生物技术有限公司 | 兔外周血b细胞的培养体系及培养方法、抗体的制备方法和应用 |
| EP3902830A1 (en) * | 2018-12-30 | 2021-11-03 | F. Hoffmann-La Roche AG | Anti-rabbit cd19 antibodies and methods of use |
| US20230158074A1 (en) * | 2020-04-16 | 2023-05-25 | The General Hospital Corporation | B cell immunomodulatory therapy for acute respiratory distress syndrome |
| CN111518765B (zh) * | 2020-05-12 | 2021-01-26 | 优睿赛思(武汉)生物科技有限公司 | 一种b淋巴细胞体外培养体系及应用 |
| CA3210091A1 (en) * | 2021-02-05 | 2022-08-11 | Amgen Inc. | Non-terminal antibody discovery methods and single cell assays |
| AR130550A1 (es) | 2022-09-21 | 2024-12-18 | Sanofi Biotechnology | Anticuerpo anti-il-1r3 humanizado y métodos de uso |
| CN120917139A (zh) | 2023-04-05 | 2025-11-07 | 豪夫迈·罗氏有限公司 | 用于抗体表达细胞的体外培养方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58116678A (ja) * | 1981-12-28 | 1983-07-11 | Ajinomoto Co Inc | 浮遊性動物細胞の培養法およびその装置 |
| JPS58216125A (ja) * | 1982-06-09 | 1983-12-15 | Asahi Chem Ind Co Ltd | ヒト抗体の産生方法 |
| WO1991016418A1 (en) * | 1990-04-17 | 1991-10-31 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Feeder cells for monoclonal antibody production |
| US5387940A (en) * | 1993-07-07 | 1995-02-07 | Rca Thomson Licensing Corporation | Method and apparatus for providing scaleable compressed video signal |
| WO1995013089A1 (en) * | 1993-11-10 | 1995-05-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Compositions and method for stimulating antibody release by b lymphocytes |
| US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| US6541225B1 (en) * | 2000-01-26 | 2003-04-01 | Raven Biotechnologies, Inc. | Methods and compositions for generating human monoclonal antibodies |
| EP1312670A4 (en) * | 2000-08-16 | 2005-11-30 | Takara Bio Inc | METHOD FOR THE EXTENSIVE CULTURE OF ANTIGEN-SPECIFIC CYTOTOXIC T CELLS |
| US20060051348A1 (en) | 2004-09-09 | 2006-03-09 | Jorn Gorlach | Method of producing a plurality of isolated antibodies to a plurality of cognate antigens |
| US20070031550A1 (en) | 2005-08-15 | 2007-02-08 | Samson Allan D | Method for continuously processing meat substrates |
| CA2622603C (en) * | 2005-09-15 | 2014-06-17 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| KR20080073293A (ko) * | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | 항체 라이브러리의 세포 디스플레이 |
| NZ592159A (en) * | 2005-12-09 | 2012-12-21 | Amc Amsterdam | Means and methods for influencing the stability of antibody producing cells |
| BRPI0619908A2 (pt) * | 2005-12-16 | 2011-10-25 | Ribovax Biotechnologies Sa | método para imortalização de uma população de células, população de células, população de células oligoclonal ou monoclonal, cultura celular, sobrenadante de uma cultura celular, biclioteca de dnas, uso de uma população de células, cultura celular, sobrenadante ou biblioteca de dnas, kit para identificar e produzir um anticorpo monoclonal, método para produzir uma cultura celular, e método para produzir um anticorpo monoclonal |
| EP2021463B1 (en) * | 2006-05-19 | 2016-11-23 | Alder Biopharmaceuticals, Inc. | Culture method for obtaining a clonal population of antigen-specific b cells |
| US8642307B2 (en) | 2006-05-25 | 2014-02-04 | Nalge Nunc International Corporation | Cell culture surface chemistries |
| US8404235B2 (en) * | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
