JP2016536005A5 - - Google Patents
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- JP2016536005A5 JP2016536005A5 JP2016543983A JP2016543983A JP2016536005A5 JP 2016536005 A5 JP2016536005 A5 JP 2016536005A5 JP 2016543983 A JP2016543983 A JP 2016543983A JP 2016543983 A JP2016543983 A JP 2016543983A JP 2016536005 A5 JP2016536005 A5 JP 2016536005A5
- Authority
- JP
- Japan
- Prior art keywords
- cell population
- test cell
- mitochondrial
- contacting
- outer membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 27
- 230000002438 mitochondrial effect Effects 0.000 claims description 15
- 230000008823 permeabilization Effects 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- 101150082208 DIABLO gene Proteins 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000035945 sensitivity Effects 0.000 claims description 3
- RZCJYMOBWVJQGV-UHFFFAOYSA-N 2-naphthyloxyacetic acid Chemical compound C1=CC=CC2=CC(OCC(=O)O)=CC=C21 RZCJYMOBWVJQGV-UHFFFAOYSA-N 0.000 claims description 2
- 102000018832 Cytochromes Human genes 0.000 claims description 2
- 108010052832 Cytochromes Proteins 0.000 claims description 2
- 102100033189 Diablo IAP-binding mitochondrial protein Human genes 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- FNEZBBILNYNQGC-UHFFFAOYSA-N methyl 2-(3,6-diamino-9h-xanthen-9-yl)benzoate Chemical compound COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=CC(N)=CC=C21 FNEZBBILNYNQGC-UHFFFAOYSA-N 0.000 claims description 2
- 231100001143 noxa Toxicity 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 238000010212 intracellular staining Methods 0.000 claims 1
- 238000012758 nuclear staining Methods 0.000 claims 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 14
- 238000004020 luminiscence type Methods 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361879869P | 2013-09-19 | 2013-09-19 | |
| US61/879,869 | 2013-09-19 | ||
| PCT/US2014/056284 WO2015042249A1 (en) | 2013-09-19 | 2014-09-18 | Methods of bh3 profiling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019188457A Division JP2020012850A (ja) | 2013-09-19 | 2019-10-15 | Ｂｈ３プロファイリングの方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536005A JP2016536005A (ja) | 2016-11-24 |
| JP2016536005A5 true JP2016536005A5 (enExample) | 2017-11-02 |
| JP6663852B2 JP6663852B2 (ja) | 2020-03-13 |
Family
ID=52689380
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543983A Active JP6663852B2 (ja) | 2013-09-19 | 2014-09-18 | Ｂｈ３プロファイリングの方法 |
| JP2019188457A Withdrawn JP2020012850A (ja) | 2013-09-19 | 2019-10-15 | Ｂｈ３プロファイリングの方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019188457A Withdrawn JP2020012850A (ja) | 2013-09-19 | 2019-10-15 | Ｂｈ３プロファイリングの方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10739333B2 (enExample) |
| EP (1) | EP3047276B1 (enExample) |
| JP (2) | JP6663852B2 (enExample) |
| AU (1) | AU2014323526B2 (enExample) |
| CA (1) | CA2922503C (enExample) |
| WO (1) | WO2015042249A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1590363A4 (en) | 2002-09-09 | 2006-11-02 | Dana Farber Cancer Inst Inc | BH3-PEPTIDES AND METHOD FOR THEIR USE |
| EP2008106A2 (en) | 2006-03-31 | 2008-12-31 | Dana-Farber Cancer Institute | Methods of determining cellular chemosensitivity |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| CA2799420C (en) | 2010-05-14 | 2018-10-02 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
| US10393733B2 (en) * | 2012-09-19 | 2019-08-27 | Dana-Farber Cancer Institute, Inc. | Dynamic BH3 profiling |
| JP2016531113A (ja) | 2013-07-25 | 2016-10-06 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 転写因子の阻害剤およびその使用 |
