JP2017526931A5 - - Google Patents
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- Publication number
- JP2017526931A5 JP2017526931A5 JP2017513644A JP2017513644A JP2017526931A5 JP 2017526931 A5 JP2017526931 A5 JP 2017526931A5 JP 2017513644 A JP2017513644 A JP 2017513644A JP 2017513644 A JP2017513644 A JP 2017513644A JP 2017526931 A5 JP2017526931 A5 JP 2017526931A5
- Authority
- JP
- Japan
- Prior art keywords
- haah
- exosomes
- item
- exosome
- magnetic beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100022108 Aspartyl/asparaginyl beta-hydroxylase Human genes 0.000 claims description 26
- 101000901030 Homo sapiens Aspartyl/asparaginyl beta-hydroxylase Proteins 0.000 claims description 26
- 210000001808 exosome Anatomy 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- 239000011324 bead Substances 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 239000012472 biological sample Substances 0.000 claims description 5
- 238000002965 ELISA Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 2
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 2
- 101001024605 Homo sapiens Next to BRCA1 gene 1 protein Proteins 0.000 claims description 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims description 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims description 2
- 108010036226 antigen CYFRA21.1 Proteins 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 238000003118 sandwich ELISA Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049582P | 2014-09-12 | 2014-09-12 | |
| US62/049,582 | 2014-09-12 | ||
| PCT/US2015/049976 WO2016040941A1 (en) | 2014-09-12 | 2015-09-14 | Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526931A JP2017526931A (ja) | 2017-09-14 |
| JP2017526931A5 true JP2017526931A5 (enExample) | 2018-09-06 |
| JP6669731B2 JP6669731B2 (ja) | 2020-03-18 |
Family
ID=55454511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513644A Expired - Fee Related JP6669731B2 (ja) | 2014-09-12 | 2015-09-14 | がん患者由来のヒト血清のエクソソーム画分からのアスパルチル（アスパラギニル）ベータヒドロキシラーゼ（ｈａａｈ）の回収 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20160077098A1 (enExample) |
| EP (1) | EP3191841A4 (enExample) |
| JP (1) | JP6669731B2 (enExample) |
| CA (1) | CA2961004A1 (enExample) |
| WO (1) | WO2016040941A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190049455A1 (en) * | 2017-08-11 | 2019-02-14 | Panacea Pharmaceuticals Inc. | HAAH and MMP-9 are Complementary Cancer Biomarkers and Predictors of Metastasis when Combined |
| CN107907689A (zh) * | 2017-10-10 | 2018-04-13 | 北京大学 | 外泌体蛋白cd5l的检测方法 |
| CN111269986A (zh) * | 2020-03-24 | 2020-06-12 | 江西惠肽生物科技有限公司 | 外泌体中asph基因在肺癌早期诊断试剂盒中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6835370B2 (en) * | 1999-11-08 | 2004-12-28 | Rhode Island Hospital | Diagnosis and treatment of malignant neoplasms |
| US20080124718A1 (en) * | 2006-01-27 | 2008-05-29 | Panacea Pharmaceuticals, Inc. | Methods of diagnosing, predicting therapeutic efficacy and screening for new therapeutic agents for leukemia |
| US20090298097A1 (en) * | 2007-07-17 | 2009-12-03 | Harris Pamela J | Methods for the diagnosis of lung cancer |
| US20130178383A1 (en) * | 2008-11-12 | 2013-07-11 | David Spetzler | Vesicle isolation methods |
| CN107254538A (zh) * | 2008-11-12 | 2017-10-17 | 卡里斯生命科学瑞士控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
| KR20130056855A (ko) * | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
| JP2014507160A (ja) * | 2011-02-22 | 2014-03-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． | 循環バイオマーカー |
| KR20140136805A (ko) * | 2013-05-21 | 2014-12-01 | 건국대학교 산학협력단 | 신규한 인간 엑소좀 단백질 및 그 용도 |
-
2015
- 2015-09-14 EP EP15839551.7A patent/EP3191841A4/en not_active Withdrawn
- 2015-09-14 US US14/853,254 patent/US20160077098A1/en not_active Abandoned
- 2015-09-14 WO PCT/US2015/049976 patent/WO2016040941A1/en not_active Ceased
- 2015-09-14 CA CA2961004A patent/CA2961004A1/en not_active Abandoned
- 2015-09-14 JP JP2017513644A patent/JP6669731B2/ja not_active Expired - Fee Related
-
2017
- 2017-12-01 US US15/828,744 patent/US20210148915A9/en not_active Abandoned
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