JP6669731B2 - がん患者由来のヒト血清のエクソソーム画分からのアスパルチル（アスパラギニル）ベータヒドロキシラーゼ（ｈａａｈ）の回収 - Google Patents

がん患者由来のヒト血清のエクソソーム画分からのアスパルチル（アスパラギニル）ベータヒドロキシラーゼ（ｈａａｈ）の回収 Download PDF

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JP6669731B2
JP6669731B2 JP2017513644A JP2017513644A JP6669731B2 JP 6669731 B2 JP6669731 B2 JP 6669731B2 JP 2017513644 A JP2017513644 A JP 2017513644A JP 2017513644 A JP2017513644 A JP 2017513644A JP 6669731 B2 JP6669731 B2 JP 6669731B2
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haah
exosomes
cancer
serum
elisa
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JP2017526931A5 (enExample
JP2017526931A (ja
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マーク セメナック，
マーク セメナック，
ホッセイン ガンバリ，
ホッセイン ガンバリ，
マイケル レボウィッツ，
マイケル レボウィッツ，
Original Assignee
パナシア ファーマシューティカルズ， インコーポレイテッド
パナシア ファーマシューティカルズ， インコーポレイテッド
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    • G01N33/57585—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G01N33/5759—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
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  • Urology & Nephrology (AREA)
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  • Biochemistry (AREA)
  • Biotechnology (AREA)
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  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017513644A 2014-09-12 2015-09-14 がん患者由来のヒト血清のエクソソーム画分からのアスパルチル（アスパラギニル）ベータヒドロキシラーゼ（ｈａａｈ）の回収 Expired - Fee Related JP6669731B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049582P 2014-09-12 2014-09-12
US62/049,582 2014-09-12
PCT/US2015/049976 WO2016040941A1 (en) 2014-09-12 2015-09-14 Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients

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JP2017526931A JP2017526931A (ja) 2017-09-14
JP2017526931A5 JP2017526931A5 (enExample) 2018-09-06
JP6669731B2 true JP6669731B2 (ja) 2020-03-18

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JP2017513644A Expired - Fee Related JP6669731B2 (ja) 2014-09-12 2015-09-14 がん患者由来のヒト血清のエクソソーム画分からのアスパルチル（アスパラギニル）ベータヒドロキシラーゼ（ｈａａｈ）の回収

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US (2) US20160077098A1 (enExample)
EP (1) EP3191841A4 (enExample)
JP (1) JP6669731B2 (enExample)
CA (1) CA2961004A1 (enExample)
WO (1) WO2016040941A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019032742A1 (en) * 2017-08-11 2019-02-14 Panacea Pharmaceticals Inc. HAAH AND MMP-9 AS COMPLEMENTARY CANCER BIOMARKERS AND METASTASE PREDICTORS WHEN COMBINING THEM
CN107907689A (zh) * 2017-10-10 2018-04-13 北京大学 外泌体蛋白cd5l的检测方法
CN111269986A (zh) * 2020-03-24 2020-06-12 江西惠肽生物科技有限公司 外泌体中asph基因在肺癌早期诊断试剂盒中的应用

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US6835370B2 (en) * 1999-11-08 2004-12-28 Rhode Island Hospital Diagnosis and treatment of malignant neoplasms
US20080124718A1 (en) * 2006-01-27 2008-05-29 Panacea Pharmaceuticals, Inc. Methods of diagnosing, predicting therapeutic efficacy and screening for new therapeutic agents for leukemia
US20090298097A1 (en) * 2007-07-17 2009-12-03 Harris Pamela J Methods for the diagnosis of lung cancer
US20130178383A1 (en) * 2008-11-12 2013-07-11 David Spetzler Vesicle isolation methods
EP2730662A1 (en) * 2008-11-12 2014-05-14 Caris Life Sciences Luxembourg Holdings Methods and systems of using exosomes for determining phenotypes
US9128101B2 (en) * 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
WO2012115885A1 (en) * 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers
KR20140136805A (ko) * 2013-05-21 2014-12-01 건국대학교 산학협력단 신규한 인간 엑소좀 단백질 및 그 용도

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US20210148915A9 (en) 2021-05-20
WO2016040941A1 (en) 2016-03-17
EP3191841A1 (en) 2017-07-19
EP3191841A4 (en) 2018-03-14
CA2961004A1 (en) 2016-03-17
JP2017526931A (ja) 2017-09-14
US20160077098A1 (en) 2016-03-17
US20180203013A1 (en) 2018-07-19

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