| EP2242836B1 (en) * | 2008-01-28 | 2015-05-20 | Thomas Jefferson University | Method of making hybrid cells that express useful antibodies |
| WO2010011894A1 (en) * | 2008-07-24 | 2010-01-28 | The Board Of Regents Of The University Of Texas System | Vh4 codon signature for multiple sclerosis |
| DK2352763T4 (da) * | 2008-10-01 | 2022-10-17 | Amgen Res Munich Gmbh | Bispecifikke enkeltkædede antistoffer med specificitet for højmolekylære målantigener |
| PL2350128T3 (pl) * | 2008-10-22 | 2015-03-31 | Inst Res Biomedicine | Sposoby wytwarzania przeciwciał z komórek plazmatycznych |
| EP2233502A1 (en) * | 2009-03-27 | 2010-09-29 | Deutsches Rheuma-Forschungszentrum Berlin | Sialylated antigen-specific antibodies for treatment or prophylaxis of unwanted inflammatory immune reactions and methods of producing them |
| US8609101B2 (en) * | 2009-04-23 | 2013-12-17 | Theraclone Sciences, Inc. | Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies |
| WO2011046623A2 (en) * | 2009-10-16 | 2011-04-21 | Duke University | Hiv-1 antibodies |
-
2010
- 2010-05-28 SI SI201030367T patent/SI2400298T1/sl unknown
- 2010-05-28 PL PL10005602T patent/PL2400298T3/pl unknown
- 2010-05-28 ES ES10005602T patent/ES2434256T3/es active Active
- 2010-05-28 DK DK10005602.7T patent/DK2400298T3/da active
- 2010-05-28 EP EP10005602.7A patent/EP2400298B1/en active Active
-
2011
- 2011-05-26 EP EP17169362.5A patent/EP3239708B1/en active Active
- 2011-05-26 MX MX2015001467A patent/MX345884B/es unknown
- 2011-05-26 RU RU2015155197A patent/RU2709531C2/ru active
- 2011-05-26 MX MX2012013437A patent/MX2012013437A/es active IP Right Grant
- 2011-05-26 PL PL17169362T patent/PL3239708T3/pl unknown
- 2011-05-26 JP JP2013510646A patent/JP5779239B2/ja active Active
- 2011-05-26 ES ES17169362T patent/ES2858450T3/es active Active
- 2011-05-26 CN CN201510482333.7A patent/CN105039252B/zh active Active
- 2011-05-26 ES ES11722402.2T patent/ES2632928T3/es active Active
- 2011-05-26 CA CA3008822A patent/CA3008822C/en active Active
- 2011-05-26 PL PL20214670.0T patent/PL3825690T3/pl unknown
- 2011-05-26 CA CA2798286A patent/CA2798286C/en active Active
- 2011-05-26 WO PCT/EP2011/058616 patent/WO2011147903A1/en not_active Ceased
- 2011-05-26 BR BR112012025695-5A patent/BR112012025695B1/pt active IP Right Grant
- 2011-05-26 EP EP11722402.2A patent/EP2577304B1/en active Active
- 2011-05-26 CN CN201180026559.6A patent/CN102918395B/zh active Active
- 2011-05-26 ES ES20214670T patent/ES3039652T3/es active Active
- 2011-05-26 KR KR1020127030603A patent/KR101495976B1/ko active Active
- 2011-05-26 EP EP20214670.0A patent/EP3825690B1/en active Active
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2012
- 2012-11-27 US US13/686,538 patent/US20130084637A1/en not_active Abandoned
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2015
- 2015-07-10 JP JP2015138308A patent/JP6204415B2/ja active Active
-
2016
- 2016-05-06 US US15/148,861 patent/US20160251621A1/en not_active Abandoned
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2017
- 2017-05-16 JP JP2017097126A patent/JP6353953B2/ja active Active
-
2018
- 2018-03-27 US US15/937,456 patent/US20180298335A1/en not_active Abandoned
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2020
- 2020-06-12 US US16/900,793 patent/US20210062149A1/en not_active Abandoned
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