| WO2015042249A1 (en) * | 2013-09-19 | 2015-03-26 | Dana-Farber Cancer Institute, Inc. | Methods of bh3 profiling |
| MX379463B (es) | 2013-11-08 | 2025-03-10 | Dana Farber Cancer Inst Inc | Terapia de combinación para el cáncer usando inhibidores de la proteína bromodominio y extra-terminal. |
| MX2016009974A (es) | 2014-01-31 | 2016-10-31 | Dana Farber Cancer Inst Inc | Derivados de diaminopirimidina bencensulfona y sus usos. |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| RU2722179C2 (ru) | 2014-02-28 | 2020-05-28 | Тэнша Терапеутикс, Инк. | Лечение состояний, ассоциированных с гиперинсулинемией |
| KR20170032474A (ko) | 2014-08-08 | 2017-03-22 | 다나-파버 캔서 인스티튜트 인크. | 디히드로프테리디논 유도체 및 그의 용도 |
| EP3177626A4 (en) | 2014-08-08 | 2017-12-27 | Dana Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| BR112017008714A2 (pt) | 2014-10-27 | 2017-12-19 | Tensha Therapeutics Inc | inibidores de bromodomínio |
| AU2016206882B2 (en) | 2015-01-12 | 2022-03-10 | Eutropics Pharmaceuticals, Inc. | Context dependent diagnostics test for guiding cancer treatment |
| HK1251655A1 (zh) | 2015-04-20 | 2019-02-01 | Tolero Pharmaceuticals, Inc. | 通过线粒体分析预测对阿伏西地的应答 |
| CA2983022C (en) | 2015-04-27 | 2023-03-07 | Dana-Farber Cancer Institute, Inc. | High throughput bh3 profiling: a rapid and scalable technology to bh3 profile on low numbers of cells |
| EP4086264B1 (en) | 2015-05-18 | 2023-10-25 | Sumitomo Pharma Oncology, Inc. | Alvocidib prodrugs having increased bioavailability |
| US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| US10568887B2 (en) | 2015-08-03 | 2020-02-25 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
| KR20180049058A (ko) | 2015-09-11 | 2018-05-10 | 다나-파버 캔서 인스티튜트 인크. | 시아노 티에노트리아졸로디아제핀 및 그의 용도 |
| CA2996977A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
| SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| MX2019007332A (es) | 2016-12-19 | 2019-11-18 | Tolero Pharmaceuticals Inc | Péptidos indicadores y métodos para caracterizar sensibilidad. |
| JP7196160B2 (ja) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン |
| AU2019391097B2 (en) | 2018-12-04 | 2025-07-03 | Sumitomo Pharma America, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| JP7589159B2 (ja) | 2019-02-26 | 2024-11-25 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ライブセルイメージング（ｌｉｖｅ ｃｅｌｌ ｉｍａｇｉｎｇ）動的ＢＨ３プロファイリング |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
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| WO2015042249A1 (en) | 2013-09-19 | 2015-03-26 | Dana-Farber Cancer Institute, Inc. | Methods of bh3 profiling |
| CA2983022C (en) | 2015-04-27 | 2023-03-07 | Dana-Farber Cancer Institute, Inc. | High throughput bh3 profiling: a rapid and scalable technology to bh3 profile on low numbers of cells |
| WO2017007858A1 (en) | 2015-07-06 | 2017-01-12 | Whitehead Institute For Biomedical Research | Methods and compositions relating to proteasome inhibitor resistance |
| JP7589159B2 (ja) | 2019-02-26 | 2024-11-25 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ライブセルイメージング（ｌｉｖｅ ｃｅｌｌ ｉｍａｇｉｎｇ）動的ＢＨ３プロファイリング |
-
2014
- 2014-09-18 WO PCT/US2014/056284 patent/WO2015042249A1/en not_active Ceased
- 2014-09-18 CA CA2922503A patent/CA2922503C/en active Active
- 2014-09-18 EP EP14845952.2A patent/EP3047276B1/en active Active
- 2014-09-18 JP JP2016543983A patent/JP6663852B2/ja active Active
- 2014-09-18 US US15/022,987 patent/US10739333B2/en active Active
- 2014-09-18 AU AU2014323526A patent/AU2014323526B2/en active Active
-
2019
- 2019-10-15 JP JP2019188457A patent/JP2020012850A/ja not_active Withdrawn
-
2020
- 2020-07-02 US US16/919,173 patent/US11867687B2/en active Active
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